MA40709A1 - Dérivé du glucagon à stabilité améliorée - Google Patents
Dérivé du glucagon à stabilité amélioréeInfo
- Publication number
- MA40709A1 MA40709A1 MA40709A MA40709A MA40709A1 MA 40709 A1 MA40709 A1 MA 40709A1 MA 40709 A MA40709 A MA 40709A MA 40709 A MA40709 A MA 40709A MA 40709 A1 MA40709 A1 MA 40709A1
- Authority
- MA
- Morocco
- Prior art keywords
- glucagon
- glucagon derivative
- improved stability
- present
- peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne un nouveau peptide dérivé du glucagon, ainsi qu'une composition destinée à la prévention ou au traitement de l'hypoglycémie et de l'obésité, comprenant le peptide en tant que principe actif. Le dérivé de glucagon de la présente invention présente une activité maintenue dans le temps contre les récepteurs du glucagon et présente des propriétés physiques améliorées en raison d'une modification de son point isoélectrique, et est ainsi capable d'améliorer l'utilisation conforme
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140193800 | 2014-12-30 | ||
PCT/KR2015/014422 WO2016108586A1 (fr) | 2014-12-30 | 2015-12-30 | Dérivé du glucagon à stabilité améliorée |
Publications (2)
Publication Number | Publication Date |
---|---|
MA40709A1 true MA40709A1 (fr) | 2017-12-29 |
MA40709B1 MA40709B1 (fr) | 2019-07-31 |
Family
ID=56284642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA40709A MA40709B1 (fr) | 2014-12-30 | 2015-12-30 | Dérivé du glucagon à stabilité améliorée |
Country Status (29)
Country | Link |
---|---|
US (1) | US11135271B2 (fr) |
EP (2) | EP3241841A4 (fr) |
JP (2) | JP6797122B2 (fr) |
KR (1) | KR102291020B1 (fr) |
CN (1) | CN107636009B (fr) |
AR (1) | AR103322A1 (fr) |
AU (1) | AU2015372818A1 (fr) |
CA (1) | CA2972748A1 (fr) |
CL (1) | CL2017001718A1 (fr) |
CO (1) | CO2017006308A2 (fr) |
CR (1) | CR20170293A (fr) |
DO (1) | DOP2017000156A (fr) |
EA (1) | EA035527B1 (fr) |
EC (1) | ECSP17040923A (fr) |
ES (1) | ES2976562T3 (fr) |
GT (1) | GT201700150A (fr) |
HK (1) | HK1248713A1 (fr) |
IL (2) | IL253206B (fr) |
MA (1) | MA40709B1 (fr) |
MX (1) | MX2017008569A (fr) |
MY (1) | MY185334A (fr) |
PE (2) | PE20230304A1 (fr) |
PH (1) | PH12017501222A1 (fr) |
SG (1) | SG11201705376SA (fr) |
TN (1) | TN2017000271A1 (fr) |
TW (1) | TW201639878A (fr) |
UA (1) | UA126960C2 (fr) |
WO (1) | WO2016108586A1 (fr) |
ZA (1) | ZA201705015B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10696725B2 (en) | 2015-06-30 | 2020-06-30 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
US10981967B2 (en) | 2015-12-31 | 2021-04-20 | Hanmi Pharm. Co., Ltd. | Long-acting conjugate of triple glucagon/GLP-1/GIP receptor agonist |
US11135271B2 (en) | 2014-12-30 | 2021-10-05 | Hanmi Pharm. Co., Ltd. | Glucagon derivatives with improved stability |
US11142559B2 (en) | 2016-06-29 | 2021-10-12 | Hanmi Pharm. Co., Ltd. | Glucagon derivative, conjugate thereof, composition comprising same, and therapeutic use thereof |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
BR112019016077A2 (pt) | 2017-02-03 | 2020-03-31 | Hanmi Pharm. Co., Ltd. | Conjugado da fórmula 1, método para preparar o conjugado, preparação de atuação longa, preparação para prevenir ou tratar diabetes e método para tratar diabetes |
CN111511910A (zh) * | 2017-12-22 | 2020-08-07 | 韩美药品株式会社 | 具有新颖结构的治疗酶融合蛋白及其用途 |
CN111936159A (zh) * | 2018-01-23 | 2020-11-13 | Xeris药物公司 | 使用微剂量的稳定胰高血糖素治疗减肥术后低血糖症 |
US20220064248A1 (en) | 2018-12-21 | 2022-03-03 | HANMl PHARM. CO., LTD | Pharmaceutical composition including insulin and glucagon |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
IL298396A (en) | 2020-05-22 | 2023-01-01 | Hanmi Pharm Ind Co Ltd | A liquid formulation of a long-acting conjugate of a glucagon derivative |
CA3186097A1 (fr) | 2020-07-15 | 2022-01-20 | Jung Kuk Kim | Utilisation therapeutique d'un derive du glucagon ou d'un conjugue de celui-ci pour une maladie hepatique |
CN117157094A (zh) | 2021-04-09 | 2023-12-01 | 韩美药品株式会社 | 包括胰高血糖素衍生物的用于预防或治疗慢性肾病的药物组合物 |
KR20230095666A (ko) | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5408037A (en) | 1991-01-17 | 1995-04-18 | Zymogenetics, Inc. | Methods for detecting glucagon antagonists |
GB9423277D0 (en) | 1994-11-18 | 1995-01-11 | Univ Nottingham | Pulsed laser deposition of coatings |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
AU728657B2 (en) | 1996-03-18 | 2001-01-18 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6677136B2 (en) | 2000-05-03 | 2004-01-13 | Amgen Inc. | Glucagon antagonists |
DE60228972D1 (de) | 2001-07-31 | 2008-10-30 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
CA2518336A1 (fr) | 2003-03-19 | 2004-11-04 | Eli Lilly And Company | Composes glp-1 a liaison polyethylene glycol |
JP4870569B2 (ja) | 2003-11-13 | 2012-02-08 | ハンミ ホールディングス カンパニー リミテッド | 免疫グロブリン断片を用いた蛋白質結合体およびその製造方法 |
US8263084B2 (en) | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
MX2008013304A (es) | 2006-04-20 | 2008-10-27 | Amgen Inc | Compuestos de peptido 1 tipo glucagon. |
JP2008169195A (ja) | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
ES2628063T3 (es) | 2007-01-05 | 2017-08-01 | Indiana University Research And Technology Corporation | Análogos de glucagón que muestran una mayor solubilidad en tampones de pH fisiológicos |
CA2677932A1 (fr) | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Co-agonistes des recepteurs du glucagon/glp-1 |
US7994122B2 (en) | 2007-06-15 | 2011-08-09 | Zealand Pharma A/S | Glucagon analogues |
SG178797A1 (en) | 2007-06-19 | 2012-03-29 | Otsuka Chemical Co Ltd | Oligosaccharide chain added glp-1 peptide |
CN101868476B (zh) | 2007-09-05 | 2015-02-25 | 诺沃-诺迪斯克有限公司 | 胰高血糖素样肽-1衍生物及其制药用途 |
US20110065633A1 (en) | 2008-01-30 | 2011-03-17 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
CL2009001425A1 (es) | 2008-06-17 | 2010-04-30 | Univ Indiana Res & Tech Corp | Analogos de glucagon con un aminoacido aromatico grande que carece de cadena lateral de imidazol que le confiere actividad agonista del receptor gip; composiciones farmaceutica; kit que los contiene y uso para reducir el aumento de peso, tratar la diabetes o inducir paralisis del tracto intestinal. |
CA2727161A1 (fr) * | 2008-06-17 | 2009-12-23 | Indiana University Research And Technology Corporation | Analogues de glucagon presentant des tampons de ph physiologique presentant une solubilite et une stabilite ameliorees |
WO2010096052A1 (fr) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Analogues d'oxyntomoduline |
IN2012DN00377A (fr) | 2009-06-16 | 2015-08-21 | Univ Indiana Res & Tech Corp | |
ES2537287T3 (es) | 2009-07-13 | 2015-06-05 | Zealand Pharma A/S | Análogos de glucagón acilados |
GB0917072D0 (en) | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
US8703701B2 (en) * | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
EA026384B1 (ru) * | 2010-01-20 | 2017-04-28 | Зилэнд Фарма А/С | Лечение заболеваний сердца |
RU2559320C2 (ru) * | 2010-03-26 | 2015-08-10 | Ново Нордиск А/С | Новые аналоги глюкагона |
MX2012013005A (es) | 2010-05-13 | 2013-02-26 | Univ Indiana Res & Tech Corp | Peptidos de la superfamilia de glucagon que presentan actividad del receptor acoplado a proteinas g. |
KR101382593B1 (ko) | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
BR112013015389A2 (pt) | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
WO2012150503A2 (fr) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Composés sélectifs de la signalisation d'agoniste mixte glu-glp-1 |
CA3134906A1 (fr) | 2011-05-18 | 2012-11-22 | Mederis Diabetes, Llc | Substances pharmaceutiques peptidiques ameliorees pour la resistance a l'insuline |
ES2692187T3 (es) | 2011-06-10 | 2018-11-30 | Hanmi Science Co., Ltd. | Nuevos derivados de oxintomodulina y composición farmacéutica para el tratamiento de obesidad que lo comprende |
KR101577734B1 (ko) * | 2011-06-17 | 2015-12-29 | 한미사이언스 주식회사 | 옥신토모듈린과 면역글로불린 단편을 포함하는 결합체 및 그의 용도 |
WO2013004983A1 (fr) | 2011-07-04 | 2013-01-10 | Imperial Innovations Limited | Nouveaux composés et leurs effets sur le comportement alimentaire |
CA2847246A1 (fr) * | 2011-11-17 | 2013-05-23 | Indiana University Research And Technology Corporation | Peptides de la superfamille du glucagon presentant une action sur les recepteurs aux glucocorticoides |
PL2864350T3 (pl) | 2012-06-21 | 2019-01-31 | Indiana University Research And Technology Corporation | Analogi glukagonu wykazujące aktywność wobec receptora GIP |
KR20150023013A (ko) | 2012-06-21 | 2015-03-04 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 수용체 활성을 나타내는 글루카곤 유사체 |
KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
WO2014049610A2 (fr) | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides en tant que triples agonistes des récepteurs de gip, glp-1 et glucagon |
WO2014073842A1 (fr) | 2012-11-06 | 2014-05-15 | Hanmi Pharm. Co., Ltd. | Formulation liquide d'un conjugué protéique comprenant l'oxyntomoduline et un fragment d'immunoglobuline |
KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
DK2922877T3 (da) | 2012-11-20 | 2019-01-02 | Eumederis Pharmaceuticals Inc | Forbedrede peptidlægemidler |
EP3653649A1 (fr) | 2012-11-20 | 2020-05-20 | Mederis Diabetes, LLC | Produits pharmaceutiques peptidiques améliorés pour la résistance à l'insuline |
CN104902920A (zh) | 2012-12-21 | 2015-09-09 | 赛诺菲 | 作为glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂的毒蜥外泌肽-4衍生物 |
MX362275B (es) * | 2013-04-18 | 2019-01-10 | Novo Nordisk As | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. |
US20160185837A1 (en) | 2013-08-16 | 2016-06-30 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
EP3080149A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Agonistes mixtes des récepteurs du glp-1/glucagon |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
TWI802396B (zh) | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
EP3206710B1 (fr) | 2014-09-24 | 2020-05-06 | Indiana University Research & Technology Corporation | Conjugués d'insuline-incrétines |
KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
EA035527B1 (ru) | 2014-12-30 | 2020-06-30 | Ханми Фарм. Ко., Лтд. | Производные глюкагона с улучшенной стабильностью |
PE20240215A1 (es) * | 2015-06-30 | 2024-02-16 | Hanmi Pharmaceutical Co Ltd | Derivado de glucagon y una composicion que comprende un conjugado de accion prolongada del mismo |
TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Fc區之蛋白質接合物 |
KR20170080521A (ko) | 2015-12-31 | 2017-07-10 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 |
-
2015
- 2015-12-30 EA EA201791333A patent/EA035527B1/ru not_active IP Right Cessation
- 2015-12-30 MY MYPI2017000967A patent/MY185334A/en unknown
- 2015-12-30 EP EP15875680.9A patent/EP3241841A4/fr not_active Withdrawn
- 2015-12-30 PE PE2022001996A patent/PE20230304A1/es unknown
- 2015-12-30 CR CR20170293A patent/CR20170293A/es unknown
- 2015-12-30 TW TW104144427A patent/TW201639878A/zh unknown
- 2015-12-30 ES ES19172184T patent/ES2976562T3/es active Active
- 2015-12-30 SG SG11201705376SA patent/SG11201705376SA/en unknown
- 2015-12-30 WO PCT/KR2015/014422 patent/WO2016108586A1/fr active Application Filing
- 2015-12-30 MA MA40709A patent/MA40709B1/fr unknown
- 2015-12-30 KR KR1020150189532A patent/KR102291020B1/ko active IP Right Grant
- 2015-12-30 MX MX2017008569A patent/MX2017008569A/es unknown
- 2015-12-30 AR ARP150104340A patent/AR103322A1/es unknown
- 2015-12-30 CA CA2972748A patent/CA2972748A1/fr active Pending
- 2015-12-30 EP EP19172184.4A patent/EP3575314B1/fr active Active
- 2015-12-30 TN TN2017000271A patent/TN2017000271A1/en unknown
- 2015-12-30 US US15/540,729 patent/US11135271B2/en active Active
- 2015-12-30 CN CN201580077186.3A patent/CN107636009B/zh active Active
- 2015-12-30 PE PE2017001168A patent/PE20171154A1/es unknown
- 2015-12-30 JP JP2017535417A patent/JP6797122B2/ja active Active
- 2015-12-30 UA UAA201707040A patent/UA126960C2/uk unknown
- 2015-12-30 AU AU2015372818A patent/AU2015372818A1/en not_active Abandoned
-
2017
- 2017-06-27 IL IL253206A patent/IL253206B/en unknown
- 2017-06-27 CO CONC2017/0006308A patent/CO2017006308A2/es unknown
- 2017-06-28 CL CL2017001718A patent/CL2017001718A1/es unknown
- 2017-06-28 EC ECIEPI201740923A patent/ECSP17040923A/es unknown
- 2017-06-28 GT GT201700150A patent/GT201700150A/es unknown
- 2017-06-29 PH PH12017501222A patent/PH12017501222A1/en unknown
- 2017-06-29 DO DO2017000156A patent/DOP2017000156A/es unknown
- 2017-07-24 ZA ZA2017/05015A patent/ZA201705015B/en unknown
-
2018
- 2018-04-10 HK HK18104685.2A patent/HK1248713A1/zh unknown
-
2020
- 2020-08-28 JP JP2020144259A patent/JP7079301B2/ja active Active
-
2021
- 2021-03-09 IL IL281375A patent/IL281375B/en unknown
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11135271B2 (en) | 2014-12-30 | 2021-10-05 | Hanmi Pharm. Co., Ltd. | Glucagon derivatives with improved stability |
US10696725B2 (en) | 2015-06-30 | 2020-06-30 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
US11261227B2 (en) | 2015-06-30 | 2022-03-01 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
US11667688B2 (en) | 2015-06-30 | 2023-06-06 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
US10981967B2 (en) | 2015-12-31 | 2021-04-20 | Hanmi Pharm. Co., Ltd. | Long-acting conjugate of triple glucagon/GLP-1/GIP receptor agonist |
US11332508B2 (en) | 2015-12-31 | 2022-05-17 | Hanmi Pharm. Co., Ltd. | Triple glucagon/GLP-1/GIP receptor agonist |
US11142559B2 (en) | 2016-06-29 | 2021-10-12 | Hanmi Pharm. Co., Ltd. | Glucagon derivative, conjugate thereof, composition comprising same, and therapeutic use thereof |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA40709B1 (fr) | Dérivé du glucagon à stabilité améliorée | |
CY1120213T1 (el) | Antαγωνιστες φθοριωμενης ιντεγκρινης | |
AU2018260800B2 (en) | Hepcidin analogues and uses therof | |
EA201591176A1 (ru) | Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном | |
EA201692301A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
EA201890343A1 (ru) | Быстродействующие инсулиновые композиции | |
EA201590058A1 (ru) | Аналоги глюкагона | |
EA201691988A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
EA201690606A1 (ru) | Аналоги глюкагона | |
EA201791617A1 (ru) | Аналоги амилина | |
MA37963A1 (fr) | Protéines de fusion pour traiter un syndrome métabolique | |
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
EA201990360A1 (ru) | Аналоги амилина | |
EA201890570A1 (ru) | [4-(1,3,3-триметил-2-оксо-3,4-дигидро-1h-хиноксалин-7-ил)фенокси]этилокси соединение или его соль | |
EA201690159A1 (ru) | Способы и композиции для лечения рака | |
FR3061856B1 (fr) | Utilisations therapeutiques d'une poudre d'insectes | |
EA201991387A1 (ru) | ТРИЦИКЛИЧЕСКИЕ ЕНОНЫ - ПРОИЗВОДНЫЕ ПИРИМИДИНА ДЛЯ ИНГИБИРОВАНИЯ ROR-γ И ДРУГИХ ПРИМЕНЕНИЙ | |
EA201791005A1 (ru) | Улучшенные антитела против il-6 | |
BR112016028227A2 (pt) | método para redução de imunogenicidade de proteína e peptídeo | |
EA201490790A1 (ru) | Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1 | |
BR112018015367A2 (pt) | carreadores oromucosais de nanofibra para tratamento terapêutico | |
CL2018001343A1 (es) | Lactoferrina para uso en el diagnóstico o el pronóstico de la enfermedad de alzheimer o en el diagnóstico de la enfermedad de parkinson | |
PE20160012A1 (es) | Tratamiento de enfermedades miopaticas y neurogenerativas por agregacion de proteina mediante administracion parenteral | |
PH12014502352A1 (en) | Aqueous pharmaceutical composition containing a biologic therapeutic agent and guanidine or a guanidine derivative and an injection including the composition | |
EA201692402A1 (ru) | Лекарственные формы для местного применения и их использование |