JP2017521371A5 - - Google Patents
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- JP2017521371A5 JP2017521371A5 JP2016569722A JP2016569722A JP2017521371A5 JP 2017521371 A5 JP2017521371 A5 JP 2017521371A5 JP 2016569722 A JP2016569722 A JP 2016569722A JP 2016569722 A JP2016569722 A JP 2016569722A JP 2017521371 A5 JP2017521371 A5 JP 2017521371A5
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- JP
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- Prior art keywords
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- moiety
- drug
- spacer
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940079593 drug Drugs 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 31
- 102000004190 Enzymes Human genes 0.000 claims 19
- 108090000790 Enzymes Proteins 0.000 claims 19
- 239000002105 nanoparticle Substances 0.000 claims 19
- 125000005647 linker group Chemical group 0.000 claims 18
- 125000006850 spacer group Chemical group 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000002202 Polyethylene glycol Substances 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 102000035195 Peptidases Human genes 0.000 claims 7
- 108091005804 Peptidases Proteins 0.000 claims 7
- 239000004365 Protease Substances 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000007850 fluorescent dye Substances 0.000 claims 6
- 230000008685 targeting Effects 0.000 claims 6
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 4
- 108010016626 Dipeptides Proteins 0.000 claims 4
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 4
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 229960002448 dasatinib Drugs 0.000 claims 4
- 229960002584 gefitinib Drugs 0.000 claims 4
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 230000002285 radioactive effect Effects 0.000 claims 4
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 4
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 4
- 229920000620 organic polymer Polymers 0.000 claims 3
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 2
- CLUOUYPICNCYNF-IPIKRLCPSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CC1=CC=CC=C1 CLUOUYPICNCYNF-IPIKRLCPSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- 102000004225 Cathepsin B Human genes 0.000 claims 2
- 108090000712 Cathepsin B Proteins 0.000 claims 2
- 102000005927 Cysteine Proteases Human genes 0.000 claims 2
- 108010005843 Cysteine Proteases Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004738P | 2014-05-29 | 2014-05-29 | |
| US62/004,738 | 2014-05-29 | ||
| US201462094923P | 2014-12-19 | 2014-12-19 | |
| US62/094,923 | 2014-12-19 | ||
| PCT/US2015/032565 WO2015183882A1 (en) | 2014-05-29 | 2015-05-27 | Nanoparticle drug conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521371A JP2017521371A (ja) | 2017-08-03 |
| JP2017521371A5 true JP2017521371A5 (enExample) | 2019-01-10 |
| JP6573633B2 JP6573633B2 (ja) | 2019-09-11 |
Family
ID=53284649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569722A Active JP6573633B2 (ja) | 2014-05-29 | 2015-05-27 | ナノ粒子薬物コンジュゲート |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10111963B2 (enExample) |
| EP (2) | EP3148591B1 (enExample) |
| JP (1) | JP6573633B2 (enExample) |
| KR (2) | KR102231672B1 (enExample) |
| CN (2) | CN113082225A (enExample) |
| AU (1) | AU2015267200B2 (enExample) |
| BR (1) | BR112016027624A8 (enExample) |
| CA (2) | CA3201974C (enExample) |
| DK (1) | DK3148591T3 (enExample) |
| ES (1) | ES2788865T3 (enExample) |
| PL (1) | PL3148591T3 (enExample) |
| RU (1) | RU2016144055A (enExample) |
| WO (1) | WO2015183882A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161734B2 (en) | 2009-07-02 | 2024-12-10 | Sloan-Kettering Institute For Cancer Research | Multimodal silica-based nanoparticles |
| US9625456B2 (en) | 2009-07-02 | 2017-04-18 | Sloan-Kettering Institute For Cancer Research | Fluorescent silica-based nanoparticles |
| RU2015132626A (ru) | 2013-03-15 | 2017-04-25 | Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч | Мультимодальные наночастицы на основе диоксида кремния |
| CN113349707A (zh) | 2013-12-31 | 2021-09-07 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
| ES2788865T3 (es) | 2014-05-29 | 2020-10-23 | Memorial Sloan Kettering Cancer Center | Conjugados farmacéuticos de nanopartículas |
| ES2794778T3 (es) | 2014-12-15 | 2020-11-19 | Memorial Sloan Kettering Cancer Center | Péptidos cíclicos con selectividad mejorada de unión a los nervios, nanoparticulos unidas con dichos péptidos cíclicos y uso de los mismos para imágenes en vivo de tejidos nerviosos en tiempo real |
| BR112017024328A2 (pt) | 2015-05-29 | 2018-07-24 | Univ Cornell | métodos de tratamento usando nanopartículas ultrapequenas para induzir morte celular de células cancerosas privadas de nutrientes via ferroptose |
| AU2017258415B2 (en) * | 2016-04-29 | 2023-03-30 | Cornell University | Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors |
| BR112019000143A2 (pt) | 2016-07-07 | 2019-04-16 | Memorial Sloan Kettering Cancer Center | sistemas de imagem e métodos para radiogenomia de câncer conduzido por partícula, baseado no conhecimento e preditivo |
| AU2018271781A1 (en) | 2017-05-25 | 2019-12-12 | Cornell University | Ultrasmall nanoparticles labeled with Zirconium-89 and methods thereof |
| EP3642599B1 (en) | 2017-06-23 | 2025-01-08 | Memorial Sloan-Kettering Cancer Center | Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye. |
| RU2679075C1 (ru) * | 2017-11-09 | 2019-02-05 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Конъюгат люминесцентных наночастиц диоксида кремния с рекомбинантными однодоменными нано - моноантителами C7b ламы, способными специфически взаимодействовать с рекомбинантным белком HER2/neu - аналогом природного рецептора эпидермального фактора роста EGFR/ERBB клеток человека |
| WO2019113004A1 (en) | 2017-12-04 | 2019-06-13 | Memorial Sloan Kettering Cancer Center | Methods of cancer treatment via regulated ferroptosis |
| CA3115355A1 (en) | 2018-10-16 | 2020-04-23 | Silicycle Inc. | Tunable process for silica capsules/spheres preparation and their use |
| GB201904336D0 (en) * | 2019-03-28 | 2019-05-15 | Sisaf Ltd | A delivery system |
| US20230381349A1 (en) * | 2020-10-06 | 2023-11-30 | Washington University | Methods and compositions for imaging and treating cancer |
| ES2963150T3 (es) | 2020-10-27 | 2024-03-25 | Elucida Oncology Inc | Procedimientos para funcionalizar nanopartículas |
| CN112168977A (zh) * | 2020-10-27 | 2021-01-05 | 西南大学 | 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用 |
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| US3870791A (en) | 1972-04-24 | 1975-03-11 | Heskel M Haddad | Solid state ophthalmic medication delivery method |
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| DE2626348C3 (de) | 1976-06-11 | 1980-01-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Implantierbare Dosiereinrichtung |
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| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
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| IN2012DN05099A (enExample) * | 2009-12-16 | 2015-10-09 | Brigham & Womens Hospital | |
| PT2528625E (pt) * | 2010-04-15 | 2013-10-17 | Spirogen Sarl | Pirrolobenzodiazepinas e conjugados das mesmas |
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| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| RU2015132626A (ru) | 2013-03-15 | 2017-04-25 | Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч | Мультимодальные наночастицы на основе диоксида кремния |
| ES2788865T3 (es) | 2014-05-29 | 2020-10-23 | Memorial Sloan Kettering Cancer Center | Conjugados farmacéuticos de nanopartículas |
| BR112017024328A2 (pt) | 2015-05-29 | 2018-07-24 | Univ Cornell | métodos de tratamento usando nanopartículas ultrapequenas para induzir morte celular de células cancerosas privadas de nutrientes via ferroptose |
| EP3642599B1 (en) | 2017-06-23 | 2025-01-08 | Memorial Sloan-Kettering Cancer Center | Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye. |
-
2015
- 2015-05-27 ES ES15727248T patent/ES2788865T3/es active Active
- 2015-05-27 AU AU2015267200A patent/AU2015267200B2/en active Active
- 2015-05-27 EP EP15727248.5A patent/EP3148591B1/en active Active
- 2015-05-27 DK DK15727248.5T patent/DK3148591T3/da active
- 2015-05-27 EP EP20152240.6A patent/EP3693026A1/en active Pending
- 2015-05-27 KR KR1020197034930A patent/KR102231672B1/ko active Active
- 2015-05-27 CN CN202110399761.9A patent/CN113082225A/zh active Pending
- 2015-05-27 BR BR112016027624A patent/BR112016027624A8/pt not_active Application Discontinuation
- 2015-05-27 KR KR1020167035356A patent/KR102051038B1/ko active Active
- 2015-05-27 WO PCT/US2015/032565 patent/WO2015183882A1/en not_active Ceased
- 2015-05-27 PL PL15727248T patent/PL3148591T3/pl unknown
- 2015-05-27 CA CA3201974A patent/CA3201974C/en active Active
- 2015-05-27 CN CN201580029280.1A patent/CN106659797B/zh active Active
- 2015-05-27 JP JP2016569722A patent/JP6573633B2/ja active Active
- 2015-05-27 RU RU2016144055A patent/RU2016144055A/ru not_active Application Discontinuation
- 2015-05-27 US US14/722,307 patent/US10111963B2/en active Active
- 2015-05-27 CA CA2947895A patent/CA2947895C/en active Active
-
2018
- 2018-09-21 US US16/137,709 patent/US10485881B2/en active Active
-
2019
- 2019-10-15 US US16/653,490 patent/US20200289668A1/en not_active Abandoned
-
2024
- 2024-10-10 US US18/911,705 patent/US20250269054A1/en active Pending
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