JP2005508849A5 - - Google Patents
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- Publication number
- JP2005508849A5 JP2005508849A5 JP2002579004A JP2002579004A JP2005508849A5 JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5 JP 2002579004 A JP2002579004 A JP 2002579004A JP 2002579004 A JP2002579004 A JP 2002579004A JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- oligosaccharide
- capsular polysaccharide
- carrier protein
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 44
- 150000004676 glycans Chemical class 0.000 claims 41
- 229920001542 oligosaccharide Polymers 0.000 claims 41
- 150000002482 oligosaccharides Chemical class 0.000 claims 41
- 229920001282 polysaccharide Polymers 0.000 claims 41
- 239000005017 polysaccharide Substances 0.000 claims 41
- 230000002163 immunogen Effects 0.000 claims 39
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 108010078791 Carrier Proteins Proteins 0.000 claims 23
- 229960005486 vaccine Drugs 0.000 claims 22
- 241000588650 Neisseria meningitidis Species 0.000 claims 15
- 241000606768 Haemophilus influenzae Species 0.000 claims 14
- 229960000814 tetanus toxoid Drugs 0.000 claims 14
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 12
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 12
- 229960003983 diphtheria toxoid Drugs 0.000 claims 11
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 6
- 241000991587 Enterovirus C Species 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229940047650 haemophilus influenzae Drugs 0.000 claims 5
- 241000588832 Bordetella pertussis Species 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 4
- 201000005702 Pertussis Diseases 0.000 claims 4
- 206010043376 Tetanus Diseases 0.000 claims 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 4
- 206010013023 diphtheria Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 208000037798 influenza B Diseases 0.000 claims 4
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 3
- 101710188053 Protein D Proteins 0.000 claims 3
- 101710132893 Resolvase Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000002672 hepatitis B Diseases 0.000 claims 3
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 claims 2
- 101710183389 Pneumolysin Proteins 0.000 claims 2
- 230000007123 defense Effects 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0108364.1 | 2001-04-03 | ||
| GBGB0108364.1A GB0108364D0 (en) | 2001-04-03 | 2001-04-03 | Vaccine composition |
| PCT/EP2002/003573 WO2002080965A2 (en) | 2001-04-03 | 2002-03-28 | Vaccine composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Division JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508849A JP2005508849A (ja) | 2005-04-07 |
| JP2005508849A5 true JP2005508849A5 (enExample) | 2005-12-22 |
| JP5281224B2 JP5281224B2 (ja) | 2013-09-04 |
Family
ID=9912183
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579004A Expired - Fee Related JP5281224B2 (ja) | 2001-04-03 | 2002-03-28 | ワクチン組成物 |
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20040202668A1 (enExample) |
| EP (4) | EP1946771B1 (enExample) |
| JP (3) | JP5281224B2 (enExample) |
| KR (7) | KR101045412B1 (enExample) |
| CN (3) | CN101112619B (enExample) |
| AR (1) | AR040922A1 (enExample) |
| AT (2) | ATE553775T1 (enExample) |
| BR (1) | BR0208595A (enExample) |
| CA (3) | CA2442865C (enExample) |
| CY (3) | CY1112879T1 (enExample) |
| CZ (1) | CZ20032698A3 (enExample) |
| DK (3) | DK1946772T3 (enExample) |
| ES (3) | ES2388690T3 (enExample) |
| GB (1) | GB0108364D0 (enExample) |
| HU (1) | HUP0303996A3 (enExample) |
| IL (2) | IL158066A0 (enExample) |
| MX (1) | MXPA03008961A (enExample) |
| MY (1) | MY129263A (enExample) |
| NO (1) | NO20034410L (enExample) |
| NZ (3) | NZ581373A (enExample) |
| PL (5) | PL211912B1 (enExample) |
| PT (3) | PT1946772E (enExample) |
| SI (3) | SI1946771T1 (enExample) |
| WO (1) | WO2002080965A2 (enExample) |
| ZA (1) | ZA200307640B (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| OA12302A (en) * | 2000-06-29 | 2003-10-24 | Glaxosmithkline Biolog Sa | Multivalent vaccine composition. |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| WO2002020059A2 (en) * | 2000-09-01 | 2002-03-14 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| BRPI0410423A (pt) | 2003-05-07 | 2006-06-06 | Sanofi Pasteur Inc | processo de imunogenicidade melhorada para vacinação meningocócica |
| JP2007516181A (ja) * | 2003-06-23 | 2007-06-21 | アヴェンティス パストゥール インコーポレイテッド | 髄膜炎菌血清群ａおよびｃに対する免疫方法 |
| SI1670506T1 (sl) | 2003-10-02 | 2013-03-29 | Novartis Ag | Tekoča cepiva proti multiplim meningokoknim seroskupinam |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0409795D0 (en) * | 2004-04-30 | 2004-06-09 | Glaxosmithkline Biolog Sa | Drying method |
| SI1740217T1 (sl) | 2004-04-30 | 2011-10-28 | Novartis Ag | Konjugirano meningokokno cepljenje |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| KR102378962B1 (ko) | 2005-04-08 | 2022-03-28 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| US9486515B2 (en) | 2005-06-27 | 2016-11-08 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| CA2621023C (en) * | 2005-09-01 | 2019-07-02 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Multiple vaccination including serogroup c meningococcus |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| US7740855B2 (en) * | 2005-11-30 | 2010-06-22 | Yeda Research & Development Co. Ltd | Inactivated CD8+ T-cells for the treatment of HIV infection |
| CN103251940A (zh) * | 2005-12-22 | 2013-08-21 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2012216698B2 (en) * | 2005-12-22 | 2014-03-06 | Glaxosmithkline Biologicals Sa | Pneumococcal polysaccharide conjugate vaccine |
| US20080305127A1 (en) * | 2005-12-23 | 2008-12-11 | Glaxosmithkline Biologicals S.A. | Conjugate Vaccines |
| AU2007229449A1 (en) | 2006-03-22 | 2007-10-04 | Novartis Ag | Regimens for immunisation with meningococcal conjugates |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) * | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| EP2491947A3 (en) * | 2006-09-07 | 2012-10-17 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| WO2008135514A1 (en) * | 2007-05-02 | 2008-11-13 | Glaxosmithkline Biologicals S.A. | Vaccine |
| MX2009013949A (es) | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
| CN101559223B (zh) * | 2008-04-18 | 2013-02-13 | 重庆智仁生物技术有限公司 | 流脑白百破联合疫苗 |
| CN102112153B (zh) | 2008-06-04 | 2014-04-16 | 一般财团法人化学及血清疗法研究所 | 灭活日本脑炎病毒颗粒作为佐剂的用途 |
| WO2010005735A2 (en) * | 2008-06-16 | 2010-01-14 | Academia Sinica | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| TWI583393B (zh) * | 2009-06-16 | 2017-05-21 | 中央研究院 | 免疫原性組合物、包含其之疫苗與治療劑及其用途 |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| WO2011150258A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| EP3170508B1 (en) | 2010-06-04 | 2019-11-13 | Wyeth LLC | Vaccine formulations |
| CN103313725B (zh) | 2010-09-01 | 2016-06-29 | 诺华有限公司 | 免疫增强剂吸附不溶性金属离子 |
| WO2012038801A1 (en) | 2010-09-21 | 2012-03-29 | National Institute Of Immunology | A spray dried powder formulation for vaccines entrapping alum and the antigen in biodegradable polymer particles |
| CN102068690A (zh) * | 2010-12-31 | 2011-05-25 | 北京民海生物科技有限公司 | 多价肺炎球菌荚膜多糖结合疫苗及其制备方法 |
| WO2012106251A2 (en) * | 2011-01-31 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pertussis vaccine |
| KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
| CN104159603A (zh) * | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
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| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN103623404B (zh) * | 2012-08-28 | 2016-08-03 | 天士力制药集团股份有限公司 | 一种b型流感嗜血杆菌多糖结合疫苗的制备方法 |
| CN103656631B (zh) * | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
| CA2896552A1 (en) * | 2012-10-03 | 2014-04-10 | Novartis Ag | Immunogenic compositions |
| CN102876707B (zh) * | 2012-10-15 | 2014-05-28 | 北京工业大学 | 一种重组脊髓灰质炎病毒ⅰ型病毒样颗粒的制备方法 |
| JP6236086B2 (ja) * | 2012-10-17 | 2017-11-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | １種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Ｅおよび／またはＰｉｌＡを含むタンパク質成分とを含む免疫原性組成物 |
| US20140193451A1 (en) * | 2012-10-17 | 2014-07-10 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
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| US11708411B2 (en) * | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| JP6612260B2 (ja) * | 2014-01-21 | 2019-11-27 | ファイザー・インク | 肺炎連鎖球菌（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅ）莢膜多糖およびそのコンジュゲート |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CA3206112A1 (en) * | 2014-01-21 | 2015-07-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PL3244917T3 (pl) * | 2015-01-15 | 2023-07-17 | Pfizer Inc. | Kompozycje immunogenne do zastosowania w szczepionkach przeciwko pneumokokom |
| CN106109486A (zh) * | 2015-07-06 | 2016-11-16 | 北京科兴中维生物技术有限公司 | 一种组合物及其制备方法与应用 |
| EP3325008B1 (en) | 2015-07-21 | 2025-09-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| CN106039301A (zh) * | 2016-06-30 | 2016-10-26 | 武汉博沃生物科技有限公司 | 肺炎球菌‑b型流感嗜血杆菌‑百白破联合疫苗的制备方法 |
| KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| MY199342A (en) | 2016-08-05 | 2023-10-24 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
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| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| DK3562503T3 (da) * | 2016-12-30 | 2025-05-26 | Vaxcyte Inc | Polypeptid-antigen-konjugater med ikke-naturlige aminosyrer |
| WO2019043245A1 (en) * | 2017-09-04 | 2019-03-07 | London School Of Hygiene And Tropical Medicine | MICROBIAL CELLS EXPRESSING STREPTOCOCCAL SERROTYPES |
| EP3694490B1 (en) * | 2017-10-13 | 2024-03-20 | The Research Foundation for The State University of New York | Vaccine composition against streptococcus pneumoniae, use thereof for immunizing an individual against s. pneumoniae and method of preparation |
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| KR102486891B1 (ko) | 2018-02-05 | 2023-01-10 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| KR20190121713A (ko) | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체 |
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| CN116942804A (zh) * | 2022-04-19 | 2023-10-27 | 上海瑞宙生物科技有限公司 | 多价肺炎球菌多糖结合疫苗的成分及其应用 |
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| GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5780606A (en) * | 1995-06-07 | 1998-07-14 | Connaught Laboratories Limited | Neisseria meningitidis capsular polysaccharide conjugates |
| IL122588A (en) * | 1995-06-23 | 2001-12-23 | Smithkline Beecham Biolog | A combination vaccine containing a polysaccharide conjugated antigen attached to a phosphate aluminum and one or more additional antibodies |
| SE9601158D0 (sv) * | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| BR9710460A (pt) * | 1996-07-02 | 1999-08-17 | Connaught Lab | Composi-Æo imunolÄgica multi-valente e seu uso em vacinas |
| GB9623233D0 (en) * | 1996-11-07 | 1997-01-08 | Smithkline Beecham Biolog | Vaccine composition |
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| AU4707097A (en) | 1997-09-15 | 1999-04-05 | Pasteur Merieux Serums Et Vaccins | Multivalent vaccines |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| KR100642044B1 (ko) * | 1999-03-19 | 2006-11-10 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| OA12302A (en) * | 2000-06-29 | 2003-10-24 | Glaxosmithkline Biolog Sa | Multivalent vaccine composition. |
-
2001
- 2001-04-03 GB GBGB0108364.1A patent/GB0108364D0/en not_active Ceased
- 2001-06-28 AR ARP010103098A patent/AR040922A1/es not_active Application Discontinuation
-
2002
- 2002-03-28 SI SI200230995T patent/SI1946771T1/sl unknown
- 2002-03-28 PL PL393618A patent/PL211912B1/pl not_active IP Right Cessation
- 2002-03-28 ES ES08153845T patent/ES2388690T3/es not_active Expired - Lifetime
- 2002-03-28 US US10/473,769 patent/US20040202668A1/en not_active Abandoned
- 2002-03-28 JP JP2002579004A patent/JP5281224B2/ja not_active Expired - Fee Related
- 2002-03-28 ES ES02735199T patent/ES2384041T3/es not_active Expired - Lifetime
- 2002-03-28 SI SI200230988T patent/SI1946772T1/sl unknown
- 2002-03-28 KR KR1020097023347A patent/KR101045412B1/ko not_active Expired - Fee Related
- 2002-03-28 KR KR1020117028214A patent/KR20120005534A/ko not_active Ceased
- 2002-03-28 ES ES08153847T patent/ES2384065T3/es not_active Expired - Lifetime
- 2002-03-28 EP EP08153845A patent/EP1946771B1/en not_active Expired - Lifetime
- 2002-03-28 DK DK08153847.2T patent/DK1946772T3/da active
- 2002-03-28 WO PCT/EP2002/003573 patent/WO2002080965A2/en not_active Ceased
- 2002-03-28 KR KR1020117027470A patent/KR101292708B1/ko not_active Expired - Fee Related
- 2002-03-28 NZ NZ581373A patent/NZ581373A/en not_active IP Right Cessation
- 2002-03-28 DK DK08153845.6T patent/DK1946771T3/da active
- 2002-03-28 MX MXPA03008961A patent/MXPA03008961A/es active IP Right Grant
- 2002-03-28 AT AT02735199T patent/ATE553775T1/de active
- 2002-03-28 NZ NZ551621A patent/NZ551621A/en not_active IP Right Cessation
- 2002-03-28 EP EP10179818A patent/EP2311488A3/en not_active Withdrawn
- 2002-03-28 KR KR1020087012215A patent/KR20080048094A/ko not_active Ceased
- 2002-03-28 CN CN2006101074116A patent/CN101112619B/zh not_active Expired - Fee Related
- 2002-03-28 EP EP02735199A patent/EP1390066B1/en not_active Revoked
- 2002-03-28 KR KR1020037012971A patent/KR100870280B1/ko not_active Expired - Fee Related
- 2002-03-28 PL PL393585A patent/PL211911B1/pl not_active IP Right Cessation
- 2002-03-28 AT AT08153847T patent/ATE553776T1/de active
- 2002-03-28 CA CA2442865A patent/CA2442865C/en not_active Expired - Fee Related
- 2002-03-28 HU HU0303996A patent/HUP0303996A3/hu unknown
- 2002-03-28 CZ CZ20032698A patent/CZ20032698A3/cs unknown
- 2002-03-28 KR KR1020117004885A patent/KR20110036641A/ko not_active Ceased
- 2002-03-28 PL PL374106A patent/PL211958B1/pl not_active IP Right Cessation
- 2002-03-28 CA CA2727715A patent/CA2727715C/en not_active Expired - Fee Related
- 2002-03-28 SI SI200230987T patent/SI1390066T1/sl unknown
- 2002-03-28 PT PT08153847T patent/PT1946772E/pt unknown
- 2002-03-28 NZ NZ568317A patent/NZ568317A/en not_active IP Right Cessation
- 2002-03-28 PL PL393582A patent/PL211909B1/pl not_active IP Right Cessation
- 2002-03-28 EP EP08153847A patent/EP1946772B1/en not_active Revoked
- 2002-03-28 CN CNB028110919A patent/CN1273190C/zh not_active Expired - Fee Related
- 2002-03-28 PL PL393583A patent/PL211910B1/pl not_active IP Right Cessation
- 2002-03-28 KR KR1020097004040A patent/KR20090026371A/ko not_active Ceased
- 2002-03-28 CN CN2006101074101A patent/CN101112618B/zh not_active Expired - Fee Related
- 2002-03-28 IL IL15806602A patent/IL158066A0/xx unknown
- 2002-03-28 BR BRPI0208595-0A patent/BR0208595A/pt not_active IP Right Cessation
- 2002-03-28 PT PT02735199T patent/PT1390066E/pt unknown
- 2002-03-28 PT PT08153845T patent/PT1946771E/pt unknown
- 2002-03-28 DK DK02735199.8T patent/DK1390066T3/da active
- 2002-03-28 CA CA2810326A patent/CA2810326A1/en not_active Abandoned
- 2002-04-01 MY MYPI20021176A patent/MY129263A/en unknown
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2003
- 2003-09-30 ZA ZA2003/07640A patent/ZA200307640B/en unknown
- 2003-10-02 NO NO20034410A patent/NO20034410L/no not_active Application Discontinuation
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2007
- 2007-09-11 US US11/853,108 patent/US20080069835A1/en not_active Abandoned
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2008
- 2008-12-17 JP JP2008320381A patent/JP5095595B2/ja not_active Expired - Fee Related
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2011
- 2011-05-09 US US13/103,397 patent/US20110212124A1/en not_active Abandoned
- 2011-12-05 JP JP2011265563A patent/JP5410498B2/ja not_active Expired - Fee Related
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2012
- 2012-06-27 CY CY20121100572T patent/CY1112879T1/el unknown
- 2012-06-27 CY CY20121100573T patent/CY1112880T1/el unknown
- 2012-08-29 CY CY20121100777T patent/CY1113078T1/el unknown
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2013
- 2013-06-03 US US13/908,064 patent/US20130266609A1/en not_active Abandoned
- 2013-08-15 IL IL227966A patent/IL227966A0/en unknown
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