JP2016506743A5 - - Google Patents

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JP2016506743A5
JP2016506743A5 JP2015556536A JP2015556536A JP2016506743A5 JP 2016506743 A5 JP2016506743 A5 JP 2016506743A5 JP 2015556536 A JP2015556536 A JP 2015556536A JP 2015556536 A JP2015556536 A JP 2015556536A JP 2016506743 A5 JP2016506743 A5 JP 2016506743A5
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glucose
seq
steviol
amino acid
acid sequence
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JP2015556536A
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JP2016506743A (ja
JP6576247B2 (ja
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Priority claimed from PCT/EP2014/052675 external-priority patent/WO2014122328A1/en
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JP2015556536A 2013-02-11 2014-02-11 組み換え宿主におけるステビオールグリコシドの効率的生産 Expired - Fee Related JP6576247B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361763308P 2013-02-11 2013-02-11
US201361763290P 2013-02-11 2013-02-11
US61/763,308 2013-02-11
US61/763,290 2013-02-11
PCT/EP2014/052675 WO2014122328A1 (en) 2013-02-11 2014-02-11 Efficient production of steviol glycosides in recombinant hosts

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JP2019072616A Division JP2019162110A (ja) 2013-02-11 2019-04-05 組み換え宿主におけるステビオールグリコシドの効率的生産

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JP2016506743A JP2016506743A (ja) 2016-03-07
JP2016506743A5 true JP2016506743A5 (enExample) 2017-03-16
JP6576247B2 JP6576247B2 (ja) 2019-09-18

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JP2019072616A Withdrawn JP2019162110A (ja) 2013-02-11 2019-04-05 組み換え宿主におけるステビオールグリコシドの効率的生産

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US (3) US10017804B2 (enExample)
EP (1) EP2954061B1 (enExample)
JP (2) JP6576247B2 (enExample)
KR (1) KR20150128705A (enExample)
CN (1) CN105189771B (enExample)
AU (2) AU2014213918B2 (enExample)
BR (1) BR112015019160A2 (enExample)
CA (1) CA2900882A1 (enExample)
MX (1) MX2015010098A (enExample)
MY (1) MY184253A (enExample)
SG (2) SG11201506127WA (enExample)
WO (1) WO2014122328A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016130609A1 (en) * 2015-02-10 2016-08-18 Purecircle Usa Inc. Rebaudioside m biosynthetic production and recovery methods
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
EP2742142B2 (en) 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
MX395285B (es) 2012-05-22 2025-03-25 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10689681B2 (en) * 2013-05-31 2020-06-23 Dsm Ip Assets B.V. Microorganisms for diterpene production
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
EP3003058B2 (en) 2013-06-07 2023-06-28 Purecircle Usa Inc. Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
WO2015007748A1 (en) * 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
US10370418B2 (en) * 2014-05-20 2019-08-06 Lawrence Livermore National Security, Llc Engineered microorganisms having resistance to ionic liquids
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
WO2016036578A1 (en) 2014-09-02 2016-03-10 Purecircle Sdn Bhd Stevia extracts
JP2017528134A (ja) * 2014-09-09 2017-09-28 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの生産
KR102557670B1 (ko) 2014-10-03 2023-07-20 코나겐 인크. 비칼로리 감미료 및 합성 방법
EP3204506B1 (en) * 2014-10-08 2022-01-12 DSM IP Assets B.V. Steviol glycoside production
CA2968280A1 (en) * 2014-11-24 2016-06-02 Cargill, Incorporated Glycoside compositions
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
BR112017016338A2 (en) * 2015-01-30 2018-03-27 Evolva Sa production of steviol glycosides in recombinant hosts
CA3255837A1 (en) 2015-03-16 2025-10-30 Dsm Ip Assets B.V. Udp-glycosyltransferases
CN113683712B (zh) 2015-04-03 2022-10-21 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷
AU2016264732A1 (en) 2015-05-20 2017-11-30 Cargill, Incorporated Glycoside compositions
AU2016271628B2 (en) 2015-05-29 2020-01-30 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom
CN107614677A (zh) * 2015-05-29 2018-01-19 嘉吉公司 用于使用多阶段进料生产甜菊醇糖苷的发酵方法
AU2016271125A1 (en) 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
CN105154348B (zh) * 2015-08-05 2018-05-04 大连理工大学 一种提高酿酒酵母对纤维素水解液抑制物耐受性的方法
CA2994288A1 (en) 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
JP2018522569A (ja) * 2015-08-07 2018-08-16 エヴォルヴァ エスアー.Evolva Sa. 組換え宿主内でのステビオールグリコシドの産生
US20180230505A1 (en) 2015-08-13 2018-08-16 Dsm Ip Assets B.V. Steviol glycoside transport
CN107922465B (zh) * 2015-08-13 2021-12-24 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
EP3337893B1 (en) 2015-08-21 2023-07-19 Manus Bio Inc. Increasing productivity of e. coli host cells that functionally express p450 enzymes
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
EP3141610A1 (en) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
PL3367816T3 (pl) 2015-10-26 2024-05-06 Purecircle Usa Inc. Kompozycje glikozydów stewiolowych
RU2764635C2 (ru) 2015-12-15 2022-01-19 ПЬЮРСЁРКЛ ЮЭсЭй ИНК. Композиция стевиол гликозида
CN109154010A (zh) 2016-03-11 2019-01-04 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
MY198001A (en) * 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3471744A4 (en) 2016-06-15 2020-07-29 Codexis, Inc. REVISED BETA-GLUCOSIDASES AND GLUCOSYLATION PROCESSES
WO2017218324A1 (en) * 2016-06-15 2017-12-21 Codexis, Inc. Enzymatic glycosylation of steviol glycosides and other compounds with glucose-1-phosphate
EP3471559A4 (en) * 2016-06-17 2020-04-08 Cargill, Incorporated STEVIOL GLYCOSIDE COMPOSITIONS FOR ORAL INGESTION OR USE
WO2018031955A2 (en) 2016-08-12 2018-02-15 Amyris, Inc. Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
CN116064264B (zh) * 2016-11-23 2025-01-28 中国科学院天津工业生物技术研究所 一种产生对萜类或含萜精油的耐受性提高的重组宿主细胞的方法及其用途
EP3564369A4 (en) 2016-12-27 2020-07-29 Suntory Holdings Limited STEVIOL GLYCOSIDE HEXOSE TRANSFERASE AND CODING GENE FOR THIS
JP7330888B2 (ja) 2017-01-26 2023-08-22 マナス バイオ インコーポレイテッド テルペノイド産物を微生物生産するための代謝工学
KR20260006703A (ko) 2017-02-03 2026-01-13 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
AU2018215537B2 (en) 2017-02-03 2023-11-09 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
WO2018190378A1 (ja) 2017-04-12 2018-10-18 サントリーホールディングス株式会社 ステビア由来ラムノース合成酵素及び遺伝子
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3068459A1 (en) * 2017-06-30 2019-01-03 Ptt Global Chemical Public Company Limited Microorganism with stabilized copy number of functional dna sequence and associated methods
US11365417B2 (en) 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
US20200347425A1 (en) * 2017-11-20 2020-11-05 Manus Bio, Inc. Microbial host cells for production of steviol glycosides
US20200291442A1 (en) 2017-12-05 2020-09-17 Evolva Sa Production of steviol glycosides in recombinant hosts
CN108070602B (zh) * 2017-12-12 2020-11-06 山东隆科特酶制剂有限公司 一种减少及推迟芽孢杆菌芽孢生成的分子改造方法
EP3788059B1 (en) 2018-04-30 2025-08-13 DSM IP Assets B.V. Steviol glycoside transport
KR101929158B1 (ko) * 2018-06-07 2018-12-13 씨제이제일제당 (주) 5'-크산틸산을 생산하는 미생물 및 이를 이용한 5'-크산틸산의 제조방법
IL319918A (en) 2018-07-30 2025-05-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside
CA3118924A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
PH12021551733A1 (en) * 2019-01-24 2022-07-25 Amyris Inc Abc transporters for the high efficiency production of rebaudiosides
SG11202111698SA (en) 2019-05-03 2021-11-29 Amyris Inc Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof
CN112322648A (zh) * 2019-07-30 2021-02-05 上海市农业科学院 一种abc转运蛋白基因mrp1s及其制备方法和应用
EP4044823A4 (en) * 2019-10-16 2024-04-24 Sweegen, Inc. STEVIOL GLYCOSIDE FORMULATIONS FOR FOOD AND BEVERAGES
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
EP4143213A1 (en) * 2020-04-27 2023-03-08 Université Libre de Bruxelles Yeast strains for reducing contamination by lactic acid bacteria
CN114214378A (zh) * 2021-11-23 2022-03-22 安徽金禾实业股份有限公司 一种利用枯草芽孢杆菌发酵催化制备莱鲍迪苷m的方法
EP4453228A4 (en) * 2021-12-24 2025-09-10 Univ California SAPONIN PRODUCTION IN YEAST
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用
CN119372219B (zh) * 2024-12-11 2026-01-02 华中农业大学 香菇ABC转运蛋白基因LeABC2及其在调控香菇耐热性中的应用
CN119639706A (zh) * 2024-12-24 2025-03-18 铭诚惠众(江苏)药物研究有限公司 一种糖基转移酶srUGT76G1及其在Reb M的生产中的应用
CN120905108B (zh) * 2025-07-29 2026-08-07 南京合谷生命生物科技有限公司 一种提高n-乙酰观蓝产物沉降性的基因工程菌株及其构建方法与应用

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
JPS591408A (ja) 1982-06-28 1984-01-06 Fukue Ito ヘヤ−トニツクの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
CN1129953A (zh) 1993-07-15 1996-08-28 尼奥斯药品公司 糖组分的合成方法
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
WO1999018224A1 (en) 1997-10-06 1999-04-15 The Centre National De Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
CA2630341C (en) 1998-04-14 2011-07-26 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
ATE490332T1 (de) 1998-07-06 2010-12-15 Dcv Inc Verfahren zur vitaminherstellung
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
PT1190068E (pt) 1999-04-15 2006-06-30 Calgene Llc Sequencias de acidos nucleicos para proteinas envolvidas na sintese de tocoferol
WO2000063400A2 (en) 1999-04-21 2000-10-26 The Samuel Roberts Noble Foundation Plant transformation process
DE60036477T2 (de) 1999-08-04 2008-06-12 Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. Isoprenoid biosynthese
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2420555C (en) 2000-08-24 2012-10-23 The Scripps Research Institute Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
CA2422730A1 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
US20030219798A1 (en) 2000-09-29 2003-11-27 Gokarn Ravi R. Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
WO2002059297A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S A library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
KR100704072B1 (ko) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
WO2003008540A2 (en) 2001-06-22 2003-01-30 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) * 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
AU2003273922A1 (en) 2002-09-27 2004-04-19 Dsm Ip Assets B.V. Squalene synthase 8sqs9 gen
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
ES2323175T3 (es) 2003-06-12 2009-07-08 Dsm Ip Assets B.V. Mevalonato-quinasas resistentes a la retroalimentacion.
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
EP1765418B1 (en) 2004-05-21 2011-12-14 The Regents of the University of California Method for enhancing production of isoprenoid compounds
WO2006069610A2 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
JPWO2006016395A1 (ja) 2004-08-09 2008-05-01 国立大学法人東北大学 Udp−グルクロニル基転移酵素およびその遺伝子
EP1778843B1 (en) 2004-08-19 2012-09-19 DSM IP Assets B.V. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
CN101080490B (zh) 2004-12-14 2012-08-15 帝斯曼知识产权资产管理有限公司 改进的甲羟戊酸激酶
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
JP4284562B2 (ja) 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Udp−キシロースの製造方法
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
US7989677B2 (en) 2005-08-17 2011-08-02 Nestec S. A. Nucleic acids and proteins associated with sucrose accumulation in coffee
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
KR101374346B1 (ko) 2005-11-23 2014-03-14 더 코카콜라 컴파니 시간 특성 및/또는 향미 특성이 개선된 천연 고효능 감미료조성물, 그 제제 방법 및 용도
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007136847A2 (en) 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
BRPI0716954B1 (pt) 2006-09-26 2024-04-30 The Regents Of The University Of California Microrganismos geneticamente modificados capazes de produzir um isoprenóide
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
AU2008254423C1 (en) 2007-05-17 2016-06-02 Eastman Renewable Materials, Llc Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
EP2594645A3 (en) 2007-09-21 2013-11-06 BASF Plant Science GmbH Plants with increased yield
JP5584937B2 (ja) 2007-12-03 2014-09-10 ディーエスエム アイピー アセッツ ビー.ブイ. ステビア抽出物またはステビア抽出物構成物質を含有する新規な栄養補給食品組成物およびその使用
CA2710629C (en) 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
EP2250268A4 (en) 2008-02-20 2011-08-24 Ceres Inc IMPROVED NITROGEN USE OF EFFICIENCY PROPERTIES IN PLANT NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES
TWI475963B (zh) 2008-02-25 2015-03-11 可口可樂公司 甜菊糖苷a衍生性產物以及製造彼的方法
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
WO2009140394A1 (en) 2008-05-13 2009-11-19 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
ES2592377T3 (es) * 2008-10-03 2016-11-29 Morita Kagaku Kogyo Co., Ltd. Nuevos glucósidos de esteviol
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品(漳州)有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
MX2011013231A (es) 2009-06-08 2012-01-20 Jennewein Biotechnologie Gmbh Sintesis de hmo.
WO2010146463A2 (en) 2009-06-16 2010-12-23 Cpc (Tianjin) Fine Chemicals Co., Ltd. Process for rebaudioside d
SG178376A1 (en) 2009-09-04 2012-03-29 Redpoint Bio Corp Sweetness enhancers including rebaudioside a or d
AU2010298437B2 (en) 2009-09-22 2014-06-19 Redpoint Bio Corporation Novel polymorphs of rebaudioside C and methods for making and using the same
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
CA2775732C (en) 2009-10-15 2018-10-09 Purecircle Sdn Bhd High-purity rebaudioside d and applications
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
BR112012011073B8 (pt) 2009-11-10 2023-01-10 Massachusetts Inst Technology Método para aumentar a produção de terpenoide em uma célula que produz um ou mais terpenoides
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
PT2816112T (pt) 2009-12-10 2018-11-20 Univ Iowa State Res Found Inc Modificação do adn modificada pelo efector tal
WO2011090709A1 (en) 2009-12-28 2011-07-28 The Coca-Cola Company Sweetness enhancers, compositions thereof, and methods for use
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
WO2011146833A1 (en) 2010-05-20 2011-11-24 Evolva Inc. Method of producing isoprenoid compounds in yeast
EP2575499A2 (en) * 2010-05-31 2013-04-10 Vib Vzw The use of transporters to modulate flavor production by yeast
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120050021A1 (en) 2010-08-27 2012-03-01 Ford Global Technologies, Llc Method and Apparatus for In-Vehicle Presence Detection and Driver Alerting
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
CA2819253A1 (en) 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
HK1199286A1 (en) 2011-08-08 2015-06-26 Evolva Sa Methods and materials for recombinant production of saffron compounds
EP2742142B2 (en) 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
EP2783009B1 (en) 2011-11-23 2016-04-13 Evolva SA Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
CA3152828A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
JP6251669B2 (ja) 2012-03-16 2017-12-20 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
MX395285B (es) 2012-05-22 2025-03-25 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
WO2014048392A1 (zh) 2012-09-29 2014-04-03 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
EP2928321A1 (en) 2012-12-05 2015-10-14 Evolva SA Steviol glycoside compositions sensory properties
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10689681B2 (en) 2013-05-31 2020-06-23 Dsm Ip Assets B.V. Microorganisms for diterpene production
CN105247064A (zh) 2013-05-31 2016-01-13 帝斯曼知识产权资产管理有限公司 细胞外的二萜生产
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
WO2015007748A1 (en) 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
CA2917615A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
EP3042953A4 (en) 2013-08-02 2017-07-12 Suntory Holdings Limited Method for using hexenol glycosyl transferase
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US20160215306A1 (en) 2013-08-30 2016-07-28 Evolva Sa Method for producing modified resveratrol
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの生産
BR112017016338A2 (en) 2015-01-30 2018-03-27 Evolva Sa production of steviol glycosides in recombinant hosts
CN104845990A (zh) 2015-06-11 2015-08-19 山东大学 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用
JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー.Evolva Sa. 組換え宿主内でのステビオールグリコシドの産生

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