CN102481345B - 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 - Google Patents

精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 Download PDF

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CN102481345B
CN102481345B CN201080023256.4A CN201080023256A CN102481345B CN 102481345 B CN102481345 B CN 102481345B CN 201080023256 A CN201080023256 A CN 201080023256A CN 102481345 B CN102481345 B CN 102481345B
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arginase
peg
enzyme
human
bacillus cereus
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CN102481345A (zh
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梁润松
劳伟雄
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Hong Kong Polytechnic University HKPU
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03001—Arginase (3.5.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201080023256.4A 2009-03-26 2010-03-26 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 Active CN102481345B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16386309P 2009-03-26 2009-03-26
US61/163,863 2009-03-26
PCT/CN2010/071357 WO2010124547A1 (en) 2009-03-26 2010-03-26 Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents

Publications (2)

Publication Number Publication Date
CN102481345A CN102481345A (zh) 2012-05-30
CN102481345B true CN102481345B (zh) 2015-04-22

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US (1) US8507245B2 (enExample)
EP (1) EP2411040B1 (enExample)
JP (1) JP5746137B2 (enExample)
CN (1) CN102481345B (enExample)
AU (1) AU2010242422B2 (enExample)
CA (1) CA2756442C (enExample)
WO (1) WO2010124547A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9382525B2 (en) * 2009-03-26 2016-07-05 The Hong Kong Polytechnic University Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
JP2012531893A (ja) * 2009-06-29 2012-12-13 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム アルギナーゼ製剤および方法
US9682132B2 (en) 2010-01-26 2017-06-20 Banyan Biomarkers, Inc Compositions and methods relating to argininosucccinate synthetase
ES2704480T3 (es) * 2010-12-21 2019-03-18 Bio Cancer Treat International Ltd Uso de arginasa humana recombinante pegilada para el tratamiento de la leucemia
CN103184208B (zh) * 2011-12-27 2015-09-16 拜奥生物科技（上海）有限公司 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用
US9011845B2 (en) 2012-06-26 2015-04-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Methods for treatment of inflammatory and infectious viral diseases
US8877183B2 (en) 2012-06-26 2014-11-04 National Institutes Of Health (Nih) Methods for treatment of ocular diseases
EP4005590B1 (en) * 2014-04-29 2024-12-04 Bio-Cancer Treatment International Ltd. Methods and compositions for modulating the immune system with arginase i
CN105112391B (zh) * 2015-09-22 2018-07-06 浙江道尔生物科技有限公司 一种人源精氨酸酶突变体及其制备方法和用途
CN106692961B (zh) * 2015-11-17 2020-12-11 长春市福迪奥美科技有限公司 精氨酸酶组合物、精氨酸酶激活剂及其应用
CN106434710A (zh) * 2016-10-14 2017-02-22 江南大学 一种耐热精氨酸酶的基因表达序列和应用
CN108265044B (zh) * 2016-12-31 2021-05-11 江苏众红生物工程创药研究院有限公司 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用
TW201910513A (zh) * 2017-08-16 2019-03-16 香港商鎧耀波麗堂（香港）有限公司 胺基酸耗竭治療的組合物及方法
CA3101667A1 (en) * 2018-05-31 2019-12-05 The Hong Kong Polytechnic University Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities
MX2021004463A (es) 2018-10-19 2021-08-24 Aerase Inc Terapia de disminución de arginina para el tratamiento de la deficiencia de gamt.
CN109793917B (zh) * 2019-02-11 2020-10-09 海南建科药业有限公司 一种预防结直肠手术后吻合口瘘的凝胶的制备方法
TW202525331A (zh) 2019-08-30 2025-07-01 瑞典商伊梅爾迪卡製藥公司 人類重組精胺酸酶 １ 之產生方法及其用途
EP4069280A4 (en) * 2019-12-02 2024-01-03 The Hong Kong Polytechnic University METHODS FOR INDUCING INTERMITTENT FASTING AND MODULATING AUTOPHAGY
AU2021256801A1 (en) * 2020-04-17 2022-11-24 Bio-Cancer Treatment International Limited Methods of treating viral infections using arginase
EP4149619A1 (en) * 2020-05-14 2023-03-22 Kyon Biotech AG Treatment of respiratory viral infections
WO2022063178A1 (en) * 2020-09-23 2022-03-31 The Hong Kong Polytechnic University Fluorescent biosensor for rapid determination of l-arginine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
WO2004001048A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation
WO2004000349A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
WO2004022004A3 (en) * 2002-09-06 2004-12-23 Bayer Pharmaceuticals Corp Modified glp-1 receptor agonists and their pharmacological methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1499342A2 (en) * 2002-01-25 2005-01-26 Cancer Treatments International Therapeutic composition for treatment of cancer by arginine depletion
CN1745847A (zh) 2004-09-08 2006-03-15 康达医药科技有限公司 用精氨酸酶治疗肝炎的药物组合物和方法
WO2006058486A1 (en) 2004-12-03 2006-06-08 Bio-Cancer Treatment International Limited Use of arginase in combination with 5fu and other compounds for treatment of human malignancies
JP2012531893A (ja) 2009-06-29 2012-12-13 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム アルギナーゼ製剤および方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
WO2004001048A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation
WO2004000349A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
CN1918298A (zh) * 2002-06-20 2007-02-21 康达医药科技有限公司 利用精氨酸剥夺治疗人恶性肿瘤的药物组合物及方法
WO2004022004A3 (en) * 2002-09-06 2004-12-23 Bayer Pharmaceuticals Corp Modified glp-1 receptor agonists and their pharmacological methods of use

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JP5746137B2 (ja) 2015-07-08
CA2756442A1 (en) 2010-11-04
US20100247508A1 (en) 2010-09-30
EP2411040A1 (en) 2012-02-01
AU2010242422B2 (en) 2014-12-04
EP2411040A4 (en) 2012-09-12
JP2012521201A (ja) 2012-09-13
CN102481345A (zh) 2012-05-30
US8507245B2 (en) 2013-08-13
EP2411040B1 (en) 2015-09-23
WO2010124547A1 (en) 2010-11-04
CA2756442C (en) 2016-03-29
AU2010242422A1 (en) 2011-10-27

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