HRP20110431T1 - Kombinirano cjepivo od inaktiviranog poliovirusa - Google Patents
Kombinirano cjepivo od inaktiviranog poliovirusa Download PDFInfo
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- HRP20110431T1 HRP20110431T1 HR20110431T HRP20110431T HRP20110431T1 HR P20110431 T1 HRP20110431 T1 HR P20110431T1 HR 20110431 T HR20110431 T HR 20110431T HR P20110431 T HRP20110431 T HR P20110431T HR P20110431 T1 HRP20110431 T1 HR P20110431T1
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- vaccine
- neisseria meningitidis
- antigen units
- inactivated poliovirus
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- 241000991587 Enterovirus C Species 0.000 title claims 3
- 229940001442 combination vaccine Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 claims abstract 18
- 239000000427 antigen Substances 0.000 claims abstract 15
- 241000588832 Bordetella pertussis Species 0.000 claims abstract 5
- 241000894006 Bacteria Species 0.000 claims abstract 4
- 101710154643 Filamentous hemagglutinin Proteins 0.000 claims abstract 4
- 241000709701 Human poliovirus 1 Species 0.000 claims abstract 4
- 201000005702 Pertussis Diseases 0.000 claims abstract 4
- 108010021711 pertactin Proteins 0.000 claims abstract 4
- 229960003983 diphtheria toxoid Drugs 0.000 claims abstract 3
- 229960000814 tetanus toxoid Drugs 0.000 claims abstract 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims abstract 3
- 229960004906 thiomersal Drugs 0.000 claims abstract 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 10
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 241000193449 Clostridium tetani Species 0.000 claims 2
- 241000186227 Corynebacterium diphtheriae Species 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 241000709721 Hepatovirus A Species 0.000 claims 2
- 241000709704 Human poliovirus 2 Species 0.000 claims 2
- 241000709727 Human poliovirus 3 Species 0.000 claims 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 101100388690 Plasmodium falciparum (isolate K1 / Thailand) MEF-1 gene Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
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- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
- A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
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- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
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Abstract
IPV cjepivo, naznačeno time što sadrži: (a) difterijski toksoid; (b) tetanusni toksoid; (c) umrtvljene cijele stanice bakterije Bordetella pertussis; ili dvije ili više acelularnih komponenti bakterije hripavca (Pa) (primjerice pertusisni toksoid, filamentozni hemaglutinin (FHA) i pertaktin (PRN)), te; (d) inaktivirani poliovirus tip 1, u dozi većoj od 10 D-antigenskih jedinica, a manjoj od 20 D-antigenskih jedinica, gdje navedeno cjepivo uglavnom ne sadrži tiomersal. Patent sadrži još 12 patentnih zahtjeva.
Claims (13)
1. IPV cjepivo, naznačeno time što sadrži:
(a) difterijski toksoid;
(b) tetanusni toksoid;
(c) umrtvljene cijele stanice bakterije Bordetella pertussis; ili dvije ili više acelularnih komponenti bakterije hripavca (Pa) (primjerice pertusisni toksoid, filamentozni hemaglutinin (FHA) i pertaktin (PRN)), te;
(d) inaktivirani poliovirus tip 1, u dozi većoj od 10 D-antigenskih jedinica, a manjoj od 20 D-antigenskih jedinica,
gdje navedeno cjepivo uglavnom ne sadrži tiomersal.
2. Cjepivo u skladu s patentnim zahtjevom 1, naznačeno time što inaktivirani poliovirus tip 1 dolazi u dozi koja je 26-49%, 30-45%, 33-40%, or 35-37% standardne doze od 40 D-antigenskih jedinica.
3. Cjepivo u skladu s patentnim zahtjevom 1 ili 2, naznačeno time što dodatno sadrži inaktivirani poliovirus tip 3, u dozi od 8-20 D-antigenskih jedinica, 9-19 D-antigenskih jedinica, 10-18 D-antigenskih jedinica, 11-17 D-antigenskih jedinica, 12-16 D-antigenskih jedinica ili 13-15 D-antigenskih jedinica; primjerice otprilike ili točno 14 D-antigenskih jedinica.
4. Cjepivo u skladu s patentnim zahtjevima 1-3, naznačeno time što dodatno sadrži inaktivirani poliovirus tip 2, u dozi od 2-4 D-antigenskih jedinica.
5. Cjepivo u skladu s patentnim zahtjevima 1-4, naznačeno time što jedno ili više od difteriskog toksoida, tetanusnog toksoida, umrtvljenih cijelih szanica bakterije Bordetella pertussis, dvije ili više acelularnih komponenti bakterije hripavca, inaktiviranog poliovirusa tip 1, inaktiviranog poliovirusa tip 2 ili inaktiviranog poliovirusa tip 3 je apsorbirano na aluminijev hidroksid ili aluminijev fosfat ili na smjesu obojeg.
6. Cjepivo u skladu s patentnim zahtjevima 1-5, naznačeno time što dodatno sadrži površinski antigen virusa hepatitisa B, koji uglavnom ne sadrži tiomersal i izborno je apsorbiran na aluminijev fosfat.
7. Cjepivo u skladu s patentnim zahtjevima 1-6, naznačeno time što dodatno sadrži konjugat proteinskog nosača s saharidom iz kapsule bakterije Haemophilus influenzae tip B (Hib), izborno apsorbiran na aluminijev fosfat ili neapsorbiran na adjuvans.
8. Cjepivo u skladu s patentnim zahtjevima 1-7, naznačeno time što dodatno sadrži jedno ili više od sljedećeg:
(i) jedan ili više konjugata proteinskog nosača sa saharidom iz bakterijske kapsule, gdje se bakteriju bira iz skupine koju čine Neisseria meningitidis tip A, Neisseria meningitidis tip C, Neisseria meningitidis tip W i Neisseria meningitidis tip Y;
(ii) vezikulu od vanjske membrane bakterije Neisseria meningitidis tip B (MenB) ili LOS ili konjugirani saharid iz kapsule MenB;
(iii) saharid Vi iz bakterije Salmonella typhi, konjugiran s proteinskim nosačem; ili
(iv) antigen virusa hepatitisa A,
gdje je svaka komponenta izborno apsorbirana na aluminijev hidroksid ili aluminijev fosfat ili na smjesu obojeg; ili gdje je komponenta i), ii) ili iii) izborno neapsorbirana na adjuvans.
9. Upotreba cjepiva u skladu s patentnim zahtjevima 1-8, naznačena time što je navedeno cjepivo namijenjeno proizvodnji medikamenta za sprječavanje bolesti koju uzrokuje poliovirus, te bakterije Clostridium tetani, Corynebacterium diphtheriae i Bordetella pertussis.
10. Upotreba cjepiva u skladu s patentnim zahtjevima 1-8, naznačena time što je navedeno cjepivo namijenjeno proizvodnji medikamenta za sprječavanje bolesti koju uzrokuje poliovirus, te bakterije Clostridium tetani, Corynebacterium diphtheriae i Bordetella pertussis, te izborno jedno ili više između virusa hepatitisa B, bakterija Haemophilus influenzae B, Neisseria meningitidis tip A, Neisseria meningitidis tip C, Neisseria meningitidis tip W, Neisseria meningitidis tip Y, Neisseria meningitidis tip B, Salmonella typhi, te virusa hepatitisa A.
11. Cjepivo ili upotreba u skladu s patentnim zahtjevima 1-10, naznačeni time što IPV tip 1 pripada soju Mahoney.
12. Cjepivo ili upotreba u skladu s patentnim zahtjevima 1-11, naznačeni time što IPV tip 2, ako je prisutan, pripada soju MEF-1.
13. Cjepivo, postupak ili upotreba u skladu s patentnim zahtjevima 1-12, naznačeni time što IPV tip 3, ako je prisutan, pripada soju Saukett.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0617602.8A GB0617602D0 (en) | 2006-09-07 | 2006-09-07 | Vaccine |
GB0625593A GB0625593D0 (en) | 2006-12-21 | 2006-12-21 | Vaccine |
PCT/EP2007/059390 WO2008028956A1 (en) | 2006-09-07 | 2007-09-07 | Vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110431T1 true HRP20110431T1 (hr) | 2011-07-31 |
Family
ID=38823705
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110431T HRP20110431T1 (hr) | 2006-09-07 | 2011-06-09 | Kombinirano cjepivo od inaktiviranog poliovirusa |
HRP20120557TT HRP20120557T1 (hr) | 2006-09-07 | 2012-07-06 | Kombinirano cjepivo sa smanjenim količinama antigena poliovirusa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20120557TT HRP20120557T1 (hr) | 2006-09-07 | 2012-07-06 | Kombinirano cjepivo sa smanjenim količinama antigena poliovirusa |
Country Status (26)
Country | Link |
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US (3) | US8956625B2 (hr) |
EP (3) | EP2066344B2 (hr) |
JP (5) | JP5814507B2 (hr) |
KR (2) | KR20090057423A (hr) |
CN (2) | CN103585624A (hr) |
AT (1) | ATE511398T1 (hr) |
AU (2) | AU2007293672B2 (hr) |
BR (2) | BRPI0716518B8 (hr) |
CA (2) | CA2662051A1 (hr) |
CO (2) | CO6160334A2 (hr) |
CR (2) | CR10669A (hr) |
CY (2) | CY1111680T1 (hr) |
DK (2) | DK2097102T3 (hr) |
EA (2) | EA016417B1 (hr) |
ES (1) | ES2387582T3 (hr) |
HK (1) | HK1129563A1 (hr) |
HR (2) | HRP20110431T1 (hr) |
IL (2) | IL197272A (hr) |
MA (2) | MA30715B1 (hr) |
MX (2) | MX2009002560A (hr) |
NO (2) | NO20090865L (hr) |
NZ (2) | NZ575272A (hr) |
PL (2) | PL2066344T3 (hr) |
PT (2) | PT2097102E (hr) |
SI (2) | SI2066344T1 (hr) |
WO (2) | WO2008028956A1 (hr) |
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