JP2013172743A5 - - Google Patents
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- Publication number
- JP2013172743A5 JP2013172743A5 JP2013101584A JP2013101584A JP2013172743A5 JP 2013172743 A5 JP2013172743 A5 JP 2013172743A5 JP 2013101584 A JP2013101584 A JP 2013101584A JP 2013101584 A JP2013101584 A JP 2013101584A JP 2013172743 A5 JP2013172743 A5 JP 2013172743A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant human
- arginase
- human arginase
- cancer
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000752037 Homo sapiens Arginase-1 Proteins 0.000 claims 9
- 102000053089 human ARG1 Human genes 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 102000004452 Arginase Human genes 0.000 claims 2
- 108700024123 Arginases Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 claims 1
- 150000002411 histidines Chemical class 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- XANRGTLFBAJYDA-UHFFFAOYSA-N propanoic acid;pyrrolidine-2,5-dione Chemical compound CCC(O)=O.O=C1CCC(=O)N1 XANRGTLFBAJYDA-UHFFFAOYSA-N 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39075702P | 2002-06-20 | 2002-06-20 | |
| US60/390,757 | 2002-06-20 | ||
| CNPCT/CN02/00635 | 2002-09-09 | ||
| PCT/CN2002/000635 WO2004001048A1 (en) | 2002-06-20 | 2002-09-09 | Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010007090A Division JP5307042B2 (ja) | 2002-06-20 | 2010-01-15 | アルギニンを欠乏させることによってヒト悪性腫瘍を治療する医薬品及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013172743A JP2013172743A (ja) | 2013-09-05 |
| JP2013172743A5 true JP2013172743A5 (enExample) | 2013-12-05 |
Family
ID=30000613
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010007090A Expired - Lifetime JP5307042B2 (ja) | 2002-06-20 | 2010-01-15 | アルギニンを欠乏させることによってヒト悪性腫瘍を治療する医薬品及び方法 |
| JP2013101584A Pending JP2013172743A (ja) | 2002-06-20 | 2013-05-13 | アルギニンを欠乏させることによってヒト悪性腫瘍を治療する医薬品及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010007090A Expired - Lifetime JP5307042B2 (ja) | 2002-06-20 | 2010-01-15 | アルギニンを欠乏させることによってヒト悪性腫瘍を治療する医薬品及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7951366B2 (enExample) |
| EP (1) | EP1517699B1 (enExample) |
| JP (2) | JP5307042B2 (enExample) |
| CN (2) | CN1918298B (enExample) |
| AT (2) | ATE385807T1 (enExample) |
| AU (1) | AU2002325782A1 (enExample) |
| DE (2) | DE60319083T2 (enExample) |
| HK (1) | HK1053577A2 (enExample) |
| IL (1) | IL165858A (enExample) |
| MX (1) | MXPA04012970A (enExample) |
| NZ (1) | NZ537774A (enExample) |
| WO (1) | WO2004001048A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1745847A (zh) * | 2004-09-08 | 2006-03-15 | 康达医药科技有限公司 | 用精氨酸酶治疗肝炎的药物组合物和方法 |
| CN101002945B (zh) * | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
| CN101478982A (zh) * | 2006-03-17 | 2009-07-08 | 康达医药科技有限公司 | 防止辐射伤害的方法与组成物 |
| US20080138858A1 (en) * | 2006-12-12 | 2008-06-12 | Bio-Cancer Treatment International Ltd. | Expression System for Recombinant Human Arginase I |
| US8815232B2 (en) * | 2008-08-26 | 2014-08-26 | Kyon Biotech Ag | Compositions and methods for treating cancer |
| US8440184B2 (en) | 2008-10-31 | 2013-05-14 | Gma Technologies Llc | Compositions of engineered human arginases and methods for treating cancer |
| CN102481345B (zh) * | 2009-03-26 | 2015-04-22 | 香港理工大学 | 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 |
| US8679479B2 (en) | 2009-06-29 | 2014-03-25 | Aerase, Inc. | Methods for purifying pegylated arginase |
| CN103184209B (zh) * | 2011-12-27 | 2015-09-16 | 拜奥生物科技（上海）有限公司 | 人精氨酸酶和聚乙二醇化人精氨酸酶及其应用 |
| CN106456723B (zh) | 2014-04-29 | 2021-03-09 | 康达医药科技有限公司 | 采用精氨酸酶i调节免疫系统的方法和组合物 |
| JP2016117702A (ja) * | 2014-12-22 | 2016-06-30 | 武輝 山田 | ガン細胞の死滅法 |
| CN105062941B (zh) * | 2015-08-25 | 2019-03-05 | 江南大学 | 一种利用重组枯草芽孢杆菌全细胞转化生产l-鸟氨酸的方法 |
| US20180271960A1 (en) * | 2015-09-21 | 2018-09-27 | Bio-Cancer Treatment International Ltd. | Method to treat cancer using arginine delpetor and ornithine decarboxylase (odc) inhibitor |
| CN105112391B (zh) * | 2015-09-22 | 2018-07-06 | 浙江道尔生物科技有限公司 | 一种人源精氨酸酶突变体及其制备方法和用途 |
| PL3496743T3 (pl) | 2016-08-08 | 2022-05-30 | Aerase, Inc. | Kompozycje i sposoby do leczenia nowotworu przy wyczerpaniu argininy ze środkami immunoonkologicznymi |
| TWI878212B (zh) | 2017-12-05 | 2025-04-01 | 瑞典商伊梅爾迪卡製藥公司 | 用於治療精胺酸酶1缺乏症之方法及組合物 |
| SG11202011838XA (en) * | 2018-05-31 | 2020-12-30 | Univ Hong Kong Polytechnic | Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities |
| EP3866837A1 (en) | 2018-10-19 | 2021-08-25 | AERase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| WO2021041904A1 (en) | 2019-08-30 | 2021-03-04 | Aeglea Biotherapeutics, Inc. | Methods for production of human recombinant arginase 1 and uses thereof |
| CN115038460A (zh) * | 2019-12-02 | 2022-09-09 | 香港理工大学 | 诱导间歇性禁食和调节自噬的方法 |
| CN115804845B (zh) * | 2022-12-02 | 2025-09-30 | 华东理工大学 | 精氨酸剥夺在延缓衰老与联合化疗药物治疗肿瘤中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780286A (en) * | 1996-03-14 | 1998-07-14 | Smithkline Beecham Corporation | Arginase II |
| US5851985A (en) | 1996-08-16 | 1998-12-22 | Tepic; Slobodan | Treatment of tumors by arginine deprivation |
| WO1998024473A1 (fr) * | 1996-12-03 | 1998-06-11 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteur de fibrose des tissus |
| AU3305999A (en) | 1998-02-26 | 1999-09-15 | Beth Israel Deaconess Medical Center | Amino acid degrading enzymes modulate cell death |
| US6413757B1 (en) * | 2000-02-28 | 2002-07-02 | Millennium Pharmaceuticals, Inc. | 25312, a novel human agmatinase-like homolog |
| CN1324945A (zh) * | 2000-05-19 | 2001-12-05 | 上海博德基因开发有限公司 | 一种新的多肽——精氨酸酶12和编码这种多肽的多核苷酸 |
| CN1324942A (zh) * | 2000-05-19 | 2001-12-05 | 上海博德基因开发有限公司 | 一种新的多肽——人精氨酸酶9和编码这种多肽的多核苷酸 |
| KR100396983B1 (ko) | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
| DE10047204A1 (de) | 2000-09-23 | 2002-04-25 | Henkel Kgaa | Topische Hautbehandlungsmittel mit Arginase |
| CN1345966A (zh) * | 2000-09-26 | 2002-04-24 | 上海博德基因开发有限公司 | 一种新的多肽——人精氨酸酶35.42和编码这种多肽的多核苷酸 |
| CN1345970A (zh) * | 2000-09-29 | 2002-04-24 | 上海博德基因开发有限公司 | 一种新的多肽——含精氨酸酶结构域的蛋白质9.35和编码这种多肽的多核苷酸 |
| AU2001289132A1 (en) | 2000-11-28 | 2002-06-11 | Phoenix Pharmacologics, Inc. | Modified arginine deiminase |
| WO2003063780A2 (en) | 2002-01-25 | 2003-08-07 | Cancer Treatments International | Therapeutic composition for treatment of cancer by arginine depletion |
-
2002
- 2002-09-06 HK HK02106593A patent/HK1053577A2/xx not_active IP Right Cessation
- 2002-09-09 CN CN028291794A patent/CN1918298B/zh not_active Expired - Lifetime
- 2002-09-09 AU AU2002325782A patent/AU2002325782A1/en not_active Abandoned
- 2002-09-09 CN CNA2008102148652A patent/CN101433714A/zh active Pending
- 2002-09-09 WO PCT/CN2002/000635 patent/WO2004001048A1/en not_active Ceased
-
2003
- 2003-06-20 AT AT03760800T patent/ATE385807T1/de active
- 2003-06-20 NZ NZ537774A patent/NZ537774A/en not_active IP Right Cessation
- 2003-06-20 DE DE60319083T patent/DE60319083T2/de not_active Expired - Lifetime
- 2003-06-20 AT AT08001266T patent/ATE461707T1/de active
- 2003-06-20 DE DE60331871T patent/DE60331871D1/de not_active Expired - Lifetime
- 2003-06-20 EP EP03760800A patent/EP1517699B1/en not_active Expired - Lifetime
- 2003-06-20 US US10/518,223 patent/US7951366B2/en not_active Expired - Fee Related
- 2003-06-20 MX MXPA04012970A patent/MXPA04012970A/es active IP Right Grant
-
2004
- 2004-12-19 IL IL165858A patent/IL165858A/en active IP Right Grant
-
2007
- 2007-02-12 US US11/673,601 patent/US8679810B2/en active Active
- 2007-11-05 US US11/930,109 patent/US20080226617A1/en not_active Abandoned
-
2008
- 2008-07-24 US US12/179,121 patent/US20090123450A1/en not_active Abandoned
-
2010
- 2010-01-15 JP JP2010007090A patent/JP5307042B2/ja not_active Expired - Lifetime
-
2013
- 2013-05-13 JP JP2013101584A patent/JP2013172743A/ja active Pending