MX362275B - Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. - Google Patents
Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico.Info
- Publication number
- MX362275B MX362275B MX2015014408A MX2015014408A MX362275B MX 362275 B MX362275 B MX 362275B MX 2015014408 A MX2015014408 A MX 2015014408A MX 2015014408 A MX2015014408 A MX 2015014408A MX 362275 B MX362275 B MX 362275B
- Authority
- MX
- Mexico
- Prior art keywords
- agonists
- stable
- glucagon receptor
- medical use
- protracted glp
- Prior art date
Links
- 108010063919 Glucagon Receptors Proteins 0.000 title abstract 2
- 102100040890 Glucagon receptor Human genes 0.000 title abstract 2
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 102100040918 Pro-glucagon Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a co-agonistas novedosos de GLP-1 estable y de larga duración/receptor de glucagón, con el uso de estos péptidos en tratamiento, con métodos de tratamiento que comprenden la administración de los péptidos a los pacientes y con el uso de los péptidos en la elaboración de medicamentos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13164272 | 2013-04-18 | ||
US201361814969P | 2013-04-23 | 2013-04-23 | |
EP13196656 | 2013-12-11 | ||
PCT/EP2014/058084 WO2014170496A1 (en) | 2013-04-18 | 2014-04-22 | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015014408A MX2015014408A (es) | 2017-07-28 |
MX362275B true MX362275B (es) | 2019-01-10 |
Family
ID=51730843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014408A MX362275B (es) | 2013-04-18 | 2014-04-22 | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. |
Country Status (16)
Country | Link |
---|---|
US (3) | US9474790B2 (es) |
EP (1) | EP2986313B1 (es) |
JP (1) | JP6594856B2 (es) |
KR (1) | KR20160021758A (es) |
CN (1) | CN105307672B (es) |
AU (1) | AU2014255608B2 (es) |
BR (1) | BR112015025464A2 (es) |
CA (1) | CA2909581A1 (es) |
MX (1) | MX362275B (es) |
MY (1) | MY174727A (es) |
PL (1) | PL2986313T3 (es) |
RS (1) | RS59124B1 (es) |
RU (1) | RU2683039C2 (es) |
SI (1) | SI2986313T1 (es) |
WO (1) | WO2014170496A1 (es) |
ZA (1) | ZA201507010B (es) |
Families Citing this family (35)
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AR088161A1 (es) | 2011-09-23 | 2014-05-14 | Novo Nordisk As | Analogos de glucagon |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
AU2013360721A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 Derivatives as dual GLP1/GIP or trigonal GLP1/GIP/Glucagon Agonists |
DK2986313T3 (da) * | 2013-04-18 | 2019-08-12 | Novo Nordisk As | Stabile, protraherendede glp-1/glucagonreceptor-co-agonister til medicinsk anvendelse |
JP6594856B2 (ja) | 2013-04-18 | 2019-10-23 | ノヴォ ノルディスク アー/エス | 医療用の安定な遷延性glp−1/グルカゴン受容体コアゴニスト |
WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽-4(exendin-4)胜肽類似物 |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
BR112016027595B1 (pt) * | 2014-05-28 | 2023-12-26 | Mederis Diabetes, Llc | Produto de peptídeos, composição farmacêutica e seus usos |
EP3151852A1 (en) | 2014-06-04 | 2017-04-12 | Novo Nordisk A/S | Glp-1/glucagon receptor co-agonists for medical use |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
EP3241841A4 (en) * | 2014-12-30 | 2018-10-17 | Hanmi Pharm. Co., Ltd. | Glucagon derivative having improved stability |
KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
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AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
EP3398961B1 (en) | 2015-12-31 | 2022-06-29 | Hanmi Pharm. Co., Ltd. | Triple activator activating glucagon, glp-1 and gip receptor |
HRP20220720T1 (hr) * | 2016-01-13 | 2022-09-30 | Novo Nordisk A/S | Analozi egf(a) s masnim kiselinama kao supstituentima |
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TW201918494A (zh) | 2017-07-19 | 2019-05-16 | 丹麥商諾佛 儂迪克股份有限公司 | 雙功能性化合物 |
GB201720187D0 (en) * | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Novel Compounds |
ES2961384T3 (es) | 2018-05-04 | 2024-03-11 | Novo Nordisk As | Derivados de GIP y usos de los mismos |
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CN117202924A (zh) * | 2020-12-07 | 2023-12-08 | 斯皮特弗尔制药有限责任公司 | 使用glp-1r和gcgr平衡激动剂降低血糖和/或体重的治疗方案和方法 |
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-
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- 2014-04-22 JP JP2016508190A patent/JP6594856B2/ja active Active
- 2014-04-22 MY MYPI2015703258A patent/MY174727A/en unknown
- 2014-04-22 MX MX2015014408A patent/MX362275B/es active IP Right Grant
- 2014-04-22 WO PCT/EP2014/058084 patent/WO2014170496A1/en active Application Filing
- 2014-04-22 SI SI201431291T patent/SI2986313T1/sl unknown
- 2014-04-22 RU RU2015146600A patent/RU2683039C2/ru active
- 2014-04-22 KR KR1020157032329A patent/KR20160021758A/ko not_active Application Discontinuation
- 2014-04-22 EP EP14719715.6A patent/EP2986313B1/en active Active
- 2014-04-22 RS RS20191031A patent/RS59124B1/sr unknown
- 2014-04-22 CN CN201480034914.8A patent/CN105307672B/zh active Active
- 2014-04-22 PL PL14719715T patent/PL2986313T3/pl unknown
- 2014-04-22 CA CA2909581A patent/CA2909581A1/en not_active Withdrawn
- 2014-04-22 BR BR112015025464A patent/BR112015025464A2/pt not_active IP Right Cessation
- 2014-04-22 AU AU2014255608A patent/AU2014255608B2/en not_active Ceased
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2015
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- 2015-09-21 ZA ZA2015/07010A patent/ZA201507010B/en unknown
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- 2016-06-10 US US15/179,316 patent/US9751927B2/en active Active
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- 2017-08-15 US US15/677,585 patent/US20180044394A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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RS59124B1 (sr) | 2019-09-30 |
RU2683039C2 (ru) | 2019-03-26 |
ZA201507010B (en) | 2017-08-30 |
RU2015146600A (ru) | 2017-05-24 |
CA2909581A1 (en) | 2014-10-23 |
EP2986313B1 (en) | 2019-06-12 |
KR20160021758A (ko) | 2016-02-26 |
JP6594856B2 (ja) | 2019-10-23 |
MX2015014408A (es) | 2017-07-28 |
BR112015025464A2 (pt) | 2017-10-10 |
US20150374794A1 (en) | 2015-12-31 |
US20160355562A1 (en) | 2016-12-08 |
PL2986313T3 (pl) | 2019-12-31 |
CN105307672A (zh) | 2016-02-03 |
RU2015146600A3 (es) | 2018-03-29 |
US9474790B2 (en) | 2016-10-25 |
CN105307672B (zh) | 2021-01-05 |
EP2986313A1 (en) | 2016-02-24 |
WO2014170496A1 (en) | 2014-10-23 |
JP2016526012A (ja) | 2016-09-01 |
US20180044394A1 (en) | 2018-02-15 |
US9751927B2 (en) | 2017-09-05 |
SI2986313T1 (sl) | 2019-09-30 |
MY174727A (en) | 2020-05-11 |
AU2014255608A1 (en) | 2015-10-08 |
AU2014255608B2 (en) | 2018-01-25 |
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