MX2008013393A - Formulaciones liofilizadas de pepticuerpos terapeuticos. - Google Patents

Info

Publication number

MX2008013393A

MX2008013393A MX2008013393A MX2008013393A MX2008013393A MX 2008013393 A MX2008013393 A MX 2008013393A MX 2008013393 A MX2008013393 A MX 2008013393A MX 2008013393 A MX2008013393 A MX 2008013393A MX 2008013393 A MX2008013393 A MX 2008013393A

Authority

MX

Mexico

Prior art keywords

seq

sucrose

composition according

therapeutic peptibody

mannitol

Prior art date

2006-04-21

Links

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• Global Dossier
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• 239000000203 mixture Substances 0.000 title claims abstract description 232
• 230000001225 therapeutic effect Effects 0.000 title claims abstract description 128
• 238000009472 formulation Methods 0.000 title abstract description 97
• 238000000034 method Methods 0.000 claims abstract description 178
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 347
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 163
• 229930006000 Sucrose Natural products 0.000 claims description 82
• 239000005720 sucrose Substances 0.000 claims description 82
• 150000001875 compounds Chemical class 0.000 claims description 79
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 72
• 229930195725 Mannitol Natural products 0.000 claims description 72
• 239000000594 mannitol Substances 0.000 claims description 72
• 235000010355 mannitol Nutrition 0.000 claims description 72
• 230000027455 binding Effects 0.000 claims description 68
• 229920001223 polyethylene glycol Polymers 0.000 claims description 67
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 65
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 63
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• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 61
• -1 gentibiosa Chemical compound 0.000 claims description 59
• 150000001413 amino acids Chemical group 0.000 claims description 58
• 239000003795 chemical substances by application Substances 0.000 claims description 57
• 239000003381 stabilizer Substances 0.000 claims description 56
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• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 40
• 239000000872 buffer Substances 0.000 claims description 38
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 32
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 28
• 238000004108 freeze drying Methods 0.000 claims description 27
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• 229930195712 glutamate Natural products 0.000 claims description 25
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 21
• 239000004067 bulking agent Substances 0.000 claims description 19
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 17
• 229920002307 Dextran Polymers 0.000 claims description 17
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• 125000000185 sucrose group Chemical group 0.000 claims description 17
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• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 14
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• 229910052708 sodium Inorganic materials 0.000 claims description 10
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• 229930195729 fatty acid Natural products 0.000 claims description 9
• 239000008103 glucose Substances 0.000 claims description 9
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• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 9
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• 239000004475 Arginine Substances 0.000 claims description 7
• 229910019142 PO4 Inorganic materials 0.000 claims description 7
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 7
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• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 6
• DSNRWDQKZIEDDB-SQYFZQSCSA-N 1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-SQYFZQSCSA-N 0.000 claims description 6
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• BPHQZTVXXXJVHI-UHFFFAOYSA-N dimyristoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-UHFFFAOYSA-N 0.000 claims description 6
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