JP2018504901A5 - - Google Patents

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Publication number
JP2018504901A5
JP2018504901A5 JP2017535417A JP2017535417A JP2018504901A5 JP 2018504901 A5 JP2018504901 A5 JP 2018504901A5 JP 2017535417 A JP2017535417 A JP 2017535417A JP 2017535417 A JP2017535417 A JP 2017535417A JP 2018504901 A5 JP2018504901 A5 JP 2018504901A5
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JP
Japan
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cysteine
receptor agonist
acid
receptor
pharmaceutical composition
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JP2017535417A
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Japanese (ja)
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JP6797122B2 (ja
JP2018504901A (ja
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Priority claimed from PCT/KR2015/014422 external-priority patent/WO2016108586A1/ko
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JP2017535417A 2014-12-30 2015-12-30 安定性が増加されたグルカゴン誘導体 Active JP6797122B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2014-0193800 2014-12-30
KR20140193800 2014-12-30
PCT/KR2015/014422 WO2016108586A1 (ko) 2014-12-30 2015-12-30 안정성이 증가된 글루카곤 유도체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020144259A Division JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

Publications (3)

Publication Number Publication Date
JP2018504901A JP2018504901A (ja) 2018-02-22
JP2018504901A5 true JP2018504901A5 (enExample) 2019-02-07
JP6797122B2 JP6797122B2 (ja) 2020-12-09

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JP2017535417A Active JP6797122B2 (ja) 2014-12-30 2015-12-30 安定性が増加されたグルカゴン誘導体
JP2020144259A Active JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

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JP2020144259A Active JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

Country Status (28)

Country Link
US (1) US11135271B2 (enExample)
EP (2) EP3575314B1 (enExample)
JP (2) JP6797122B2 (enExample)
KR (1) KR102291020B1 (enExample)
CN (1) CN107636009B (enExample)
AR (1) AR103322A1 (enExample)
AU (1) AU2015372818A1 (enExample)
CL (1) CL2017001718A1 (enExample)
CO (1) CO2017006308A2 (enExample)
CR (1) CR20170293A (enExample)
DO (1) DOP2017000156A (enExample)
EA (1) EA035527B1 (enExample)
EC (1) ECSP17040923A (enExample)
ES (1) ES2976562T3 (enExample)
GT (1) GT201700150A (enExample)
HK (1) HK1248713A1 (enExample)
IL (2) IL253206B (enExample)
MA (1) MA40709B1 (enExample)
MX (1) MX2017008569A (enExample)
MY (1) MY185334A (enExample)
PE (2) PE20171154A1 (enExample)
PH (1) PH12017501222B1 (enExample)
SG (1) SG11201705376SA (enExample)
TN (1) TN2017000271A1 (enExample)
TW (1) TW201639878A (enExample)
UA (1) UA126960C2 (enExample)
WO (1) WO2016108586A1 (enExample)
ZA (1) ZA201705015B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20170293A (es) * 2014-12-30 2017-11-03 Hanmi Pharm Ind Co Ltd Derivados de glucagón con estabilidad mejorada
TN2017000555A1 (en) 2015-06-30 2019-04-12 Hanmi Pharm Ind Co Ltd Glucagon derivative and a composition comprising a long acting conjugate of the same
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
JP6712323B2 (ja) 2015-12-31 2020-06-17 ハンミ ファーマシューティカル カンパニー リミテッド グルカゴン、glp−1及びgip受容体のすべてに活性を有する三重活性体
SG11201811697SA (en) 2016-06-29 2019-01-30 Hanmi Pharmaceutical Co Ltd Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
AU2018215840A1 (en) 2017-02-03 2019-08-01 Hanmi Pharm. Co., Ltd. Long-Acting Conjugate Of A Physiologically Active Material And Use Thereof
BR112020012346A2 (pt) * 2017-12-22 2020-11-24 Hanmi Pharm. Co., Ltd. proteína de fusão enzimática terapêutica tendo uma nova estrutura e uso da mesma
US20210030847A1 (en) * 2018-01-23 2021-02-04 Xeris Pharmaceuticals, Inc. Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon
AU2019405389B2 (en) * 2018-12-21 2025-06-05 Hanmi Pharm. Co., Ltd. Pharmaceutical composition containing insulin and glucagon
CN109836486B (zh) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 成纤维生长因子21变体、其融合蛋白及其用途
IL298396A (en) 2020-05-22 2023-01-01 Hanmi Pharm Ind Co Ltd Liquid formulation of long-acting conjugate of glucagon derivative
CN116096397A (zh) 2020-07-15 2023-05-09 韩美药品株式会社 胰高血糖素衍生物或其缀合物对于肝脏疾病的治疗用途
AU2022254588A1 (en) 2021-04-09 2023-09-21 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for preventing or treating chronic renal disease including glucagon derivative
KR20230095666A (ko) * 2021-12-22 2023-06-29 한미약품 주식회사 간 표적 물질 및 이의 용도
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408037A (en) 1991-01-17 1995-04-18 Zymogenetics, Inc. Methods for detecting glucagon antagonists
GB9423277D0 (en) 1994-11-18 1995-01-11 Univ Nottingham Pulsed laser deposition of coatings
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
ATE279947T1 (de) 1996-03-18 2004-11-15 Univ Texas Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
US6677136B2 (en) 2000-05-03 2004-01-13 Amgen Inc. Glucagon antagonists
JP2005501058A (ja) 2001-07-31 2005-01-13 ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ Glp−1、exendin−4、そのペプチド・アナログ及びその使用
AU2004231461B2 (en) 2003-03-19 2009-11-12 Eli Lilly And Company Polyethelene glycol linked GLP-1 compounds
US8263084B2 (en) 2003-11-13 2012-09-11 Hanmi Science Co., Ltd Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate
WO2005047337A1 (en) 2003-11-13 2005-05-26 Hanmi Pharmaceutical Co., Ltd. A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
AU2007240313B2 (en) 2006-04-20 2012-02-02 Amgen Inc. GLP-1 compounds
US20090098130A1 (en) 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
CN101578102B (zh) * 2007-01-05 2013-07-17 印第安纳大学研究及科技有限公司 在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物
MX2009008241A (es) * 2007-02-15 2009-10-08 Univ Indiana Res & Tech Corp Co-agonistas de receptor de glucagon/glp-1.
JP5385266B2 (ja) 2007-06-15 2014-01-08 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
KR20100049032A (ko) 2007-06-19 2010-05-11 오츠카 가가쿠 가부시키가이샤 당사슬 부가 glp―1 펩티드
ES2672770T3 (es) 2007-09-05 2018-06-18 Novo Nordisk A/S Derivados del péptido-1 similar al glucagón y su uso farmacéutico
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
TWI541023B (zh) 2008-06-17 2016-07-11 印第安納大學科技研究公司 在生理ph緩衝液中呈現增強之溶解度及穩定性之升糖激素類似物
TWI474835B (zh) 2008-06-17 2015-03-01 Univ Indiana Res & Tech Corp 用於治療代謝病症及肥胖症之基於gip之混合激動劑
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
WO2010148089A1 (en) 2009-06-16 2010-12-23 Indiana University Research And Technology Corporation Gip receptor-active glucagon compounds
AP3329A (en) 2009-07-13 2015-06-30 Zealand Pharma As Acylated glucagon analogues
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
US8703701B2 (en) * 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
EA026384B1 (ru) * 2010-01-20 2017-04-28 Зилэнд Фарма А/С Лечение заболеваний сердца
EP2552950A1 (en) 2010-03-26 2013-02-06 Novo Nordisk A/S Novel glucagon analogues
WO2011143208A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
KR101382593B1 (ko) 2010-07-21 2014-04-10 한미사이언스 주식회사 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물
WO2012088116A2 (en) 2010-12-22 2012-06-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
KR102011924B1 (ko) 2011-05-18 2019-08-21 메더리스 다이어비티즈, 엘엘씨 인슐린 저항성에 대한 개선된 펩티드 제약
UA126465C2 (uk) 2011-06-10 2022-10-12 Ханмі Сайенс Ко., Лтд. Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить
PL2721062T3 (pl) 2011-06-17 2019-05-31 Hanmi Science Co Ltd Koniugat zawierający oksyntomodulinę oraz fragment immunoglobuliny i jego zastosowanie
EP2729493B1 (en) 2011-07-04 2020-06-10 IP2IPO Innovations Limited Novel compounds and their effects on feeding behaviour
HK1198810A1 (en) * 2011-11-17 2015-06-12 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
CN104583233B (zh) 2012-06-21 2018-10-23 印第安纳大学研究及科技有限公司 表现出gip受体活性的胰高血糖素的类似物
US9340600B2 (en) 2012-06-21 2016-05-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting GIP receptor activity
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
PT2916819T (pt) 2012-11-06 2019-10-28 Hanmi Pharm Ind Co Ltd Formulação líquida de conjugado proteico que compreende a oxintomodulina e um fragmento de imunoglobulina.
KR101993393B1 (ko) * 2012-11-06 2019-10-01 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
JP6525456B2 (ja) 2012-11-20 2019-06-05 メデリス ダイアビーティーズ,エルエルシー インスリン抵抗性のための改善されたペプチド製剤
EP3444281B1 (en) 2012-11-20 2021-11-03 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
JP2016506401A (ja) 2012-12-21 2016-03-03 サノフイ 二重glp1/gipまたは三方glp1/gip/グルカゴンアゴニストとしてのエキセンジン−4誘導体
MY174727A (en) * 2013-04-18 2020-05-11 Novo Nordisk As Stable, protracted glp-1/glucagon receptor co-agonists for medical use
WO2015022420A1 (en) 2013-08-16 2015-02-19 Medimmune Limited Gip and glp-1 receptor dual-agonists for the treatment of diabetes
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
TWI802396B (zh) 2014-09-16 2023-05-11 南韓商韓美藥品股份有限公司 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
KR102418477B1 (ko) * 2014-12-30 2022-07-08 한미약품 주식회사 글루카곤 유도체
CR20170293A (es) 2014-12-30 2017-11-03 Hanmi Pharm Ind Co Ltd Derivados de glucagón con estabilidad mejorada
TN2017000555A1 (en) 2015-06-30 2019-04-12 Hanmi Pharm Ind Co Ltd Glucagon derivative and a composition comprising a long acting conjugate of the same
TW201718629A (zh) * 2015-09-25 2017-06-01 韓美藥品股份有限公司 包含多個生理多肽及免疫球蛋白Fc區之蛋白質接合物
JP6712323B2 (ja) 2015-12-31 2020-06-17 ハンミ ファーマシューティカル カンパニー リミテッド グルカゴン、glp−1及びgip受容体のすべてに活性を有する三重活性体

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