JP2012521201A5 - - Google Patents
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- Publication number
- JP2012521201A5 JP2012521201A5 JP2012501126A JP2012501126A JP2012521201A5 JP 2012521201 A5 JP2012521201 A5 JP 2012521201A5 JP 2012501126 A JP2012501126 A JP 2012501126A JP 2012501126 A JP2012501126 A JP 2012501126A JP 2012521201 A5 JP2012521201 A5 JP 2012521201A5
- Authority
- JP
- Japan
- Prior art keywords
- arginase
- peg
- pharmaceutical composition
- genetically modified
- bacillus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004452 Arginase Human genes 0.000 claims 15
- 108700024123 Arginases Proteins 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 241000193830 Bacillus <bacterium> Species 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000004475 Arginine Substances 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000005847 immunogenicity Effects 0.000 claims 3
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 101000792852 Bacillus caldovelox Arginase Proteins 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16386309P | 2009-03-26 | 2009-03-26 | |
| US61/163,863 | 2009-03-26 | ||
| PCT/CN2010/071357 WO2010124547A1 (en) | 2009-03-26 | 2010-03-26 | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521201A JP2012521201A (ja) | 2012-09-13 |
| JP2012521201A5 true JP2012521201A5 (enExample) | 2013-05-09 |
| JP5746137B2 JP5746137B2 (ja) | 2015-07-08 |
Family
ID=42784510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501126A Active JP5746137B2 (ja) | 2009-03-26 | 2010-03-26 | アルギナーゼの部位指定的ペグ化並びにその抗がん剤及び抗ウイルス剤としての使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8507245B2 (enExample) |
| EP (1) | EP2411040B1 (enExample) |
| JP (1) | JP5746137B2 (enExample) |
| CN (1) | CN102481345B (enExample) |
| AU (1) | AU2010242422B2 (enExample) |
| CA (1) | CA2756442C (enExample) |
| WO (1) | WO2010124547A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9382525B2 (en) * | 2009-03-26 | 2016-07-05 | The Hong Kong Polytechnic University | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
| US8679479B2 (en) * | 2009-06-29 | 2014-03-25 | Aerase, Inc. | Methods for purifying pegylated arginase |
| ES2735530T3 (es) | 2010-01-26 | 2019-12-19 | Bioregency Inc | Composiciones y métodos relacionados con la argininosuccinato sintetasa |
| US20130295073A1 (en) * | 2010-12-21 | 2013-11-07 | Bio-Cancer Treatment International Ltd. | Use of pegylated recombinant human arginase for treatment of leukemia |
| CN103184208B (zh) | 2011-12-27 | 2015-09-16 | 拜奥生物科技（上海）有限公司 | 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用 |
| US9011845B2 (en) | 2012-06-26 | 2015-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods for treatment of inflammatory and infectious viral diseases |
| US8877183B2 (en) | 2012-06-26 | 2014-11-04 | National Institutes Of Health (Nih) | Methods for treatment of ocular diseases |
| CA2944554A1 (en) | 2014-04-29 | 2015-11-05 | Bio-Cancer Treatment International Limited | Methods and compositions for modulating the immune system with arginase i |
| CN105112391B (zh) * | 2015-09-22 | 2018-07-06 | 浙江道尔生物科技有限公司 | 一种人源精氨酸酶突变体及其制备方法和用途 |
| CN106692961B (zh) * | 2015-11-17 | 2020-12-11 | 长春市福迪奥美科技有限公司 | 精氨酸酶组合物、精氨酸酶激活剂及其应用 |
| CN106434710A (zh) * | 2016-10-14 | 2017-02-22 | 江南大学 | 一种耐热精氨酸酶的基因表达序列和应用 |
| CN108265044B (zh) * | 2016-12-31 | 2021-05-11 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
| TW201910513A (zh) * | 2017-08-16 | 2019-03-16 | 香港商鎧耀波麗堂（香港）有限公司 | 胺基酸耗竭治療的組合物及方法 |
| EP3802621B8 (en) | 2018-05-31 | 2025-10-15 | The Chinese University of Hong Kong | Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities |
| CA3116736A1 (en) | 2018-10-19 | 2020-04-23 | Aerase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| CN109793917B (zh) * | 2019-02-11 | 2020-10-09 | 海南建科药业有限公司 | 一种预防结直肠手术后吻合口瘘的凝胶的制备方法 |
| CA3149592A1 (en) | 2019-08-30 | 2021-03-04 | Scott W. Rowlinson | Methods for production of human recombinant arginase 1 and uses thereof |
| EP4069280A4 (en) * | 2019-12-02 | 2024-01-03 | The Hong Kong Polytechnic University | METHODS FOR INDUCING INTERMITTENT FASTING AND MODULATING AUTOPHAGY |
| CN116056720A (zh) * | 2020-04-17 | 2023-05-02 | 香港商康达医药科技有限公司 | 使用精胺酸酶治疗病毒感染的方法 |
| WO2021228875A1 (en) * | 2020-05-14 | 2021-11-18 | Kyon Biotech Ag | Treatment of respiratory viral infections |
| US20230348884A1 (en) * | 2020-09-23 | 2023-11-02 | The Hong Kong Polytechnic University | Fluorescent Biosensor for Rapid Determination of L-arginine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| AU2003216109A1 (en) * | 2002-01-25 | 2003-09-02 | Cancer Treatments International | Therapeutic composition for treatment of cancer by arginine depletion |
| AU2003250371B2 (en) | 2002-06-20 | 2009-01-29 | Bio-Cancer Treatment International Limited | Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation |
| HK1053577A2 (en) * | 2002-06-20 | 2003-10-10 | Bio-Cancer Treatment International Limited | Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation |
| EP1539210A4 (en) | 2002-09-06 | 2006-06-07 | Bayer Pharmaceuticals Corp | GLP-1 RECEPTOR MODIFIED AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE |
| CN1745847A (zh) | 2004-09-08 | 2006-03-15 | 康达医药科技有限公司 | 用精氨酸酶治疗肝炎的药物组合物和方法 |
| WO2006058486A1 (en) | 2004-12-03 | 2006-06-08 | Bio-Cancer Treatment International Limited | Use of arginase in combination with 5fu and other compounds for treatment of human malignancies |
| US8679479B2 (en) * | 2009-06-29 | 2014-03-25 | Aerase, Inc. | Methods for purifying pegylated arginase |
-
2010
- 2010-03-26 WO PCT/CN2010/071357 patent/WO2010124547A1/en not_active Ceased
- 2010-03-26 CN CN201080023256.4A patent/CN102481345B/zh active Active
- 2010-03-26 EP EP10769236.0A patent/EP2411040B1/en active Active
- 2010-03-26 CA CA2756442A patent/CA2756442C/en active Active
- 2010-03-26 AU AU2010242422A patent/AU2010242422B2/en active Active
- 2010-03-26 JP JP2012501126A patent/JP5746137B2/ja active Active
- 2010-03-26 US US12/732,188 patent/US8507245B2/en active Active
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