JP2009524595A5 - - Google Patents
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- JP2009524595A5 JP2009524595A5 JP2008547721A JP2008547721A JP2009524595A5 JP 2009524595 A5 JP2009524595 A5 JP 2009524595A5 JP 2008547721 A JP2008547721 A JP 2008547721A JP 2008547721 A JP2008547721 A JP 2008547721A JP 2009524595 A5 JP2009524595 A5 JP 2009524595A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- formulation
- surfactant
- buffer
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75215005P | 2005-12-20 | 2005-12-20 | |
| US60/752,150 | 2005-12-20 | ||
| PCT/US2006/062297 WO2007076354A2 (en) | 2005-12-20 | 2006-12-19 | Stable protein formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011141983A Division JP5538309B2 (ja) | 2005-12-20 | 2011-06-27 | 安定なタンパク質製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524595A JP2009524595A (ja) | 2009-07-02 |
| JP2009524595A5 true JP2009524595A5 (enExample) | 2010-02-12 |
| JP5247467B2 JP5247467B2 (ja) | 2013-07-24 |
Family
ID=38057529
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008547721A Active JP5247467B2 (ja) | 2005-12-20 | 2006-12-19 | 安定なタンパク質製剤 |
| JP2011141983A Active JP5538309B2 (ja) | 2005-12-20 | 2011-06-27 | 安定なタンパク質製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011141983A Active JP5538309B2 (ja) | 2005-12-20 | 2011-06-27 | 安定なタンパク質製剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8476239B2 (enExample) |
| EP (1) | EP1962886B2 (enExample) |
| JP (2) | JP5247467B2 (enExample) |
| KR (1) | KR101378194B1 (enExample) |
| CN (3) | CN101378773B (enExample) |
| AR (2) | AR058567A1 (enExample) |
| AU (1) | AU2006330593B2 (enExample) |
| BR (1) | BRPI0622256A2 (enExample) |
| CA (1) | CA2634547C (enExample) |
| CL (1) | CL2010000816A1 (enExample) |
| DK (1) | DK1962886T4 (enExample) |
| EA (1) | EA014232B1 (enExample) |
| ES (1) | ES2436616T5 (enExample) |
| HR (1) | HRP20131196T4 (enExample) |
| IL (1) | IL192104A (enExample) |
| NO (1) | NO347247B1 (enExample) |
| NZ (1) | NZ569108A (enExample) |
| PE (1) | PE20071063A1 (enExample) |
| PL (1) | PL1962886T6 (enExample) |
| PT (1) | PT1962886E (enExample) |
| RS (1) | RS53127B2 (enExample) |
| SG (1) | SG153832A1 (enExample) |
| TW (3) | TW200738261A (enExample) |
| WO (1) | WO2007076354A2 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140186361A1 (en) | 2012-09-07 | 2014-07-03 | Coherus Biosciences, Inc. | Stable Aqueous Formulations of Adalimumab |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| TW200738261A (en) * | 2005-12-20 | 2007-10-16 | Bristol Myers Squibb Co | Stable protein formulations |
| PT2253644E (pt) | 2005-12-20 | 2014-01-23 | Bristol Myers Squibb Co | Composições e métodos para a produção de uma composição |
| US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
| US7915222B2 (en) | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
| CN105435211A (zh) | 2008-10-06 | 2016-03-30 | 三维肽胶株式会社 | 组织闭塞剂 |
| EP2445616B1 (en) * | 2009-06-23 | 2018-05-02 | GE Healthcare Bio-Sciences AB | Simulator device |
| GB201009676D0 (en) * | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| JP5847418B2 (ja) | 2011-03-30 | 2016-01-20 | 富士フイルム株式会社 | 細胞接着性タンパク質 |
| EP2699258A4 (en) * | 2011-04-15 | 2014-10-29 | Us Sec Dep Of Health And Human Services | AAV-mediated CTLA-4 gene transfer for the treatment of SJÖGREN SYNDROME |
| CA2833623A1 (en) | 2011-04-20 | 2012-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Aav mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity |
| TWI527590B (zh) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Fgf-18之凍乾調配物 |
| US8648079B2 (en) | 2011-10-07 | 2014-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| SMT202000091T1 (it) | 2011-10-13 | 2020-05-08 | Bristol Myers Squibb Co | Polipeptidi anticorpali che antagonizzano cd40l |
| US10485869B2 (en) | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
| AU2012326170B2 (en) * | 2011-10-18 | 2016-12-22 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with metal ions |
| WO2014004780A1 (en) | 2012-06-29 | 2014-01-03 | Bristol-Myers Squibb Company | Methods for reducing glycoprotein aggregation |
| EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
| WO2014011629A1 (en) | 2012-07-09 | 2014-01-16 | Coherus Biosciences, Inc. | Stable aqueous formulations of etanercept |
| WO2014018747A2 (en) | 2012-07-26 | 2014-01-30 | Momenta Pharmaceuticals, Inc. | Glycoproteins with anti-inflammatory properties |
| AU2013308470B2 (en) | 2012-08-31 | 2017-04-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | AAV mediated aquaporin gene transfer to treat Sjogren's syndrome |
| KR102250937B1 (ko) | 2012-09-11 | 2021-05-12 | 코히러스 바이오사이언시즈, 인코포레이티드 | 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트 |
| US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
| ES2708759T3 (es) | 2013-05-13 | 2019-04-11 | Momenta Pharmaceuticals Inc | Procedimientos para el tratamiento de la neurodegeneración |
| CN103385852B (zh) * | 2013-08-06 | 2015-03-11 | 南京正大天晴制药有限公司 | 一种盐酸法舒地尔注射液及其制备方法 |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| EP3058084A4 (en) | 2013-10-16 | 2017-07-05 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| DK3116896T3 (en) | 2014-03-10 | 2019-03-18 | 3 D Matrix Ltd | SELF-PREPARING PEPTIME COMPOSITIONS |
| ES3037364T3 (en) | 2014-03-10 | 2025-10-01 | 3 D Matrix Ltd | Sterilization and filtration of peptide compositions |
| US20170051059A1 (en) | 2014-03-19 | 2017-02-23 | Bristol-Myers Squibb Company | Methods of treating transplant rejection using a domain antibody directed against cd40 |
| RU2689145C2 (ru) * | 2014-04-16 | 2019-05-24 | Биокон Лтд. | Стабильные белковые препараты, содержащие молярный избыток сорбитола |
| WO2015164595A1 (en) | 2014-04-25 | 2015-10-29 | Bristol-Myers Squibb Company | Use of ctla4 compound for achieving drug-free remission in subjects with early ra |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| WO2015196091A1 (en) | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
| EP3157947A1 (en) | 2014-06-23 | 2017-04-26 | Novartis AG | Hsa-gdf-15 fusion polypeptide and use thereof |
| CN106573955B (zh) | 2014-06-23 | 2021-02-26 | 诺华股份有限公司 | 位点特异性蛋白质修饰 |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| SG11201702614SA (en) | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| US20180200325A1 (en) | 2014-11-18 | 2018-07-19 | Shionogi & Co., Ltd. | Stabilized peptide composition |
| SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| DK3303394T3 (da) | 2015-05-29 | 2020-07-06 | Agenus Inc | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf |
| DK3347031T3 (da) * | 2015-09-11 | 2021-04-26 | Nutrition & Biosciences Usa 1 Llc | Sammensætning, der omfatter et protein og en polyalkoxyfedtforbindelse |
| US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
| DK3386541T3 (da) * | 2015-12-07 | 2020-09-28 | Merck Patent Gmbh | Vandig farmaceutisk formulering omfattende anti-pd-1-antistof avelumab |
| US20190000923A1 (en) | 2015-12-22 | 2019-01-03 | Novartis Ag | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
| EP3192805A1 (en) | 2016-01-15 | 2017-07-19 | Humanitas Mirasole S.p.A. | Inhibitors of t cell activation or stimulation and uses thereof |
| US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
| IL307242B1 (en) | 2016-12-07 | 2026-07-01 | Agenus Inc | Anti-CTLA-4 antibodies and methods of using them |
| EP3630843A2 (en) | 2017-05-24 | 2020-04-08 | ALS Therapy Development Institute | Therapeutic anti-cd40 ligand antibodies |
| WO2019123427A1 (en) | 2017-12-22 | 2019-06-27 | Novartis Ag | Methods of treating metabolic disorders with fgf21 variants |
| CN108014338A (zh) * | 2018-01-22 | 2018-05-11 | 安徽未名生物医药有限公司 | 一种注射用巴利昔单抗冻干粉针及其制备方法 |
| CN112512561A (zh) * | 2018-05-25 | 2021-03-16 | 雷迪博士实验室有限公司 | 稳定的融合蛋白制剂 |
| CN112512562A (zh) * | 2018-05-25 | 2021-03-16 | 雷迪博士实验室有限公司 | CTLA4-Ig融合蛋白制剂 |
| EP3813791A2 (en) * | 2018-06-26 | 2021-05-05 | Lupin Limited | Stable lyophilized dosage form of protein |
| EP3814492A4 (en) * | 2018-06-29 | 2022-02-23 | Wuhan Neurophth Biotechnology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| CN113396158A (zh) | 2018-11-26 | 2021-09-14 | 诺华股份有限公司 | Lpl-gpihbp1融合多肽 |
| US12703762B2 (en) | 2018-12-18 | 2026-08-11 | Novartis Ag | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| CN113508129B (zh) | 2019-01-15 | 2025-02-18 | 法国国家健康和医学研究院 | 突变的白介素-34(il-34)多肽及其在治疗中的用途 |
| US20220098252A1 (en) | 2019-01-25 | 2022-03-31 | Ospedale San Raffaele S.R.L. | Inhibitor of dux4 and uses thereof |
| GB201913697D0 (en) | 2019-09-23 | 2019-11-06 | King S College London | DAP10/DAP12 fusion polypeptides |
| JP2023507795A (ja) * | 2019-12-20 | 2023-02-27 | アントス セラピューティクス, インコーポレイテッド | 第XI/XIa因子抗体の医薬製剤および投薬レジメン |
| GB202003277D0 (en) | 2020-03-06 | 2020-04-22 | King S College London | Therapeutic agents |
| GB202007655D0 (en) | 2020-05-22 | 2020-07-08 | King S College London | Chimeric nkg2d protein |
| WO2022162704A1 (en) * | 2021-02-01 | 2022-08-04 | Dr. Reddy's Laboratories Limited | Compositions comprising fusion protein and analytical attributes thereof |
| BR112023019385A2 (pt) | 2021-03-23 | 2023-12-05 | King S College London | Composições compreendendo polipeptídeos de fusão nkg2d, cxcr2 e dap10/dap12 e seus métodos de uso |
| CN113925963B (zh) * | 2021-10-15 | 2023-08-11 | 江苏太平洋美诺克生物药业股份有限公司 | 一种稳定的包含抗cd147单克隆抗体的药物制剂 |
| GB202214120D0 (en) | 2022-09-27 | 2022-11-09 | King S College London | Compositions comprising NKG2D, CXCR2, and DAP10/DAP12 fusion polypeptides and methods of use thereof |
| KR20250054810A (ko) * | 2022-09-29 | 2025-04-23 | 화이자 인코포레이티드 | Rsv f 단백질 삼량체를 포함하는 면역원성 조성물 |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| WO2025196207A1 (en) | 2024-03-20 | 2025-09-25 | King's College London | Compositions and methods for use in depleting senescent cells and treating aging |
| WO2026021575A1 (zh) * | 2024-07-26 | 2026-01-29 | 鸿运华宁(杭州)生物医药有限公司 | 一种gipr抗体融合蛋白质的药用稳定溶液制剂及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0686045T3 (da) * | 1993-02-23 | 2001-03-05 | Genentech Inc | Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof |
| DE4405426A1 (de) | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| CA2226575C (en) * | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| WO2003005465A1 (en) | 2001-04-25 | 2003-01-16 | Quallion, Llc | Rechargeable lithium battery for tolerating discharge to zero volts |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| US7183376B2 (en) * | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| CA2630062C (en) * | 2000-07-03 | 2014-10-14 | Bristol-Myers Squibb Company | Methods for treating graft versus host disease and immune disorders associated with rejection using a soluble ctla4 molecule |
| MXPA03006699A (es) * | 2001-01-26 | 2004-05-31 | Univ Emory | Metodos de induccion de tolerancia al trasplante de organos y correccion de hemoglobinopatias. |
| CA2466054C (en) | 2001-11-13 | 2012-01-03 | Genentech, Inc. | Apo-2 ligand/trail formulations |
| DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| WO2003068260A1 (fr) | 2002-02-14 | 2003-08-21 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
| TWI328614B (en) | 2002-12-23 | 2010-08-11 | Bristol Myers Squibb Co | Product quality enhancement in mammalian cell culture processes for protein production |
| EP1575998A4 (en) * | 2002-12-23 | 2007-07-25 | Bristol Myers Squibb Co | PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION |
| PT1610820E (pt) | 2003-04-04 | 2010-12-16 | Novartis Ag | Formulações de elevada concentração de anticorpos e proteínas |
| NZ545314A (en) * | 2003-08-04 | 2009-03-31 | Bristol Myers Squibb Co | Methods for treating cardiovascular disease using a soluble CTLA4 molecule |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CA2618068C (en) * | 2005-08-05 | 2016-02-16 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
| TW200738261A (en) * | 2005-12-20 | 2007-10-16 | Bristol Myers Squibb Co | Stable protein formulations |
-
2006
- 2006-12-19 TW TW095147647A patent/TW200738261A/zh unknown
- 2006-12-19 PT PT68466838T patent/PT1962886E/pt unknown
- 2006-12-19 US US12/086,876 patent/US8476239B2/en active Active
- 2006-12-19 TW TW098139141A patent/TW201008595A/zh unknown
- 2006-12-19 DK DK06846683.8T patent/DK1962886T4/da active
- 2006-12-19 TW TW098139142A patent/TWI393575B/zh active
- 2006-12-19 NO NO20082628A patent/NO347247B1/no unknown
- 2006-12-19 ES ES06846683T patent/ES2436616T5/es active Active
- 2006-12-19 CA CA2634547A patent/CA2634547C/en active Active
- 2006-12-19 NZ NZ569108A patent/NZ569108A/en unknown
- 2006-12-19 WO PCT/US2006/062297 patent/WO2007076354A2/en not_active Ceased
- 2006-12-19 EP EP06846683.8A patent/EP1962886B2/en active Active
- 2006-12-19 HR HRP20131196TT patent/HRP20131196T4/hr unknown
- 2006-12-19 PE PE2006001649A patent/PE20071063A1/es active IP Right Grant
- 2006-12-19 CN CN2006800530514A patent/CN101378773B/zh active Active
- 2006-12-19 AR ARP060105626A patent/AR058567A1/es not_active Application Discontinuation
- 2006-12-19 EA EA200801570A patent/EA014232B1/ru active Protection Beyond IP Right Term
- 2006-12-19 KR KR1020087017544A patent/KR101378194B1/ko active Active
- 2006-12-19 SG SG200904148-4A patent/SG153832A1/en unknown
- 2006-12-19 PL PL06846683.8T patent/PL1962886T6/pl unknown
- 2006-12-19 JP JP2008547721A patent/JP5247467B2/ja active Active
- 2006-12-19 CN CN200910139825A patent/CN101822820A/zh active Pending
- 2006-12-19 CN CNA2009101398246A patent/CN101584858A/zh active Pending
- 2006-12-19 AU AU2006330593A patent/AU2006330593B2/en active Active
- 2006-12-19 BR BRPI0622256-0A patent/BRPI0622256A2/pt not_active Application Discontinuation
- 2006-12-20 RS RS20130553A patent/RS53127B2/sr unknown
-
2008
- 2008-06-12 IL IL192104A patent/IL192104A/en active IP Right Grant
-
2010
- 2010-07-30 CL CL2010000816A patent/CL2010000816A1/es unknown
-
2011
- 2011-06-27 JP JP2011141983A patent/JP5538309B2/ja active Active
-
2014
- 2014-09-04 AR ARP140103315A patent/AR097561A2/es unknown
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