CL2017001718A1 - Derivados de glucagón con estabilidad mejorada - Google Patents
Derivados de glucagón con estabilidad mejoradaInfo
- Publication number
- CL2017001718A1 CL2017001718A1 CL2017001718A CL2017001718A CL2017001718A1 CL 2017001718 A1 CL2017001718 A1 CL 2017001718A1 CL 2017001718 A CL2017001718 A CL 2017001718A CL 2017001718 A CL2017001718 A CL 2017001718A CL 2017001718 A1 CL2017001718 A1 CL 2017001718A1
- Authority
- CL
- Chile
- Prior art keywords
- glucagon
- improved stability
- hypoglucemia
- prevention
- accordance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN SE REFIERE A UN NUEVO PÉPTIDO DERIVADO DEL GLUCAGÓN Y A UNA COMPOSICIÓN PARA LA PREVENCIÓN O EL TRATAMIENTO DE HIPOGLUCEMIA, QUE CONTIENE EL NUEVO PÉPTIDO DERIVADO DEL GLUCAGÓN COMO PRINCIPIO ACTIVO. EL DERIVADO DE GLUCAGÓN DE ACUERDO CON LA PRESENTE INVENCIÓN TIENE PROPIEDADES FÍSICAS MEJORADAS DEBIDO AL CAMBIO EN EL PUNTO ISOELÉCTRICO (PI) MIENTRAS QUE ES CAPAZ DE MANTENER UNA ACTIVIDAD EN LOS RECEPTORES DEL GLUCAGÓN Y, POR TANTO, PUEDE MEJORAR LA CONFORMIDAD DEL PACIENTE CUANDO SE USA COMO UN AGENTE HIPOGLUCÉMICO Y TAMBIÉN ES ADECUADO PARA LA ADMINISTRACIÓN EN COMBINACIÓN CON OTROS AGENTES ANTIOBESIDAD. POR CONSIGUIENTE, EL DERIVADO DE GLUCAGÓN DE ACUERDO CON LA PRESENTE INVENCIÓN SE PUEDE USAR DE MANERA EFICAZ PARA LA PREVENCIÓN Y EL TRATAMIENTO DE LA HIPOGLUCEMIA Y LA OBESIDAD.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140193800 | 2014-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017001718A1 true CL2017001718A1 (es) | 2018-01-12 |
Family
ID=56284642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017001718A CL2017001718A1 (es) | 2014-12-30 | 2017-06-28 | Derivados de glucagón con estabilidad mejorada |
Country Status (29)
Country | Link |
---|---|
US (1) | US11135271B2 (es) |
EP (2) | EP3241841A4 (es) |
JP (2) | JP6797122B2 (es) |
KR (1) | KR102291020B1 (es) |
CN (1) | CN107636009B (es) |
AR (1) | AR103322A1 (es) |
AU (1) | AU2015372818A1 (es) |
CA (1) | CA2972748A1 (es) |
CL (1) | CL2017001718A1 (es) |
CO (1) | CO2017006308A2 (es) |
CR (1) | CR20170293A (es) |
DO (1) | DOP2017000156A (es) |
EA (1) | EA035527B1 (es) |
EC (1) | ECSP17040923A (es) |
GT (1) | GT201700150A (es) |
HK (1) | HK1248713A1 (es) |
IL (2) | IL253206B (es) |
MA (1) | MA40709B1 (es) |
MX (1) | MX2017008569A (es) |
MY (1) | MY185334A (es) |
NZ (1) | NZ733464A (es) |
PE (2) | PE20230304A1 (es) |
PH (1) | PH12017501222A1 (es) |
SG (1) | SG11201705376SA (es) |
TN (1) | TN2017000271A1 (es) |
TW (1) | TW201639878A (es) |
UA (1) | UA126960C2 (es) |
WO (1) | WO2016108586A1 (es) |
ZA (1) | ZA201705015B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11135271B2 (en) | 2014-12-30 | 2021-10-05 | Hanmi Pharm. Co., Ltd. | Glucagon derivatives with improved stability |
US10696725B2 (en) | 2015-06-30 | 2020-06-30 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
MX2018008027A (es) | 2015-12-31 | 2018-11-29 | Hanmi Pharm Ind Co Ltd | Activador triple que activa receptor de glucagon, glp-1 y gip. |
CA3029518A1 (en) * | 2016-06-29 | 2018-01-04 | Hanmi Pharm. Co., Ltd. | Glucagon derivative, conjugate thereof, composition comprising same, and therapeutic use thereof |
AU2018215840A1 (en) | 2017-02-03 | 2019-08-01 | Hanmi Pharm. Co., Ltd. | Long-Acting Conjugate Of A Physiologically Active Material And Use Thereof |
NZ765453A (en) * | 2017-12-22 | 2024-03-22 | Hanmi Pharmaceutical Co Ltd | Therapeutic enzyme fusion protein having novel structure and use thereof |
MX2020007768A (es) * | 2018-01-23 | 2020-11-12 | Xeris Pharmaceuticals Inc | Tratamiento contra hipoglucemia posbariátrica usando pequeñas dosis de glucagón estable. |
JP2022514835A (ja) * | 2018-12-21 | 2022-02-16 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン及びグルカゴンを含む薬学組成物 |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
JP2023526551A (ja) | 2020-05-22 | 2023-06-21 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン誘導体の持続型結合体の液状製剤 |
EP4183407A1 (en) | 2020-07-15 | 2023-05-24 | Hanmi Pharm. Co., Ltd. | Therapeutic use of glucagon derivative or conjugate thereof for liver disease |
EP4321170A1 (en) | 2021-04-09 | 2024-02-14 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for preventing or treating chronic kidney disease containing glucagon derivative |
KR20230095666A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
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US11135271B2 (en) | 2014-12-30 | 2021-10-05 | Hanmi Pharm. Co., Ltd. | Glucagon derivatives with improved stability |
KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
US10696725B2 (en) * | 2015-06-30 | 2020-06-30 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Fc區之蛋白質接合物 |
MX2018008027A (es) | 2015-12-31 | 2018-11-29 | Hanmi Pharm Ind Co Ltd | Activador triple que activa receptor de glucagon, glp-1 y gip. |
-
2015
- 2015-12-30 US US15/540,729 patent/US11135271B2/en active Active
- 2015-12-30 KR KR1020150189532A patent/KR102291020B1/ko active IP Right Grant
- 2015-12-30 MA MA40709A patent/MA40709B1/fr unknown
- 2015-12-30 UA UAA201707040A patent/UA126960C2/uk unknown
- 2015-12-30 EA EA201791333A patent/EA035527B1/ru not_active IP Right Cessation
- 2015-12-30 MX MX2017008569A patent/MX2017008569A/es unknown
- 2015-12-30 NZ NZ733464A patent/NZ733464A/en unknown
- 2015-12-30 SG SG11201705376SA patent/SG11201705376SA/en unknown
- 2015-12-30 TW TW104144427A patent/TW201639878A/zh unknown
- 2015-12-30 TN TN2017000271A patent/TN2017000271A1/en unknown
- 2015-12-30 AU AU2015372818A patent/AU2015372818A1/en not_active Abandoned
- 2015-12-30 CA CA2972748A patent/CA2972748A1/en active Pending
- 2015-12-30 WO PCT/KR2015/014422 patent/WO2016108586A1/ko active Application Filing
- 2015-12-30 EP EP15875680.9A patent/EP3241841A4/en not_active Withdrawn
- 2015-12-30 MY MYPI2017000967A patent/MY185334A/en unknown
- 2015-12-30 CN CN201580077186.3A patent/CN107636009B/zh active Active
- 2015-12-30 AR ARP150104340A patent/AR103322A1/es unknown
- 2015-12-30 EP EP19172184.4A patent/EP3575314B1/en active Active
- 2015-12-30 CR CR20170293A patent/CR20170293A/es unknown
- 2015-12-30 PE PE2022001996A patent/PE20230304A1/es unknown
- 2015-12-30 PE PE2017001168A patent/PE20171154A1/es unknown
- 2015-12-30 JP JP2017535417A patent/JP6797122B2/ja active Active
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2017
- 2017-06-27 IL IL253206A patent/IL253206B/en unknown
- 2017-06-27 CO CONC2017/0006308A patent/CO2017006308A2/es unknown
- 2017-06-28 CL CL2017001718A patent/CL2017001718A1/es unknown
- 2017-06-28 GT GT201700150A patent/GT201700150A/es unknown
- 2017-06-28 EC ECIEPI201740923A patent/ECSP17040923A/es unknown
- 2017-06-29 DO DO2017000156A patent/DOP2017000156A/es unknown
- 2017-06-29 PH PH12017501222A patent/PH12017501222A1/en unknown
- 2017-07-24 ZA ZA2017/05015A patent/ZA201705015B/en unknown
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2018
- 2018-04-10 HK HK18104685.2A patent/HK1248713A1/zh unknown
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2020
- 2020-08-28 JP JP2020144259A patent/JP7079301B2/ja active Active
-
2021
- 2021-03-09 IL IL281375A patent/IL281375B/en unknown
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