JP2010508276A5 - - Google Patents

Info

Publication number

JP2010508276A5

JP2010508276A5 JP2009534694A JP2009534694A JP2010508276A5 JP 2010508276 A5 JP2010508276 A5 JP 2010508276A5 JP 2009534694 A JP2009534694 A JP 2009534694A JP 2009534694 A JP2009534694 A JP 2009534694A JP 2010508276 A5 JP2010508276 A5 JP 2010508276A5

Authority

JP

Japan

Prior art keywords

seq

antigen

slo

active agent

composition

Prior art date

2007-10-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000427 antigen Substances 0.000 claims description 38
• 102000036639 antigens Human genes 0.000 claims description 38
• 108091007433 antigens Proteins 0.000 claims description 38
• 239000000203 mixture Substances 0.000 claims description 24
• 239000013543 active substance Substances 0.000 claims description 23
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• 241000193996 Streptococcus pyogenes Species 0.000 claims description 11
• 238000000034 method Methods 0.000 claims description 9
• 102000039446 nucleic acids Human genes 0.000 claims description 9
• 108020004707 nucleic acids Proteins 0.000 claims description 9
• 150000007523 nucleic acids Chemical class 0.000 claims description 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
• 230000036039 immunity Effects 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 229960005486 vaccine Drugs 0.000 claims description 6
• 102000014914 Carrier Proteins Human genes 0.000 claims description 4
• 108010078791 Carrier Proteins Proteins 0.000 claims description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
• 150000001413 amino acids Chemical class 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 208000015181 infectious disease Diseases 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 108090000623 proteins and genes Proteins 0.000 claims description 4
• 231100000699 Bacterial toxin Toxicity 0.000 claims description 2
• 102000004127 Cytokines Human genes 0.000 claims description 2
• 108090000695 Cytokines Proteins 0.000 claims description 2
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 2
• 241000606768 Haemophilus influenzae Species 0.000 claims description 2
• 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 2
• 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 2
• 206010061598 Immunodeficiency Diseases 0.000 claims description 2
• 101710116435 Outer membrane protein Proteins 0.000 claims description 2
• 201000005702 Pertussis Diseases 0.000 claims description 2
• 101710188053 Protein D Proteins 0.000 claims description 2
• 101710132893 Resolvase Proteins 0.000 claims description 2
• 101710084578 Short neurotoxin 1 Proteins 0.000 claims description 2
• 101710182223 Toxin B Proteins 0.000 claims description 2
• 101710182532 Toxin a Proteins 0.000 claims description 2
• 239000002671 adjuvant Substances 0.000 claims description 2
• 230000001580 bacterial effect Effects 0.000 claims description 2
• 239000000688 bacterial toxin Substances 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 239000013604 expression vector Substances 0.000 claims description 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 2
• 239000003102 growth factor Substances 0.000 claims description 2
• 239000005556 hormone Substances 0.000 claims description 2
• 229940088597 hormone Drugs 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 229910052742 iron Inorganic materials 0.000 claims description 2
• 239000000178 monomer Substances 0.000 claims description 2
• 231100000252 nontoxic Toxicity 0.000 claims description 2
• 230000003000 nontoxic effect Effects 0.000 claims description 2
• 206010061372 Streptococcal infection Diseases 0.000 claims 1
• 241000194017 Streptococcus Species 0.000 claims 1
• 239000012190 activator Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1