|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
DE2848965A1
(de)
|
1978-11-11 |
1980-05-22 |
Behringwerke Ag |
Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
|
|
CA1200773A
(en)
*
|
1980-02-29 |
1986-02-18 |
William J. Rutter |
Expression linkers
|
|
AU545912B2
(en)
|
1980-03-10 |
1985-08-08 |
Cetus Corporation |
Cloned heterologous jive products in bacillies
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
DK188582A
(da)
|
1981-04-29 |
1982-10-30 |
Biogen Nv |
Bacillus-kloningsvektorer rekombinations-dna-molekyler bacillus-vaerter transformeret dermed samt fremgangsmaader til ekspressionaf fremmede dna-sekvenser og fremstilling af polypeptideer som er kodede dermed
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4673574A
(en)
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
|
SE8205892D0
(sv)
|
1982-10-18 |
1982-10-18 |
Bror Morein |
Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
|
|
US4459286A
(en)
|
1983-01-31 |
1984-07-10 |
Merck & Co., Inc. |
Coupled H. influenzae type B vaccine
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4663160A
(en)
|
1983-03-14 |
1987-05-05 |
Miles Laboratories, Inc. |
Vaccines for gram-negative bacteria
|
|
JPS59205983A
(ja)
|
1983-04-28 |
1984-11-21 |
ジエネツクス・コ−ポレイシヨン |
異種遺伝子を原核微生物で発現させる方法
|
|
US4663280A
(en)
|
1983-05-19 |
1987-05-05 |
Public Health Research Institute Of The City Of New York |
Expression and secretion vectors and method of constructing vectors
|
|
US4761283A
(en)
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
JPS6054685A
(ja)
|
1983-09-02 |
1985-03-29 |
Suntory Ltd |
改良発現ベクタ−およびその利用
|
|
EP0136907A3
(en)
|
1983-10-03 |
1986-12-30 |
Genentech, Inc. |
A xenogeneic expression control system, a method of using it, expression vectors containing it, cells transformed thereby and heterologous proteins produced therefrom
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US4695624A
(en)
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4882317A
(en)
|
1984-05-10 |
1989-11-21 |
Merck & Co., Inc. |
Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
|
|
US4808700A
(en)
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4745056A
(en)
|
1984-10-23 |
1988-05-17 |
Biotechnica International, Inc. |
Streptomyces secretion vector
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US4865974A
(en)
|
1985-09-20 |
1989-09-12 |
Cetus Corporation |
Bacterial methionine N-terminal peptidase
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節dna配列および発現ベクタ−
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
RU2023448C1
(ru)
|
1987-07-30 |
1994-11-30 |
Сентро Насьональ Де Биопрепарадос |
Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
|
|
NL8802046A
(nl)
|
1988-08-18 |
1990-03-16 |
Gen Electric |
Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
|
|
JPH04500203A
(ja)
|
1988-08-25 |
1992-01-16 |
ザ リポソーム カンパニー,インコーポレイテッド |
インフルエンザワクチンおよび新規なアジュバント
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
AU640118B2
(en)
|
1988-12-19 |
1993-08-19 |
De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur |
Meningococcal class 1 outer-membrane protein vaccine
|
|
DE68907045T2
(de)
|
1989-01-17 |
1993-12-02 |
Eniricerche Spa |
Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind.
|
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
FI920131A7
(fi)
|
1989-07-14 |
1992-01-13 |
American Cyanamid Co |
Sytokiini- ja hormonikantajia konjugaattirokotteita varten
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
|
FR2682114B1
(fr)
*
|
1991-10-03 |
1996-02-23 |
Pasteur Merieux Serums Vacc |
Vaccin de sous-unite contre les infections a neisseria meningitidis et sous-unites correspondantes a l'etat purifie.
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
US5279937A
(en)
*
|
1992-04-30 |
1994-01-18 |
Detechnology Canada |
Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
|
|
ES2108278T3
(es)
|
1992-06-25 |
1997-12-16 |
Smithkline Beecham Biolog |
Composicion de vacuna con coadyuvantes.
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
NL9201716A
(nl)
|
1992-10-02 |
1994-05-02 |
Nederlanden Staat |
Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
|
|
EP0812593B8
(en)
|
1993-03-23 |
2010-11-10 |
SmithKline Beecham Biologicals S.A. |
Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
|
|
CA2171942C
(en)
|
1993-09-22 |
2010-12-14 |
Andrew Lees |
Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
|
|
GB9326174D0
(en)
|
1993-12-22 |
1994-02-23 |
Biocine Sclavo |
Mucosal adjuvant
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
|
IL117483A
(en)
|
1995-03-17 |
2008-03-20 |
Bernard Brodeur |
MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
US6180111B1
(en)
|
1995-05-18 |
2001-01-30 |
University Of Maryland |
Vaccine delivery system
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6558677B2
(en)
|
1996-10-15 |
2003-05-06 |
Wendell D. Zollinger |
Vaccine against gram negative bacteria
|
|
DK1005368T3
(da)
|
1997-03-10 |
2010-01-04 |
Ottawa Hospital Res Inst |
Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer
|
|
US6818222B1
(en)
|
1997-03-21 |
2004-11-16 |
Chiron Corporation |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
|
|
GB9711964D0
(en)
|
1997-06-09 |
1997-08-06 |
Medical Res Council |
Live attenuated vaccines
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
AU748973B2
(en)
*
|
1997-07-17 |
2002-06-13 |
Baxter Healthcare Sa |
Immunogenic conjugates comprising a group B meningococcal porin and an H. influenzae polysaccharide
|
|
WO1999010497A1
(en)
|
1997-08-21 |
1999-03-04 |
De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur |
Novel mutants of gram negative mucosal bacteria and application thereof in vaccines
|
|
AU1145699A
(en)
|
1997-09-05 |
1999-03-22 |
Smithkline Beecham Biologicals (Sa) |
Oil in water emulsions containing saponins
|
|
BR9813930A
(pt)
|
1997-11-06 |
2006-12-19 |
Chiron Spa |
antìgeno neisserial
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
SG123535A1
(en)
|
1998-01-14 |
2006-07-26 |
Chiron Srl |
Neisseria meningitidis antigens
|
|
WO1999040936A2
(en)
|
1998-02-12 |
1999-08-19 |
American Cyanamid Company |
Pneumococcal and meningococcal vaccines formulated with interleukin-12
|
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
|
IL138000A0
(en)
|
1998-04-09 |
2001-10-31 |
Smithkline Beecham Biolog |
Adjuvant compositions
|
|
EP2261348A3
(en)
|
1998-05-01 |
2012-01-25 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
US8007815B1
(en)
*
|
1998-05-29 |
2011-08-30 |
Novartis Ag |
Combination meningitidis B/C vaccines
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
HK1041825B
(zh)
|
1998-08-19 |
2007-02-23 |
Baxter Healthcare S.A. |
多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用
|
|
CN100406060C
(zh)
|
1998-10-16 |
2008-07-30 |
史密丝克莱恩比彻姆生物有限公司 |
一种佐剂组合物
|
|
CA2347849C
(en)
|
1998-10-22 |
2013-06-25 |
The University Of Montana |
Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof
|
|
GB9823978D0
(en)
|
1998-11-02 |
1998-12-30 |
Microbiological Res Authority |
Multicomponent meningococcal vaccine
|
|
AU1626199A
(en)
|
1998-12-04 |
2000-06-26 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
A vi-repa conjugate vaccine for immunization against salmonella typhi
|
|
JP2002539273A
(ja)
|
1999-03-19 |
2002-11-19 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
EP1165796A2
(en)
|
1999-04-09 |
2002-01-02 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
PT1228217E
(pt)
|
1999-04-30 |
2013-01-28 |
Novartis Vaccines & Diagnostic |
Antígenos de neisseria conservados
|
|
GB9918319D0
(en)
|
1999-08-03 |
1999-10-06 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
JP2003509452A
(ja)
|
1999-09-24 |
2003-03-11 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ポリオキシエチレンアルキルエーテル又はエステル及び少なくとも一つのノニオン界面活性剤を含有するアジュバント
|
|
CO5200837A1
(es)
|
1999-09-24 |
2002-09-27 |
Smithkline Beecham Corp |
Vacunas
|
|
GB9925559D0
(en)
|
1999-10-28 |
1999-12-29 |
Smithkline Beecham Biolog |
Novel method
|
|
WO2001034642A2
(en)
|
1999-11-12 |
2001-05-17 |
University Of Iowa Research Foundation |
Control of neisserial membrane synthesis
|
|
CN1433471A
(zh)
|
1999-11-29 |
2003-07-30 |
启龙股份公司 |
85kgDa奈瑟球菌的抗原
|
|
WO2001052885A1
(en)
|
2000-01-17 |
2001-07-26 |
Chiron Spa |
Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
|
|
US20010044416A1
(en)
|
2000-01-20 |
2001-11-22 |
Mccluskie Michael J. |
Immunostimulatory nucleic acids for inducing a Th2 immune response
|
|
JP2003523208A
(ja)
|
2000-01-25 |
2003-08-05 |
ザ ユニバーシティ オブ クイーンズランド |
髄膜炎菌表面抗原NhhAの保存領域を含むタンパク質
|
|
US7803387B2
(en)
|
2000-02-28 |
2010-09-28 |
Novartis Vaccines And Diagnostics Srl |
Heterologous expression of Neisserial proteins
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
NO20002828D0
(no)
|
2000-06-02 |
2000-06-02 |
Statens Inst For Folkehelse |
Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
|
|
US6936261B2
(en)
|
2000-07-27 |
2005-08-30 |
Children's Hospital & Research Center At Oakland |
Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
|
|
GB0103170D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
ATE384072T1
(de)
|
2000-09-26 |
2008-02-15 |
Idera Pharmaceuticals Inc |
Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
|
|
WO2002034771A2
(en)
|
2000-10-27 |
2002-05-02 |
Chiron Srl |
Nucleic acids and proteins from streptococcus groups a & b
|
|
GB0103169D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
GB0103171D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
WO2002091998A2
(en)
|
2001-05-11 |
2002-11-21 |
Aventis Pasteur, Inc. |
Novel meningitis conjugate vaccine
|
|
GB0115176D0
(en)
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
RU2323002C2
(ru)
|
2001-07-26 |
2008-04-27 |
Чирон Срл. |
Вакцины, содержащие алюминиевые адъюванты и гистидин
|
|
GB0121591D0
(en)
|
2001-09-06 |
2001-10-24 |
Chiron Spa |
Hybrid and tandem expression of neisserial proteins
|
|
DE60234375D1
(de)
|
2001-09-14 |
2009-12-24 |
Cytos Biotechnology Ag |
VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
|
|
AU2002347404A1
(en)
|
2001-09-14 |
2003-04-01 |
Cytos Biotechnology Ag |
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
|
|
MX339524B
(es)
|
2001-10-11 |
2016-05-30 |
Wyeth Corp |
Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
GB0130123D0
(en)
|
2001-12-17 |
2002-02-06 |
Microbiological Res Agency |
Outer membrane vesicle vaccine and its preparation
|
|
EP1490409B1
(en)
|
2002-03-26 |
2008-12-31 |
Novartis Vaccines and Diagnostics S.r.l. |
Modified saccharides having improved stability in water
|
|
ES2408251T3
(es)
|
2002-08-02 |
2013-06-19 |
Glaxosmithkline Biologicals S.A. |
Composiciones de vacuna contra Neisseria que comprenden una combinación de antígenos
|
|
GB0220194D0
(en)
|
2002-08-30 |
2002-10-09 |
Chiron Spa |
Improved vesicles
|
|
DK2351579T3
(en)
*
|
2002-10-11 |
2017-01-09 |
Novartis Vaccines And Diagnostics S R L |
Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages.
|
|
PT2279746E
(pt)
|
2002-11-15 |
2013-12-09 |
Novartis Vaccines & Diagnostic |
Proteínas de superfície de neisseria meningitidis
|
|
GB0227346D0
(en)
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
|
AU2004233012A1
(en)
|
2003-04-16 |
2004-11-04 |
Wyeth Holdings Corporation |
Novel immunogenic compositions for the prevention and treatment of meningococcal disease
|
|
GB0316560D0
(en)
|
2003-07-15 |
2003-08-20 |
Chiron Srl |
Vesicle filtration
|
|
GB0408977D0
(en)
*
|
2004-04-22 |
2004-05-26 |
Chiron Srl |
Immunising against meningococcal serogroup Y using proteins
|
|
GB0419408D0
(en)
|
2004-09-01 |
2004-10-06 |
Chiron Srl |
741 chimeric polypeptides
|
|
EP2433647A3
(en)
|
2005-01-27 |
2012-06-06 |
Children's Hospital & Research Center at Oakland |
GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
|
|
GB0524066D0
(en)
*
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
|
BRPI0907843A2
(pt)
*
|
2008-02-21 |
2015-08-04 |
Novartis Ag |
Polipeptídeos de fhbp menigocócicos
|