CO2017006308A2 - Derivados de glucagón - Google Patents
Derivados de glucagónInfo
- Publication number
- CO2017006308A2 CO2017006308A2 CONC2017/0006308A CO2017006308A CO2017006308A2 CO 2017006308 A2 CO2017006308 A2 CO 2017006308A2 CO 2017006308 A CO2017006308 A CO 2017006308A CO 2017006308 A2 CO2017006308 A2 CO 2017006308A2
- Authority
- CO
- Colombia
- Prior art keywords
- glucagon
- present
- hypoglycemia
- prevention
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un nuevo péptido derivado del glucagón y a una composición para la prevención o el tratamiento de hipoglucemia, que contiene el nuevo péptido derivado del glucagón como principio activo. El derivado de glucagón de acuerdo con la presente invención tiene propiedades físicas mejoradas debido al cambio en el punto isoeléctrico (pI) mientras que es capaz de mantener una actividad en los receptores del glucagón y, por tanto, puede mejorar la conformidad del paciente cuando se usa como un agente hipoglucémico y también es adecuado para la administración en combinación con otros agentes antiobesidad. Por consiguiente, el derivado de glucagón de acuerdo con la presente invención se puede usar de manera eficaz para la prevención y el tratamiento de la hipoglucemia y la obesidad.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140193800 | 2014-12-30 | ||
PCT/KR2015/014422 WO2016108586A1 (ko) | 2014-12-30 | 2015-12-30 | 안정성이 증가된 글루카곤 유도체 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017006308A2 true CO2017006308A2 (es) | 2017-09-29 |
Family
ID=56284642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0006308A CO2017006308A2 (es) | 2014-12-30 | 2017-06-27 | Derivados de glucagón |
Country Status (28)
Country | Link |
---|---|
US (1) | US11135271B2 (es) |
EP (2) | EP3241841A4 (es) |
JP (2) | JP6797122B2 (es) |
KR (1) | KR102291020B1 (es) |
CN (1) | CN107636009B (es) |
AR (1) | AR103322A1 (es) |
AU (1) | AU2015372818A1 (es) |
CA (1) | CA2972748A1 (es) |
CL (1) | CL2017001718A1 (es) |
CO (1) | CO2017006308A2 (es) |
CR (1) | CR20170293A (es) |
DO (1) | DOP2017000156A (es) |
EA (1) | EA035527B1 (es) |
EC (1) | ECSP17040923A (es) |
GT (1) | GT201700150A (es) |
HK (1) | HK1248713A1 (es) |
IL (2) | IL253206B (es) |
MA (1) | MA40709B1 (es) |
MX (1) | MX2017008569A (es) |
MY (1) | MY185334A (es) |
PE (2) | PE20171154A1 (es) |
PH (1) | PH12017501222A1 (es) |
SG (1) | SG11201705376SA (es) |
TN (1) | TN2017000271A1 (es) |
TW (1) | TW201639878A (es) |
UA (1) | UA126960C2 (es) |
WO (1) | WO2016108586A1 (es) |
ZA (1) | ZA201705015B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016108586A1 (ko) * | 2014-12-30 | 2016-07-07 | 한미약품 주식회사 | 안정성이 증가된 글루카곤 유도체 |
PE20180449A1 (es) * | 2015-06-30 | 2018-03-05 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon y una composicion que comprende un conjugado de accion prolongada del mismo |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
HRP20220995T1 (hr) | 2015-12-31 | 2022-11-11 | Hanmi Pharm. Co., Ltd. | Trostruki aktivator koji aktivira glukagonski, glp-1 i gip receptore |
TN2018000452A1 (en) * | 2016-06-29 | 2020-06-15 | Hanmi Pharm Ind Co Ltd | Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof |
EP3578204A4 (en) | 2017-02-03 | 2021-01-06 | Hanmi Pharm. Co., Ltd. | BIOACTIVE SUBSTANCE CONJUGATE WITH ENHANCED DURABILITY AND ITS USE |
EA202091239A1 (ru) * | 2017-12-22 | 2020-09-09 | Ханми Фарм. Ко., Лтд. | Слитый белок на основе терапевтического фермента, имеющий новую структуру, и его применение |
EP3743097A1 (en) * | 2018-01-23 | 2020-12-02 | Xeris Pharmaceuticals, Inc. | Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon |
JP2022514835A (ja) | 2018-12-21 | 2022-02-16 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン及びグルカゴンを含む薬学組成物 |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
CA3179603A1 (en) | 2020-05-22 | 2021-11-25 | Hanmi Pharm. Co., Ltd. | Liquid formulation of long-acting conjugate of glucagon derivative |
KR20220009354A (ko) | 2020-07-15 | 2022-01-24 | 한미약품 주식회사 | 글루카곤 유도체 또는 이의 결합체의 간질환에 대한 치료적 용도 |
JP2024512895A (ja) | 2021-04-09 | 2024-03-21 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン誘導体を含む慢性腎臓疾患予防又は治療用薬学組成物 |
KR20230095666A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
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PE20180449A1 (es) | 2015-06-30 | 2018-03-05 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon y una composicion que comprende un conjugado de accion prolongada del mismo |
TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Fc區之蛋白質接合物 |
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-
2015
- 2015-12-30 WO PCT/KR2015/014422 patent/WO2016108586A1/ko active Application Filing
- 2015-12-30 SG SG11201705376SA patent/SG11201705376SA/en unknown
- 2015-12-30 TN TN2017000271A patent/TN2017000271A1/en unknown
- 2015-12-30 AR ARP150104340A patent/AR103322A1/es unknown
- 2015-12-30 PE PE2017001168A patent/PE20171154A1/es unknown
- 2015-12-30 JP JP2017535417A patent/JP6797122B2/ja active Active
- 2015-12-30 CR CR20170293A patent/CR20170293A/es unknown
- 2015-12-30 CN CN201580077186.3A patent/CN107636009B/zh active Active
- 2015-12-30 MX MX2017008569A patent/MX2017008569A/es unknown
- 2015-12-30 MA MA40709A patent/MA40709B1/fr unknown
- 2015-12-30 AU AU2015372818A patent/AU2015372818A1/en not_active Abandoned
- 2015-12-30 MY MYPI2017000967A patent/MY185334A/en unknown
- 2015-12-30 EP EP15875680.9A patent/EP3241841A4/en not_active Withdrawn
- 2015-12-30 US US15/540,729 patent/US11135271B2/en active Active
- 2015-12-30 CA CA2972748A patent/CA2972748A1/en active Pending
- 2015-12-30 KR KR1020150189532A patent/KR102291020B1/ko active IP Right Grant
- 2015-12-30 TW TW104144427A patent/TW201639878A/zh unknown
- 2015-12-30 EP EP19172184.4A patent/EP3575314B1/en active Active
- 2015-12-30 EA EA201791333A patent/EA035527B1/ru not_active IP Right Cessation
- 2015-12-30 UA UAA201707040A patent/UA126960C2/uk unknown
- 2015-12-30 PE PE2022001996A patent/PE20230304A1/es unknown
-
2017
- 2017-06-27 CO CONC2017/0006308A patent/CO2017006308A2/es unknown
- 2017-06-27 IL IL253206A patent/IL253206B/en unknown
- 2017-06-28 CL CL2017001718A patent/CL2017001718A1/es unknown
- 2017-06-28 EC ECIEPI201740923A patent/ECSP17040923A/es unknown
- 2017-06-28 GT GT201700150A patent/GT201700150A/es unknown
- 2017-06-29 PH PH12017501222A patent/PH12017501222A1/en unknown
- 2017-06-29 DO DO2017000156A patent/DOP2017000156A/es unknown
- 2017-07-24 ZA ZA2017/05015A patent/ZA201705015B/en unknown
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2018
- 2018-04-10 HK HK18104685.2A patent/HK1248713A1/zh unknown
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2020
- 2020-08-28 JP JP2020144259A patent/JP7079301B2/ja active Active
-
2021
- 2021-03-09 IL IL281375A patent/IL281375B/en unknown
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