JP2015512432A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015512432A5 JP2015512432A5 JP2015503847A JP2015503847A JP2015512432A5 JP 2015512432 A5 JP2015512432 A5 JP 2015512432A5 JP 2015503847 A JP2015503847 A JP 2015503847A JP 2015503847 A JP2015503847 A JP 2015503847A JP 2015512432 A5 JP2015512432 A5 JP 2015512432A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- eosinophilic
- chloride
- composition according
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 17
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 12
- 201000005667 central retinal vein occlusion Diseases 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 12
- 150000001450 anions Chemical group 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims description 8
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims description 8
- 208000015768 polyposis Diseases 0.000 claims description 8
- NTBIYBAYFBNTCD-UHFFFAOYSA-N dibenzoyl 2,3-dihydroxybutanedioate Chemical compound C=1C=CC=CC=1C(=O)OC(=O)C(O)C(O)C(=O)OC(=O)C1=CC=CC=C1 NTBIYBAYFBNTCD-UHFFFAOYSA-N 0.000 claims description 7
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims description 7
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims description 4
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims description 4
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims description 4
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 4
- 208000011325 dry age related macular degeneration Diseases 0.000 claims description 4
- 201000001561 eosinophilic gastritis Diseases 0.000 claims description 4
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims description 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- -1 dibenzoyl tartrate ions Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12162937.2 | 2012-04-03 | ||
| EP12162937 | 2012-04-03 | ||
| PCT/EP2013/056864 WO2013149986A1 (en) | 2012-04-03 | 2013-04-02 | Use of ccr3-inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246173A Division JP2018080183A (ja) | 2012-04-03 | 2017-12-22 | Ｃｃｒ３阻害薬の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015512432A JP2015512432A (ja) | 2015-04-27 |
| JP2015512432A5 true JP2015512432A5 (enExample) | 2016-06-02 |
Family
ID=48040249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503847A Pending JP2015512432A (ja) | 2012-04-03 | 2013-04-02 | Ｃｃｒ３阻害薬の使用 |
| JP2017246173A Withdrawn JP2018080183A (ja) | 2012-04-03 | 2017-12-22 | Ｃｃｒ３阻害薬の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246173A Withdrawn JP2018080183A (ja) | 2012-04-03 | 2017-12-22 | Ｃｃｒ３阻害薬の使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US20130261153A1 (enExample) |
| EP (3) | EP3763369B1 (enExample) |
| JP (2) | JP2015512432A (enExample) |
| KR (5) | KR20140144200A (enExample) |
| CN (2) | CN110384699A (enExample) |
| AU (1) | AU2013245027B2 (enExample) |
| BR (1) | BR112014023795B1 (enExample) |
| CA (1) | CA2869269C (enExample) |
| CL (1) | CL2014002523A1 (enExample) |
| CY (1) | CY1123222T1 (enExample) |
| DK (1) | DK2833884T3 (enExample) |
| EA (1) | EA032263B1 (enExample) |
| ES (2) | ES2987267T3 (enExample) |
| HR (1) | HRP20201165T1 (enExample) |
| HU (1) | HUE051648T2 (enExample) |
| IL (1) | IL234262A (enExample) |
| IN (1) | IN2014DN06989A (enExample) |
| LT (1) | LT2833884T (enExample) |
| MX (1) | MX2014011786A (enExample) |
| NZ (1) | NZ628882A (enExample) |
| PH (1) | PH12014502239A1 (enExample) |
| PL (1) | PL2833884T3 (enExample) |
| PT (1) | PT2833884T (enExample) |
| RS (1) | RS60665B1 (enExample) |
| SI (1) | SI2833884T1 (enExample) |
| SM (1) | SMT202000499T1 (enExample) |
| WO (1) | WO2013149986A1 (enExample) |
| ZA (1) | ZA201406082B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| AR090566A1 (es) | 2012-04-02 | 2014-11-19 | Boehringer Ingelheim Int | Proceso para la produccion de inhibidores de crr |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| JP6684363B2 (ja) | 2016-11-24 | 2020-04-22 | キリシマ精工株式会社 | 歯列矯正具 |
| ES3046717T3 (en) * | 2017-04-05 | 2025-12-02 | Alkahest Inc | Compounds and pharmaceutical compositions for use in treating retina-associated disease using ccr3-inhibitors |
| EP3606525B1 (en) | 2017-04-05 | 2025-12-10 | Alkahest, Inc. | Compositions for treating aging-associated impairments using ccr3-inhibitors |
| CN111343983A (zh) * | 2017-10-13 | 2020-06-26 | 万能溶剂有限公司 | 使用ccr3抑制剂治疗瘙痒、干燥症和相关疾病的方法和组合物 |
| BR112020023001A2 (pt) | 2018-05-15 | 2021-02-02 | Alkahest, Inc. | tratamento de doença associada ao envelhecimento com moduladores da leucotrieno a4 hidrolase |
| JP7528065B2 (ja) * | 2018-09-26 | 2024-08-05 | アルカヘスト，インコーポレイテッド | Ｃｃｒ３阻害剤を用いて、加齢性機能障害を治療するための方法および組成物 |
| CA3180401A1 (en) * | 2020-06-11 | 2021-12-16 | Bartosz SIKORSKI | Methods of improving retina-associated disease outcome using ccr3-inhibitors |
| EP4426284A4 (en) | 2021-11-01 | 2025-11-12 | Alkahest Inc | Benzodioxane Leukotriene A4 Hydrolase (LTA4H) Modulators for the Prevention and Treatment of Age-Related Diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339087B1 (en) * | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| EP1259615B1 (en) * | 2000-03-03 | 2008-11-12 | Cambridge Antibody Technology Limited | Antibodies against eotaxin and their use |
| US20020151064A1 (en) * | 2001-02-07 | 2002-10-17 | Children's Hospital Medical Center | Regulation of CCR3 expression |
| WO2006083390A2 (en) * | 2004-12-07 | 2006-08-10 | Children's Hospital Medical Center | Eotaxin-3 in eosinophilic esophagitis |
| US8008092B2 (en) * | 2007-10-09 | 2011-08-30 | University Of Kentucky Research Foundation | CCR3 inhibition for ocular angiogenesis and macular degeneration |
| WO2010069979A1 (en) * | 2008-12-16 | 2010-06-24 | Nycomed Gmbh | Pyran derivatives as ccr3 modulators |
| EP2236520A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Stabilizing composition for immobilized biomolecules |
| US8278302B2 (en) * | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| WO2010138591A1 (en) * | 2009-05-26 | 2010-12-02 | University Of Kentucky Research Foundation | Ccr3 and its ligands are therapeutic and diagnostic targets for neovascular age-related macular degeneration |
| UA109290C2 (uk) * | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) * | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| WO2020115836A1 (ja) * | 2018-12-05 | 2020-06-11 | 東浜工業株式会社 | ブロワー装置 |
-
2013
- 2013-03-27 US US13/851,564 patent/US20130261153A1/en not_active Abandoned
- 2013-04-02 CN CN201910406245.7A patent/CN110384699A/zh active Pending
- 2013-04-02 LT LTEP13713199.1T patent/LT2833884T/lt unknown
- 2013-04-02 JP JP2015503847A patent/JP2015512432A/ja active Pending
- 2013-04-02 KR KR1020147027679A patent/KR20140144200A/ko not_active Ceased
- 2013-04-02 HR HRP20201165TT patent/HRP20201165T1/hr unknown
- 2013-04-02 KR KR1020207011392A patent/KR20200044988A/ko not_active Ceased
- 2013-04-02 KR KR1020217015686A patent/KR20210063481A/ko not_active Ceased
- 2013-04-02 EA EA201401083A patent/EA032263B1/ru unknown
- 2013-04-02 KR KR1020257028220A patent/KR20250133980A/ko active Pending
- 2013-04-02 MX MX2014011786A patent/MX2014011786A/es unknown
- 2013-04-02 PL PL13713199T patent/PL2833884T3/pl unknown
- 2013-04-02 ES ES20174399T patent/ES2987267T3/es active Active
- 2013-04-02 BR BR112014023795-6A patent/BR112014023795B1/pt active IP Right Grant
- 2013-04-02 EP EP20174399.4A patent/EP3763369B1/en active Active
- 2013-04-02 IN IN6989DEN2014 patent/IN2014DN06989A/en unknown
- 2013-04-02 EP EP13713199.1A patent/EP2833884B1/en active Active
- 2013-04-02 RS RS20200868A patent/RS60665B1/sr unknown
- 2013-04-02 NZ NZ628882A patent/NZ628882A/en unknown
- 2013-04-02 WO PCT/EP2013/056864 patent/WO2013149986A1/en not_active Ceased
- 2013-04-02 DK DK13713199.1T patent/DK2833884T3/da active
- 2013-04-02 SI SI201331753T patent/SI2833884T1/sl unknown
- 2013-04-02 SM SM20200499T patent/SMT202000499T1/it unknown
- 2013-04-02 AU AU2013245027A patent/AU2013245027B2/en active Active
- 2013-04-02 CA CA2869269A patent/CA2869269C/en active Active
- 2013-04-02 KR KR1020227031439A patent/KR20220132012A/ko not_active Ceased
- 2013-04-02 EP EP24158785.6A patent/EP4389217A3/en active Pending
- 2013-04-02 ES ES13713199T patent/ES2811554T3/es active Active
- 2013-04-02 PT PT137131991T patent/PT2833884T/pt unknown
- 2013-04-02 HU HUE13713199A patent/HUE051648T2/hu unknown
- 2013-04-02 CN CN201380016333.7A patent/CN104220073A/zh active Pending
-
2014
- 2014-08-19 ZA ZA2014/06082A patent/ZA201406082B/en unknown
- 2014-08-24 IL IL234262A patent/IL234262A/en active IP Right Grant
- 2014-09-24 CL CL2014002523A patent/CL2014002523A1/es unknown
- 2014-10-03 PH PH12014502239A patent/PH12014502239A1/en unknown
- 2014-12-15 US US14/570,298 patent/US20150099783A1/en not_active Abandoned
-
2015
- 2015-11-30 US US14/953,480 patent/US20160081998A1/en not_active Abandoned
-
2017
- 2017-07-25 US US15/658,918 patent/US20170319567A1/en not_active Abandoned
- 2017-12-22 JP JP2017246173A patent/JP2018080183A/ja not_active Withdrawn
-
2020
- 2020-07-23 CY CY20201100678T patent/CY1123222T1/el unknown
- 2020-08-19 US US16/997,772 patent/US20200375971A1/en not_active Abandoned