JP2008525423A5 - - Google Patents
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- Publication number
- JP2008525423A5 JP2008525423A5 JP2007547709A JP2007547709A JP2008525423A5 JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5 JP 2007547709 A JP2007547709 A JP 2007547709A JP 2007547709 A JP2007547709 A JP 2007547709A JP 2008525423 A5 JP2008525423 A5 JP 2008525423A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- composition according
- composition
- carrier protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014914 Carrier Proteins Human genes 0.000 claims 15
- 108010078791 Carrier Proteins Proteins 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 150000001720 carbohydrates Chemical class 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 101710154606 Hemagglutinin Proteins 0.000 claims 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 3
- 101710176177 Protein A56 Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000185 hemagglutinin Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 108010055044 Tetanus Toxin Proteins 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 229940118376 tetanus toxin Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 241000776296 Cryptococcus neoformans var. grubii Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000186366 Mycobacterium bovis Species 0.000 claims 1
- 241000186362 Mycobacterium leprae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940030998 streptococcus agalactiae Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428394.1A GB0428394D0 (en) | 2004-12-24 | 2004-12-24 | Saccharide conjugate vaccines |
| GB0428394.1 | 2004-12-24 | ||
| PCT/IB2005/004050 WO2006067632A2 (en) | 2004-12-24 | 2005-12-23 | Saccharide conjugate vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Division JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525423A JP2008525423A (ja) | 2008-07-17 |
| JP2008525423A5 true JP2008525423A5 (enExample) | 2009-02-12 |
| JP5737824B2 JP5737824B2 (ja) | 2015-06-17 |
Family
ID=34130952
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547709A Expired - Fee Related JP5737824B2 (ja) | 2004-12-24 | 2005-12-23 | 糖結合体ワクチン |
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267162A Withdrawn JP2013049717A (ja) | 2004-12-24 | 2012-12-06 | 糖結合体ワクチン |
| JP2015105889A Pending JP2015155464A (ja) | 2004-12-24 | 2015-05-25 | 糖結合体ワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20080260773A1 (enExample) |
| EP (1) | EP1838345B1 (enExample) |
| JP (3) | JP5737824B2 (enExample) |
| CN (1) | CN101111261B (enExample) |
| AT (1) | ATE492290T1 (enExample) |
| AU (1) | AU2005317683B2 (enExample) |
| BR (1) | BRPI0519232A2 (enExample) |
| CA (1) | CA2594524C (enExample) |
| DE (1) | DE602005025531D1 (enExample) |
| ES (1) | ES2356670T3 (enExample) |
| GB (1) | GB0428394D0 (enExample) |
| NZ (2) | NZ556486A (enExample) |
| RU (1) | RU2454244C2 (enExample) |
| WO (1) | WO2006067632A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788796B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788797B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788794B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788795B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788798B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| EP1946769B1 (en) * | 2000-06-29 | 2012-05-30 | SmithKline Beecham Biologicals S.A. | Multivalent vaccine composition with reduced dose of Haemophilus influenzae type B |
| AU2000278267A1 (en) | 2000-09-01 | 2002-03-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| US7939087B2 (en) * | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| KR101838938B1 (ko) | 2006-03-17 | 2018-03-15 | 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 복합 다가 면역원성 콘쥬게이트의 제조 방법 |
| EP2601969B1 (en) | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| CN104740624B (zh) | 2007-09-18 | 2018-04-24 | 武田疫苗股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| US20110189223A1 (en) * | 2008-04-16 | 2011-08-04 | Glaxosmithkline Biologicals S.A. | Vaccine |
| JP2011524375A (ja) * | 2008-06-16 | 2011-09-01 | アカデミア シニカ | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| JP5852883B2 (ja) | 2008-08-08 | 2016-02-03 | タケダ ワクチン，インコーポレイテッド | 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子 |
| CN102215862B (zh) * | 2009-06-16 | 2016-04-06 | 中央研究院 | Globo h及含新颖糖脂质佐剂的相关抗癌疫苗 |
| US8974799B2 (en) * | 2009-09-30 | 2015-03-10 | Novartis Ag | Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides |
| EP2482843A4 (en) * | 2009-10-02 | 2013-05-15 | Univ Iowa Res Found | PROCESS FOR IMPROVED VACCINE IMMUNOGENICITY |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| WO2011123042A1 (en) * | 2010-04-01 | 2011-10-06 | Independent Pharmaceutica Ab | Vaccination procedure and products for use therein |
| CA2808975C (en) | 2010-08-23 | 2018-10-30 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| CA2849391A1 (en) * | 2010-10-20 | 2012-04-26 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| CN103826657A (zh) | 2011-04-04 | 2014-05-28 | 衣阿华大学研究基金会 | 改进疫苗免疫原性的方法 |
| RU2632651C2 (ru) | 2011-05-11 | 2017-10-06 | Чилдрен'С Медикал Сентер Корпорейшн | Модифицированный биотин-связывающий белок, слитые белки на его основе и их применение |
| KR101839496B1 (ko) * | 2011-06-01 | 2018-03-19 | 시아먼 유니버시티 | 디프테리아 독소 무독성 돌연변이 씨알엠197 또는 그의 단편을 포함하는 융합 단백질 |
| PH12014500093A1 (en) | 2011-07-11 | 2014-03-17 | Takeda Vaccines Inc | Parenteral norovirus vaccine formulations |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| WO2014008406A2 (en) | 2012-07-05 | 2014-01-09 | Children's Medical Center Corporation | The bacterial biofilm matrix as a platform for protein delivery |
| CA2879272A1 (en) | 2012-07-16 | 2014-01-23 | Robert G.K. DONALD | Saccharides and uses thereof |
| MX2015004171A (es) * | 2012-10-02 | 2015-10-22 | Glaxosmithkline Biolog Sa | Conjugados de sacaridos no lineales. |
| EP4272750A3 (en) | 2013-02-07 | 2024-01-24 | Children's Medical Center, Corp. | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN104069504B (zh) * | 2014-05-11 | 2019-09-24 | 江苏康泰生物医学技术有限公司 | 一种增强多糖蛋白结合物免疫原性的方法 |
| CN104004085B (zh) * | 2014-05-28 | 2017-01-11 | 山东大学 | 一种结核杆菌lam寡糖缀合物及其制备方法与应用 |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| KR20250058066A (ko) * | 2015-07-21 | 2025-04-29 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| MX2018006785A (es) | 2015-12-04 | 2018-11-09 | Dana Farber Cancer Inst Inc | Vacunacion con el dominio alfa 3 de mica/b para el tratamiento del cancer. |
| KR20180129926A (ko) * | 2016-06-02 | 2018-12-05 | 조에티스 서비시즈 엘엘씨 | 감염성 기관지염에 대한 백신 |
| WO2017219004A2 (en) * | 2016-06-17 | 2017-12-21 | Children's Medical Center Corporation | Biofilm matrix-boosted vaccine |
| US11097000B2 (en) * | 2016-10-03 | 2021-08-24 | National Taiwan University | Klebsiella pneumoniae capsule polysaccharide vaccines |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| EP3600400A4 (en) | 2017-03-28 | 2021-01-13 | The Children's Medical Center Corporation | MULTIPLE ANTIGEN (MAPS) BASED STAPHYLOCOCCUS AUREUS VACCINE, IMMUNOGENIC COMPOSITION AND USES THEREOF |
| US10729763B2 (en) * | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX2019014829A (es) * | 2017-06-10 | 2020-08-17 | Inventprise Llc | Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. |
| SG11201912601RA (en) | 2017-06-23 | 2020-01-30 | Nosocomial Vaccine Corp | Immunogenic compositions |
| CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
| CN112969474A (zh) | 2018-09-12 | 2021-06-15 | 艾芬尼维克斯公司 | 多价肺炎球菌疫苗 |
| CN113164580B (zh) | 2018-09-12 | 2025-06-10 | 儿童医疗中心公司 | 肺炎球菌融合蛋白疫苗 |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CA3167081A1 (en) | 2020-02-06 | 2021-08-12 | Luke T. Daum | Immunogenic compositions to treat and prevent microbial infections |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
| CN113150084B (zh) * | 2021-03-23 | 2023-03-21 | 江苏坤力生物制药有限责任公司 | 一种纳米化的冠状病毒抗原及其应用 |
| CN113274489B (zh) * | 2021-04-30 | 2023-08-29 | 山东省药学科学院 | 一种预防真菌感染的几丁质寡糖疫苗及其制备方法 |
| MX2024002779A (es) | 2021-09-09 | 2024-06-11 | Affinivax Inc | Vacunas neumocócicas multivalentes. |
| CN114767846B (zh) * | 2022-04-21 | 2025-10-14 | 中国医学科学院医学生物学研究所 | 一种轮状非结构蛋白4在提高重组轮状病毒亚单位疫苗免疫功能中的应用 |
| CN115721711B (zh) * | 2022-10-28 | 2024-01-23 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌荚膜多糖-带状疱疹病毒重组蛋白结合疫苗及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| RO111416B1 (ro) * | 1989-12-14 | 1996-10-31 | Ca Nat Research Council | Polizaharide modificate de neisseria meningitidis si e coli, combinatii antigenice si metoda de imunizare |
| NZ311000A (en) * | 1995-06-07 | 1999-04-29 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein |
| CN1215337A (zh) * | 1995-06-23 | 1999-04-28 | 史密斯克莱·比奇曼生物公司 | 包含一种多糖抗原－载体蛋白共轭物和游离载体蛋白的疫苗 |
| EP0969873B1 (en) * | 1997-03-27 | 2006-06-07 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| CA2435681C (en) * | 2001-01-23 | 2011-06-21 | Aventis Pasteur | Multivalent meningococcal polysaccharide-protein conjugate vaccine |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
-
2004
- 2004-12-24 GB GBGB0428394.1A patent/GB0428394D0/en not_active Ceased
-
2005
- 2005-12-23 NZ NZ556486A patent/NZ556486A/en not_active IP Right Cessation
- 2005-12-23 RU RU2007127993/10A patent/RU2454244C2/ru not_active IP Right Cessation
- 2005-12-23 ES ES05850768T patent/ES2356670T3/es not_active Expired - Lifetime
- 2005-12-23 AT AT05850768T patent/ATE492290T1/de not_active IP Right Cessation
- 2005-12-23 CN CN2005800474204A patent/CN101111261B/zh not_active Expired - Fee Related
- 2005-12-23 US US11/793,996 patent/US20080260773A1/en not_active Abandoned
- 2005-12-23 CA CA2594524A patent/CA2594524C/en not_active Expired - Fee Related
- 2005-12-23 JP JP2007547709A patent/JP5737824B2/ja not_active Expired - Fee Related
- 2005-12-23 WO PCT/IB2005/004050 patent/WO2006067632A2/en not_active Ceased
- 2005-12-23 DE DE602005025531T patent/DE602005025531D1/de not_active Expired - Lifetime
- 2005-12-23 NZ NZ593954A patent/NZ593954A/xx not_active IP Right Cessation
- 2005-12-23 EP EP05850768A patent/EP1838345B1/en not_active Expired - Lifetime
- 2005-12-23 BR BRPI0519232-3A patent/BRPI0519232A2/pt not_active IP Right Cessation
- 2005-12-23 AU AU2005317683A patent/AU2005317683B2/en not_active Ceased
-
2012
- 2012-12-06 JP JP2012267162A patent/JP2013049717A/ja not_active Withdrawn
-
2014
- 2014-08-05 US US14/451,907 patent/US20150165019A1/en not_active Abandoned
-
2015
- 2015-05-25 JP JP2015105889A patent/JP2015155464A/ja active Pending
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