GB201414130D0 - Mutants of the bacteriophage lambda integrase - Google Patents

Mutants of the bacteriophage lambda integrase

Info

Publication number
GB201414130D0
GB201414130D0 GBGB1414130.3A GB201414130A GB201414130D0 GB 201414130 D0 GB201414130 D0 GB 201414130D0 GB 201414130 A GB201414130 A GB 201414130A GB 201414130 D0 GB201414130 D0 GB 201414130D0
Authority
GB
United Kingdom
Prior art keywords
mutants
bacteriophage lambda
lambda integrase
integrase
bacteriophage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1414130.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science, Technology and Research
Original Assignee
Agency for Science, Technology and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Science, Technology and Research filed Critical Agency for Science, Technology and Research
Priority to GBGB1414130.3A priority Critical patent/GB201414130D0/en
Publication of GB201414130D0 publication Critical patent/GB201414130D0/en
Priority to SG11201700955SA priority patent/SG11201700955SA/en
Priority to US15/502,783 priority patent/US10344301B2/en
Priority to CN201580054345.8A priority patent/CN108064279B/zh
Priority to SG10202005089XA priority patent/SG10202005089XA/en
Priority to JP2017506963A priority patent/JP6616822B2/ja
Priority to PCT/SG2015/050255 priority patent/WO2016022075A1/en
Priority to EP15829802.6A priority patent/EP3177717A4/en
Priority to US16/430,410 priority patent/US11414681B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
GBGB1414130.3A 2014-08-08 2014-08-08 Mutants of the bacteriophage lambda integrase Ceased GB201414130D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB1414130.3A GB201414130D0 (en) 2014-08-08 2014-08-08 Mutants of the bacteriophage lambda integrase
SG11201700955SA SG11201700955SA (en) 2014-08-08 2015-08-11 Mutants of the bacteriophage lambda integrase
US15/502,783 US10344301B2 (en) 2014-08-08 2015-08-11 Mutants of the bacteriophage lambda integrase
CN201580054345.8A CN108064279B (zh) 2014-08-08 2015-08-11 噬菌体λ整合酶的突变体
SG10202005089XA SG10202005089XA (en) 2014-08-08 2015-08-11 Mutants of the bacteriophage lambda integrase
JP2017506963A JP6616822B2 (ja) 2014-08-08 2015-08-11 バクテリオファージ・ラムダ・インテグラーゼの変異体
PCT/SG2015/050255 WO2016022075A1 (en) 2014-08-08 2015-08-11 Mutants of the bacteriophage lambda integrase
EP15829802.6A EP3177717A4 (en) 2014-08-08 2015-08-11 Mutants of the bacteriophage lambda integrase
US16/430,410 US11414681B2 (en) 2014-08-08 2019-06-03 Mutants of the bacteriophage lambda integrase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1414130.3A GB201414130D0 (en) 2014-08-08 2014-08-08 Mutants of the bacteriophage lambda integrase

Publications (1)

Publication Number Publication Date
GB201414130D0 true GB201414130D0 (en) 2014-09-24

Family

ID=51629549

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1414130.3A Ceased GB201414130D0 (en) 2014-08-08 2014-08-08 Mutants of the bacteriophage lambda integrase

Country Status (7)

Country Link
US (2) US10344301B2 (enExample)
EP (1) EP3177717A4 (enExample)
JP (1) JP6616822B2 (enExample)
CN (1) CN108064279B (enExample)
GB (1) GB201414130D0 (enExample)
SG (2) SG11201700955SA (enExample)
WO (1) WO2016022075A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201414130D0 (en) * 2014-08-08 2014-09-24 Agency Science Tech & Res Mutants of the bacteriophage lambda integrase
GB201603577D0 (en) * 2016-03-01 2016-04-13 Oxford Genetics Ltd Promoter
US11078493B2 (en) 2016-06-21 2021-08-03 Nanyang Technological University Site-specific DNA recombination
PL3638776T3 (pl) 2017-06-14 2026-02-23 Technische Universität Dresden Sposoby i środki do zmiany genetycznej genomów z wykorzystaniem projektowanych enzymów rekombinujących dna
US12566178B2 (en) 2019-07-29 2026-03-03 Larimar Therapeutics, Inc. Methods of quantifying frataxin and frataxin fusion proteins
DK4004022T3 (da) * 2019-07-29 2026-04-07 Univ Indiana Trustees Materialer og fremgangsmåder til behandling af friedreichs ataksi
US11988675B2 (en) 2019-11-25 2024-05-21 Larimar Therapeutics, Inc. Methods for quantifying frataxin activity
BR112022021823A2 (pt) 2020-04-30 2023-01-17 Larimar Therapeutics Inc Métodos para tratar doenças associadas à mielina e doenças associadas à mitocôndria
US12390509B2 (en) 2020-12-12 2025-08-19 Larimar Therapeutics, Inc. Pharmaceutical composition comprising frataxin fusion protein and methods of use thereof
CN117178056A (zh) * 2021-03-12 2023-12-05 南洋理工大学 用于生产无缝dna载体的方法
CN119317717A (zh) * 2022-05-31 2025-01-14 南洋理工大学 产生用于λ整合酶介导的重组的真核宿主细胞或细胞系的方法
CN118546903A (zh) * 2023-02-24 2024-08-27 尧唐(上海)生物科技有限公司 能介导大片段dna整合到哺乳动物基因组的酶及其应用
WO2024181932A1 (en) * 2023-03-02 2024-09-06 Nanyang Technological University Lambda integrase mutants and methods of their use
KR20260044268A (ko) 2023-06-26 2026-04-01 유니버시티 오브 하와이 진화한 인테그라제 및 이를 이용한 게놈 편집 방법
CN117417916A (zh) * 2023-10-25 2024-01-19 南方科技大学 酪氨酸整合酶、核酸分子、载体、宿主细胞、应用、遗传操作工具

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4489424B2 (ja) * 2001-05-30 2010-06-23 グラクソ グループ リミテッド 染色体に基くプラットホーム
CA2522166C (en) * 2001-05-30 2011-05-03 Chromos Molecular Systems, Inc. Lambda integrase mutein for use in recombination
CN103396904B (zh) * 2008-11-11 2015-12-23 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法
SG170652A1 (en) * 2009-11-06 2011-05-30 Agency Science Tech & Res Muteins of the bacteriophage lambda integrases
GB201414130D0 (en) * 2014-08-08 2014-09-24 Agency Science Tech & Res Mutants of the bacteriophage lambda integrase

Also Published As

Publication number Publication date
US11414681B2 (en) 2022-08-16
US20170327847A1 (en) 2017-11-16
WO2016022075A1 (en) 2016-02-11
US10344301B2 (en) 2019-07-09
CN108064279A (zh) 2018-05-22
JP6616822B2 (ja) 2019-12-04
EP3177717A4 (en) 2017-12-27
EP3177717A1 (en) 2017-06-14
SG10202005089XA (en) 2020-07-29
SG11201700955SA (en) 2017-03-30
JP2017525355A (ja) 2017-09-07
CN108064279B (zh) 2022-03-11
US20200063165A1 (en) 2020-02-27

Similar Documents

Publication Publication Date Title
SG10202005089XA (en) Mutants of the bacteriophage lambda integrase
IL247515A0 (en) Snekribirock for the treatment of leprosy
SI3380530T1 (sl) Izboljšan postopek za pripravo sugamadeksa in njegovih intermediatov
IL254476A0 (en) Heterocyclylmethyl-thianouracil as adenosine-a2b receptor antagonists
PL3133153T3 (pl) Nowy bakteriofag i zawierająca go kompozycja
LT3201323T (lt) Bakteriofagų modifikavimas
IL253617A0 (en) Snekribirock for the treatment of leprosy
GB201417805D0 (en) Modifield bacteriophage
PL3133151T3 (pl) Nowy bakteriofag i zawierająca go kompozycja
ZA201702248B (en) Recombinase mutants
IL258137A (en) HIV treatment measures
GB201417808D0 (en) Modified bacteriophage
GB201614687D0 (en) fHbp scaffold
ZA201608823B (en) Processes for the preparation of azd5363 and novel intermediate used therein
IL255819A (en) An improved process for the preparation of sofosbuvir and intermediates
GB201417811D0 (en) Modifying bacteriophage
PL3135761T3 (pl) Nowy bakteriofag i zawierająca go kompozycja
PT3440200T (pt) Bacteriófago modificado
IL253077A0 (en) Process and intermediates for the preparation of Fermpanel
GB2544957B (en) Modifying bacteriophage
GB201402924D0 (en) The theory of instantransmission
GB201600495D0 (en) Shotguns
GB201603145D0 (en) Postie Mate
GB201515981D0 (en) Crutch resistant
SG10201402964RA (en) Dehydration of 2,3-butanediole

Legal Events

Date Code Title Description
COOA Change in applicant's name or ownership of the application

Owner name: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Free format text: FORMER OWNERS: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NANYANG TECHNOLOGICAL UNIVERSITY

AT Applications terminated before publication under section 16(1)