JP2010536714A5 - - Google Patents

Info

Publication number

JP2010536714A5

JP2010536714A5 JP2010506728A JP2010506728A JP2010536714A5 JP 2010536714 A5 JP2010536714 A5 JP 2010536714A5 JP 2010506728 A JP2010506728 A JP 2010506728A JP 2010506728 A JP2010506728 A JP 2010506728A JP 2010536714 A5 JP2010536714 A5 JP 2010536714A5

Authority

JP

Japan

Prior art keywords

seq

peptide

amino acid

group

leucine

Prior art date

2008-08-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 108
• 150000001413 amino acids Chemical group 0.000 claims description 75
• 229940024606 amino acid Drugs 0.000 claims description 51
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 36
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 36
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 36
• 229930182817 methionine Natural products 0.000 claims description 36
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 24
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 24
• 206010028980 Neoplasm Diseases 0.000 claims description 24
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 24
• 201000011510 cancer Diseases 0.000 claims description 24
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 24
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 24
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 21
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 14
• 229960005277 gemcitabine Drugs 0.000 claims description 14
• 239000002246 antineoplastic agent Substances 0.000 claims description 13
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 12
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 12
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 12
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 12
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 12
• 229960000310 isoleucine Drugs 0.000 claims description 12
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 12
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 12
• 201000002528 pancreatic cancer Diseases 0.000 claims description 12
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 12
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 12
• 239000004474 valine Substances 0.000 claims description 12
• 230000001225 therapeutic effect Effects 0.000 claims description 9
• 229940127089 cytotoxic agent Drugs 0.000 claims description 7
• 229940002612 prodrug Drugs 0.000 claims description 7
• 239000000651 prodrug Substances 0.000 claims description 7
• 150000003839 salts Chemical class 0.000 claims description 7
• 239000004480 active ingredient Substances 0.000 claims description 4
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims description 4
• 230000002708 enhancing effect Effects 0.000 claims description 3
• 239000003937 drug carrier Substances 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• -1 respectively Substances 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000000034 method Methods 0.000 description 6