JP2010502734A5 - - Google Patents
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- JP2010502734A5 JP2010502734A5 JP2009527565A JP2009527565A JP2010502734A5 JP 2010502734 A5 JP2010502734 A5 JP 2010502734A5 JP 2009527565 A JP2009527565 A JP 2009527565A JP 2009527565 A JP2009527565 A JP 2009527565A JP 2010502734 A5 JP2010502734 A5 JP 2010502734A5
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- elp component
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- elp
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- 239000000203 mixture Substances 0.000 claims 26
- 230000001225 therapeutic effect Effects 0.000 claims 24
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 4
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 4
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 235000004554 glutamine Nutrition 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84246406P | 2006-09-06 | 2006-09-06 | |
| US60/842,464 | 2006-09-06 | ||
| PCT/US2007/077767 WO2008030968A2 (en) | 2006-09-06 | 2007-09-06 | Fusion peptide therapeutic compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013217181A Division JP5802250B2 (ja) | 2006-09-06 | 2013-10-18 | 融合ペプチド治療用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010502734A JP2010502734A (ja) | 2010-01-28 |
| JP2010502734A5 true JP2010502734A5 (enExample) | 2010-10-14 |
| JP5395664B2 JP5395664B2 (ja) | 2014-01-22 |
Family
ID=39158053
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527565A Active JP5395664B2 (ja) | 2006-09-06 | 2007-09-06 | 融合ペプチド治療用組成物 |
| JP2013217181A Active JP5802250B2 (ja) | 2006-09-06 | 2013-10-18 | 融合ペプチド治療用組成物 |
| JP2015168457A Pending JP2016026167A (ja) | 2006-09-06 | 2015-08-28 | 融合ペプチド治療用組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013217181A Active JP5802250B2 (ja) | 2006-09-06 | 2013-10-18 | 融合ペプチド治療用組成物 |
| JP2015168457A Pending JP2016026167A (ja) | 2006-09-06 | 2015-08-28 | 融合ペプチド治療用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20110039776A1 (enExample) |
| EP (1) | EP2059606A4 (enExample) |
| JP (3) | JP5395664B2 (enExample) |
| CN (2) | CN101578373A (enExample) |
| AU (1) | AU2007292295B2 (enExample) |
| CA (1) | CA2663047A1 (enExample) |
| IL (2) | IL197442A (enExample) |
| MX (1) | MX2009002547A (enExample) |
| WO (1) | WO2008030968A2 (enExample) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2616701C (en) * | 2005-07-28 | 2018-10-02 | Global Research Technologies, Llc | Removal of carbon dioxide from air |
| ES2779992T3 (es) | 2005-12-20 | 2020-08-21 | Univ Duke | Métodos y composiciones para suministrar agentes activos con propiedades farmacológicas potenciadas |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US7709227B2 (en) * | 2006-01-04 | 2010-05-04 | Phasebio Pharmaceuticals, Inc. | Multimeric ELP fusion constructs |
| US9359635B2 (en) | 2006-04-03 | 2016-06-07 | Promega Corporation | Permuted and nonpermuted luciferase biosensors |
| JP6110591B2 (ja) | 2008-05-19 | 2017-04-05 | プロメガ コーポレイションPromega Corporation | cAMPのためのルシフェラーゼバイオセンサー |
| WO2009158704A2 (en) | 2008-06-27 | 2009-12-30 | Duke University | Therapeutic agents comprising elastin-like peptides |
| CN102245760A (zh) | 2008-07-07 | 2011-11-16 | 牛津纳米孔技术有限公司 | 酶-孔构建体 |
| CN102144037A (zh) | 2008-07-07 | 2011-08-03 | 牛津纳米孔技术有限公司 | 检测碱基的孔 |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| CN101418290A (zh) * | 2008-12-02 | 2009-04-29 | 中山大学 | 一种高效的elp融合蛋白酶及其制备和应用 |
| US8214916B2 (en) | 2009-01-26 | 2012-07-03 | Nanoink, Inc. | Large area, homogeneous array fabrication including leveling with use of bright spots |
| US9222082B2 (en) * | 2009-01-30 | 2015-12-29 | Oxford Nanopore Technologies Limited | Hybridization linkers |
| WO2010086622A1 (en) | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2010124180A1 (en) * | 2009-04-23 | 2010-10-28 | Phasebio Pharmaceuticals, Inc. | Phenylalanine hydroxylase fusion protein and methods for treating phenylketonuria |
| HUE054744T2 (hu) | 2009-08-14 | 2021-12-28 | Phasebio Pharmaceuticals Inc | Módosított vazoaktív intesztinális peptidek |
| US8940868B2 (en) * | 2009-10-08 | 2015-01-27 | The General Hospital Corporation | Elastin based growth factor delivery platform for wound healing and regeneration |
| WO2011112549A2 (en) * | 2010-03-10 | 2011-09-15 | Emory University | Temperature sensitive conjugate compositions, and uses related thereto |
| US9290794B2 (en) | 2010-05-11 | 2016-03-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| JP5961163B2 (ja) | 2010-05-11 | 2016-08-02 | プロメガ コーポレイションPromega Corporation | 増強された検出特性を有する変異プロテアーゼバイオセンサー |
| CN101955960B (zh) * | 2010-08-03 | 2012-05-23 | 中山大学 | 一种利用类弹性蛋白标签纯化重组乳糖酶的方法 |
| JP6169976B2 (ja) | 2011-02-11 | 2017-07-26 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体細孔 |
| CA2827170A1 (en) | 2011-02-11 | 2012-08-16 | David M. Hilbert | Monovalent and multivalent multispecific complexes and uses thereof |
| EP2717902B1 (en) | 2011-06-06 | 2018-01-24 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
| CN102241747A (zh) * | 2011-06-17 | 2011-11-16 | 李立文 | 类人弹性蛋白及其生产方法 |
| WO2013014451A1 (en) | 2011-07-25 | 2013-01-31 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| US9102763B2 (en) | 2011-07-26 | 2015-08-11 | University Of Southern California | Controlled release of ocular biopharmaceuticals using bioresponsive protein polymers |
| EP2747832A4 (en) * | 2011-08-24 | 2015-01-07 | Phasebio Pharmaceuticals Inc | AGGREGATE FORMULATIONS FOR DELAYED RELEASE |
| EP2817025A2 (en) * | 2012-02-08 | 2014-12-31 | Seneb Biosciences, Inc. | Treatment of hypoglycemia |
| US20130210747A1 (en) | 2012-02-13 | 2013-08-15 | University Of Southern California | Methods and Therapeutics Comprising Ligand-Targeted ELPs |
| JP6157877B2 (ja) * | 2012-02-28 | 2017-07-05 | 三洋化成工業株式会社 | 組織再生用ゲル、組織再生用タンパク質溶液及び組織再生用ゲルの製造方法 |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| WO2014013259A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
| WO2014026054A2 (en) | 2012-08-10 | 2014-02-13 | University Of Southern California | CD20 scFv-ELPs METHODS AND THERAPEUTICS |
| WO2014028776A1 (en) * | 2012-08-15 | 2014-02-20 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
| JP2016505627A (ja) * | 2013-01-15 | 2016-02-25 | フェーズバイオ ファーマシューティカルズ,インコーポレイテッド | 治療剤、組成物、および血糖コントロールのための方法 |
| SG11201507138RA (en) | 2013-03-08 | 2015-10-29 | Oxford Nanopore Tech Ltd | Enzyme stalling method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| EP3052125B1 (en) * | 2013-10-01 | 2020-09-30 | University of Mississippi Medical Center | Elastin-like polypeptide coupled to therapeutic agent for delivery during pregnancy |
| US11268127B2 (en) | 2014-02-04 | 2022-03-08 | Duke University | Systems and devices for protease detection based on engineered polymers and biopolymers and methods of use |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| AU2015250039B2 (en) | 2014-04-21 | 2018-03-22 | D&D Pharmatech Inc. | TRAIL receptor agonists for treatment of fibrotic diseases |
| WO2015166275A1 (en) | 2014-05-02 | 2015-11-05 | Oxford Nanopore Technologies Limited | Mutant pores |
| ES2818824T3 (es) | 2014-05-08 | 2021-04-14 | Phasebio Pharmaceuticals Inc | Composiciones que comprenden una proteína de fusión de VIP-ELP para su uso en el tratamiento de fibrosis quística |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| WO2016081884A2 (en) * | 2014-11-21 | 2016-05-26 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins for controlled and sustained release |
| EP3229845B1 (en) | 2014-12-10 | 2020-05-27 | University of Southern California | Generation of hemoglobin-based oxygen carriers using elastin-like polypeptides |
| CN114652817A (zh) | 2015-02-09 | 2022-06-24 | 费斯生物制药公司 | 用于治疗肌肉疾病和病症的方法和组合物 |
| WO2017020025A1 (en) * | 2015-07-29 | 2017-02-02 | Kiick Kristi | Thermoresponsive bioconjugates and their controlled delivery of cargo |
| CN106632682A (zh) * | 2015-08-04 | 2017-05-10 | 清华大学 | 融合蛋白ifn-elp及其应用 |
| WO2017024182A1 (en) | 2015-08-04 | 2017-02-09 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
| KR101759122B1 (ko) | 2015-08-07 | 2017-07-18 | 계명대학교 산학협력단 | 오렉신 a를 함유하는 당뇨병 치료용 약학 조성물 |
| WO2017106627A1 (en) | 2015-12-17 | 2017-06-22 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| US11059870B2 (en) | 2016-03-14 | 2021-07-13 | Industry-University Cooperation Foundation Hanyang University Erica Campus | Polypeptides with phase transition, triblock polypeptides of the polypeptide-calmodulin-polypeptide with multi-stimuli responsiveness, hydrogel of the triblock polypeptides, and its uses |
| KR102028931B1 (ko) * | 2016-03-24 | 2019-10-08 | 한양대학교 에리카산학협력단 | 지능형 약물 전달을 위한 다중 자극 반응성을 지닌 칼모듈린-엘라스틴 이중 블럭 폴리펩타이드의 동적 나노 전달체 및 제조방법 |
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| US20190218274A1 (en) | 2016-05-06 | 2019-07-18 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins for controlled and sustained release |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
| CN107459580A (zh) * | 2016-06-06 | 2017-12-12 | 易金阳 | 一种利用酵母菌表达含有穿膜肽的寡肽‑1(egf)创新制备工艺 |
| RU2019110848A (ru) | 2016-09-14 | 2020-10-15 | Дьюк Юниверсити | Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств |
| WO2018057847A1 (en) | 2016-09-23 | 2018-03-29 | Duke University | Unstructured non-repetitive polypeptides having lcst behavior |
| CN106519040B (zh) * | 2016-11-02 | 2020-03-27 | 南京大学 | 一种含肿瘤坏死因子相关凋亡诱导配体的融合蛋白和其制备方法及由该蛋白自组装的纳米粒 |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| KR101955366B1 (ko) * | 2017-06-02 | 2019-03-07 | 인제대학교 산학협력단 | 인터페론 베타-엘라스틴 재조합 단백질 및 이의 생산방법 |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| JP7074995B2 (ja) * | 2017-10-13 | 2022-05-25 | 林兼産業株式会社 | 線維芽細胞増殖促進剤及び線維芽細胞におけるエラスチン産生促進剤 |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| CN108531492A (zh) * | 2018-04-23 | 2018-09-14 | 内蒙古农业大学 | 利用类弹性蛋白elp构建活性绵羊β-防御素sbd-1体外表达的方法 |
| WO2019213150A1 (en) | 2018-04-30 | 2019-11-07 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
| CA3109082A1 (en) | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| US20220289812A1 (en) * | 2019-08-09 | 2022-09-15 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins comprising parathyroid hormone for controlled and sustained release |
| WO2021168270A1 (en) * | 2020-02-19 | 2021-08-26 | Isolere Bio, Inc. | Protein-based purification matrices and methods of using the same |
| US20230128032A1 (en) | 2020-03-31 | 2023-04-27 | Curtails Llc | Early Drug Interventions to Reduce COVID-19 Related Respiratory Distress, Need for Respirator Assist and Death |
| US11767353B2 (en) | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
| KR102687389B1 (ko) * | 2020-08-25 | 2024-07-25 | 한양대학교 에리카산학협력단 | 자극 반응성 및 표면 부착성을 가진 점착성 엘라스틴 및 서커린 기반 다중 블록 코폴리펩타이드, 그의 자가조립 구조체 및 주사형 하이드로겔의 생접착제 응용 |
| IL303948A (en) | 2020-12-23 | 2023-08-01 | Jazz Pharmaceuticals Ireland Ltd | Methods of purifying charge-shielded fusion proteins |
| US20250368708A1 (en) * | 2022-05-23 | 2025-12-04 | Fudan University | TREFOIL FACTOR 2/INTERFERON alpha2 FUSION PROTEIN AND APPLICATION THEREOF IN PREVENTION AND TREATMENT OF VIRAL INFECTIOUS DISEASES |
| CN115724915B (zh) * | 2022-08-17 | 2025-08-12 | 上普博源(北京)生物科技有限公司 | 类弹性蛋白多肽粘合剂及其制备方法与应用 |
| CN117777303A (zh) * | 2022-09-27 | 2024-03-29 | 北京大学 | 一种高亲和力pd1蛋白偶联物及其应用 |
| EP4644412A1 (en) * | 2022-12-27 | 2025-11-05 | NexThera Co., Ltd. | Manufacture of elastin-like polypeptide-based recombinant protein and animal cell expression platform thereof |
| WO2025076213A1 (en) * | 2023-10-04 | 2025-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Isothermally phase-separable elastin-like polypeptides, compositions, and methods of use thereof |
| WO2025100511A1 (ja) * | 2023-11-10 | 2025-05-15 | 地方独立行政法人神奈川県立産業技術総合研究所 | 融合ペプチド |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100627590B1 (ko) * | 1998-01-30 | 2006-09-25 | 다이이치 아스비오파마 가부시키가이샤 | 보조 펩타이드를 사용하는 펩타이드의 제조방법 |
| US6852834B2 (en) * | 2000-03-20 | 2005-02-08 | Ashutosh Chilkoti | Fusion peptides isolatable by phase transition |
| US20050255554A1 (en) * | 2000-03-20 | 2005-11-17 | Ashutosh Chilkoti | Fusion peptides isolatable by phase transition |
| AU2001261024A1 (en) * | 2000-04-12 | 2001-10-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| MXPA03005036A (es) * | 2000-12-07 | 2003-09-05 | Lilly Co Eli | Proteinas de fusion glp-1. |
| US20030098869A1 (en) * | 2001-11-09 | 2003-05-29 | Arnold Glenn Christopher | Real time interactive video system |
| JP4873860B2 (ja) * | 2002-08-30 | 2012-02-08 | バイオレクシス ファーマシューティカル コーポレーション | 改変トランスフェリン融合タンパク質 |
| ATE525395T1 (de) * | 2003-06-12 | 2011-10-15 | Lilly Co Eli | Fusions proteine von glp-1-analoga |
| JP4149867B2 (ja) * | 2003-07-28 | 2008-09-17 | キヤノンファインテック株式会社 | プリンタ、その制御方法 |
| US7019845B1 (en) * | 2004-10-06 | 2006-03-28 | Rudolph Technologies, Inc. | Measuring elastic moduli of dielectric thin films using an optical metrology system |
| WO2006110292A2 (en) * | 2005-03-25 | 2006-10-19 | The Regents Of The University Of California | Temperature-triggered immobilization and purification of antibodies |
-
2007
- 2007-09-06 CN CNA2007800411806A patent/CN101578373A/zh active Pending
- 2007-09-06 CN CN2013101274907A patent/CN103230598A/zh active Pending
- 2007-09-06 MX MX2009002547A patent/MX2009002547A/es active IP Right Grant
- 2007-09-06 JP JP2009527565A patent/JP5395664B2/ja active Active
- 2007-09-06 US US12/440,294 patent/US20110039776A1/en not_active Abandoned
- 2007-09-06 AU AU2007292295A patent/AU2007292295B2/en active Active
- 2007-09-06 EP EP07814724A patent/EP2059606A4/en not_active Ceased
- 2007-09-06 WO PCT/US2007/077767 patent/WO2008030968A2/en not_active Ceased
- 2007-09-06 CA CA002663047A patent/CA2663047A1/en not_active Abandoned
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2009
- 2009-03-05 IL IL197442A patent/IL197442A/en active IP Right Grant
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2012
- 2012-07-09 US US13/544,595 patent/US20130143802A1/en not_active Abandoned
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2013
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- 2013-10-18 JP JP2013217181A patent/JP5802250B2/ja active Active
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- 2015-08-28 JP JP2015168457A patent/JP2016026167A/ja active Pending
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