TWI352598B - Lyophilized therapeutic peptibody formulations - Google Patents

Info

Publication number

TWI352598B

TWI352598B TW096114064A TW96114064A TWI352598B TW I352598 B TWI352598 B TW I352598B TW 096114064 A TW096114064 A TW 096114064A TW 96114064 A TW96114064 A TW 96114064A TW I352598 B TWI352598 B TW I352598B

Authority

TW

Taiwan

Prior art keywords

composition

therapeutic

seq

peptide

doc

Prior art date

2006-04-21

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 title abstract description 128
• 238000000034 method Methods 0.000 claims abstract description 199
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 330
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 120
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• 239000005720 sucrose Substances 0.000 claims description 86
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• 239000000594 mannitol Substances 0.000 claims description 78
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• 229930195725 Mannitol Natural products 0.000 claims description 77
• -1 Octyl ester Chemical class 0.000 claims description 77
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• RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 4
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• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
• LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 4
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