JP2013522287A5 - - Google Patents
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- Publication number
- JP2013522287A5 JP2013522287A5 JP2012557654A JP2012557654A JP2013522287A5 JP 2013522287 A5 JP2013522287 A5 JP 2013522287A5 JP 2012557654 A JP2012557654 A JP 2012557654A JP 2012557654 A JP2012557654 A JP 2012557654A JP 2013522287 A5 JP2013522287 A5 JP 2013522287A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- immunogenic composition
- serogroup
- polycationic polymer
- immunostimulatory oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 51
- 230000002163 immunogen Effects 0.000 claims description 44
- 239000000427 antigen Substances 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 108091034117 Oligonucleotide Proteins 0.000 claims description 25
- 230000003308 immunostimulating effect Effects 0.000 claims description 19
- 229920002851 polycationic polymer Polymers 0.000 claims description 19
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 claims description 18
- 239000002671 adjuvant Substances 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 claims description 9
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007764 o/w emulsion Substances 0.000 claims description 8
- 201000005702 Pertussis Diseases 0.000 claims description 4
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229960000814 tetanus toxoid Drugs 0.000 claims description 4
- 241000588650 Neisseria meningitidis Species 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 108010016626 Dipeptides Proteins 0.000 claims description 2
- ATIPDCIQTUXABX-UWVGGRQHSA-N Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ATIPDCIQTUXABX-UWVGGRQHSA-N 0.000 claims description 2
- RBEATVHTWHTHTJ-KKUMJFAQSA-N Lys-Leu-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O RBEATVHTWHTHTJ-KKUMJFAQSA-N 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 108010068380 arginylarginine Proteins 0.000 claims description 2
- 230000036039 immunity Effects 0.000 claims description 2
- 108010091798 leucylleucine Proteins 0.000 claims description 2
- 108010054155 lysyllysine Proteins 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31533610P | 2010-03-18 | 2010-03-18 | |
| US61/315,336 | 2010-03-18 | ||
| US31757210P | 2010-03-25 | 2010-03-25 | |
| US61/317,572 | 2010-03-25 | ||
| PCT/IB2011/051148 WO2012020326A1 (en) | 2010-03-18 | 2011-03-18 | Adjuvanted vaccines for serogroup b meningococcus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522287A JP2013522287A (ja) | 2013-06-13 |
| JP2013522287A5 true JP2013522287A5 (enExample) | 2014-02-20 |
Family
ID=44512325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557654A Pending JP2013522287A (ja) | 2010-03-18 | 2011-03-18 | 血清群ｂ髄膜炎菌のためのアジュバント添加ワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20130071422A1 (enExample) |
| EP (1) | EP2547357A1 (enExample) |
| JP (1) | JP2013522287A (enExample) |
| CN (1) | CN102802662A (enExample) |
| AU (1) | AU2011288203A1 (enExample) |
| BR (1) | BR112012022896A2 (enExample) |
| CA (1) | CA2793510A1 (enExample) |
| MX (1) | MX2012010609A (enExample) |
| WO (1) | WO2012020326A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| PL3246044T5 (pl) | 2010-08-23 | 2024-06-17 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
| PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
| IN2012MU00206A (enExample) * | 2012-01-20 | 2013-08-09 | ||
| EP4043029A1 (en) | 2012-03-09 | 2022-08-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| AU2013311702A1 (en) * | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
| EP2897635A1 (en) * | 2012-09-18 | 2015-07-29 | Novartis AG | Outer membrane vesicles |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| EP3041502A2 (en) | 2013-09-08 | 2016-07-13 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10138594B2 (en) * | 2014-09-26 | 2018-11-27 | The Chemours Company Fc, Llc | Partially fluorinated urethane based coatings |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN104707134A (zh) * | 2015-03-27 | 2015-06-17 | 成都欧林生物科技股份有限公司 | 一种无细胞百日破联合疫苗及其制备方法 |
| JP7010961B2 (ja) | 2017-01-31 | 2022-02-10 | ファイザー・インク | 髄膜炎菌組成物およびその方法 |
| PL240667B1 (pl) * | 2018-03-26 | 2022-05-16 | Gdanski Univ Medyczny | Peptyd, będący fragmentem płytkopochodnego czynnika wzrostu do zastosowania jako środek leczniczy do podania na skórę w zaburzeniach naskórka do stymulacji odbudowy naskórka |
| KR102871663B1 (ko) | 2019-09-27 | 2025-10-16 | 화이자 인코포레이티드 | 네이세리아 메닌기티디스 조성물 및 그의 방법 |
| EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
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| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| FI945483A7 (fi) | 1992-05-23 | 1995-01-20 | Smithkline Beecham Biologicals S A | Hepatiitti B - pinta-antigeenejä ja muita antigeenejä sisältäviä yhdistelmärokotteita |
| NL9201716A (nl) | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| BR9608612A (pt) | 1995-06-07 | 1999-05-04 | Smithkline Beecham Biolog | Vacina compreendendo um conjugado de antígeno de polissacarídeo - proteína portadora e proteína portadora livre |
| PT939647E (pt) * | 1996-08-27 | 2002-04-29 | Chiron Corp | Glicpconjugados do serogrupo b de neisseria meningitidis e metodos de utilizacao dos mesmos |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| FR2763244B1 (fr) | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO1998053851A1 (en) | 1997-05-28 | 1998-12-03 | University Of Iowa Research Foundation | Laft mutants of pathogenic gram-negative bacteria |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| DK0991761T3 (da) | 1997-08-21 | 2008-05-19 | Nederlanden Staat | Hidtil ukendte mutaner af gramnegative mucosale bakterier og anvendelse deraf i vacciner |
| US6645503B1 (en) | 1998-03-10 | 2003-11-11 | Wyeth Holdings Corporation | Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria |
| DE69937419T2 (de) | 1998-05-01 | 2008-07-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria Meningitidis Antigene und Zusammenstellungen |
| CA2347849C (en) | 1998-10-22 | 2013-06-25 | The University Of Montana | Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| JP3595264B2 (ja) | 1998-11-03 | 2004-12-02 | デ・スタート・デル・ネーデルランデン・ベルテゲンボールディクト・ドール・デ・ミニステル・バン・ベルジーン・ボルクスゲツォントヘイト・エン・クルトゥール | 遺伝的に修飾されたグラム陰性細菌由来の低毒性ｌｐｓ |
| PL203951B1 (pl) * | 1999-04-19 | 2009-11-30 | Smithkline Beecham Biolog | Kompozycja adiuwantowa, kompozycja szczepionki oraz sposób jej wytwarzania, szczepionka oraz zastosowanie |
| GB9908885D0 (en) * | 1999-04-19 | 1999-06-16 | Smithkline Beecham Biolog | Vccine |
| US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| US6531131B1 (en) | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| WO2001034642A2 (en) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Control of neisserial membrane synthesis |
| CA2390344C (en) | 1999-11-29 | 2014-08-26 | Chiron Spa | 85kda neisserial antigen |
| EP2275129A3 (en) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
| BR0107857A (pt) | 2000-01-25 | 2002-10-29 | Univ Queensland | Proteìnas compreendendo regiões conservadas de antìgeno nhha de superfìcie de neisseria meningitidis |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| HU228264B1 (en) | 2000-06-08 | 2013-02-28 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| KR20030024811A (ko) | 2000-07-27 | 2003-03-26 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 나이세리아 메닌지티디스에 의하여 유발되는 질병에 대한광범위하게 유효한 보호를 위한 백신 |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| EP2957300B1 (en) | 2001-01-23 | 2021-07-14 | Sanofi Pasteur Inc. | Multivalent meningococcal polysaccharide-protein conjugate vaccine |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0202901D0 (en) | 2002-02-07 | 2002-03-27 | Glaxosmithkline Biolog Sa | Novel vaccine |
| ATE419873T1 (de) | 2002-02-22 | 2009-01-15 | Ca Nat Research Council | Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüs |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| WO2004014417A2 (en) | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| SI2353608T1 (sl) | 2002-10-11 | 2020-12-31 | Glaxosmithkline Biologicals Sa | Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam |
| PT2172213E (pt) * | 2003-01-30 | 2013-06-03 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| CN100355453C (zh) * | 2003-03-24 | 2007-12-19 | 英特塞尔股份公司 | 改进的疫苗 |
| EP1608402B1 (en) * | 2003-03-24 | 2010-10-20 | Intercell AG | Improved vaccines |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| BRPI0509606B1 (pt) | 2004-04-05 | 2019-01-15 | Pah Usa 15 Llc | emulsões de óleo-em-água microfluidizadas e composições para vacinas |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| BRPI0607374B8 (pt) | 2005-01-27 | 2021-05-25 | Childrens Hospital & Res Center At Oakland | vacinas de vesículas baseadas em gna1870 para proteção de amplo espectro contra doenças causadas por neisseria meningitidis |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| JP2009514850A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | アジュバントとして減少した量の水中油型エマルションを有するインフルエンザワクチン |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| EP2032160B2 (en) | 2006-06-12 | 2013-04-03 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| WO2008043774A1 (en) | 2006-10-12 | 2008-04-17 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
| US9452209B2 (en) | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
| NZ586439A (en) | 2007-12-24 | 2012-10-26 | Novartis Ag | Method for peforming an immunodiffusion assay (SRID) for influenza hemagglutinin antigen based on desorbing the antigen from the aluminium adjuvant salt |
| ES2532946T3 (es) * | 2008-02-21 | 2015-04-06 | Novartis Ag | Polipéptidos PUfH meningocócicos |
-
2011
- 2011-03-18 EP EP11712679A patent/EP2547357A1/en not_active Withdrawn
- 2011-03-18 AU AU2011288203A patent/AU2011288203A1/en not_active Abandoned
- 2011-03-18 CA CA2793510A patent/CA2793510A1/en not_active Abandoned
- 2011-03-18 JP JP2012557654A patent/JP2013522287A/ja active Pending
- 2011-03-18 MX MX2012010609A patent/MX2012010609A/es not_active Application Discontinuation
- 2011-03-18 CN CN2011800142952A patent/CN102802662A/zh active Pending
- 2011-03-18 BR BR112012022896A patent/BR112012022896A2/pt not_active IP Right Cessation
- 2011-03-18 US US13/634,852 patent/US20130071422A1/en not_active Abandoned
- 2011-03-18 WO PCT/IB2011/051148 patent/WO2012020326A1/en not_active Ceased
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