JP6608807B2 - Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 - Google Patents
Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 Download PDFInfo
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- JP6608807B2 JP6608807B2 JP2016515681A JP2016515681A JP6608807B2 JP 6608807 B2 JP6608807 B2 JP 6608807B2 JP 2016515681 A JP2016515681 A JP 2016515681A JP 2016515681 A JP2016515681 A JP 2016515681A JP 6608807 B2 JP6608807 B2 JP 6608807B2
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- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201370297 | 2013-05-29 | ||
| DKPA201370297 | 2013-05-29 | ||
| US201361888259P | 2013-10-08 | 2013-10-08 | |
| US61/888,259 | 2013-10-08 | ||
| US201361907874P | 2013-11-22 | 2013-11-22 | |
| US201361907858P | 2013-11-22 | 2013-11-22 | |
| US61/907,874 | 2013-11-22 | ||
| US61/907,858 | 2013-11-22 | ||
| DKPA201370771 | 2013-12-13 | ||
| DKPA201370771 | 2013-12-13 | ||
| EPPCT/EP2014/051458 | 2014-01-24 | ||
| EP2014051458 | 2014-01-24 | ||
| PCT/EP2014/056534 WO2014191128A1 (en) | 2013-05-29 | 2014-04-01 | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018205501A Division JP2019047801A (ja) | 2013-05-29 | 2018-10-31 | Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525888A JP2016525888A (ja) | 2016-09-01 |
| JP2016525888A5 JP2016525888A5 (enExample) | 2018-12-13 |
| JP6608807B2 true JP6608807B2 (ja) | 2019-11-20 |
Family
ID=51988043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515681A Active JP6608807B2 (ja) | 2013-05-29 | 2014-04-01 | Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9890393B2 (enExample) |
| EP (2) | EP3309248B1 (enExample) |
| JP (1) | JP6608807B2 (enExample) |
| AU (1) | AU2014273490B2 (enExample) |
| CA (1) | CA2913830C (enExample) |
| DK (2) | DK3309248T3 (enExample) |
| ES (1) | ES2645393T3 (enExample) |
| WO (1) | WO2014191128A1 (enExample) |
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| US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| ES2633098T3 (es) * | 2009-11-02 | 2017-09-19 | Children's Healthcare Of Atlanta, Inc. | Inmunoterapia resistente a fármaco para el tratamiento de un cáncer |
| US20130065314A1 (en) | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
| US10391126B2 (en) * | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| CA3084919A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| EA201492222A1 (ru) | 2012-05-25 | 2015-05-29 | Селлектис | Способы конструирования неаллореактивной и устойчивой к иммуносупрессии т-клетки для иммунотерапии |
| EP2872526B1 (en) | 2012-07-13 | 2020-04-01 | The Trustees of the University of Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
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| US9890393B2 (en) | 2018-02-13 |
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| ES2645393T3 (es) | 2017-12-05 |
| EP3309248B1 (en) | 2021-06-09 |
| DK3004337T3 (da) | 2017-11-13 |
| EP3004337A1 (en) | 2016-04-13 |
| AU2014273490A1 (en) | 2015-12-17 |
| DK3309248T3 (da) | 2021-08-02 |
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