JP2018506534A5 - - Google Patents

Info

Publication number

JP2018506534A5

JP2018506534A5 JP2017541934A JP2017541934A JP2018506534A5 JP 2018506534 A5 JP2018506534 A5 JP 2018506534A5 JP 2017541934 A JP2017541934 A JP 2017541934A JP 2017541934 A JP2017541934 A JP 2017541934A JP 2018506534 A5 JP2018506534 A5 JP 2018506534A5

Authority

JP

Japan

Prior art keywords

ghr

stat5

socs

halogen

alkyl

Prior art date

2016-02-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229910052739 hydrogen Inorganic materials 0.000 claims 16
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 10
• 102100032218 Cytokine-inducible SH2-containing protein Human genes 0.000 claims 8
• 102100020948 Growth hormone receptor Human genes 0.000 claims 8
• 102000001712 STAT5 Transcription Factor Human genes 0.000 claims 8
• 125000000217 alkyl group Chemical group 0.000 claims 8
• 229910052736 halogen Inorganic materials 0.000 claims 8
• 150000002367 halogens Chemical class 0.000 claims 8
• 150000002431 hydrogen Chemical class 0.000 claims 8
• 239000001257 hydrogen Substances 0.000 claims 8
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 101000943420 Homo sapiens Cytokine-inducible SH2-containing protein Proteins 0.000 claims 5
• 101001075374 Homo sapiens Gamma-glutamyl hydrolase Proteins 0.000 claims 5
• 101100534458 Homo sapiens STAT5A gene Proteins 0.000 claims 5
• 101000664737 Homo sapiens Somatotropin Proteins 0.000 claims 5
• 102000004877 Insulin Human genes 0.000 claims 5
• 229940125396 insulin Drugs 0.000 claims 5
• 108010033419 somatotropin-binding protein Proteins 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 101710132484 Cytokine-inducible SH2-containing protein Proteins 0.000 claims 3
• 101001075287 Homo sapiens Growth hormone receptor Proteins 0.000 claims 3
• 101000976075 Homo sapiens Insulin Proteins 0.000 claims 3
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 3
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
• 108010029477 STAT5 Transcription Factor Proteins 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 230000001105 regulatory effect Effects 0.000 claims 3
• 108090001061 Insulin Proteins 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 0 **1C=CC(OCc([o]2)nnc2SCCCN(C(C=C*(*)C=C2)=C2N2)C2=O)=CC=C1 Chemical compound **1C=CC(OCc([o]2)nnc2SCCCN(C(C=C*(*)C=C2)=C2N2)C2=O)=CC=C1 0.000 description 2