CA2718146C - Novel n- and c-terminal substituted antagonistic analogs of gh-rh - Google Patents

Novel n- and c-terminal substituted antagonistic analogs of gh-rh Download PDF

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Publication number
CA2718146C
CA2718146C CA2718146A CA2718146A CA2718146C CA 2718146 C CA2718146 C CA 2718146C CA 2718146 A CA2718146 A CA 2718146A CA 2718146 A CA2718146 A CA 2718146A CA 2718146 C CA2718146 C CA 2718146C
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CA
Canada
Prior art keywords
boc
tyr
arg2
arg28
har9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2718146A
Other languages
English (en)
French (fr)
Other versions
CA2718146A1 (en
Inventor
Andrew V. Schally
Jozsef L. Varga
Zarandi Marta
Cai Renzhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
United States Department of Veterans Affairs
Original Assignee
University of Miami
United States Department of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of Miami, United States Department of Veterans Affairs filed Critical University of Miami
Publication of CA2718146A1 publication Critical patent/CA2718146A1/en
Application granted granted Critical
Publication of CA2718146C publication Critical patent/CA2718146C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2718146A 2008-03-28 2009-03-26 Novel n- and c-terminal substituted antagonistic analogs of gh-rh Active CA2718146C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4041808P 2008-03-28 2008-03-28
US61/040,418 2008-03-28
PCT/US2009/038351 WO2009120831A2 (en) 2008-03-28 2009-03-26 Novel n-and c-terminal substituted antagonistic analogs of gh-rh

Publications (2)

Publication Number Publication Date
CA2718146A1 CA2718146A1 (en) 2009-10-01
CA2718146C true CA2718146C (en) 2016-09-20

Family

ID=40886425

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2718146A Active CA2718146C (en) 2008-03-28 2009-03-26 Novel n- and c-terminal substituted antagonistic analogs of gh-rh

Country Status (11)

Country Link
US (1) US8227405B2 (enExample)
EP (1) EP2288374B1 (enExample)
JP (1) JP5588963B2 (enExample)
CN (1) CN101983068B (enExample)
AU (1) AU2009228244A1 (enExample)
BR (1) BRPI0910873A2 (enExample)
CA (1) CA2718146C (enExample)
IL (1) IL208099A0 (enExample)
MX (1) MX2010010642A (enExample)
WO (1) WO2009120831A2 (enExample)
ZA (1) ZA201006843B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691942B2 (en) * 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
CN104582796A (zh) * 2012-06-27 2015-04-29 迈阿密大学 治疗阿尔茨海默病的组合物和方法
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
CA3129405A1 (en) * 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
WO2021011874A1 (en) 2019-07-18 2021-01-21 University Of Miami Ghrh antagonists for use in a method of treating sarcoidosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists

Also Published As

Publication number Publication date
WO2009120831A2 (en) 2009-10-01
WO2009120831A8 (en) 2010-09-30
US8227405B2 (en) 2012-07-24
CN101983068B (zh) 2014-12-24
JP2011517675A (ja) 2011-06-16
ZA201006843B (en) 2012-03-28
WO2009120831A3 (en) 2009-12-23
CA2718146A1 (en) 2009-10-01
US20100092539A1 (en) 2010-04-15
CN101983068A (zh) 2011-03-02
IL208099A0 (en) 2010-12-30
MX2010010642A (es) 2011-03-29
EP2288374A2 (en) 2011-03-02
JP5588963B2 (ja) 2014-09-10
BRPI0910873A2 (pt) 2015-10-06
AU2009228244A1 (en) 2009-10-01
EP2288374B1 (en) 2017-02-01

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US7452865B2 (en) Antagonistic analogs of GH RH (2003)
CA2253663C (en) Hgh-rh(1-29)nh2 analogues having antagonistic activity
AU757222B2 (en) Antagonistic analogs of GH-RH inhibiting IGF-I and -II
US9260504B2 (en) N- and C-terminal substituted antagonistic analogs of GH-RH
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