JP2017525355A5 - - Google Patents
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- Publication number
- JP2017525355A5 JP2017525355A5 JP2017506963A JP2017506963A JP2017525355A5 JP 2017525355 A5 JP2017525355 A5 JP 2017525355A5 JP 2017506963 A JP2017506963 A JP 2017506963A JP 2017506963 A JP2017506963 A JP 2017506963A JP 2017525355 A5 JP2017525355 A5 JP 2017525355A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- molecule according
- regulatory sequence
- operably linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1414130.3A GB201414130D0 (en) | 2014-08-08 | 2014-08-08 | Mutants of the bacteriophage lambda integrase |
| GB1414130.3 | 2014-08-08 | ||
| PCT/SG2015/050255 WO2016022075A1 (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525355A JP2017525355A (ja) | 2017-09-07 |
| JP2017525355A5 true JP2017525355A5 (enExample) | 2018-09-13 |
| JP6616822B2 JP6616822B2 (ja) | 2019-12-04 |
Family
ID=51629549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506963A Active JP6616822B2 (ja) | 2014-08-08 | 2015-08-11 | バクテリオファージ・ラムダ・インテグラーゼの変異体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10344301B2 (enExample) |
| EP (1) | EP3177717A4 (enExample) |
| JP (1) | JP6616822B2 (enExample) |
| CN (1) | CN108064279B (enExample) |
| GB (1) | GB201414130D0 (enExample) |
| SG (2) | SG11201700955SA (enExample) |
| WO (1) | WO2016022075A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
| GB201603577D0 (en) * | 2016-03-01 | 2016-04-13 | Oxford Genetics Ltd | Promoter |
| US11078493B2 (en) | 2016-06-21 | 2021-08-03 | Nanyang Technological University | Site-specific DNA recombination |
| PL3638776T3 (pl) | 2017-06-14 | 2026-02-23 | Technische Universität Dresden | Sposoby i środki do zmiany genetycznej genomów z wykorzystaniem projektowanych enzymów rekombinujących dna |
| US12566178B2 (en) | 2019-07-29 | 2026-03-03 | Larimar Therapeutics, Inc. | Methods of quantifying frataxin and frataxin fusion proteins |
| DK4004022T3 (da) * | 2019-07-29 | 2026-04-07 | Univ Indiana Trustees | Materialer og fremgangsmåder til behandling af friedreichs ataksi |
| US11988675B2 (en) | 2019-11-25 | 2024-05-21 | Larimar Therapeutics, Inc. | Methods for quantifying frataxin activity |
| BR112022021823A2 (pt) | 2020-04-30 | 2023-01-17 | Larimar Therapeutics Inc | Métodos para tratar doenças associadas à mielina e doenças associadas à mitocôndria |
| US12390509B2 (en) | 2020-12-12 | 2025-08-19 | Larimar Therapeutics, Inc. | Pharmaceutical composition comprising frataxin fusion protein and methods of use thereof |
| CN117178056A (zh) * | 2021-03-12 | 2023-12-05 | 南洋理工大学 | 用于生产无缝dna载体的方法 |
| CN119317717A (zh) * | 2022-05-31 | 2025-01-14 | 南洋理工大学 | 产生用于λ整合酶介导的重组的真核宿主细胞或细胞系的方法 |
| CN118546903A (zh) * | 2023-02-24 | 2024-08-27 | 尧唐(上海)生物科技有限公司 | 能介导大片段dna整合到哺乳动物基因组的酶及其应用 |
| WO2024181932A1 (en) * | 2023-03-02 | 2024-09-06 | Nanyang Technological University | Lambda integrase mutants and methods of their use |
| KR20260044268A (ko) | 2023-06-26 | 2026-04-01 | 유니버시티 오브 하와이 | 진화한 인테그라제 및 이를 이용한 게놈 편집 방법 |
| CN117417916A (zh) * | 2023-10-25 | 2024-01-19 | 南方科技大学 | 酪氨酸整合酶、核酸分子、载体、宿主细胞、应用、遗传操作工具 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4489424B2 (ja) * | 2001-05-30 | 2010-06-23 | グラクソ グループ リミテッド | 染色体に基くプラットホーム |
| CA2522166C (en) * | 2001-05-30 | 2011-05-03 | Chromos Molecular Systems, Inc. | Lambda integrase mutein for use in recombination |
| CN103396904B (zh) * | 2008-11-11 | 2015-12-23 | 宝洁公司 | 包含丝氨酸蛋白酶变体的组合物和方法 |
| SG170652A1 (en) * | 2009-11-06 | 2011-05-30 | Agency Science Tech & Res | Muteins of the bacteriophage lambda integrases |
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
-
2014
- 2014-08-08 GB GBGB1414130.3A patent/GB201414130D0/en not_active Ceased
-
2015
- 2015-08-11 SG SG11201700955SA patent/SG11201700955SA/en unknown
- 2015-08-11 WO PCT/SG2015/050255 patent/WO2016022075A1/en not_active Ceased
- 2015-08-11 US US15/502,783 patent/US10344301B2/en active Active
- 2015-08-11 JP JP2017506963A patent/JP6616822B2/ja active Active
- 2015-08-11 EP EP15829802.6A patent/EP3177717A4/en active Pending
- 2015-08-11 CN CN201580054345.8A patent/CN108064279B/zh active Active
- 2015-08-11 SG SG10202005089XA patent/SG10202005089XA/en unknown
-
2019
- 2019-06-03 US US16/430,410 patent/US11414681B2/en active Active