AU2010288240B2 - Hybrid polypeptides including meningococcal fHBP sequences - Google Patents

Hybrid polypeptides including meningococcal fHBP sequences Download PDF

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Publication number
AU2010288240B2
AU2010288240B2 AU2010288240A AU2010288240A AU2010288240B2 AU 2010288240 B2 AU2010288240 B2 AU 2010288240B2 AU 2010288240 A AU2010288240 A AU 2010288240A AU 2010288240 A AU2010288240 A AU 2010288240A AU 2010288240 B2 AU2010288240 B2 AU 2010288240B2
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AU
Australia
Prior art keywords
amino acid
seq
acid sequence
polypeptide
immunogenic
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Ceased
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AU2010288240A
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AU2010288240A1 (en
Inventor
Maria Arico
Marzia Monica Giuliani
Mariagrazia Pizza
Rino Rappuoli
Maria Scarselli
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Novartis AG
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Novartis AG
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Priority to AU2013202472A priority Critical patent/AU2013202472A1/en
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Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2010288240A 2009-08-27 2010-08-27 Hybrid polypeptides including meningococcal fHBP sequences Ceased AU2010288240B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013202472A AU2013202472A1 (en) 2009-08-27 2013-04-04 Hybrid polypeptides including meningococcal fHBP sequences

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23757609P 2009-08-27 2009-08-27
US61/237,576 2009-08-27
PCT/IB2010/002260 WO2011024072A2 (en) 2009-08-27 2010-08-27 Hybrid polypeptides including meningococcal fhbp sequences

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013202472A Division AU2013202472A1 (en) 2009-08-27 2013-04-04 Hybrid polypeptides including meningococcal fHBP sequences

Publications (2)

Publication Number Publication Date
AU2010288240A1 AU2010288240A1 (en) 2012-03-22
AU2010288240B2 true AU2010288240B2 (en) 2014-03-27

Family

ID=43428588

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010288240A Ceased AU2010288240B2 (en) 2009-08-27 2010-08-27 Hybrid polypeptides including meningococcal fHBP sequences

Country Status (10)

Country Link
US (1) US20110076300A1 (enExample)
EP (2) EP2470204B1 (enExample)
JP (2) JP2013502918A (enExample)
CN (2) CN104650241A (enExample)
AU (1) AU2010288240B2 (enExample)
BR (1) BR112012004275A2 (enExample)
CA (1) CA2772104A1 (enExample)
ES (1) ES2562259T3 (enExample)
NZ (2) NZ598458A (enExample)
WO (1) WO2011024072A2 (enExample)

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RU2580620C2 (ru) 2010-08-23 2016-04-10 ВАЙЕТ ЭлЭлСи СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086
MX343914B (es) 2010-09-01 2016-11-18 Glaxosmithkline Biologicals Sa Adsorcion de inmunopotenciadores en sales metalicas insolubles.
WO2012032489A1 (en) 2010-09-10 2012-03-15 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
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JP6345603B2 (ja) 2012-03-08 2018-06-20 ノバルティス アーゲー 追加免疫ワクチンのアジュバント化された処方物
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HK1205138A1 (en) 2012-07-27 2015-12-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
EP2892553A1 (en) 2012-09-06 2015-07-15 Novartis AG Combination vaccines with serogroup b meningococcus and d/t/p
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
EP3298031B1 (en) * 2015-05-18 2020-10-21 BiOMVis Srl Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
RS65362B1 (sr) 2016-09-02 2024-04-30 Sanofi Pasteur Inc Vakcina protiv neisseria meningitidis
US10183070B2 (en) 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN107151270B (zh) * 2017-03-22 2018-07-31 武汉博沃生物科技有限公司 重组ΔfHbp-NadA融合蛋白载体及其制备方法和应用
GB201809622D0 (en) * 2018-06-12 2018-07-25 Evox Therapeutics Ltd Engineering extracellular vesicles for affinity purification
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
IN202321021121A (enExample) * 2023-03-24 2024-04-19

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