IN2014MN02459A - - Google Patents

Info

Publication number
IN2014MN02459A
IN2014MN02459A IN2459MUN2014A IN2014MN02459A IN 2014MN02459 A IN2014MN02459 A IN 2014MN02459A IN 2459MUN2014 A IN2459MUN2014 A IN 2459MUN2014A IN 2014MN02459 A IN2014MN02459 A IN 2014MN02459A
Authority
IN
India
Prior art keywords
compounds
administration
preparing
disclosure
processes
Prior art date
Application number
Inventor
John O Link
Jeromy J Cottell
Martin Teresa Alejandra Trejo
Elizabeth M Bacon
Original Assignee
Gilead Pharmasset Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Pharmasset Llc filed Critical Gilead Pharmasset Llc
Publication of IN2014MN02459A publication Critical patent/IN2014MN02459A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The disclosure is related to anti viral compounds of formula (I) compositions containing such compounds and therapeutic methods that include the administration of such compounds as well as to processes and intermediates useful for preparing such compounds.
IN2459MUN2014 2012-05-16 2013-05-15 IN2014MN02459A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647966P 2012-05-16 2012-05-16
US13/831,116 US20130309196A1 (en) 2012-05-16 2013-03-14 Antiviral compounds
PCT/US2013/041201 WO2013173488A1 (en) 2012-05-16 2013-05-15 Antiviral compounds inhibitors of hcv ns5b

Publications (1)

Publication Number Publication Date
IN2014MN02459A true IN2014MN02459A (en) 2015-07-10

Family

ID=49581469

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2459MUN2014 IN2014MN02459A (en) 2012-05-16 2013-05-15

Country Status (19)

Country Link
US (5) US20130309196A1 (en)
EP (2) EP3239153B1 (en)
JP (2) JP6209209B2 (en)
KR (2) KR102078233B1 (en)
CN (3) CN106432254B (en)
AU (3) AU2013262874B2 (en)
BR (1) BR112014028221B1 (en)
CA (1) CA2873485C (en)
EA (2) EA034749B1 (en)
ES (2) ES2628350T3 (en)
HK (1) HK1245262B (en)
IL (1) IL235645A0 (en)
IN (1) IN2014MN02459A (en)
MX (1) MX362060B (en)
PL (2) PL3239153T3 (en)
PT (2) PT2850085T (en)
SG (2) SG10201703451RA (en)
SI (2) SI2850085T1 (en)
WO (1) WO2013173488A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3521297T (en) 2003-05-30 2022-03-18 Gilead Pharmasset Llc Modified fluorinated nucleoside analogues
EP2640719B1 (en) 2010-11-17 2017-05-10 Gilead Pharmasset LLC Antiviral compounds
MD4403C1 (en) 2011-11-16 2016-09-30 Gilead Pharmasset Llc. Antiviral compounds based on condensed dihydroxyisochromene-naphthoimidazoles
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
US9233974B2 (en) * 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds
WO2015030854A1 (en) * 2013-08-27 2015-03-05 Gilead Pharmasset Llc Solid dispersion formulation of an antiviral compound
SG11201600919UA (en) 2013-08-27 2016-03-30 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
TWI679203B (en) * 2014-06-11 2019-12-11 美商基利法瑪席特有限責任公司 Processes for preparing antiviral compounds
TWI721947B (en) 2014-06-11 2021-03-21 美商基利法瑪席特有限責任公司 Solid forms of an antiviral compound
WO2016004166A1 (en) * 2014-07-02 2016-01-07 Xavier University Of Louisiana Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group
LT3236972T (en) 2014-12-26 2021-11-10 Emory University ANTIVIRAL N4-HYDROXICITIDINE DERIVATIVES
MX384836B (en) 2016-03-07 2025-03-14 Enanta Pharm Inc ANTIVIRAL AGENTS AGAINST HEPATITIS B
WO2017191546A1 (en) * 2016-05-05 2017-11-09 Laurus Labs Private Ltd. Process for the preparation of intermediates useful in the preparation of hepatitis c virus (hcv) inhibitors
CN118178444A (en) 2016-05-27 2024-06-14 吉利德科学公司 Methods of treating hepatitis B virus infection using NS5A, NS5B or NS3 inhibitors
WO2018006811A1 (en) * 2016-07-08 2018-01-11 深圳市塔吉瑞生物医药有限公司 Substituted imidazolyl compound and pharmaceutical composition thereof
CN106220639A (en) * 2016-07-22 2016-12-14 上海众强药业有限公司 A kind of Wei Patawei intermediate novel crystal forms
CN110698489B (en) * 2016-11-30 2022-02-22 上海新礼泰药业有限公司 Wipatasvir intermediate, preparation method and application
CN111263586B (en) 2017-08-28 2021-12-03 英安塔制药有限公司 Hepatitis B antiviral agent
CN107501280A (en) * 2017-09-05 2017-12-22 安徽华昌高科药业有限公司 A kind of Wei Patawei synthetic method
HRP20241620T1 (en) 2017-12-07 2025-01-31 Emory University N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTIVIRAL USE RELATED THERETO
CN113271946A (en) 2018-11-21 2021-08-17 英安塔制药有限公司 Functionalized heterocyclic compounds as antiviral agents
CN111018870B (en) * 2019-11-29 2021-07-23 南京正济医药研究有限公司 A kind of preparation method of velpatasvir intermediate
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
WO2022040058A1 (en) * 2020-08-18 2022-02-24 Merck Sharp & Dohme Corp. Cyclopentapyrrole orexin receptor agonists
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
US12037340B2 (en) * 2021-05-21 2024-07-16 Gilead Sciences, Inc. Pentacyclic derivatives as Zika virus inhibitors

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
ES2118069T3 (en) 1990-09-14 1998-09-16 Acad Of Science Czech Republic PHOSPHONATE DRUGS.
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
JP4558314B2 (en) 2001-07-20 2010-10-06 ベーリンガー インゲルハイム （カナダ） リミテッド Viral polymerase inhibitor
CN100457776C (en) * 2003-05-09 2009-02-04 贝林格尔.英格海姆国际有限公司 Hepatitis c virus NS5B polymerase inhibitor binding pocket
US7157492B2 (en) 2004-02-26 2007-01-02 Wyeth Dibenzo chromene derivatives and their use as ERβ selective ligands
PL1778702T3 (en) 2004-07-16 2011-12-30 Gilead Sciences Inc Antiviral compounds
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7759495B2 (en) 2006-08-11 2010-07-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741347B2 (en) 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR101468765B1 (en) 2008-02-12 2014-12-04 브리스톨-마이어스 스큅 컴퍼니 Hepatitis c virus inhibitors
JP5312486B2 (en) 2008-02-13 2013-10-09 ブリストル−マイヤーズ スクイブ カンパニー Hepatitis C virus inhibitor
US8147818B2 (en) * 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2010062821A1 (en) 2008-11-28 2010-06-03 Glaxosmithkline Llc Anti-viral compounds, compositions, and methods of use
BRPI0922364A2 (en) 2008-12-03 2017-08-29 Presidio Pharmaceuticals Inc COMPOUND, PHARMACEUTICAL COMPOSITION AND USE OF A COMPOUND
WO2010096777A1 (en) * 2009-02-23 2010-08-26 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
CA2753382C (en) 2009-02-27 2014-12-23 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
AU2010229795A1 (en) 2009-03-27 2011-10-13 Presidio Pharmaceuticals, Inc. Fused ring inhibitors of hepatitis C
AU2010249080A1 (en) 2009-05-12 2012-01-12 Merck Sharp & Dohme Corp. Fused tricyclic aryl compounds useful for the treatment of viral diseases
EP2430014B1 (en) * 2009-05-13 2015-08-19 Gilead Pharmasset LLC Antiviral compounds
TWI583692B (en) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8138215B2 (en) 2009-05-29 2012-03-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
BR112012003578A8 (en) 2009-09-04 2018-02-14 Glaxosmithkline Llc COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT, SULFATE SALT, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING A VIRAL INFECTION, AND, USE OF A COMPOUND OR SALT
WO2011031904A1 (en) 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc Hepatitis c virus inhibitors
JP2013512246A (en) 2009-11-25 2013-04-11 メルク・シャープ・アンド・ドーム・コーポレーション Condensed tricyclic compounds and derivatives useful for the treatment of viral diseases
US8476225B2 (en) 2009-12-04 2013-07-02 Gilead Sciences, Inc. Antiviral compounds
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20130156731A1 (en) 2009-12-22 2013-06-20 Kevin X. Chen Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas
JP2013522202A (en) 2010-03-09 2013-06-13 メルク・シャープ・エンド・ドーム・コーポレイション Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases
US20110312996A1 (en) 2010-05-17 2011-12-22 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
CA2800530A1 (en) * 2010-05-28 2011-12-01 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
CA2809261A1 (en) 2010-08-26 2012-03-01 Rfs Pharma, Llc Potent and selective inhibitors of hepatitis c virus
US8999967B2 (en) * 2010-09-29 2015-04-07 Presidio Pharmaceuticals, Inc. Tricyclic fused ring inhibitors of hepatitis C
WO2012048421A1 (en) 2010-10-14 2012-04-19 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
EP2640719B1 (en) 2010-11-17 2017-05-10 Gilead Pharmasset LLC Antiviral compounds
WO2012087976A2 (en) 2010-12-21 2012-06-28 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
MD4403C1 (en) 2011-11-16 2016-09-30 Gilead Pharmasset Llc. Antiviral compounds based on condensed dihydroxyisochromene-naphthoimidazoles
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
US9233974B2 (en) 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds

Also Published As

Publication number Publication date
CN106432254B (en) 2018-12-28
KR102078233B1 (en) 2020-02-17
JP6209209B2 (en) 2017-10-04
EP2850085B1 (en) 2017-03-15
PL2850085T3 (en) 2017-10-31
JP2017160276A (en) 2017-09-14
CN106432254A (en) 2017-02-22
AU2013262874A2 (en) 2015-01-22
JP2015517527A (en) 2015-06-22
US10800789B2 (en) 2020-10-13
US20170342085A1 (en) 2017-11-30
EP3239153A1 (en) 2017-11-01
EA201790963A1 (en) 2018-02-28
EA034749B1 (en) 2020-03-17
CA2873485A1 (en) 2013-11-21
SG11201407533SA (en) 2014-12-30
BR112014028221B1 (en) 2022-05-03
US20160115175A1 (en) 2016-04-28
PL3239153T3 (en) 2019-09-30
SG10201703451RA (en) 2017-06-29
HK1245262B (en) 2020-01-10
SI2850085T1 (en) 2017-08-31
ES2738012T3 (en) 2020-01-17
CA2873485C (en) 2020-05-05
MX362060B (en) 2019-01-07
US9682989B2 (en) 2017-06-20
SI3239153T1 (en) 2019-08-30
EA028026B1 (en) 2017-09-29
US20190337960A1 (en) 2019-11-07
AU2017248566A1 (en) 2017-11-09
US20140316144A1 (en) 2014-10-23
EP3239153B1 (en) 2019-05-08
IL235645A0 (en) 2015-02-01
AU2013262874B2 (en) 2017-11-02
BR112014028221A2 (en) 2020-10-27
PT3239153T (en) 2019-07-30
AU2019204423A1 (en) 2019-07-11
PT2850085T (en) 2017-06-26
JP6408656B2 (en) 2018-10-17
EP2850085A1 (en) 2015-03-25
MX2014013660A (en) 2015-04-17
CN104487442B (en) 2016-10-26
KR20150008908A (en) 2015-01-23
AU2013262874A1 (en) 2014-12-11
EA201492002A1 (en) 2015-11-30
HK1205126A1 (en) 2015-12-11
CN104487442A (en) 2015-04-01
US20130309196A1 (en) 2013-11-21
KR20200017557A (en) 2020-02-18
WO2013173488A1 (en) 2013-11-21
CN109970749A (en) 2019-07-05
ES2628350T3 (en) 2017-08-02

Similar Documents

Publication Publication Date Title
IN2014MN02459A (en)
MY201670A (en) Condensed imidazolylimidazoles as antiviral compounds
SG190785A1 (en) Antiviral compounds
MX2020011251A (en) Antiviral compounds.
MD20140136A2 (en) Inhibitors of hepatitis C virus
EA201790781A2 (en) ANTI-VIRUS COMPOUNDS
NZ739760A (en) Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
IN2014CN04530A (en)
GEP20156372B (en) Pyridazinone compounds and their use as daao inhibitors
SG195319A1 (en) Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
HK1208677A1 (en) Antiviral compound with imidazole-biphenyl-imidazole core
MX2014007897A (en) New azetidine derivatives, pharmaceutical compositions and uses thereof.
MX2017003254A (en) Substituted 2-azabicycles and their use as orexin receptor modulators.
PH12014501195A1 (en) Novel 2h-indazoles as ep2, receptor antagonists
IN2014MN01469A (en)
IN2013DN02555A (en)
NZ726343A (en) Antiviral compounds
MX348841B (en) Pyrimidooxazocine derivatives as mtor - inhibitors.
MX337610B (en) Processes for the preparation of (r)-2-acetamido-n-benzyl- 3-methoxypropionamide and intermediates thereof.
IN2014DN07498A (en)
NZ725365A (en) Antiviral compounds inhibitors of hcv ns5b
GEP20156398B (en) Indazoles