JP5588963B2 - Ｇｈ−ｒｈの新規なｎ−およびｃ−末端が置換されたアンタゴニスト類似体 - Google Patents

Ｇｈ−ｒｈの新規なｎ−およびｃ−末端が置換されたアンタゴニスト類似体 Download PDF

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Publication number
JP5588963B2
JP5588963B2 JP2011502041A JP2011502041A JP5588963B2 JP 5588963 B2 JP5588963 B2 JP 5588963B2 JP 2011502041 A JP2011502041 A JP 2011502041A JP 2011502041 A JP2011502041 A JP 2011502041A JP 5588963 B2 JP5588963 B2 JP 5588963B2
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boc
peptide
arg
tyr
ala
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JP2011502041A
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English (en)
Japanese (ja)
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JP2011517675A (ja
JP2011517675A5 (enExample
Inventor
シャリー，アンドリュー，ブイ．
ヴァルガ，ジョゼフ，エル．
ザランディ，マルタ
ツァイ，レンチィ
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University of Miami
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University of Miami
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2011502041A 2008-03-28 2009-03-26 Ｇｈ−ｒｈの新規なｎ−およびｃ−末端が置換されたアンタゴニスト類似体 Active JP5588963B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4041808P 2008-03-28 2008-03-28
US61/040,418 2008-03-28
PCT/US2009/038351 WO2009120831A2 (en) 2008-03-28 2009-03-26 Novel n-and c-terminal substituted antagonistic analogs of gh-rh

Publications (3)

Publication Number Publication Date
JP2011517675A JP2011517675A (ja) 2011-06-16
JP2011517675A5 JP2011517675A5 (enExample) 2011-11-17
JP5588963B2 true JP5588963B2 (ja) 2014-09-10

Family

ID=40886425

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011502041A Active JP5588963B2 (ja) 2008-03-28 2009-03-26 Ｇｈ−ｒｈの新規なｎ−およびｃ−末端が置換されたアンタゴニスト類似体

Country Status (11)

Country Link
US (1) US8227405B2 (enExample)
EP (1) EP2288374B1 (enExample)
JP (1) JP5588963B2 (enExample)
CN (1) CN101983068B (enExample)
AU (1) AU2009228244A1 (enExample)
BR (1) BRPI0910873A2 (enExample)
CA (1) CA2718146C (enExample)
IL (1) IL208099A0 (enExample)
MX (1) MX2010010642A (enExample)
WO (1) WO2009120831A2 (enExample)
ZA (1) ZA201006843B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691942B2 (en) * 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
CN104582796A (zh) * 2012-06-27 2015-04-29 迈阿密大学 治疗阿尔茨海默病的组合物和方法
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
CA3129405A1 (en) * 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
WO2021011874A1 (en) 2019-07-18 2021-01-21 University Of Miami Ghrh antagonists for use in a method of treating sarcoidosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists

Also Published As

Publication number Publication date
WO2009120831A2 (en) 2009-10-01
WO2009120831A8 (en) 2010-09-30
US8227405B2 (en) 2012-07-24
CN101983068B (zh) 2014-12-24
JP2011517675A (ja) 2011-06-16
ZA201006843B (en) 2012-03-28
WO2009120831A3 (en) 2009-12-23
CA2718146A1 (en) 2009-10-01
US20100092539A1 (en) 2010-04-15
CN101983068A (zh) 2011-03-02
IL208099A0 (en) 2010-12-30
MX2010010642A (es) 2011-03-29
CA2718146C (en) 2016-09-20
EP2288374A2 (en) 2011-03-02
BRPI0910873A2 (pt) 2015-10-06
AU2009228244A1 (en) 2009-10-01
EP2288374B1 (en) 2017-02-01

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EP2288374B1 (en) Novel n-and c-terminal substituted antagonistic analogs of human gh-rh
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US7452865B2 (en) Antagonistic analogs of GH RH (2003)
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JPH09506616A (ja) 拮抗活性を有するｈＧＨ−ＲＨ（１−２９）ＮＨ▲下２▼の類似体
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