IN2014DN07082A - - Google Patents
Info
- Publication number
- IN2014DN07082A IN2014DN07082A IN7082DEN2014A IN2014DN07082A IN 2014DN07082 A IN2014DN07082 A IN 2014DN07082A IN 7082DEN2014 A IN7082DEN2014 A IN 7082DEN2014A IN 2014DN07082 A IN2014DN07082 A IN 2014DN07082A
- Authority
- IN
- India
- Prior art keywords
- alkyl
- dibenzoyltartrate
- haloalkyl
- cycloalkyl
- chloride
- Prior art date
Links
- OCQAXYHNMWVLRH-UHFFFAOYSA-N 2,3-dibenzoyl-2,3-dihydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)C(O)(C(O)=O)C(O)(C(=O)O)C(=O)C1=CC=CC=C1 OCQAXYHNMWVLRH-UHFFFAOYSA-N 0.000 abstract 1
- 102000004499 CCR3 Receptors Human genes 0.000 abstract 1
- 108010017316 CCR3 Receptors Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 150000001450 anions Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/2833—Organic macromolecular compounds
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
THE PRESENT INVENTION RELATES TO PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS OF FORMULA (1) WHEREIN R IS H C ALKYL C ALKYL C CYCLOALKYL C HALOALKYL; R IS H C ALKYL; X IS AN ANION SELECTED FROM THE GROUP CONSISTING OF CHLORIDE OR ½ DIBENZOYLTARTRATE J IS 1 OR 2. PROCESSES FOR THE PREPARATION THEREOF AND THEIR USE TO TREAT DISEASES CONNECTED WITH THE CCR3 RECEPTOR
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12163078 | 2012-04-04 | ||
| PCT/EP2013/056867 WO2013149987A1 (en) | 2012-04-04 | 2013-04-02 | Pharmaceutical formulations comprising ccr3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN07082A true IN2014DN07082A (en) | 2015-04-10 |
Family
ID=49292482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN7082DEN2014 IN2014DN07082A (en) | 2012-04-04 | 2013-04-02 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10213421B2 (en) |
| EP (3) | EP3524230B1 (en) |
| JP (4) | JP6320990B2 (en) |
| KR (2) | KR102138709B1 (en) |
| CN (1) | CN104203213A (en) |
| AR (1) | AR090596A1 (en) |
| AU (1) | AU2013245028B2 (en) |
| BR (1) | BR112014024479A8 (en) |
| CA (1) | CA2869058C (en) |
| CL (1) | CL2014002524A1 (en) |
| CY (1) | CY1121137T1 (en) |
| DK (2) | DK2833864T3 (en) |
| EA (1) | EA027627B1 (en) |
| ES (3) | ES2715844T3 (en) |
| HR (1) | HRP20190069T1 (en) |
| HU (2) | HUE056943T2 (en) |
| IL (1) | IL234299A (en) |
| IN (1) | IN2014DN07082A (en) |
| LT (1) | LT2833864T (en) |
| MX (1) | MX358307B (en) |
| NZ (1) | NZ628993A (en) |
| PH (1) | PH12014502241A1 (en) |
| PL (2) | PL3524230T3 (en) |
| PT (2) | PT3524230T (en) |
| RS (1) | RS58360B1 (en) |
| SI (1) | SI2833864T1 (en) |
| SM (1) | SMT201900121T1 (en) |
| TR (1) | TR201821285T4 (en) |
| TW (1) | TW201400115A (en) |
| UY (1) | UY34730A (en) |
| WO (1) | WO2013149987A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (en) | 2010-10-07 | 2015-08-10 | Common Crystals and Salts of CCR3 Inhibitors | |
| US8680280B2 (en) | 2012-04-02 | 2014-03-25 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of CRR inhibitors |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| BR112019020798A2 (en) * | 2017-04-05 | 2020-04-28 | Alkahest Inc | methods and compositions for treating age-related damage using ccr3 inhibitors |
| ES3046717T3 (en) * | 2017-04-05 | 2025-12-02 | Alkahest Inc | Compounds and pharmaceutical compositions for use in treating retina-associated disease using ccr3-inhibitors |
| US20190111042A1 (en) * | 2017-10-13 | 2019-04-18 | Alkahest, Inc. | Methods and Compositions for Treating Pruritus, Xerosis, and Associated Disease Using CCR-Inhibitors |
| US11426399B2 (en) | 2018-05-15 | 2022-08-30 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
| EP3856195A4 (en) * | 2018-09-26 | 2022-06-22 | Alkahest, Inc. | METHODS AND COMPOSITIONS FOR TREATING DISORDERS RELATED TO AGING USING CCR3 INHIBITORS |
| US20230312697A1 (en) | 2020-06-11 | 2023-10-05 | Alkahest Inc. | Methods of improving retina-associated disease outcome using ccr3-inhibitors |
| KR20230056017A (en) | 2020-08-27 | 2023-04-26 | 에이지씨 가부시키가이샤 | Alkali-free glass and glass plates |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7907121L (en) | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | FTALIMIDINDERIVAT |
| US4992277A (en) | 1989-08-25 | 1991-02-12 | Schering Corporation | Immediate release diltiazem formulation |
| JP2807577B2 (en) | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | Cyclic amide derivative |
| IL116539A (en) * | 1995-01-06 | 2002-02-10 | Noven Pharma | Compositions for transdermal delivery of acid-labile drugs |
| KR20010012402A (en) * | 1997-05-09 | 2001-02-15 | 세이지 파마슈티칼스, 인크. | Stable oral pharmaceutical dosage forms |
| AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US6140349A (en) | 1998-02-02 | 2000-10-31 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| AU2654399A (en) | 1998-02-02 | 1999-08-16 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| SE9802973D0 (en) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| WO2004004716A1 (en) * | 2002-07-08 | 2004-01-15 | Chemgenex Pharmaceuticals Limited | Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof |
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