AU2010242422B2 - Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents - Google Patents
Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents Download PDFInfo
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- AU2010242422B2 AU2010242422B2 AU2010242422A AU2010242422A AU2010242422B2 AU 2010242422 B2 AU2010242422 B2 AU 2010242422B2 AU 2010242422 A AU2010242422 A AU 2010242422A AU 2010242422 A AU2010242422 A AU 2010242422A AU 2010242422 B2 AU2010242422 B2 AU 2010242422B2
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- arginase
- pegylated
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- cys
- arginine
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| WO2011008495A2 (en) * | 2009-06-29 | 2011-01-20 | The Board Of Regents Of The University Of Texas System | Arginase formulations and methods |
| EP2531224B1 (en) | 2010-01-26 | 2019-06-05 | Bioregency, Inc. | Compositions and methods relating to argininosuccinate synthetase |
| WO2012085793A1 (en) * | 2010-12-21 | 2012-06-28 | Ning Man Cheng | Use of pegylated recombinant human arginase for treatment of leukemia |
| CN103184208B (zh) | 2011-12-27 | 2015-09-16 | 拜奥生物科技（上海）有限公司 | 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用 |
| WO2014003850A2 (en) | 2012-06-26 | 2014-01-03 | Timothy Paul Foster | Methods for treatment of ocular diseases |
| US9011845B2 (en) | 2012-06-26 | 2015-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods for treatment of inflammatory and infectious viral diseases |
| ES2897635T3 (es) | 2014-04-29 | 2022-03-02 | Bio Cancer Treat International Ltd | Métodos y composiciones para modular el sistema inmunológico con la arginasa I |
| CN105112391B (zh) * | 2015-09-22 | 2018-07-06 | 浙江道尔生物科技有限公司 | 一种人源精氨酸酶突变体及其制备方法和用途 |
| CN106692961B (zh) * | 2015-11-17 | 2020-12-11 | 长春市福迪奥美科技有限公司 | 精氨酸酶组合物、精氨酸酶激活剂及其应用 |
| CN106434710A (zh) * | 2016-10-14 | 2017-02-22 | 江南大学 | 一种耐热精氨酸酶的基因表达序列和应用 |
| CN108265044B (zh) * | 2016-12-31 | 2021-05-11 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
| TW201910513A (zh) * | 2017-08-16 | 2019-03-16 | 香港商鎧耀波麗堂（香港）有限公司 | 胺基酸耗竭治療的組合物及方法 |
| AU2019275733B2 (en) * | 2018-05-31 | 2025-07-31 | The Chinese University Of Hong Kong | Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities |
| EP3866837A1 (en) | 2018-10-19 | 2021-08-25 | AERase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| CN109793917B (zh) * | 2019-02-11 | 2020-10-09 | 海南建科药业有限公司 | 一种预防结直肠手术后吻合口瘘的凝胶的制备方法 |
| JP2022545738A (ja) | 2019-08-30 | 2022-10-28 | アエグリア バイオセラピューティクス， インク． | ヒト組換えアルギナーゼ１の製造方法およびその使用 |
| US20210162028A1 (en) * | 2019-12-02 | 2021-06-03 | The Hong Kong Polytechnic University | Methods for Inducing Intermittent Fasting and Modulating Autophagy |
| CA3180529A1 (en) * | 2020-04-17 | 2021-10-21 | Bio-Cancer Treatment International Limited | Methods of treating viral infections using arginase |
| WO2021228875A1 (en) * | 2020-05-14 | 2021-11-18 | Kyon Biotech Ag | Treatment of respiratory viral infections |
| WO2022063178A1 (en) * | 2020-09-23 | 2022-03-31 | The Hong Kong Polytechnic University | Fluorescent biosensor for rapid determination of l-arginine |
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| WO2003063780A2 (en) * | 2002-01-25 | 2003-08-07 | Cancer Treatments International | Therapeutic composition for treatment of cancer by arginine depletion |
| HK1053577A2 (en) * | 2002-06-20 | 2003-10-10 | Bio-Cancer Treatment International Limited | Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation |
| CA2497794A1 (en) * | 2002-09-06 | 2004-03-18 | Bayer Pharmaceuticals Corporation | Modified glp-1 receptor agonists and their pharmacological methods of use |
| CN1745847A (zh) | 2004-09-08 | 2006-03-15 | 康达医药科技有限公司 | 用精氨酸酶治疗肝炎的药物组合物和方法 |
| WO2006058486A1 (en) | 2004-12-03 | 2006-06-08 | Bio-Cancer Treatment International Limited | Use of arginase in combination with 5fu and other compounds for treatment of human malignancies |
| WO2011008495A2 (en) * | 2009-06-29 | 2011-01-20 | The Board Of Regents Of The University Of Texas System | Arginase formulations and methods |
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2010
- 2010-03-26 AU AU2010242422A patent/AU2010242422B2/en active Active
- 2010-03-26 WO PCT/CN2010/071357 patent/WO2010124547A1/en not_active Ceased
- 2010-03-26 CN CN201080023256.4A patent/CN102481345B/zh active Active
- 2010-03-26 US US12/732,188 patent/US8507245B2/en active Active
- 2010-03-26 EP EP10769236.0A patent/EP2411040B1/en active Active
- 2010-03-26 JP JP2012501126A patent/JP5746137B2/ja active Active
- 2010-03-26 CA CA2756442A patent/CA2756442C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004000349A1 (en) * | 2002-06-20 | 2003-12-31 | Bio-Cancer Treatment International Limited | Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation |
Also Published As
| Publication number | Publication date |
|---|---|
| US8507245B2 (en) | 2013-08-13 |
| US20100247508A1 (en) | 2010-09-30 |
| EP2411040A4 (en) | 2012-09-12 |
| AU2010242422A1 (en) | 2011-10-27 |
| CN102481345A (zh) | 2012-05-30 |
| JP2012521201A (ja) | 2012-09-13 |
| EP2411040B1 (en) | 2015-09-23 |
| EP2411040A1 (en) | 2012-02-01 |
| WO2010124547A1 (en) | 2010-11-04 |
| CA2756442A1 (en) | 2010-11-04 |
| JP5746137B2 (ja) | 2015-07-08 |
| CA2756442C (en) | 2016-03-29 |
| CN102481345B (zh) | 2015-04-22 |
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| FGA | Letters patent sealed or granted (standard patent) |