|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
DE2848965A1
(de)
|
1978-11-11 |
1980-05-22 |
Behringwerke Ag |
Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
|
|
CA1200773A
(en)
*
|
1980-02-29 |
1986-02-18 |
William J. Rutter |
Expression linkers
|
|
AU545912B2
(en)
|
1980-03-10 |
1985-08-08 |
Cetus Corporation |
Cloned heterologous jive products in bacillies
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
FI821466A7
(fi)
|
1981-04-29 |
1982-10-30 |
Biogen Nv |
Bacillus-kloonausvektorit, yhdistelmä- DNA-molekyylit, niiden transformoimat Bacillus-isännät sekä menetelmätvieraiden DNA- sekvenssien ekspressiota varten sekä näiden koodaamien polypeptidien tuottamiseksi.
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4673574A
(en)
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
|
SE8205892D0
(sv)
|
1982-10-18 |
1982-10-18 |
Bror Morein |
Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
|
|
US4459286A
(en)
|
1983-01-31 |
1984-07-10 |
Merck & Co., Inc. |
Coupled H. influenzae type B vaccine
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4663160A
(en)
|
1983-03-14 |
1987-05-05 |
Miles Laboratories, Inc. |
Vaccines for gram-negative bacteria
|
|
JPS59205983A
(ja)
|
1983-04-28 |
1984-11-21 |
ジエネツクス・コ−ポレイシヨン |
異種遺伝子を原核微生物で発現させる方法
|
|
US4663280A
(en)
|
1983-05-19 |
1987-05-05 |
Public Health Research Institute Of The City Of New York |
Expression and secretion vectors and method of constructing vectors
|
|
US4761283A
(en)
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
JPS6054685A
(ja)
|
1983-09-02 |
1985-03-29 |
Suntory Ltd |
改良発現ベクタ−およびその利用
|
|
EP0136907A3
(en)
|
1983-10-03 |
1986-12-30 |
Genentech, Inc. |
A xenogeneic expression control system, a method of using it, expression vectors containing it, cells transformed thereby and heterologous proteins produced therefrom
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US4882317A
(en)
|
1984-05-10 |
1989-11-21 |
Merck & Co., Inc. |
Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
|
|
US4695624A
(en)
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4808700A
(en)
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4745056A
(en)
|
1984-10-23 |
1988-05-17 |
Biotechnica International, Inc. |
Streptomyces secretion vector
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US4865974A
(en)
|
1985-09-20 |
1989-09-12 |
Cetus Corporation |
Bacterial methionine N-terminal peptidase
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節ｄｎａ配列および発現ベクタ−
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
JPH01125328A
(ja)
|
1987-07-30 |
1989-05-17 |
Centro Natl De Biopreparados |
髄膜炎菌ワクチン
|
|
NL8802046A
(nl)
|
1988-08-18 |
1990-03-16 |
Gen Electric |
Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
|
|
AU627226B2
(en)
|
1988-08-25 |
1992-08-20 |
Liposome Company, Inc., The |
Influenza vaccine and novel adjuvants
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
EP0449958B9
(en)
|
1988-12-19 |
2003-05-28 |
American Cyanamid Company |
Meningococcal class 1 outer-membrane protein vaccine
|
|
DE68907045T2
(de)
|
1989-01-17 |
1993-12-02 |
Eniricerche Spa |
Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind.
|
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
JPH04506662A
(ja)
|
1989-07-14 |
1992-11-19 |
アメリカン・サイアナミド・カンパニー |
接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
|
FR2682114B1
(fr)
*
|
1991-10-03 |
1996-02-23 |
Pasteur Merieux Serums Vacc |
Vaccin de sous-unite contre les infections a neisseria meningitidis et sous-unites correspondantes a l'etat purifie.
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
US5279937A
(en)
*
|
1992-04-30 |
1994-01-18 |
Detechnology Canada |
Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
|
|
CA2138997C
(en)
|
1992-06-25 |
2003-06-03 |
Jean-Paul Prieels |
Vaccine composition containing adjuvants
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
NL9201716A
(nl)
|
1992-10-02 |
1994-05-02 |
Nederlanden Staat |
Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
|
|
SG48309A1
(en)
|
1993-03-23 |
1998-04-17 |
Smithkline Beecham Biolog |
Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
|
|
ES2210262T3
(es)
|
1993-09-22 |
2004-07-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas.
|
|
GB9326174D0
(en)
|
1993-12-22 |
1994-02-23 |
Biocine Sclavo |
Mucosal adjuvant
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
|
IL117483A
(en)
|
1995-03-17 |
2008-03-20 |
Bernard Brodeur |
MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
US6180111B1
(en)
|
1995-05-18 |
2001-01-30 |
University Of Maryland |
Vaccine delivery system
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6558677B2
(en)
|
1996-10-15 |
2003-05-06 |
Wendell D. Zollinger |
Vaccine against gram negative bacteria
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US6818222B1
(en)
|
1997-03-21 |
2004-11-16 |
Chiron Corporation |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
|
|
GB9711964D0
(en)
|
1997-06-09 |
1997-08-06 |
Medical Res Council |
Live attenuated vaccines
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
CA2297072A1
(en)
*
|
1997-07-17 |
1999-01-28 |
Baxter Healthcare S.A. |
Immunogenic conjugates comprising a group b meningococcal porin and an h. influenzae polysaccharide
|
|
EP0991761B1
(en)
|
1997-08-21 |
2008-01-16 |
De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur |
Novel mutants of gram negative mucosal bacteria and application thereof in vaccines
|
|
AU1145699A
(en)
|
1997-09-05 |
1999-03-22 |
Smithkline Beecham Biologicals (Sa) |
Oil in water emulsions containing saponins
|
|
EP1900818A3
(en)
|
1997-11-06 |
2008-06-11 |
Novartis Vaccines and Diagnostics S.r.l. |
Neisserial antigens
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
WO1999036544A2
(en)
|
1998-01-14 |
1999-07-22 |
Chiron S.P.A. |
Neisseria meningitidis antigens
|
|
EP1053015A2
(en)
|
1998-02-12 |
2000-11-22 |
American Cyanamid Company |
Pneumococcal and meningococcal vaccines formulated with interleukin-12
|
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
|
WO1999052549A1
(en)
|
1998-04-09 |
1999-10-21 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
|
EP2261347A3
(en)
|
1998-05-01 |
2012-01-11 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
JP5074644B2
(ja)
*
|
1998-05-29 |
2012-11-14 |
ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド |
組合わせの髄膜炎菌ｂ／ｃワクチン
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
CN1263510C
(zh)
|
1998-08-19 |
2006-07-12 |
巴克斯特健康护理股份有限公司 |
多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用
|
|
AU750587B2
(en)
|
1998-10-16 |
2002-07-25 |
Smithkline Beecham Biologicals (Sa) |
Adjuvant systems and vaccines
|
|
CA2347849C
(en)
|
1998-10-22 |
2013-06-25 |
The University Of Montana |
Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof
|
|
GB9823978D0
(en)
|
1998-11-02 |
1998-12-30 |
Microbiological Res Authority |
Multicomponent meningococcal vaccine
|
|
AU1626199A
(en)
|
1998-12-04 |
2000-06-26 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
A vi-repa conjugate vaccine for immunization against salmonella typhi
|
|
JP2002539273A
(ja)
|
1999-03-19 |
2002-11-19 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
CA2365914A1
(en)
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
CA2372235A1
(en)
|
1999-04-30 |
2000-11-09 |
Rino Rappuoli |
Conserved neisserial antigens
|
|
GB9918319D0
(en)
|
1999-08-03 |
1999-10-06 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
CO5200838A1
(es)
|
1999-09-24 |
2002-09-27 |
Smithkline Beecham Corp |
Vacunas
|
|
JP2003509473A
(ja)
|
1999-09-24 |
2003-03-11 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
GB9925559D0
(en)
|
1999-10-28 |
1999-12-29 |
Smithkline Beecham Biolog |
Novel method
|
|
AU1917501A
(en)
|
1999-11-12 |
2001-06-06 |
University Of Iowa Research Foundation, The |
Control of neisserial membrane synthesis
|
|
EP1234039A2
(en)
|
1999-11-29 |
2002-08-28 |
Chiron Spa |
85kDa NEISSERIAL ANTIGEN
|
|
CA2871789C
(en)
|
2000-01-17 |
2017-04-04 |
Novartis Vaccines And Diagnostics S.R.L. |
Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
|
|
US20010044416A1
(en)
|
2000-01-20 |
2001-11-22 |
Mccluskie Michael J. |
Immunostimulatory nucleic acids for inducing a Th2 immune response
|
|
MXPA02007184A
(es)
|
2000-01-25 |
2004-02-26 |
Univ Queensland |
Proteinas que comprenden regiones conservadas de antigenos de superficie nhha de neisseria meningitidis.
|
|
DK1947187T5
(da)
|
2000-02-28 |
2011-10-24 |
Novartis Vaccines & Diagnostic |
Hybrid ekspression af neisserial-proteiner
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
NO20002828D0
(no)
|
2000-06-02 |
2000-06-02 |
Statens Inst For Folkehelse |
Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
|
|
KR20030024811A
(ko)
|
2000-07-27 |
2003-03-26 |
칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 |
나이세리아 메닌지티디스에 의하여 유발되는 질병에 대한광범위하게 유효한 보호를 위한 백신
|
|
GB0103170D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
ATE384072T1
(de)
|
2000-09-26 |
2008-02-15 |
Idera Pharmaceuticals Inc |
Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
|
|
ATE439372T1
(de)
|
2000-10-27 |
2009-08-15 |
Novartis Vaccines & Diagnostic |
Nukleinsäuren und proteine von gruppen a und b- streptokokken
|
|
GB0103171D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
GB0103169D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
US20030035806A1
(en)
|
2001-05-11 |
2003-02-20 |
D'ambra Anello J. |
Novel meningitis conjugate vaccine
|
|
GB0115176D0
(en)
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
EP1409013B1
(en)
|
2001-07-26 |
2009-11-18 |
Novartis Vaccines and Diagnostics S.r.l. |
Vaccines comprising aluminium adjuvants and histidine
|
|
GB0121591D0
(en)
|
2001-09-06 |
2001-10-24 |
Chiron Spa |
Hybrid and tandem expression of neisserial proteins
|
|
EP1450856B1
(en)
|
2001-09-14 |
2009-11-11 |
Cytos Biotechnology AG |
Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
|
|
CA2492823A1
(en)
|
2001-09-14 |
2003-03-27 |
Cytos Biotechnology Ag |
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
|
|
MX339524B
(es)
|
2001-10-11 |
2016-05-30 |
Wyeth Corp |
Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
GB0130123D0
(en)
|
2001-12-17 |
2002-02-06 |
Microbiological Res Agency |
Outer membrane vesicle vaccine and its preparation
|
|
DK1777236T3
(en)
|
2002-03-26 |
2017-02-27 |
Glaxosmithkline Biologicals Sa |
MODIFIED SUCCARIDES WHICH IMPROVED WATER STABILITY FOR USE AS A MEDICINE
|
|
CA2493124C
(en)
|
2002-08-02 |
2014-04-29 |
Glaxosmithkline Biologicals S.A. |
Vaccine
|
|
GB0220194D0
(en)
|
2002-08-30 |
2002-10-09 |
Chiron Spa |
Improved vesicles
|
|
CN1809380B
(zh)
*
|
2002-10-11 |
2010-05-12 |
启龙有限公司 |
广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗
|
|
WO2004046177A2
(en)
|
2002-11-15 |
2004-06-03 |
Chiron Srl |
Unexpected surface proteins in neisseria meningitidis
|
|
GB0227346D0
(en)
*
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
|
BRPI0409459A
(pt)
|
2003-04-16 |
2006-05-02 |
Wyeth Corp |
novas composições imunogênicas para a prevenção e tratamento de doença meningocócica
|
|
GB0316560D0
(en)
|
2003-07-15 |
2003-08-20 |
Chiron Srl |
Vesicle filtration
|
|
GB0408977D0
(en)
*
|
2004-04-22 |
2004-05-26 |
Chiron Srl |
Immunising against meningococcal serogroup Y using proteins
|
|
GB0419408D0
(en)
|
2004-09-01 |
2004-10-06 |
Chiron Srl |
741 chimeric polypeptides
|
|
LT2682126T
(lt)
|
2005-01-27 |
2017-02-27 |
Children`s Hospital & Research Center at Oakland |
Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų
|
|
GB0524066D0
(en)
*
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
|
EP2886551A3
(en)
|
2008-02-21 |
2015-09-23 |
Novartis AG |
Meningococcal fhbp polypeptides
|