MX2010010642A - Nuevos analogos antagonistas, sustituidos, n- y c- terminales, de hormona liberadora de hormona de crecimiento (gh-rh). - Google Patents
Nuevos analogos antagonistas, sustituidos, n- y c- terminales, de hormona liberadora de hormona de crecimiento (gh-rh).Info
- Publication number
- MX2010010642A MX2010010642A MX2010010642A MX2010010642A MX2010010642A MX 2010010642 A MX2010010642 A MX 2010010642A MX 2010010642 A MX2010010642 A MX 2010010642A MX 2010010642 A MX2010010642 A MX 2010010642A MX 2010010642 A MX2010010642 A MX 2010010642A
- Authority
- MX
- Mexico
- Prior art keywords
- ada
- dca
- amc
- analogs
- novel
- Prior art date
Links
- -1 substituted Chemical group 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000036515 potency Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4041808P | 2008-03-28 | 2008-03-28 | |
| PCT/US2009/038351 WO2009120831A2 (en) | 2008-03-28 | 2009-03-26 | Novel n-and c-terminal substituted antagonistic analogs of gh-rh |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010010642A true MX2010010642A (es) | 2011-03-29 |
Family
ID=40886425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010010642A MX2010010642A (es) | 2008-03-28 | 2009-03-26 | Nuevos analogos antagonistas, sustituidos, n- y c- terminales, de hormona liberadora de hormona de crecimiento (gh-rh). |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8227405B2 (enExample) |
| EP (1) | EP2288374B1 (enExample) |
| JP (1) | JP5588963B2 (enExample) |
| CN (1) | CN101983068B (enExample) |
| AU (1) | AU2009228244A1 (enExample) |
| BR (1) | BRPI0910873A2 (enExample) |
| CA (1) | CA2718146C (enExample) |
| IL (1) | IL208099A0 (enExample) |
| MX (1) | MX2010010642A (enExample) |
| WO (1) | WO2009120831A2 (enExample) |
| ZA (1) | ZA201006843B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8691942B2 (en) * | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
| WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| CN104582796A (zh) * | 2012-06-27 | 2015-04-29 | 迈阿密大学 | 治疗阿尔茨海默病的组合物和方法 |
| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| EP2935317B1 (en) | 2012-12-21 | 2019-03-27 | University of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| CA3129405A1 (en) * | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
| WO2021011874A1 (en) | 2019-07-18 | 2021-01-21 | University Of Miami | Ghrh antagonists for use in a method of treating sarcoidosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016923A1 (en) * | 1990-05-04 | 1991-11-14 | The Administrators Of The Tulane University Educational Fund | Novel synthetic grf analogs |
| US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
| US6057422A (en) * | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
| TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
-
2009
- 2009-03-26 AU AU2009228244A patent/AU2009228244A1/en not_active Abandoned
- 2009-03-26 JP JP2011502041A patent/JP5588963B2/ja active Active
- 2009-03-26 WO PCT/US2009/038351 patent/WO2009120831A2/en not_active Ceased
- 2009-03-26 EP EP09723785.3A patent/EP2288374B1/en active Active
- 2009-03-26 CA CA2718146A patent/CA2718146C/en active Active
- 2009-03-26 BR BRPI0910873A patent/BRPI0910873A2/pt not_active IP Right Cessation
- 2009-03-26 MX MX2010010642A patent/MX2010010642A/es not_active Application Discontinuation
- 2009-03-26 CN CN200980111242.5A patent/CN101983068B/zh active Active
- 2009-09-17 US US12/562,096 patent/US8227405B2/en active Active
-
2010
- 2010-09-12 IL IL208099A patent/IL208099A0/en unknown
- 2010-09-27 ZA ZA2010/06843A patent/ZA201006843B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009120831A2 (en) | 2009-10-01 |
| WO2009120831A8 (en) | 2010-09-30 |
| US8227405B2 (en) | 2012-07-24 |
| CN101983068B (zh) | 2014-12-24 |
| JP2011517675A (ja) | 2011-06-16 |
| ZA201006843B (en) | 2012-03-28 |
| WO2009120831A3 (en) | 2009-12-23 |
| CA2718146A1 (en) | 2009-10-01 |
| US20100092539A1 (en) | 2010-04-15 |
| CN101983068A (zh) | 2011-03-02 |
| IL208099A0 (en) | 2010-12-30 |
| CA2718146C (en) | 2016-09-20 |
| EP2288374A2 (en) | 2011-03-02 |
| JP5588963B2 (ja) | 2014-09-10 |
| BRPI0910873A2 (pt) | 2015-10-06 |
| AU2009228244A1 (en) | 2009-10-01 |
| EP2288374B1 (en) | 2017-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |