IN2014DN06989A - - Google Patents
Info
- Publication number
- IN2014DN06989A IN2014DN06989A IN6989DEN2014A IN2014DN06989A IN 2014DN06989 A IN2014DN06989 A IN 2014DN06989A IN 6989DEN2014 A IN6989DEN2014 A IN 6989DEN2014A IN 2014DN06989 A IN2014DN06989 A IN 2014DN06989A
- Authority
- IN
- India
- Prior art keywords
- eosinophilic
- alkyl
- macular degeneration
- related macular
- age related
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
THE PRESENT INVENTION RELATES TO CCR3 INHIBITORS OF FORMULA (1) WHEREIN R1 IS H C ALKYL C ALKYL C CYCLOALKYL C HALOALKYL; R2 IS H C ALKYL; X IS AN ANION SELECTED FROM THE GROUP CONSISTING OF CHLORIDE OR ½ DIBENZOYLTARTRATE J IS 1 OR 2. FOR USE AS A MEDICAMENT FOR THE TREATMENT OF DISEASES SELECTED FROM DRY AGE RELATED MACULAR DEGENERATION (DAMD) WET AGE RELATED MACULAR DEGENERATION (WAMD) RETINOPATHY OF PREMATURITY (ROP) CENTRAL RETINAL VEIN OCCLUSION (CRVO) NASAL POLYPOSIS EOSINOPHILIC ESOPHAGITIS EOSINOPHILLIC GASTROENTERITIS (E.G. EOSINOPHILIC GASTRITIS AND EOSINOPHILIC ENTENTERITIS) HYPER EOSINOPHILIC SYNDROME AND CHURG STRAUSS SYNDROME.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12162937 | 2012-04-03 | ||
| PCT/EP2013/056864 WO2013149986A1 (en) | 2012-04-03 | 2013-04-02 | Use of ccr3-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN06989A true IN2014DN06989A (en) | 2015-04-10 |
Family
ID=48040249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6989DEN2014 IN2014DN06989A (en) | 2012-04-03 | 2013-04-02 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US20130261153A1 (en) |
| EP (2) | EP3763369B1 (en) |
| JP (2) | JP2015512432A (en) |
| KR (4) | KR20210063481A (en) |
| CN (2) | CN110384699A (en) |
| AU (1) | AU2013245027B2 (en) |
| BR (1) | BR112014023795B1 (en) |
| CA (1) | CA2869269C (en) |
| CL (1) | CL2014002523A1 (en) |
| CY (1) | CY1123222T1 (en) |
| DK (1) | DK2833884T3 (en) |
| EA (1) | EA032263B1 (en) |
| ES (1) | ES2811554T3 (en) |
| HR (1) | HRP20201165T1 (en) |
| HU (1) | HUE051648T2 (en) |
| IL (1) | IL234262A (en) |
| IN (1) | IN2014DN06989A (en) |
| LT (1) | LT2833884T (en) |
| MX (1) | MX2014011786A (en) |
| NZ (1) | NZ628882A (en) |
| PH (1) | PH12014502239A1 (en) |
| PL (1) | PL2833884T3 (en) |
| PT (1) | PT2833884T (en) |
| RS (1) | RS60665B1 (en) |
| SI (1) | SI2833884T1 (en) |
| WO (1) | WO2013149986A1 (en) |
| ZA (1) | ZA201406082B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (en) | 2010-10-07 | 2015-08-10 | Common Crystals and Salts of CCR3 Inhibitors | |
| AR090566A1 (en) | 2012-04-02 | 2014-11-19 | Boehringer Ingelheim Int | PROCESS FOR THE PRODUCTION OF CRR INHIBITORS |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| EP3449866B1 (en) | 2016-11-24 | 2021-10-20 | Kirishima Seiko Co., Ltd. | Orthodontic appliance |
| KR20190131078A (en) | 2017-04-05 | 2019-11-25 | 알카헤스트 인코포레이티드 | Methods and compositions for treating aging-related disorders with CCR3-inhibitors |
| IL269743B (en) * | 2017-04-05 | 2022-09-01 | Alkahest Inc | Methods and compositions for treating retina-associated disease using ccr3-inhibitors |
| WO2019075351A1 (en) * | 2017-10-13 | 2019-04-18 | Alkahest, Inc. | Methods and compositions for treating pruritus, xerosis, and associated disease using ccr3-inhibitors |
| MX2020011114A (en) | 2018-05-15 | 2021-01-29 | Alkahest Inc | Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase. |
| SG11202102105VA (en) * | 2018-09-26 | 2021-04-29 | Alkahest Inc | Methods and compositions for treating aging-associated impairments using ccr3-inhibitors |
| WO2023076679A1 (en) | 2021-11-01 | 2023-05-04 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339087B1 (en) * | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| US7323311B2 (en) * | 2000-03-03 | 2008-01-29 | Cambridge Antibody Technology Limited | Methods of obtaining a specific binding member that binds eotaxin |
| US20020151064A1 (en) * | 2001-02-07 | 2002-10-17 | Children's Hospital Medical Center | Regulation of CCR3 expression |
| US8030003B2 (en) * | 2004-12-07 | 2011-10-04 | Children's Hospital Medical Center | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 |
| US8008092B2 (en) * | 2007-10-09 | 2011-08-30 | University Of Kentucky Research Foundation | CCR3 inhibition for ocular angiogenesis and macular degeneration |
| WO2010069979A1 (en) * | 2008-12-16 | 2010-06-24 | Nycomed Gmbh | Pyran derivatives as ccr3 modulators |
| EP2236520A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Stabilizing composition for immobilized biomolecules |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| US8778616B2 (en) * | 2009-05-26 | 2014-07-15 | University Of Kentucky Research Foundation | Method of using CCR3 binding agents to detect choroidal neovascularization |
| UA109290C2 (en) * | 2010-10-07 | 2015-08-10 | Common Crystals and Salts of CCR3 Inhibitors | |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) * | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| WO2020115836A1 (en) * | 2018-12-05 | 2020-06-11 | 東浜工業株式会社 | Blower device |
-
2013
- 2013-03-27 US US13/851,564 patent/US20130261153A1/en not_active Abandoned
- 2013-04-02 DK DK13713199.1T patent/DK2833884T3/en active
- 2013-04-02 ES ES13713199T patent/ES2811554T3/en active Active
- 2013-04-02 WO PCT/EP2013/056864 patent/WO2013149986A1/en active Application Filing
- 2013-04-02 BR BR112014023795-6A patent/BR112014023795B1/en active IP Right Grant
- 2013-04-02 NZ NZ628882A patent/NZ628882A/en unknown
- 2013-04-02 EP EP20174399.4A patent/EP3763369B1/en active Active
- 2013-04-02 IN IN6989DEN2014 patent/IN2014DN06989A/en unknown
- 2013-04-02 AU AU2013245027A patent/AU2013245027B2/en active Active
- 2013-04-02 MX MX2014011786A patent/MX2014011786A/en unknown
- 2013-04-02 CA CA2869269A patent/CA2869269C/en active Active
- 2013-04-02 KR KR1020217015686A patent/KR20210063481A/en not_active IP Right Cessation
- 2013-04-02 SI SI201331753T patent/SI2833884T1/en unknown
- 2013-04-02 RS RS20200868A patent/RS60665B1/en unknown
- 2013-04-02 EP EP13713199.1A patent/EP2833884B1/en active Active
- 2013-04-02 CN CN201910406245.7A patent/CN110384699A/en active Pending
- 2013-04-02 HU HUE13713199A patent/HUE051648T2/en unknown
- 2013-04-02 KR KR1020207011392A patent/KR20200044988A/en active Application Filing
- 2013-04-02 LT LTEP13713199.1T patent/LT2833884T/en unknown
- 2013-04-02 KR KR1020147027679A patent/KR20140144200A/en active Application Filing
- 2013-04-02 JP JP2015503847A patent/JP2015512432A/en active Pending
- 2013-04-02 EA EA201401083A patent/EA032263B1/en unknown
- 2013-04-02 PL PL13713199T patent/PL2833884T3/en unknown
- 2013-04-02 CN CN201380016333.7A patent/CN104220073A/en active Pending
- 2013-04-02 PT PT137131991T patent/PT2833884T/en unknown
- 2013-04-02 KR KR1020227031439A patent/KR20220132012A/en not_active Application Discontinuation
-
2014
- 2014-08-19 ZA ZA2014/06082A patent/ZA201406082B/en unknown
- 2014-08-24 IL IL234262A patent/IL234262A/en active IP Right Grant
- 2014-09-24 CL CL2014002523A patent/CL2014002523A1/en unknown
- 2014-10-03 PH PH12014502239A patent/PH12014502239A1/en unknown
- 2014-12-15 US US14/570,298 patent/US20150099783A1/en not_active Abandoned
-
2015
- 2015-11-30 US US14/953,480 patent/US20160081998A1/en not_active Abandoned
-
2017
- 2017-07-25 US US15/658,918 patent/US20170319567A1/en not_active Abandoned
- 2017-12-22 JP JP2017246173A patent/JP2018080183A/en not_active Withdrawn
-
2020
- 2020-07-23 CY CY20201100678T patent/CY1123222T1/en unknown
- 2020-07-27 HR HRP20201165TT patent/HRP20201165T1/en unknown
- 2020-08-19 US US16/997,772 patent/US20200375971A1/en not_active Abandoned
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