JP2005508849A5 - - Google Patents
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- Publication number
- JP2005508849A5 JP2005508849A5 JP2002579004A JP2002579004A JP2005508849A5 JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5 JP 2002579004 A JP2002579004 A JP 2002579004A JP 2002579004 A JP2002579004 A JP 2002579004A JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- oligosaccharide
- capsular polysaccharide
- carrier protein
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 44
- 150000004676 glycans Chemical class 0.000 claims 41
- 229920001542 oligosaccharide Polymers 0.000 claims 41
- 150000002482 oligosaccharides Chemical class 0.000 claims 41
- 229920001282 polysaccharide Polymers 0.000 claims 41
- 239000005017 polysaccharide Substances 0.000 claims 41
- 230000002163 immunogen Effects 0.000 claims 39
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 108010078791 Carrier Proteins Proteins 0.000 claims 23
- 229960005486 vaccine Drugs 0.000 claims 22
- 241000588650 Neisseria meningitidis Species 0.000 claims 15
- 241000606768 Haemophilus influenzae Species 0.000 claims 14
- 229960000814 tetanus toxoid Drugs 0.000 claims 14
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 12
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 12
- 229960003983 diphtheria toxoid Drugs 0.000 claims 11
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 6
- 241000991587 Enterovirus C Species 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229940047650 haemophilus influenzae Drugs 0.000 claims 5
- 241000588832 Bordetella pertussis Species 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 4
- 201000005702 Pertussis Diseases 0.000 claims 4
- 206010043376 Tetanus Diseases 0.000 claims 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 4
- 206010013023 diphtheria Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 208000037798 influenza B Diseases 0.000 claims 4
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 3
- 101710188053 Protein D Proteins 0.000 claims 3
- 101710132893 Resolvase Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000002672 hepatitis B Diseases 0.000 claims 3
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 claims 2
- 101710183389 Pneumolysin Proteins 0.000 claims 2
- 230000007123 defense Effects 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0108364.1 | 2001-04-03 | ||
| GBGB0108364.1A GB0108364D0 (en) | 2001-04-03 | 2001-04-03 | Vaccine composition |
| PCT/EP2002/003573 WO2002080965A2 (en) | 2001-04-03 | 2002-03-28 | Vaccine composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Division JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508849A JP2005508849A (ja) | 2005-04-07 |
| JP2005508849A5 true JP2005508849A5 (enExample) | 2005-12-22 |
| JP5281224B2 JP5281224B2 (ja) | 2013-09-04 |
Family
ID=9912183
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579004A Expired - Fee Related JP5281224B2 (ja) | 2001-04-03 | 2002-03-28 | ワクチン組成物 |
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20040202668A1 (enExample) |
| EP (4) | EP1390066B1 (enExample) |
| JP (3) | JP5281224B2 (enExample) |
| KR (7) | KR20120005534A (enExample) |
| CN (3) | CN101112618B (enExample) |
| AR (1) | AR040922A1 (enExample) |
| AT (2) | ATE553776T1 (enExample) |
| BR (1) | BR0208595A (enExample) |
| CA (3) | CA2810326A1 (enExample) |
| CY (3) | CY1112879T1 (enExample) |
| CZ (1) | CZ20032698A3 (enExample) |
| DK (3) | DK1390066T3 (enExample) |
| ES (3) | ES2384041T3 (enExample) |
| GB (1) | GB0108364D0 (enExample) |
| HU (1) | HUP0303996A3 (enExample) |
| IL (2) | IL158066A0 (enExample) |
| MX (1) | MXPA03008961A (enExample) |
| MY (1) | MY129263A (enExample) |
| NO (1) | NO20034410L (enExample) |
| NZ (3) | NZ581373A (enExample) |
| PL (5) | PL211910B1 (enExample) |
| PT (3) | PT1946771E (enExample) |
| SI (3) | SI1946771T1 (enExample) |
| WO (1) | WO2002080965A2 (enExample) |
| ZA (1) | ZA200307640B (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| SI1296715T2 (sl) * | 2000-06-29 | 2016-03-31 | Smithkline Beecham Biologicals S.A. | Multivalentni sestavek cepiva |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| WO2002020059A2 (en) | 2000-09-01 | 2002-03-14 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| BRPI0410423A (pt) | 2003-05-07 | 2006-06-06 | Sanofi Pasteur Inc | processo de imunogenicidade melhorada para vacinação meningocócica |
| BRPI0411875A (pt) * | 2003-06-23 | 2006-08-08 | Sanofi Pasteur Inc | método de imunização contra os sorogrupos a e c de neisseria meningitidis |
| CA2540896C (en) | 2003-10-02 | 2015-06-02 | Chiron Srl | Liquid vaccines for multiple meningococcal serogroups |
| PL1740217T3 (pl) | 2004-04-30 | 2012-03-30 | Novartis Ag | Szczepienie koniugatem meningokokowym |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0500787D0 (en) * | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409795D0 (en) * | 2004-04-30 | 2004-06-09 | Glaxosmithkline Biolog Sa | Drying method |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| CN113198012B (zh) | 2005-04-08 | 2024-09-17 | 惠氏有限责任公司 | 多价肺炎球菌多糖－蛋白质缀合物组合物 |
| EP2201961B1 (en) | 2005-06-27 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| WO2007026249A2 (en) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Multiple vaccination including serogroup c meningococcus |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| US7740855B2 (en) * | 2005-11-30 | 2010-06-22 | Yeda Research & Development Co. Ltd | Inactivated CD8+ T-cells for the treatment of HIV infection |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2808919C (en) * | 2005-12-22 | 2016-04-19 | Glaxosmithkline Biologicals S.A. | Streptococcus pneumoniae capsular saccharide vaccine |
| AU2012216698B2 (en) * | 2005-12-22 | 2014-03-06 | Glaxosmithkline Biologicals Sa | Pneumococcal polysaccharide conjugate vaccine |
| AU2006327023A1 (en) * | 2005-12-23 | 2007-06-28 | Glaxosmithkline Biologicals Sa | Conjugate vaccines |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| DK2004225T3 (da) | 2006-03-22 | 2012-08-06 | Novartis Ag | Programmer for vaccination med meningocockonjugater |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| SI2097102T1 (sl) * | 2006-09-07 | 2012-09-28 | Glaxosmithkline Biolog Sa | Kombinirano cepivo, ki ima zmanjšane količine antigena za poliovirus |
| PE20090212A1 (es) * | 2007-05-02 | 2009-03-30 | Glaxosmithkline Biolog Sa | Kit de vacuna para la inmunizacion primaria |
| KR101579947B1 (ko) | 2007-06-26 | 2015-12-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신 |
| CN101559223B (zh) * | 2008-04-18 | 2013-02-13 | 重庆智仁生物技术有限公司 | 流脑白百破联合疫苗 |
| EP2298344B1 (en) | 2008-06-04 | 2016-08-17 | The Chemo-Sero-Therapeutic Research Institute | Use of inactivated japanese encephalitis virus particle as adjuvant |
| CA2728344A1 (en) | 2008-06-16 | 2010-01-14 | Academia Sinica | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| TWI392502B (zh) * | 2009-06-16 | 2013-04-11 | Academia Sinica | 聚己醣抗原及含新穎醣脂質佐劑之相關抗癌疫苗 |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CN106177940A (zh) * | 2010-05-26 | 2016-12-07 | 西莱克塔生物科技公司 | 含有佐剂的合成纳米载体的剂量选择 |
| RU2607024C2 (ru) | 2010-06-04 | 2017-01-10 | УАЙТ ЭлЭлСи | Вакцины streptococcus pneumoniae |
| US20120177681A1 (en) | 2010-09-01 | 2012-07-12 | Manmohan Singh | Formulation of immunopotentiators |
| WO2012038801A1 (en) | 2010-09-21 | 2012-03-29 | National Institute Of Immunology | A spray dried powder formulation for vaccines entrapping alum and the antigen in biodegradable polymer particles |
| CN102068690A (zh) * | 2010-12-31 | 2011-05-25 | 北京民海生物科技有限公司 | 多价肺炎球菌荚膜多糖结合疫苗及其制备方法 |
| WO2012106251A2 (en) * | 2011-01-31 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pertussis vaccine |
| TR201811280T4 (tr) | 2011-03-02 | 2018-08-27 | Glaxosmithkline Biologicals Sa | Düşük antijen ve/ veya adjuvan dozları olan karma aşılar. |
| CN104159603A (zh) * | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
| EP2822581A2 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Adjuvanted formulations of dtp booster vaccines |
| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN103623404B (zh) * | 2012-08-28 | 2016-08-03 | 天士力制药集团股份有限公司 | 一种b型流感嗜血杆菌多糖结合疫苗的制备方法 |
| CN103656631B (zh) * | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
| MX2015002483A (es) | 2012-10-03 | 2016-01-08 | Glaxosmithkline Biolog Sa | Composiciones inmunogenicas. |
| CN102876707B (zh) * | 2012-10-15 | 2014-05-28 | 北京工业大学 | 一种重组脊髓灰质炎病毒ⅰ型病毒样颗粒的制备方法 |
| CN104968366B (zh) * | 2012-10-17 | 2017-12-01 | 葛兰素史密丝克莱恩生物有限公司 | 包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 |
| US20140193451A1 (en) * | 2012-10-17 | 2014-07-10 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| KR20140075196A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
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| US11708411B2 (en) * | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| KR102157200B1 (ko) * | 2014-01-21 | 2020-09-21 | 화이자 인코포레이티드 | 접합된 캡슐 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
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| CN106109486A (zh) * | 2015-07-06 | 2016-11-16 | 北京科兴中维生物技术有限公司 | 一种组合物及其制备方法与应用 |
| IL303998A (en) | 2015-07-21 | 2023-08-01 | Pfizer | Immunogenic preparations containing conjugated capsular sugar antigens, kits containing them and their uses |
| CN106039301A (zh) * | 2016-06-30 | 2016-10-26 | 武汉博沃生物科技有限公司 | 肺炎球菌‑b型流感嗜血杆菌‑百白破联合疫苗的制备方法 |
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| BR112019001995A2 (pt) | 2016-08-05 | 2019-05-07 | Sanofi Pasteur, Inc. | composição de conjugado de polissacarídeo pneumocócico multivalente ? proteína |
| CN106432512B (zh) * | 2016-09-30 | 2022-03-01 | 康希诺生物股份公司 | 一种增强多糖抗原免疫原性蛋白载体及其制备方法与应用 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
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| WO2019043245A1 (en) * | 2017-09-04 | 2019-03-07 | London School Of Hygiene And Tropical Medicine | MICROBIAL CELLS EXPRESSING STREPTOCOCCAL SERROTYPES |
| CA3079111A1 (en) * | 2017-10-13 | 2019-04-18 | The Research Foundation For The State University Of New York | Comprehensive vaccine design for commensal disease progression |
| KR102812816B1 (ko) | 2018-02-05 | 2025-05-27 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| KR20230008923A (ko) | 2018-02-05 | 2023-01-16 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| JP2021522213A (ja) | 2018-04-18 | 2021-08-30 | エスケー バイオサイエンス カンパニー リミテッド | ストレプトコッカス・ニューモニエ莢膜多糖類及びその免疫原性接合体 |
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| CN116942804A (zh) * | 2022-04-19 | 2023-10-27 | 上海瑞宙生物科技有限公司 | 多价肺炎球菌多糖结合疫苗的成分及其应用 |
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| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5780606A (en) * | 1995-06-07 | 1998-07-14 | Connaught Laboratories Limited | Neisseria meningitidis capsular polysaccharide conjugates |
| EP1082965B1 (en) * | 1995-06-23 | 2009-06-10 | GlaxoSmithKline Biologicals S.A. | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
| SE9601158D0 (sv) * | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| DK0914153T3 (da) * | 1996-07-02 | 2007-01-29 | Sanofi Pasteur Ltd | Multivalente DTP-poliovacciner |
| GB9623233D0 (en) * | 1996-11-07 | 1997-01-08 | Smithkline Beecham Biolog | Vaccine composition |
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| WO1999013906A1 (en) * | 1997-09-15 | 1999-03-25 | Pasteur Merieux Msd | Multivalent vaccines |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| WO2000056359A2 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| SI1296715T2 (sl) * | 2000-06-29 | 2016-03-31 | Smithkline Beecham Biologicals S.A. | Multivalentni sestavek cepiva |
-
2001
- 2001-04-03 GB GBGB0108364.1A patent/GB0108364D0/en not_active Ceased
- 2001-06-28 AR ARP010103098A patent/AR040922A1/es not_active Application Discontinuation
-
2002
- 2002-03-28 SI SI200230995T patent/SI1946771T1/sl unknown
- 2002-03-28 CA CA2810326A patent/CA2810326A1/en not_active Abandoned
- 2002-03-28 EP EP02735199A patent/EP1390066B1/en not_active Revoked
- 2002-03-28 PL PL393583A patent/PL211910B1/pl not_active IP Right Cessation
- 2002-03-28 KR KR1020117028214A patent/KR20120005534A/ko not_active Ceased
- 2002-03-28 CA CA2727715A patent/CA2727715C/en not_active Expired - Fee Related
- 2002-03-28 PL PL393618A patent/PL211912B1/pl not_active IP Right Cessation
- 2002-03-28 DK DK02735199.8T patent/DK1390066T3/da active
- 2002-03-28 PT PT08153845T patent/PT1946771E/pt unknown
- 2002-03-28 DK DK08153847.2T patent/DK1946772T3/da active
- 2002-03-28 PL PL374106A patent/PL211958B1/pl not_active IP Right Cessation
- 2002-03-28 CA CA2442865A patent/CA2442865C/en not_active Expired - Fee Related
- 2002-03-28 CZ CZ20032698A patent/CZ20032698A3/cs unknown
- 2002-03-28 MX MXPA03008961A patent/MXPA03008961A/es active IP Right Grant
- 2002-03-28 IL IL15806602A patent/IL158066A0/xx unknown
- 2002-03-28 PT PT08153847T patent/PT1946772E/pt unknown
- 2002-03-28 EP EP08153845A patent/EP1946771B1/en not_active Expired - Lifetime
- 2002-03-28 SI SI200230987T patent/SI1390066T1/sl unknown
- 2002-03-28 HU HU0303996A patent/HUP0303996A3/hu unknown
- 2002-03-28 DK DK08153845.6T patent/DK1946771T3/da active
- 2002-03-28 KR KR1020117027470A patent/KR101292708B1/ko not_active Expired - Fee Related
- 2002-03-28 ES ES02735199T patent/ES2384041T3/es not_active Expired - Lifetime
- 2002-03-28 JP JP2002579004A patent/JP5281224B2/ja not_active Expired - Fee Related
- 2002-03-28 CN CN2006101074101A patent/CN101112618B/zh not_active Expired - Fee Related
- 2002-03-28 KR KR1020097023347A patent/KR101045412B1/ko not_active Expired - Fee Related
- 2002-03-28 CN CN2006101074116A patent/CN101112619B/zh not_active Expired - Fee Related
- 2002-03-28 SI SI200230988T patent/SI1946772T1/sl unknown
- 2002-03-28 PT PT02735199T patent/PT1390066E/pt unknown
- 2002-03-28 BR BRPI0208595-0A patent/BR0208595A/pt not_active IP Right Cessation
- 2002-03-28 PL PL393582A patent/PL211909B1/pl not_active IP Right Cessation
- 2002-03-28 ES ES08153845T patent/ES2388690T3/es not_active Expired - Lifetime
- 2002-03-28 KR KR1020037012971A patent/KR100870280B1/ko not_active Expired - Fee Related
- 2002-03-28 AT AT08153847T patent/ATE553776T1/de active
- 2002-03-28 NZ NZ581373A patent/NZ581373A/en not_active IP Right Cessation
- 2002-03-28 NZ NZ568317A patent/NZ568317A/en not_active IP Right Cessation
- 2002-03-28 KR KR1020117004885A patent/KR20110036641A/ko not_active Ceased
- 2002-03-28 KR KR1020087012215A patent/KR20080048094A/ko not_active Ceased
- 2002-03-28 AT AT02735199T patent/ATE553775T1/de active
- 2002-03-28 PL PL393585A patent/PL211911B1/pl not_active IP Right Cessation
- 2002-03-28 CN CNB028110919A patent/CN1273190C/zh not_active Expired - Fee Related
- 2002-03-28 ES ES08153847T patent/ES2384065T3/es not_active Expired - Lifetime
- 2002-03-28 WO PCT/EP2002/003573 patent/WO2002080965A2/en not_active Ceased
- 2002-03-28 US US10/473,769 patent/US20040202668A1/en not_active Abandoned
- 2002-03-28 EP EP08153847A patent/EP1946772B1/en not_active Revoked
- 2002-03-28 KR KR1020097004040A patent/KR20090026371A/ko not_active Ceased
- 2002-03-28 NZ NZ551621A patent/NZ551621A/en not_active IP Right Cessation
- 2002-03-28 EP EP10179818A patent/EP2311488A3/en not_active Withdrawn
- 2002-04-01 MY MYPI20021176A patent/MY129263A/en unknown
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2003
- 2003-09-30 ZA ZA2003/07640A patent/ZA200307640B/en unknown
- 2003-10-02 NO NO20034410A patent/NO20034410L/no not_active Application Discontinuation
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2007
- 2007-09-11 US US11/853,108 patent/US20080069835A1/en not_active Abandoned
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2008
- 2008-12-17 JP JP2008320381A patent/JP5095595B2/ja not_active Expired - Fee Related
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2011
- 2011-05-09 US US13/103,397 patent/US20110212124A1/en not_active Abandoned
- 2011-12-05 JP JP2011265563A patent/JP5410498B2/ja not_active Expired - Fee Related
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2012
- 2012-06-27 CY CY20121100572T patent/CY1112879T1/el unknown
- 2012-06-27 CY CY20121100573T patent/CY1112880T1/el unknown
- 2012-08-29 CY CY20121100777T patent/CY1113078T1/el unknown
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2013
- 2013-06-03 US US13/908,064 patent/US20130266609A1/en not_active Abandoned
- 2013-08-15 IL IL227966A patent/IL227966A0/en unknown
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