JP2015509963A5 - - Google Patents
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- JP2015509963A5 JP2015509963A5 JP2014560384A JP2014560384A JP2015509963A5 JP 2015509963 A5 JP2015509963 A5 JP 2015509963A5 JP 2014560384 A JP2014560384 A JP 2014560384A JP 2014560384 A JP2014560384 A JP 2014560384A JP 2015509963 A5 JP2015509963 A5 JP 2015509963A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- motomeko
- toxoid
- composition
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 41
- 239000002671 adjuvant Substances 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 241000991587 Enterovirus C Species 0.000 claims description 8
- 201000005702 Pertussis Diseases 0.000 claims description 8
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 8
- 229960000814 tetanus toxoid Drugs 0.000 claims description 8
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 7
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 6
- 241000588650 Neisseria meningitidis Species 0.000 claims description 6
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 6
- 239000000556 agonist Substances 0.000 claims description 6
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 241000700721 Hepatitis B virus Species 0.000 claims description 2
- 108700026633 Neisseria meningitidis factor H-binding Proteins 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 230000001268 conjugating effect Effects 0.000 claims 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000024777 Prion disease Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608409P | 2012-03-08 | 2012-03-08 | |
| US61/608,409 | 2012-03-08 | ||
| US201261697745P | 2012-09-06 | 2012-09-06 | |
| US61/697,745 | 2012-09-06 | ||
| PCT/EP2013/054674 WO2013132043A1 (en) | 2012-03-08 | 2013-03-08 | Combination vaccines with tlr4 agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509963A JP2015509963A (ja) | 2015-04-02 |
| JP2015509963A5 true JP2015509963A5 (enExample) | 2016-04-28 |
Family
ID=47844315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560384A Pending JP2015509963A (ja) | 2012-03-08 | 2013-03-08 | Ｔｌｒ４アゴニストを含む混合ワクチン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150125486A1 (enExample) |
| EP (1) | EP2822584A1 (enExample) |
| JP (1) | JP2015509963A (enExample) |
| CN (1) | CN104159603A (enExample) |
| WO (1) | WO2013132043A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| SG11201400210RA (en) * | 2011-09-01 | 2014-03-28 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
| MY202505A (en) * | 2017-11-03 | 2024-05-01 | Takeda Vaccines Inc | Zika vaccines and immunogenic compositions, and methods of using the same |
| SG11202003975WA (en) | 2017-11-30 | 2020-06-29 | Takeda Vaccines Inc | Method for inactivating zika virus and related methods |
| BR112020016314A2 (pt) | 2018-02-12 | 2020-12-15 | Inimmune Corporation | Compostos ou um sais farmaceuticamente aceitáveis, composição farmacêutica, kit, e, métodos para elicitar, intensificar ou modificar uma resposta imunológica, para tratar, prevenir ou reduzir a suscetibilidade a câncer, para tratar, prevenir ou reduzir a suscetibilidade a uma doença infecciosa, para tratar, prevenir ou reduzir a suscetibilidade a uma alergia, para tratar, prevenir ou reduzir a suscetibilidade a uma afecção autoimune, para tratar, prevenir ou reduzir a suscetibilidade em um sujeito à infecção bacteriana, viral, priônica, autoimunidade, câncer ou alergia, para tratar, prevenir ou reduzir a suscetibilidade à autoimunidade, alergia, reperfusão de isquemia ou sepse, para tratar, prevenir ou reduzir a gravidade de ataques epiléticos e para tratar, prevenir ou reduzir a suscetibilidade a doenças oculares como degeneração macular, hipertensão ocular e infecção ocular |
| JP7605739B2 (ja) * | 2018-12-05 | 2024-12-24 | サノフィ パスツール インコーポレイテッド | 百日咳ブースターワクチン |
| EP3972636A4 (en) | 2019-05-23 | 2023-08-02 | The University Of Montana | VACCINE ADJUVANTS BASED ON TLR RECEPTOR LIGANDS |
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| US5204098A (en) | 1988-02-16 | 1993-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-protein conjugates |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
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| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
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| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
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| KR100310510B1 (ko) | 1993-03-23 | 2002-07-04 | 장 스테판느 | 3-0-탈아세틸화모노포스포릴지질a를함유하는백신조성물 |
| NZ311000A (en) | 1995-06-07 | 1999-04-29 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| GB9806456D0 (en) * | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
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| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用 |
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| KR101266552B1 (ko) | 2003-06-23 | 2013-05-23 | 박스터 헬쓰케어 에스.에이. | 그룹 ｙ 수막염균에 대한 백신 및 그의 수막염균성 조합 |
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| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| PL1866342T3 (pl) | 2005-04-08 | 2019-04-30 | Wyeth Llc | Oddzielanie zanieczyszczeń od polisacharydu Streptococcus pneumoniae przez manipulację pH |
| IL308456A (en) | 2005-04-08 | 2024-01-01 | Wyeth Llc | A multivalent pneumomuroral protein-polysaccharide conjugate preparation |
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| HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| AR056591A1 (es) | 2005-10-28 | 2007-10-10 | Vaxinnate Corp | Polipeptidos ligandos para receptor 4 simil toll (tlr4) |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| JP5792920B2 (ja) | 2005-12-22 | 2015-10-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0616306D0 (en) * | 2006-08-16 | 2006-09-27 | Novartis Ag | Vaccines |
| SI2097102T1 (sl) | 2006-09-07 | 2012-09-28 | Glaxosmithkline Biolog Sa | Kombinirano cepivo, ki ima zmanjšane količine antigena za poliovirus |
| CA2665169C (en) | 2006-10-10 | 2017-02-21 | Wyeth | Purification of streptococcus pneumoniae type 3 polysaccharides |
| JP2013538217A (ja) | 2010-09-01 | 2013-10-10 | ノバルティス アーゲー | 不溶性金属塩への免疫増強物質の吸着 |
| CN103533954B (zh) * | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | 含较低剂量的抗原和/或佐剂的联合疫苗 |
-
2013
- 2013-03-08 EP EP13708414.1A patent/EP2822584A1/en not_active Withdrawn
- 2013-03-08 CN CN201380012958.6A patent/CN104159603A/zh active Pending
- 2013-03-08 JP JP2014560384A patent/JP2015509963A/ja active Pending
- 2013-03-08 WO PCT/EP2013/054674 patent/WO2013132043A1/en not_active Ceased
- 2013-03-08 US US14/381,438 patent/US20150125486A1/en not_active Abandoned
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