JP2016065060A5 - - Google Patents
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- JP2016065060A5 JP2016065060A5 JP2015208065A JP2015208065A JP2016065060A5 JP 2016065060 A5 JP2016065060 A5 JP 2016065060A5 JP 2015208065 A JP2015208065 A JP 2015208065A JP 2015208065 A JP2015208065 A JP 2015208065A JP 2016065060 A5 JP2016065060 A5 JP 2016065060A5
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- JP
- Japan
- Prior art keywords
- composition
- peptibody
- seq
- terminus
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 10
- 230000001225 therapeutic effect Effects 0.000 claims 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79399706P | 2006-04-21 | 2006-04-21 | |
| US60/793,997 | 2006-04-21 | ||
| US11/788,697 | 2007-04-19 | ||
| US11/788,697 US9283260B2 (en) | 2006-04-21 | 2007-04-19 | Lyophilized therapeutic peptibody formulations |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013201931A Division JP5873854B2 (ja) | 2006-04-21 | 2013-09-27 | 凍結乾燥された治療用ペプチボディ製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111720A Division JP6787953B2 (ja) | 2006-04-21 | 2018-06-12 | 凍結乾燥された治療用ペプチボディ製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016065060A JP2016065060A (ja) | 2016-04-28 |
| JP2016065060A5 true JP2016065060A5 (enExample) | 2016-07-14 |
| JP6356106B2 JP6356106B2 (ja) | 2018-07-11 |
Family
ID=38625630
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506615A Active JP5432705B2 (ja) | 2006-04-21 | 2007-04-20 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2013201931A Active JP5873854B2 (ja) | 2006-04-21 | 2013-09-27 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2015208065A Active JP6356106B2 (ja) | 2006-04-21 | 2015-10-22 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2018111720A Active JP6787953B2 (ja) | 2006-04-21 | 2018-06-12 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2020128961A Pending JP2021006525A (ja) | 2006-04-21 | 2020-07-30 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2022130437A Pending JP2022166219A (ja) | 2006-04-21 | 2022-08-18 | 凍結乾燥された治療用ペプチボディ製剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506615A Active JP5432705B2 (ja) | 2006-04-21 | 2007-04-20 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2013201931A Active JP5873854B2 (ja) | 2006-04-21 | 2013-09-27 | 凍結乾燥された治療用ペプチボディ製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111720A Active JP6787953B2 (ja) | 2006-04-21 | 2018-06-12 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2020128961A Pending JP2021006525A (ja) | 2006-04-21 | 2020-07-30 | 凍結乾燥された治療用ペプチボディ製剤 |
| JP2022130437A Pending JP2022166219A (ja) | 2006-04-21 | 2022-08-18 | 凍結乾燥された治療用ペプチボディ製剤 |
Country Status (38)
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL219605B1 (pl) | 1998-10-23 | 2015-06-30 | Kirin Amgen Inc | Dimeryczne mimetyki peptydów trombopoetynowych wiążące się z receptorem MP1 i wykazujące aktywność trombopoetyczną |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| DE60035260T2 (de) | 1999-02-22 | 2007-10-18 | The University Of Connecticut, Farmington | Neue albuminfreie faktor viii formulierungen |
| SI1488806T1 (sl) | 1999-06-01 | 2016-02-29 | Biogen Ma Inc. | Blokirno monoklonsko protitelo proti vla-1 in njegova uporaba za zdravljenje žilnih obolenj |
| SK288124B6 (sk) | 2001-04-13 | 2013-09-03 | Biogen Idec Ma Inc. | Anti-VLA-1 antibody, composition comprising such antibodies, isolated nucleic acids sequence, use of composition, in vitro method of determining level of VLA-1 in tissue, cell of cell line hAQC2, haAQC2, hsAQC2 or hybridoma mAQC2 and method for identifying inhibitor of I domain of integrin |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CA2638823A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| AU2007235251B2 (en) | 2006-04-07 | 2013-02-07 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| JO3324B1 (ar) * | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| AU2011265555B2 (en) * | 2006-04-21 | 2016-03-10 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| AU2007267579B2 (en) | 2006-05-25 | 2013-05-30 | Biogen Ma Inc. | Methods of treating stroke |
| BRPI0912384A2 (pt) | 2008-05-07 | 2015-10-13 | Merrion Res Iii Ltd | composição, e, método para preparar uma composição |
| AU2009313325B2 (en) | 2008-11-07 | 2014-05-01 | Takeda Pharmaceutical Company Limited | Factor VIII formulations |
| US20120183546A1 (en) | 2009-09-23 | 2012-07-19 | Amgen Inc. | Treatment of ovarian cancer using a specific binding agent of human angiopoietin-2 in combination with a taxane |
| MX2012008453A (es) * | 2010-01-19 | 2012-11-21 | Hanmi Science Co Ltd | Formulaciones liquiddas para un conjugado de eritropoientina de accion prolongada. |
| US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| CA2819236A1 (en) | 2010-12-02 | 2012-06-07 | Oncolytics Biotech Inc. | Lyophilized viral formulations |
| WO2012075379A2 (en) | 2010-12-02 | 2012-06-07 | Oncolytics Biotech Inc. | Liquid viral formulations |
| JP5759211B2 (ja) * | 2011-03-11 | 2015-08-05 | 三洋化成工業株式会社 | 凍結乾燥方法 |
| JP6069312B2 (ja) | 2011-06-29 | 2017-02-01 | アムジェン インコーポレイテッド | 腎細胞癌の治療における生存の予測バイオマーカー |
| DE102011055889B4 (de) * | 2011-11-30 | 2013-08-01 | Otc Gmbh | Verfahren zur Herstellung eines Protein-Hydrolysates |
| CN102586217A (zh) * | 2011-12-16 | 2012-07-18 | 深圳市海普瑞药业股份有限公司 | 肝素黄杆菌肝素酶ⅰ、ⅱ、ⅲ的冻干保存方法 |
| RU2482128C1 (ru) * | 2011-12-28 | 2013-05-20 | Замертон Холдингс Лимитед | Пептиды, обладающие цитопротекторной активностью |
| WO2013123114A2 (en) | 2012-02-16 | 2013-08-22 | Santarus, Inc. | Antibody formulations |
| EP2644186A1 (en) * | 2012-03-26 | 2013-10-02 | OTC GmbH | Hair conditioning composition for permanent and semi-permanent hair coloration applications |
| EP2863898A4 (en) * | 2012-06-25 | 2016-04-27 | Emergent Product Dev Gaithersburg Inc | STABLE TEMPERATURE VACCINE FORMULATIONS |
| CA2928851A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| EP2698162A1 (en) * | 2012-08-15 | 2014-02-19 | Credentis AG | Method for producing a composition for treating a tooth lesion |
| CA2906835A1 (en) * | 2013-03-15 | 2014-09-18 | Amgen Inc. | Myostatin antagonism in human subjects |
| CN104274827B (zh) * | 2013-07-01 | 2020-07-14 | 上海贺普药业股份有限公司 | 贺普拉肽的制剂 |
| WO2015035405A1 (en) * | 2013-09-09 | 2015-03-12 | Pinta Biotherapeutics, Inc. | Myostatin antagonist for treatment of pew in esrd patients |
| RU2684915C2 (ru) * | 2013-11-07 | 2019-04-16 | Др. Аугуст Вольфф Гмбх Унд Ко. Кг Арцнаймиттель | Устойчивые при хранении лиофилизованные составы трипептидов |
| US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3076992B1 (en) * | 2013-12-06 | 2022-04-06 | The Broad Institute, Inc. | Formulations for neoplasia vaccines |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| WO2015100344A1 (en) | 2013-12-27 | 2015-07-02 | Emergent Product Development Gaithersburg Inc. | Temperature stable vaccine formulations |
| WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
| EP3125923B1 (en) * | 2014-03-29 | 2024-10-16 | Intas Pharmaceuticals Limited | Lyophilized pharmaceutical composition of fc-peptide fusion protein |
| CN106661126B (zh) * | 2014-05-28 | 2021-12-10 | 诺诺公司 | TAT-NR2B9c的氯盐 |
| EA201692568A1 (ru) * | 2014-06-13 | 2017-05-31 | Санта Мария Биотерапевтикс, Инк. | Составы с полипептидами-рецепторами и связанные с ними способы |
| CN113171447B (zh) * | 2014-08-20 | 2024-05-17 | 博尔托拉制药公司 | Xa因子解毒剂的冻干制剂 |
| JP6671141B2 (ja) * | 2014-10-21 | 2020-03-25 | 大日本住友製薬株式会社 | 懸濁液剤 |
| WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
| EP3250191B1 (en) | 2015-01-29 | 2024-01-17 | Novo Nordisk A/S | Tablets comprising glp-1 agonist and enteric coating |
| US10857229B2 (en) | 2015-04-30 | 2020-12-08 | Amgen Inc. | Treatment of ovarian cancer in patients with ascites using a specific binding agent of human angiopoietin-2 in combination with a taxane |
| IL302102A (en) | 2015-05-20 | 2023-06-01 | Dana Farber Cancer Inst Inc | shared neoantigens |
| CN108601819B (zh) | 2015-12-17 | 2022-03-15 | 约翰霍普金斯大学 | 用死亡受体激动剂改善系统性硬化症 |
| WO2017118703A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with low initial npr-b activity |
| WO2017118698A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with carrier attachment at the ring moiety |
| CN108472380B (zh) | 2016-01-08 | 2022-03-01 | 阿森迪斯药物生长障碍股份有限公司 | 具有增加的nep稳定性的控制释放cnp激动剂 |
| JP6992262B2 (ja) * | 2016-03-31 | 2022-02-15 | 東ソー株式会社 | 変性抗体測定試薬の製造方法 |
| CA3020339C (en) | 2016-04-07 | 2022-05-03 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
| GB201608323D0 (en) | 2016-05-12 | 2016-06-29 | Ucb Biopharma Sprl | Pharmaceutical compositions |
| EP3454903A4 (en) * | 2016-05-13 | 2020-08-19 | Askgene Pharma, Inc. | NEW DOUBLE ANTAGONISTS OF ANGIOPOIETIN 2, VEGF |
| AU2017366709A1 (en) | 2016-12-02 | 2019-07-18 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| EP3574116A1 (en) | 2017-01-24 | 2019-12-04 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| JP2017155046A (ja) * | 2017-04-05 | 2017-09-07 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
| PT3681483T (pt) | 2017-09-15 | 2022-08-22 | Amgen Inc | Processo para formulação farmacêutica liofilizada de uma proteína terapêutica |
| WO2019055902A1 (en) * | 2017-09-18 | 2019-03-21 | Amgen Inc. | FUSION PROTEIN FORMULATIONS VEGFR-FC |
| US20200390693A1 (en) * | 2017-12-22 | 2020-12-17 | Samsung Bioepis Co., Ltd. | Liquid composition comprising vegf antagonist |
| CN108159413B (zh) * | 2018-01-10 | 2021-07-06 | 杭州洪桥中科基因技术有限公司 | 一种动物用冻干活疫苗及其制备方法 |
| GB201804835D0 (en) * | 2018-03-26 | 2018-05-09 | Ge Healthcare As | Formulation and method of preparation |
| TW202015723A (zh) | 2018-05-18 | 2020-05-01 | 美商百歐維拉提夫治療公司 | 治療a型血友病的方法 |
| JP7412409B2 (ja) * | 2018-07-31 | 2024-01-12 | アムジェン インコーポレイテッド | マスクされた抗体の医薬製剤 |
| MX2021008708A (es) | 2019-02-11 | 2021-09-21 | Ascendis Pharma Growth Disorders As | Formulaciones farmaceuticas secas de conjugados de peptido natriuretico tipo c (cnp). |
| US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
| CN113660953A (zh) * | 2019-04-01 | 2021-11-16 | 豪夫迈·罗氏有限公司 | 用于稳定含蛋白质制剂的组合物和方法 |
| EP3736574A1 (en) * | 2019-05-07 | 2020-11-11 | Atlas Antibodies AB | A formulation comprising an isotope labeled fusion polypeptide |
| DK3744319T3 (da) | 2019-05-28 | 2023-01-16 | Ilkogen Ilac Sanayi Ve Ticaret A S | Stabil lyofiliseret formulering til hybrid fc-fusioneret g-csf |
| JP2019178154A (ja) * | 2019-06-18 | 2019-10-17 | イーストポンド・ラボラトリーズ・リミテッド | シクロデキストリンを含有する細胞水和組成物 |
| GB201911461D0 (en) * | 2019-08-09 | 2019-09-25 | Arecor Ltd | Novel composition |
| KR20220164690A (ko) * | 2019-12-02 | 2022-12-13 | 알타반트 사이언시스 게엠베하 | 하기도 장애의 치료 |
| WO2021113440A2 (en) * | 2019-12-03 | 2021-06-10 | China Medical University | Oligopeptide, testing kit thereof, medical composition thereof and use of medical composition |
| US11767353B2 (en) | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
| AU2022251523A1 (en) * | 2021-03-31 | 2023-09-28 | Hangzhou Exegenesis Bio Ltd. | Fusion molecules targeting vegf and angiopoietin and uses thereof |
| KR20240109277A (ko) | 2021-12-01 | 2024-07-10 | 유씨비 바이오파마 에스알엘 | Fab-peg를 포함하는 제제 |
| US20240076597A1 (en) * | 2022-09-02 | 2024-03-07 | Terumo Bct, Inc. | Methods for cell expansion, differentiation, and/or harvesting of natural killer cells using hollow-fiber membranes |
| WO2024133908A1 (en) * | 2022-12-23 | 2024-06-27 | Syna Therapeutics, S.L. | Stable pharmaceutical compositions comprising romiplostim |
| WO2024263570A1 (en) * | 2023-06-23 | 2024-12-26 | The Regents Of The University Of Michigan | Nanoparticle compositions associated with peptides |
| CN118126120B (zh) * | 2023-09-14 | 2024-12-06 | 海南大学 | 抑制Aβ42聚集并降低其细胞毒作用的三肽化合物 |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| DE3244265A1 (de) | 1982-11-30 | 1984-05-30 | Cassella Ag, 6000 Frankfurt | Weichmacheremulsion, verfahren zu ihrer herstellung und ihre anwendung |
| US4503235A (en) | 1983-03-11 | 1985-03-05 | Warner-Lambert Company | Process for producing 4-carbamoyl-1H-imidazolium-5-olate |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| EP0315456B1 (en) | 1987-11-05 | 1994-06-01 | Hybritech Incorporated | Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5627262A (en) | 1989-07-05 | 1997-05-06 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
| DK0417563T3 (da) | 1989-09-12 | 2000-11-06 | Hoffmann La Roche | TNF-bindende proteiner |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| JP3693671B2 (ja) | 1991-03-15 | 2005-09-07 | アムゲン インコーポレーテッド | ポリペプチドのpeg化 |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| US5362852A (en) | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| NZ244778A (en) | 1991-10-21 | 1994-03-25 | Ortho Pharma Corp | Peg imidates and protein derivatives thereof |
| ATE311895T1 (de) | 1992-05-26 | 2005-12-15 | Immunex Corp | Neue zytokine die cd30 binden |
| DE69332485T2 (de) | 1992-08-11 | 2003-11-13 | The President And Fellows Of Harvard College, Cambridge | Immunmodulierende peptide |
| GB9225448D0 (en) | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5880096A (en) | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5786331A (en) | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5608035A (en) | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5844929A (en) * | 1994-02-24 | 1998-12-01 | British Telecommunications Public Limited Company | Optical device with composite passive and tapered active waveguide regions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| AU693478B2 (en) | 1994-11-10 | 1998-07-02 | Metabolic Pharmaceuticals Limited | Treatment of obesity |
| IL116026A (en) | 1994-11-22 | 2005-08-31 | Rhone Poulenc Rorer Sa | Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses |
| US5888763A (en) | 1994-12-30 | 1999-03-30 | The Rockefeller University | Peptides specific for the first Crk-SH3 domain |
| EP0820299B1 (en) * | 1995-02-06 | 2002-04-24 | Genetics Institute, Inc. | Formulations for il-12 |
| IL113159A0 (en) | 1995-03-28 | 1995-06-29 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| DK2275119T3 (da) * | 1995-07-27 | 2013-11-11 | Genentech Inc | Stabil, isotonisk lyofiliseret proteinformulering |
| US5746516A (en) | 1995-08-11 | 1998-05-05 | Hitachi Powdered Metals Co., Ltd. | Porous bearing system having internal grooves and electric motor provided with the same |
| US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
| JPH09151200A (ja) | 1995-09-29 | 1997-06-10 | Ajinomoto Co Inc | ヒト胃癌に対する免疫応答を誘導できるペプチド及び該ペプチドを含むヒト胃癌治療、予防剤 |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| US5714577A (en) | 1996-01-26 | 1998-02-03 | University Of Pittsburgh | Antimicrobial peptides |
| IL117223A0 (en) | 1996-02-22 | 1996-06-18 | Yeda Res & Dev | Antipathogenic polypeptides and compositions comprising them |
| WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| EP0906419A2 (en) | 1996-03-28 | 1999-04-07 | Chiron Corporation | Peptide ligands of the urokinase receptor |
| IL118003A0 (en) | 1996-04-23 | 1996-08-04 | Yeda Res & Dev | Novel vip fragments and pharmaceutical compositions comprising them |
| FR2748028B1 (fr) | 1996-04-30 | 1998-08-14 | Lab Francais Du Fractionnement | Peptides derives du facteur von willebrand et leur utilisation comme anticoagulant |
| WO1997046668A1 (en) | 1996-06-07 | 1997-12-11 | Takeda Chemical Industries, Ltd. | Novel peptide, process for the production of the same, and use of the same |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| EP0927045B1 (en) | 1996-09-10 | 2005-12-14 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
| AU4344697A (en) | 1996-10-04 | 1998-04-24 | Amgen, Inc. | Pharmaceutical compositions containing an mpl ligand |
| ES2190543T3 (es) | 1996-10-08 | 2003-08-01 | Bisys B V U | Procedimientos y sistemas que permiten seleccionar peptidos y proteinas que tienen una afinidad especifica respecto a un blanco. |
| WO1998033812A1 (en) | 1997-02-05 | 1998-08-06 | Brigham And Women's Hospital, Inc. | Mast cell protease peptide inhibitors |
| PL190092B1 (pl) | 1997-04-16 | 2005-10-31 | Amgen Inc | Proteiny wiążące osteoprotegerynę oraz ich receptory |
| US6265535B1 (en) | 1997-05-30 | 2001-07-24 | The Trustees Of The University Of Pennsylvania | Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| JP2001522863A (ja) | 1997-11-07 | 2001-11-20 | コンジュケム,インコーポレーテッド | Rgd含有ペプチドおよび内因性担体の新規コンジュゲート |
| AU2481399A (en) | 1998-01-29 | 1999-08-16 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Variant peptide ligands that selectively induce apoptosis |
| DE69921102T2 (de) | 1998-03-05 | 2006-02-02 | Chiron Corp., Emeryville | Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen |
| US6235872B1 (en) | 1998-03-12 | 2001-05-22 | The Burnham Institute | Proapoptotic peptides dependence polypeptides and methods of use |
| JP4361684B2 (ja) | 1998-03-20 | 2009-11-11 | 中外製薬株式会社 | エリトロポエチン受容体のためのペプチドリガンド |
| EP0947524A1 (en) | 1998-03-30 | 1999-10-06 | Upither B.V. | Novel peptides for the treatment of autoimmune diseases |
| AU744044B2 (en) | 1998-04-06 | 2002-02-14 | Advanced Immunit, Inc. | Short peptides for treatment of neurological degenerative diseases |
| JP2002512982A (ja) | 1998-04-28 | 2002-05-08 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | Peg−lhrhアナログ複合体 |
| EP0972780A1 (en) | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| NZ507912A (en) | 1998-05-22 | 2002-10-25 | Abbott Lab | Nonapeptide antiangiogenic drugs |
| US5932548A (en) | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
| WO2000001402A1 (en) | 1998-07-02 | 2000-01-13 | Envision Biomedical Consulting | Antiproliferative and antiviral proteins and peptides |
| US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| WO2000011028A2 (en) | 1998-08-21 | 2000-03-02 | Yeda Research And Development Co. Ltd. | Anti-inflammatory peptides derived from il-2 and analogues thereof |
| ES2265693T3 (es) | 1998-10-16 | 2007-02-16 | Biogen Idec Ma Inc. | Proteinas de fusion con interferon-beta y usos. |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| PL219605B1 (pl) | 1998-10-23 | 2015-06-30 | Kirin Amgen Inc | Dimeryczne mimetyki peptydów trombopoetynowych wiążące się z receptorem MP1 i wykazujące aktywność trombopoetyczną |
| WO2000047740A2 (en) | 1999-02-12 | 2000-08-17 | Amgen Inc. | Tnf-related proteins |
| US6635646B1 (en) | 1999-05-04 | 2003-10-21 | Schering Corporation | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001259432B2 (en) | 2000-05-03 | 2005-04-21 | Amgen Inc. | Modified peptides, comprising an FC domain, as therapeutic agents |
| US6853809B2 (en) | 2001-01-30 | 2005-02-08 | Koninklijke Philips Electronics N.V. | Camera system for providing instant switching between wide angle and full resolution views of a subject |
| AU2002342669C1 (en) | 2001-05-11 | 2010-10-07 | Amgen, Inc. | Peptides and related molecules that bind to TALL-1 |
| RU2180233C1 (ru) | 2001-06-26 | 2002-03-10 | Общество с ограниченной ответственностью "Протеиновый контур" | Способ получения жидких лекарственных форм рекомбинантных белков |
| US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| WO2004019860A2 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Formulations of modified antibodies and methods of making the same |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| WO2004039337A2 (en) | 2002-10-31 | 2004-05-13 | Protein Design Labs, Inc. | Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization |
| BR0317538A (pt) | 2002-12-20 | 2005-11-29 | Amgen Inc | Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo |
| MX2007000216A (es) | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
| EP1797127B1 (en) | 2004-09-24 | 2017-06-14 | Amgen Inc. | Modified fc molecules |
| JO3324B1 (ar) * | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| EP3035305B1 (en) | 2014-12-18 | 2016-11-16 | Axis AB | Enclosure and arrangement for recess mounting of a camera or camera head |
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