JP2012506421A5 - - Google Patents
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- JP2012506421A5 JP2012506421A5 JP2011532774A JP2011532774A JP2012506421A5 JP 2012506421 A5 JP2012506421 A5 JP 2012506421A5 JP 2011532774 A JP2011532774 A JP 2011532774A JP 2011532774 A JP2011532774 A JP 2011532774A JP 2012506421 A5 JP2012506421 A5 JP 2012506421A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- amount
- present
- hib
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 44
- 102000036639 antigens Human genes 0.000 claims 44
- 108091007433 antigens Proteins 0.000 claims 44
- 238000002360 preparation method Methods 0.000 claims 13
- 229960005486 vaccine Drugs 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 7
- 229960005323 phenoxyethanol Drugs 0.000 claims 7
- 201000005702 Pertussis Diseases 0.000 claims 6
- 206010043376 Tetanus Diseases 0.000 claims 5
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 5
- 229940001442 combination vaccine Drugs 0.000 claims 5
- 206010013023 diphtheria Diseases 0.000 claims 5
- 239000007788 liquid Substances 0.000 claims 4
- 241000991587 Enterovirus C Species 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims 2
- 241000274177 Juniperus sabina Species 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 101150047505 FIM1 gene Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- SGSXWFDMRKAVLS-UHFFFAOYSA-N [6'-acetyloxy-5-[3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propylcarbamoyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] acetate Chemical compound C1=C(C=2C(NC(=O)C=2C=2C3=CC=CC=C3N(C)C=2)=O)C2=CC=CC=C2N1CCCNC(=O)C(C=C1C(=O)O2)=CC=C1C12C2=CC=C(OC(C)=O)C=C2OC2=CC(OC(=O)C)=CC=C12 SGSXWFDMRKAVLS-UHFFFAOYSA-N 0.000 claims 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims 1
- 201000006599 congenital myasthenic syndrome 4C Diseases 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010021711 pertactin Proteins 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2438/DEL/2008 | 2008-10-24 | ||
| IN2438DE2008 | 2008-10-24 | ||
| PCT/IN2009/000600 WO2010046935A1 (en) | 2008-10-24 | 2009-10-23 | Combination vaccine with acellular pertussis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012506421A JP2012506421A (ja) | 2012-03-15 |
| JP2012506421A5 true JP2012506421A5 (enExample) | 2012-12-06 |
Family
ID=42119003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532774A Pending JP2012506421A (ja) | 2008-10-24 | 2009-10-23 | 新規な無細胞百日咳ワクチン組成物およびその製造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8551451B2 (enExample) |
| EP (2) | EP2529749A1 (enExample) |
| JP (1) | JP2012506421A (enExample) |
| CN (1) | CN102196818A (enExample) |
| AP (1) | AP2011005701A0 (enExample) |
| AR (1) | AR073959A1 (enExample) |
| BR (1) | BRPI0920630A2 (enExample) |
| CA (1) | CA2741396A1 (enExample) |
| CL (1) | CL2011000914A1 (enExample) |
| CO (1) | CO6430434A2 (enExample) |
| MA (1) | MA32819B1 (enExample) |
| PE (1) | PE20100366A1 (enExample) |
| RU (2) | RU2526214C2 (enExample) |
| WO (1) | WO2010046935A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5814507B2 (ja) * | 2006-09-07 | 2015-11-17 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| EP2661277A2 (en) | 2011-01-05 | 2013-11-13 | Bharat Biotech International Limited | A combination heptavalent vaccine |
| FR2985663B1 (fr) * | 2012-01-17 | 2015-03-27 | Sanofi Pasteur | Procede de formulation d'un vaccin contenant au moins deux antigenes susceptibles de s'adsorber sur de l'oxy hydroxyde d'aluminium |
| FR2992656B1 (fr) * | 2012-07-02 | 2016-10-07 | Sanofi Pasteur | Procede de production d'antigenes haemophilus influenzae type b |
| CN104582719B (zh) * | 2012-08-17 | 2017-09-15 | 英特维特国际股份有限公司 | 灭活钩端螺旋体细菌的免疫原性组合物 |
| WO2014135651A1 (en) * | 2013-03-08 | 2014-09-12 | Crucell Holland B.V. | Acellular pertussis vaccine |
| US9849066B2 (en) | 2013-04-24 | 2017-12-26 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| MX2016001695A (es) * | 2013-08-05 | 2016-05-02 | Glaxosmithkline Biolog Sa | Composiciones inmunogenas de combinacion. |
| CN105861535B (zh) * | 2015-01-20 | 2019-10-25 | 中国人民解放军军事医学科学院生物工程研究所 | 伤寒糖蛋白的生物制备方法及其应用 |
| CN106075428A (zh) * | 2015-07-01 | 2016-11-09 | 北京科兴中维生物技术有限公司 | 一种免疫原性组合物及其制备方法 |
| CN111032078A (zh) * | 2017-07-18 | 2020-04-17 | 血清研究所印度私人有限公司 | 具有改善的稳定性、增强的免疫原性和降低的反应原性的免疫原性组合物及其制备方法 |
| CN109550046B (zh) * | 2018-12-21 | 2020-08-25 | 北京民海生物科技有限公司 | 一种吸附无细胞百白破-脊髓灰质炎-b型流感嗜血杆菌联合疫苗及其制备方法 |
| WO2020165920A1 (en) * | 2019-02-12 | 2020-08-20 | Biological E Limited | Multivalent vaccine composition |
| CN110917344B (zh) * | 2019-12-26 | 2022-11-04 | 北京科兴中维生物技术有限公司 | 一种液体疫苗组合物及其应用 |
| CN111053898B (zh) * | 2019-12-26 | 2023-05-16 | 北京科兴中维生物技术有限公司 | 一种疫苗组合物及其应用 |
| WO2021176409A1 (en) | 2020-03-05 | 2021-09-10 | Sanofi Healthcare India Private Limited | Preservative combination for vaccine composition |
| US20240238298A1 (en) * | 2021-05-26 | 2024-07-18 | Emory University | JAK Inhibitors for Managing Conditions in Patients with Down's Syndrome or Other Trisomy |
| WO2025109417A1 (en) * | 2023-11-21 | 2025-05-30 | Panacea Biotec Limited | Immunogenic composition of haemophilus influenzae conjugated to protein d |
| CN119548620B (zh) * | 2025-01-23 | 2025-09-12 | 康希诺生物股份公司 | 一种用于预防白喉、百日咳和破伤风的免疫原性组合物、疫苗及其制备方法和应用 |
| CN119524117B (zh) * | 2025-01-23 | 2025-09-23 | 康希诺生物股份公司 | 免疫原性组合物、百白破联合疫苗及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG48365A1 (en) * | 1992-05-23 | 1998-04-17 | Smithkline Beecham Biolog | Combined vaccines comprising hepatitis b surface antigen and other antigens |
| US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
| FR2734484B1 (fr) * | 1995-05-24 | 1997-06-27 | Pasteur Merieux Serums Vacc | Composition vaccinale liquide et procede de fabrication |
| US20020054884A1 (en) | 1995-06-23 | 2002-05-09 | Smithkline Beecham Biologicals, Sa | Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
| DE69736709T2 (de) * | 1996-07-02 | 2007-10-04 | Sanofi Pasteur Ltd., Toronto | Vielwertige dtp-polio-impfstoffe |
| BR9714980A (pt) | 1997-09-15 | 2001-11-06 | Pasteur Merieux Msd | Vacinas multivalentes |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| GB0405787D0 (en) | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
| JP5135220B2 (ja) | 2005-09-01 | 2013-02-06 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 血清群ｃ髄膜炎菌を含む複数ワクチン接種 |
| US20070065462A1 (en) * | 2005-09-21 | 2007-03-22 | Ryall Robert P | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
-
2009
- 2009-10-22 PE PE2009001196A patent/PE20100366A1/es not_active Application Discontinuation
- 2009-10-23 CN CN200980142461XA patent/CN102196818A/zh active Pending
- 2009-10-23 JP JP2011532774A patent/JP2012506421A/ja active Pending
- 2009-10-23 US US13/125,708 patent/US8551451B2/en not_active Expired - Fee Related
- 2009-10-23 EP EP11172591.7A patent/EP2529749A1/en not_active Withdrawn
- 2009-10-23 WO PCT/IN2009/000600 patent/WO2010046935A1/en not_active Ceased
- 2009-10-23 BR BRPI0920630A patent/BRPI0920630A2/pt not_active Application Discontinuation
- 2009-10-23 CA CA2741396A patent/CA2741396A1/en not_active Abandoned
- 2009-10-23 AP AP2011005701A patent/AP2011005701A0/xx unknown
- 2009-10-23 EP EP09821706A patent/EP2362781A4/en not_active Withdrawn
- 2009-10-23 AR ARP090104080A patent/AR073959A1/es not_active Application Discontinuation
- 2009-10-23 RU RU2011120308/10A patent/RU2526214C2/ru active
-
2011
- 2011-04-21 CL CL2011000914A patent/CL2011000914A1/es unknown
- 2011-05-20 MA MA33875A patent/MA32819B1/fr unknown
- 2011-05-24 CO CO11063979A patent/CO6430434A2/es not_active Application Discontinuation
-
2013
- 2013-01-14 RU RU2013101418A patent/RU2634393C2/ru active
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