EA035527B1 - Производные глюкагона с улучшенной стабильностью - Google Patents
Производные глюкагона с улучшенной стабильностью Download PDFInfo
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- EA035527B1 EA035527B1 EA201791333A EA201791333A EA035527B1 EA 035527 B1 EA035527 B1 EA 035527B1 EA 201791333 A EA201791333 A EA 201791333A EA 201791333 A EA201791333 A EA 201791333A EA 035527 B1 EA035527 B1 EA 035527B1
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- Eurasian Patent Office
- Prior art keywords
- cysteine
- glucagon
- seq
- receptor agonist
- pharmaceutical composition
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07K14/575—Hormones
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Landscapes
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- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CN108025041A (zh) * | 2015-06-30 | 2018-05-11 | 韩美药品株式会社 | 胰高血糖素衍生物和包含其长效缀合物的组合物 |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| HK1258177A1 (en) | 2015-12-31 | 2019-11-08 | Hanmi Pharm. Co., Ltd. | Persistent conjugate of triple activator activating glucagon, glp-1 and gip receptor |
| SG11201811697SA (en) * | 2016-06-29 | 2019-01-30 | Hanmi Pharmaceutical Co Ltd | Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof |
| WO2018143729A1 (ko) | 2017-02-03 | 2018-08-09 | 한미약품 주식회사 | 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도 |
| AR113430A1 (es) * | 2017-12-22 | 2020-04-29 | Hanmi Pharm Ind Co Ltd | Proteína de fusión enzimática terapéutica que tiene una nueva estructura y su uso |
| BR112020014719A2 (pt) * | 2018-01-23 | 2020-12-08 | Xeris Pharmaceuticals, Inc. | Tratamento de hipoglicemia pós-bariátrica usando glucagon estável em minidose |
| WO2020130751A1 (ko) | 2018-12-21 | 2020-06-25 | 한미약품 주식회사 | 인슐린 및 글루카곤을 포함하는 약학 조성물 |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
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| WO2022216129A1 (ko) | 2021-04-09 | 2022-10-13 | 한미약품 주식회사 | 글루카곤 유도체를 포함하는 만성 신장 질환 예방 또는 치료용 약학 조성물 |
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| CN115490760B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物 |
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| WO2011117415A1 (en) * | 2010-03-26 | 2011-09-29 | Novo Nordisk A/S | Novel glucagon analogues |
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