CR20170293A - Derivados de glucagón con estabilidad mejorada - Google Patents

Derivados de glucagón con estabilidad mejorada

Info

Publication number
CR20170293A
CR20170293A CR20170293A CR20170293A CR20170293A CR 20170293 A CR20170293 A CR 20170293A CR 20170293 A CR20170293 A CR 20170293A CR 20170293 A CR20170293 A CR 20170293A CR 20170293 A CR20170293 A CR 20170293A
Authority
CR
Costa Rica
Prior art keywords
glucagon
present
improved stability
hypoglycemia
prevention
Prior art date
Application number
CR20170293A
Other languages
English (en)
Inventor
Jong Min Lee
Sung Min Bae
Jung Kuk Kim
Sung Youb Jung
Sang Yun Kim
Se Chang Kwon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of CR20170293A publication Critical patent/CR20170293A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un nuevo péptido derivado del glucagón y a una composición para la prevención o el tratamiento de hipoglucemia, que contiene el nuevo péptido derivado del glucagón como principio activo. El derivado de glucagón de acuerdo con la presente invención tiene propiedades físicas mejoradas debido al cambio en el punto isoeléctrico (pI) mientras que es capaz de mantener una actividad en los receptores del glucagón y, por tanto, puede mejorar la conformidad del paciente cuando se usa como un agente hipoglucémico y también es adecuado para la administración en combinación con otros agentes antiobesidad. Por consiguiente, el derivado de glucagón de acuerdo con la presente invención se puede usar de manera eficaz para la prevención y el tratamiento de la hipoglucemia y la obesidad.
CR20170293A 2014-12-30 2015-12-30 Derivados de glucagón con estabilidad mejorada CR20170293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140193800 2014-12-30
PCT/KR2015/014422 WO2016108586A1 (ko) 2014-12-30 2015-12-30 안정성이 증가된 글루카곤 유도체

Publications (1)

Publication Number Publication Date
CR20170293A true CR20170293A (es) 2017-11-03

Family

ID=56284642

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170293A CR20170293A (es) 2014-12-30 2015-12-30 Derivados de glucagón con estabilidad mejorada

Country Status (28)

Country Link
US (1) US11135271B2 (es)
EP (2) EP3575314B1 (es)
JP (2) JP6797122B2 (es)
KR (1) KR102291020B1 (es)
CN (1) CN107636009B (es)
AR (1) AR103322A1 (es)
AU (1) AU2015372818A1 (es)
CA (1) CA2972748A1 (es)
CL (1) CL2017001718A1 (es)
CO (1) CO2017006308A2 (es)
CR (1) CR20170293A (es)
DO (1) DOP2017000156A (es)
EA (1) EA035527B1 (es)
EC (1) ECSP17040923A (es)
GT (1) GT201700150A (es)
HK (1) HK1248713A1 (es)
IL (2) IL253206B (es)
MA (1) MA40709B1 (es)
MX (1) MX2017008569A (es)
MY (1) MY185334A (es)
PE (2) PE20171154A1 (es)
PH (1) PH12017501222A1 (es)
SG (1) SG11201705376SA (es)
TN (1) TN2017000271A1 (es)
TW (1) TW201639878A (es)
UA (1) UA126960C2 (es)
WO (1) WO2016108586A1 (es)
ZA (1) ZA201705015B (es)

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CN108025041A (zh) 2015-06-30 2018-05-11 韩美药品株式会社 胰高血糖素衍生物和包含其长效缀合物的组合物
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AU2018388331A1 (en) * 2017-12-22 2020-07-02 Hanmi Pharm. Co., Ltd. Therapeutic enzyme fusion protein having a novel structure and use thereof
JP7444786B2 (ja) * 2018-01-23 2024-03-06 ゼリス ファーマシューティカルズ インコーポレイテッド 低用量の安定なグルカゴンを使用する肥満治療手術後の低血糖症の処置
CN113365651A (zh) * 2018-12-21 2021-09-07 韩美药品株式会社 包含胰岛素和胰高血糖素的药物组合物
CN109836486B (zh) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 成纤维生长因子21变体、其融合蛋白及其用途
CA3179603A1 (en) 2020-05-22 2021-11-25 Hanmi Pharm. Co., Ltd. Liquid formulation of long-acting conjugate of glucagon derivative
AU2021308828A1 (en) 2020-07-15 2023-02-23 Hanmi Pharm. Co., Ltd. Therapeutic use of glucagon derivative or conjugate thereof for liver disease
KR20220140443A (ko) 2021-04-09 2022-10-18 한미약품 주식회사 글루카곤 유도체를 포함하는 만성 신장 질환 예방 또는 치료용 약학 조성물
KR20230095666A (ko) * 2021-12-22 2023-06-29 한미약품 주식회사 간 표적 물질 및 이의 용도
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法

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Also Published As

Publication number Publication date
EP3575314B1 (en) 2024-02-14
AR103322A1 (es) 2017-05-03
ECSP17040923A (es) 2017-12-01
CN107636009B (zh) 2021-04-16
EP3241841A4 (en) 2018-10-17
TN2017000271A1 (en) 2018-10-19
SG11201705376SA (en) 2017-08-30
CL2017001718A1 (es) 2018-01-12
UA126960C2 (uk) 2023-03-01
EA035527B1 (ru) 2020-06-30
KR102291020B1 (ko) 2021-08-20
EP3575314A3 (en) 2020-01-22
MX2017008569A (es) 2017-10-20
EP3241841A1 (en) 2017-11-08
KR20160082482A (ko) 2016-07-08
US20170360892A1 (en) 2017-12-21
MA40709B1 (fr) 2019-07-31
PE20230304A1 (es) 2023-02-13
PH12017501222A1 (en) 2018-01-15
EP3575314C0 (en) 2024-02-14
JP2020188819A (ja) 2020-11-26
PE20171154A1 (es) 2017-08-16
IL253206B (en) 2021-10-31
CA2972748A1 (en) 2016-07-07
CO2017006308A2 (es) 2017-09-29
DOP2017000156A (es) 2017-10-15
ZA201705015B (en) 2018-04-25
BR112017014205A2 (pt) 2018-03-06
WO2016108586A1 (ko) 2016-07-07
CN107636009A (zh) 2018-01-26
NZ733464A (en) 2024-01-26
IL281375B (en) 2021-10-31
MA40709A1 (fr) 2017-12-29
AU2015372818A1 (en) 2017-07-27
JP6797122B2 (ja) 2020-12-09
GT201700150A (es) 2018-12-12
EP3575314A2 (en) 2019-12-04
HK1248713A1 (zh) 2018-10-19
JP7079301B2 (ja) 2022-06-01
TW201639878A (zh) 2016-11-16
US11135271B2 (en) 2021-10-05
JP2018504901A (ja) 2018-02-22
MY185334A (en) 2021-05-06
IL253206A0 (en) 2017-08-31
IL281375A (en) 2021-04-29
EA201791333A1 (ru) 2017-12-29

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