JP2020523323A5 - - Google Patents
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- Publication number
- JP2020523323A5 JP2020523323A5 JP2019567989A JP2019567989A JP2020523323A5 JP 2020523323 A5 JP2020523323 A5 JP 2020523323A5 JP 2019567989 A JP2019567989 A JP 2019567989A JP 2019567989 A JP2019567989 A JP 2019567989A JP 2020523323 A5 JP2020523323 A5 JP 2020523323A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- divalent
- streptococcus pneumoniae
- polysaccharides
- capsular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001282 polysaccharide Polymers 0.000 claims 79
- 239000005017 polysaccharide Substances 0.000 claims 79
- 150000004676 glycans Chemical class 0.000 claims 77
- 239000000203 mixture Substances 0.000 claims 55
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 36
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 36
- 102000014914 Carrier Proteins Human genes 0.000 claims 27
- 108010078791 Carrier Proteins Proteins 0.000 claims 27
- 230000002163 immunogen Effects 0.000 claims 22
- 241000606768 Haemophilus influenzae Species 0.000 claims 8
- 241000701806 Human papillomavirus Species 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 229940047650 haemophilus influenzae Drugs 0.000 claims 5
- -1 35B polysaccharides Chemical class 0.000 claims 4
- 108010083528 Adenylate Cyclase Toxin Proteins 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 4
- 229960000814 tetanus toxoid Drugs 0.000 claims 4
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 3
- 241000588832 Bordetella pertussis Species 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 201000005702 Pertussis Diseases 0.000 claims 2
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 2
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 2
- 229940124613 TLR 7/8 agonist Drugs 0.000 claims 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 235000011010 calcium phosphates Nutrition 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 2
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 claims 1
- 101710118506 69 kDa protein Proteins 0.000 claims 1
- 241000588807 Bordetella Species 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517905P | 2017-06-10 | 2017-06-10 | |
| US62/517,905 | 2017-06-10 | ||
| PCT/US2018/036868 WO2018227177A1 (en) | 2017-06-10 | 2018-06-11 | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523323A JP2020523323A (ja) | 2020-08-06 |
| JP2020523323A5 true JP2020523323A5 (enExample) | 2021-04-30 |
| JP7132954B2 JP7132954B2 (ja) | 2022-09-07 |
Family
ID=64562792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567989A Active JP7132954B2 (ja) | 2017-06-10 | 2018-06-11 | 改善された免疫原性及び結合活性を提供する２価又は多価コンジュゲート多糖を含む多価コンジュゲートワクチン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10688170B2 (enExample) |
| EP (1) | EP3634481A4 (enExample) |
| JP (1) | JP7132954B2 (enExample) |
| KR (3) | KR20240018697A (enExample) |
| CN (2) | CN111132691A (enExample) |
| AU (1) | AU2018280272C1 (enExample) |
| BR (1) | BR112019026192B1 (enExample) |
| CA (1) | CA3066911C (enExample) |
| MX (2) | MX2019014829A (enExample) |
| MY (1) | MY198400A (enExample) |
| WO (1) | WO2018227177A1 (enExample) |
| ZA (1) | ZA201908528B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170137867A (ko) * | 2015-04-16 | 2017-12-13 | 인벤트프라이즈 엘엘씨 | 보르데텔라 퍼투시스 면역원성 백신 조성물 |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| BR112019026192B1 (pt) | 2017-06-10 | 2022-05-10 | Inventprise, Llc | Vacinas de conjugado multivalente com polissacarídeos de conjugado bivalente ou multivalente que fornecem imunogenicidade e avidez melhoradas |
| US10729763B2 (en) * | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| US20210177957A1 (en) | 2017-12-06 | 2021-06-17 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| EP3893926A1 (en) * | 2018-12-12 | 2021-10-20 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| CA3123414A1 (en) | 2018-12-19 | 2020-06-25 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| EP3980055A4 (en) * | 2019-06-05 | 2023-07-26 | Merck Sharp & Dohme LLC | An immunogenic serotype 35b pneumococcal polysaccharide-protein conjugate and conjugation process for making the same |
| CN110804097B (zh) * | 2019-10-30 | 2021-02-26 | 云南沃森生物技术股份有限公司 | 一种同时制备两种单克隆抗体的方法 |
| AU2021207701B2 (en) * | 2020-01-17 | 2025-08-14 | Bill & Melinda Gates Foundation | Multivalent Streptococcus vaccines |
| CN111643661A (zh) * | 2020-06-08 | 2020-09-11 | 王竹林 | 新型免疫佐剂、化合物及其应用 |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
| KR20230097160A (ko) * | 2020-11-04 | 2023-06-30 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| CN113173977B (zh) * | 2021-05-12 | 2024-03-29 | 江苏坤力生物制药有限责任公司 | 一种双功能抗原、其制备方法及应用 |
| CN115721709A (zh) * | 2021-08-27 | 2023-03-03 | 康希诺生物股份公司 | 一种肺炎球菌结合疫苗制备方法 |
| GB2614916A (en) * | 2022-01-25 | 2023-07-26 | Optivalent Ltd | Intradermal vaccine complement |
| CN118871591A (zh) * | 2022-03-18 | 2024-10-29 | 电化株式会社 | 包含通过接头连接的衣壳蛋白的病毒样颗粒 |
| CN117643624A (zh) * | 2024-01-30 | 2024-03-05 | 成都康华生物制品股份有限公司 | 一种双价多糖结合疫苗的制备方法及双价多糖结合疫苗 |
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| BR112019026192B1 (pt) | 2017-06-10 | 2022-05-10 | Inventprise, Llc | Vacinas de conjugado multivalente com polissacarídeos de conjugado bivalente ou multivalente que fornecem imunogenicidade e avidez melhoradas |
-
2018
- 2018-06-11 BR BR112019026192-3A patent/BR112019026192B1/pt active IP Right Grant
- 2018-06-11 CN CN201880051935.9A patent/CN111132691A/zh active Pending
- 2018-06-11 WO PCT/US2018/036868 patent/WO2018227177A1/en not_active Ceased
- 2018-06-11 CA CA3066911A patent/CA3066911C/en active Active
- 2018-06-11 CN CN202410331847.1A patent/CN118356485A/zh active Pending
- 2018-06-11 KR KR1020247004035A patent/KR20240018697A/ko active Pending
- 2018-06-11 EP EP18813972.9A patent/EP3634481A4/en active Pending
- 2018-06-11 KR KR1020207000802A patent/KR102634811B1/ko active Active
- 2018-06-11 AU AU2018280272A patent/AU2018280272C1/en active Active
- 2018-06-11 MY MYPI2019007342A patent/MY198400A/en unknown
- 2018-06-11 KR KR1020247004036A patent/KR20240018698A/ko active Pending
- 2018-06-11 JP JP2019567989A patent/JP7132954B2/ja active Active
- 2018-06-11 US US16/004,743 patent/US10688170B2/en active Active
- 2018-06-11 MX MX2019014829A patent/MX2019014829A/es unknown
-
2019
- 2019-12-09 MX MX2023009362A patent/MX2023009362A/es unknown
- 2019-12-20 ZA ZA2019/08528A patent/ZA201908528B/en unknown
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