JP2006506989A5 - - Google Patents
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- Publication number
- JP2006506989A5 JP2006506989A5 JP2004551863A JP2004551863A JP2006506989A5 JP 2006506989 A5 JP2006506989 A5 JP 2006506989A5 JP 2004551863 A JP2004551863 A JP 2004551863A JP 2004551863 A JP2004551863 A JP 2004551863A JP 2006506989 A5 JP2006506989 A5 JP 2006506989A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- immune response
- expression vector
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims 52
- 108090000765 processed proteins & peptides Proteins 0.000 claims 52
- 239000013604 expression vector Substances 0.000 claims 35
- 230000028993 immune response Effects 0.000 claims 32
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 21
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 13
- 150000004676 glycans Chemical class 0.000 claims 13
- 229920001282 polysaccharide Polymers 0.000 claims 13
- 239000005017 polysaccharide Substances 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 12
- 101710183389 Pneumolysin Proteins 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 5
- 230000024932 T cell mediated immunity Effects 0.000 claims 4
- 230000028996 humoral immune response Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- 230000000890 antigenic effect Effects 0.000 claims 3
- 230000002949 hemolytic effect Effects 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000588650 Neisseria meningitidis Species 0.000 claims 2
- 101900032831 Streptococcus pneumoniae Pneumolysin Proteins 0.000 claims 2
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 2
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
- 102400000368 Surface protein Human genes 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42449702P | 2002-11-07 | 2002-11-07 | |
| PCT/US2003/035529 WO2004043376A2 (en) | 2002-11-07 | 2003-11-06 | Compositions and methods for treating or preventing pneumococcal infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009253536A Division JP2010057501A (ja) | 2002-11-07 | 2009-11-04 | 肺炎球菌感染を治療または予防するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506989A JP2006506989A (ja) | 2006-03-02 |
| JP2006506989A5 true JP2006506989A5 (enExample) | 2008-08-21 |
Family
ID=32312819
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551863A Pending JP2006506989A (ja) | 2002-11-07 | 2003-11-06 | 肺炎球菌感染を治療または予防するための組成物および方法 |
| JP2009253536A Pending JP2010057501A (ja) | 2002-11-07 | 2009-11-04 | 肺炎球菌感染を治療または予防するための組成物および方法 |
| JP2012025451A Pending JP2012139221A (ja) | 2002-11-07 | 2012-02-08 | 肺炎球菌感染を治療または予防するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009253536A Pending JP2010057501A (ja) | 2002-11-07 | 2009-11-04 | 肺炎球菌感染を治療または予防するための組成物および方法 |
| JP2012025451A Pending JP2012139221A (ja) | 2002-11-07 | 2012-02-08 | 肺炎球菌感染を治療または予防するための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7217791B2 (enExample) |
| EP (1) | EP1558280B1 (enExample) |
| JP (3) | JP2006506989A (enExample) |
| KR (1) | KR20050086427A (enExample) |
| CN (1) | CN100443116C (enExample) |
| AU (1) | AU2003291365B2 (enExample) |
| CA (1) | CA2504938C (enExample) |
| ES (1) | ES2451620T3 (enExample) |
| TW (1) | TWI315986B (enExample) |
| WO (1) | WO2004043376A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8128939B2 (en) | 2007-04-13 | 2012-03-06 | The Board Of Regents Of The University Of Oklahoma | Mutants of cholesterol-dependent cytolysins and uses thereof |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| WO2009094730A1 (en) * | 2008-02-01 | 2009-08-06 | Newcastle Innovation Limited | Vaccine compositions |
| BRPI1009829A2 (pt) | 2009-03-24 | 2016-11-16 | Novartis Ag | combinações de proteína de ligação de fator h meningocócico e conjugados de sacarídeos pneumocócicos |
| US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| WO2011112906A2 (en) | 2010-03-12 | 2011-09-15 | Children's Medical Center Corporation | Novel immunogens and methods for discovery and screening thereof |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| CA2833409A1 (en) * | 2011-04-21 | 2012-10-26 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| BR112013029514A2 (pt) | 2011-05-17 | 2019-09-24 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, método de tratar ou impedir uma doença |
| DK3369742T3 (da) * | 2011-10-05 | 2020-10-19 | Univ Rockefeller | Dimere bakteriofaglysiner |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| WO2014124228A1 (en) | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| WO2016081839A1 (en) | 2014-11-21 | 2016-05-26 | The Board Of Regents Of The University Of Oklahoma | Pneumolysin mutants and methods of use thereof |
| GB201610599D0 (en) * | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| PT3678654T (pt) | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| JP2021535921A (ja) | 2018-09-12 | 2021-12-23 | アフィニバックス、インコーポレイテッド | 多価肺炎球菌ワクチン |
| WO2023039223A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT58804A (en) * | 1988-12-16 | 1992-03-30 | James Cleland Paton | Process for producing pneumolysine mutants and pneumococcus vaccines |
| EP0687688A1 (en) * | 1993-12-17 | 1995-12-20 | Universidad De Oviedo | Antibodies against pneumolysine and their applications |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| JP2001510031A (ja) * | 1997-07-21 | 2001-07-31 | ノース・アメリカン・ヴァクシン・インコーポレーテッド | ワクチンとしての修飾された免疫原ニューモリシン組成物 |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| JP2002531055A (ja) * | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | 肺炎連鎖球菌のタンパク質及び核酸分子 |
| WO2000034498A1 (en) * | 1998-12-04 | 2000-06-15 | University Of Manitoba | Two-step immunization procedure against chlamydia infection |
| EP1980617A1 (en) * | 1998-12-31 | 2008-10-15 | Novartis Vaccines and Diagnostics, Inc. | Improved expression of HIV polypeptides and production of virus-like particles |
| ATE319833T1 (de) * | 1999-12-17 | 2006-03-15 | Wyeth Corp | Impfstoffe zur erhöhung der immunantworten gegen herpes simplex virus |
-
2003
- 2003-11-06 US US10/702,305 patent/US7217791B2/en not_active Expired - Lifetime
- 2003-11-06 KR KR1020057008095A patent/KR20050086427A/ko not_active Ceased
- 2003-11-06 EP EP03768757.1A patent/EP1558280B1/en not_active Expired - Lifetime
- 2003-11-06 ES ES03768757.1T patent/ES2451620T3/es not_active Expired - Lifetime
- 2003-11-06 WO PCT/US2003/035529 patent/WO2004043376A2/en not_active Ceased
- 2003-11-06 CN CNB2003801027586A patent/CN100443116C/zh not_active Expired - Lifetime
- 2003-11-06 TW TW092131025A patent/TWI315986B/zh not_active IP Right Cessation
- 2003-11-06 AU AU2003291365A patent/AU2003291365B2/en not_active Expired
- 2003-11-06 CA CA2504938A patent/CA2504938C/en not_active Expired - Lifetime
- 2003-11-06 JP JP2004551863A patent/JP2006506989A/ja active Pending
-
2007
- 2007-05-14 US US11/748,270 patent/US7585669B2/en not_active Expired - Lifetime
-
2009
- 2009-11-04 JP JP2009253536A patent/JP2010057501A/ja active Pending
-
2012
- 2012-02-08 JP JP2012025451A patent/JP2012139221A/ja active Pending
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