CN101983068B - N末端和c末端取代的人gh-rh拮抗类似物 - Google Patents

N末端和c末端取代的人gh-rh拮抗类似物 Download PDF

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Publication number
CN101983068B
CN101983068B CN200980111242.5A CN200980111242A CN101983068B CN 101983068 B CN101983068 B CN 101983068B CN 200980111242 A CN200980111242 A CN 200980111242A CN 101983068 B CN101983068 B CN 101983068B
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CN
China
Prior art keywords
boc
arg
peptide
ala
tyr
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Active
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CN200980111242.5A
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English (en)
Chinese (zh)
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CN101983068A (zh
Inventor
A·V·沙利
J·L·瓦格加
M·扎兰蒂
蔡仁治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
US Department of Veterans Affairs
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University of Miami
US Department of Veterans Affairs
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN200980111242.5A 2008-03-28 2009-03-26 N末端和c末端取代的人gh-rh拮抗类似物 Active CN101983068B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4041808P 2008-03-28 2008-03-28
US61/040,418 2008-03-28
PCT/US2009/038351 WO2009120831A2 (en) 2008-03-28 2009-03-26 Novel n-and c-terminal substituted antagonistic analogs of gh-rh

Publications (2)

Publication Number Publication Date
CN101983068A CN101983068A (zh) 2011-03-02
CN101983068B true CN101983068B (zh) 2014-12-24

Family

ID=40886425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980111242.5A Active CN101983068B (zh) 2008-03-28 2009-03-26 N末端和c末端取代的人gh-rh拮抗类似物

Country Status (11)

Country Link
US (1) US8227405B2 (enExample)
EP (1) EP2288374B1 (enExample)
JP (1) JP5588963B2 (enExample)
CN (1) CN101983068B (enExample)
AU (1) AU2009228244A1 (enExample)
BR (1) BRPI0910873A2 (enExample)
CA (1) CA2718146C (enExample)
IL (1) IL208099A0 (enExample)
MX (1) MX2010010642A (enExample)
WO (1) WO2009120831A2 (enExample)
ZA (1) ZA201006843B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
WO2014004934A2 (en) * 2012-06-27 2014-01-03 University Of Miami Compositions and methods of treating alzheimer's disease
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
WO2020163833A2 (en) * 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
JP7719466B2 (ja) 2019-07-18 2025-08-06 ユニバーシティー オブ マイアミ サルコイドーシスを処置する方法での使用のためのｇｈｒｈアンタゴニスト

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
WO1997042223A1 (en) * 1996-05-03 1997-11-13 The Administrators Of The Tulane Educational Fund hGH-RH(1-29)NH2 ANALOGUES HAVING ANTAGONISTIC ACTIVITY
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
WO1997042223A1 (en) * 1996-05-03 1997-11-13 The Administrators Of The Tulane Educational Fund hGH-RH(1-29)NH2 ANALOGUES HAVING ANTAGONISTIC ACTIVITY
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Also Published As

Publication number Publication date
US20100092539A1 (en) 2010-04-15
ZA201006843B (en) 2012-03-28
CA2718146C (en) 2016-09-20
EP2288374A2 (en) 2011-03-02
CA2718146A1 (en) 2009-10-01
WO2009120831A8 (en) 2010-09-30
IL208099A0 (en) 2010-12-30
AU2009228244A1 (en) 2009-10-01
MX2010010642A (es) 2011-03-29
BRPI0910873A2 (pt) 2015-10-06
CN101983068A (zh) 2011-03-02
JP2011517675A (ja) 2011-06-16
JP5588963B2 (ja) 2014-09-10
WO2009120831A2 (en) 2009-10-01
WO2009120831A3 (en) 2009-12-23
US8227405B2 (en) 2012-07-24
EP2288374B1 (en) 2017-02-01

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