JP2011517675A5 - - Google Patents
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- Publication number
- JP2011517675A5 JP2011517675A5 JP2011502041A JP2011502041A JP2011517675A5 JP 2011517675 A5 JP2011517675 A5 JP 2011517675A5 JP 2011502041 A JP2011502041 A JP 2011502041A JP 2011502041 A JP2011502041 A JP 2011502041A JP 2011517675 A5 JP2011517675 A5 JP 2011517675A5
- Authority
- JP
- Japan
- Prior art keywords
- ada
- igf
- levels
- suppressing
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 13
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 10
- 239000003937 drug carrier Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
- XXEWFEBMSGLYBY-ZETCQYMHSA-N N(6),N(6)-dimethyl-L-lysine Chemical compound CN(C)CCCC[C@H](N)C(O)=O XXEWFEBMSGLYBY-ZETCQYMHSA-N 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4041808P | 2008-03-28 | 2008-03-28 | |
| US61/040,418 | 2008-03-28 | ||
| PCT/US2009/038351 WO2009120831A2 (en) | 2008-03-28 | 2009-03-26 | Novel n-and c-terminal substituted antagonistic analogs of gh-rh |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517675A JP2011517675A (ja) | 2011-06-16 |
| JP2011517675A5 true JP2011517675A5 (enExample) | 2011-11-17 |
| JP5588963B2 JP5588963B2 (ja) | 2014-09-10 |
Family
ID=40886425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502041A Active JP5588963B2 (ja) | 2008-03-28 | 2009-03-26 | Ｇｈ−ｒｈの新規なｎ−およびｃ−末端が置換されたアンタゴニスト類似体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8227405B2 (enExample) |
| EP (1) | EP2288374B1 (enExample) |
| JP (1) | JP5588963B2 (enExample) |
| CN (1) | CN101983068B (enExample) |
| AU (1) | AU2009228244A1 (enExample) |
| BR (1) | BRPI0910873A2 (enExample) |
| CA (1) | CA2718146C (enExample) |
| IL (1) | IL208099A0 (enExample) |
| MX (1) | MX2010010642A (enExample) |
| WO (1) | WO2009120831A2 (enExample) |
| ZA (1) | ZA201006843B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
| WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| WO2014004934A2 (en) * | 2012-06-27 | 2014-01-03 | University Of Miami | Compositions and methods of treating alzheimer's disease |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| WO2020163833A2 (en) * | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
| JP7719466B2 (ja) | 2019-07-18 | 2025-08-06 | ユニバーシティー オブ マイアミ | サルコイドーシスを処置する方法での使用のためのｇｈｒｈアンタゴニスト |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU651976B2 (en) * | 1990-05-04 | 1994-08-11 | The Administrators Of The Tulane Eductional Fund | Novel synthetic GRF analogs |
| US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
| US6057422A (en) * | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
| TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
-
2009
- 2009-03-26 AU AU2009228244A patent/AU2009228244A1/en not_active Abandoned
- 2009-03-26 CN CN200980111242.5A patent/CN101983068B/zh active Active
- 2009-03-26 BR BRPI0910873A patent/BRPI0910873A2/pt not_active IP Right Cessation
- 2009-03-26 MX MX2010010642A patent/MX2010010642A/es not_active Application Discontinuation
- 2009-03-26 JP JP2011502041A patent/JP5588963B2/ja active Active
- 2009-03-26 EP EP09723785.3A patent/EP2288374B1/en active Active
- 2009-03-26 WO PCT/US2009/038351 patent/WO2009120831A2/en not_active Ceased
- 2009-03-26 CA CA2718146A patent/CA2718146C/en active Active
- 2009-09-17 US US12/562,096 patent/US8227405B2/en active Active
-
2010
- 2010-09-12 IL IL208099A patent/IL208099A0/en unknown
- 2010-09-27 ZA ZA2010/06843A patent/ZA201006843B/en unknown