|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
US4356170A
(en)
*
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
SE8205892D0
(sv)
|
1982-10-18 |
1982-10-18 |
Bror Morein |
Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
|
|
US4761283A
(en)
*
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
JPS626698A
(ja)
*
|
1985-07-03 |
1987-01-13 |
Hayashibara Biochem Lab Inc |
ガラクチト−ルの測定方法
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US5785973A
(en)
*
|
1988-02-01 |
1998-07-28 |
Praxis Biologics, Inc. |
Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
|
|
AU627226B2
(en)
|
1988-08-25 |
1992-08-20 |
Liposome Company, Inc., The |
Influenza vaccine and novel adjuvants
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
DE68907045T2
(de)
|
1989-01-17 |
1993-12-02 |
Eniricerche Spa |
Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind.
|
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
JPH04506662A
(ja)
|
1989-07-14 |
1992-11-19 |
アメリカン・サイアナミド・カンパニー |
接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
CA2095642C
(en)
*
|
1990-08-02 |
1999-12-14 |
Howard C. Krivan |
Adhesion receptors for pathogenic or opportunistic microorganisms
|
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
|
US5153312A
(en)
|
1990-09-28 |
1992-10-06 |
American Cyanamid Company |
Oligosaccharide conjugate vaccines
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
CA2138997C
(en)
|
1992-06-25 |
2003-06-03 |
Jean-Paul Prieels |
Vaccine composition containing adjuvants
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
IL107103A
(en)
*
|
1992-09-24 |
2001-03-19 |
Brigham & Womens Hospital |
Multivalent vaccine based on conjugated molecule comprising a capsular polysaccharide linked to a protein and a method for the preparation thereof
|
|
ZA937034B
(en)
*
|
1992-09-24 |
1995-06-23 |
Brigham & Womens Hospital |
Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
|
|
SG48309A1
(en)
|
1993-03-23 |
1998-04-17 |
Smithkline Beecham Biolog |
Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
|
|
GB9326174D0
(en)
|
1993-12-22 |
1994-02-23 |
Biocine Sclavo |
Mucosal adjuvant
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
|
IL117483A
(en)
|
1995-03-17 |
2008-03-20 |
Bernard Brodeur |
MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
NZ311000A
(en)
|
1995-06-07 |
1999-04-29 |
Smithkline Beecham Biolog |
Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein
|
|
US6284884B1
(en)
*
|
1995-06-07 |
2001-09-04 |
North American Vaccine, Inc. |
Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US6426074B1
(en)
*
|
1997-03-19 |
2002-07-30 |
The Brigham And Women's Hospital Inc. |
Group B Streptococcus vaccine
|
|
US6818222B1
(en)
|
1997-03-21 |
2004-11-16 |
Chiron Corporation |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
|
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
|
JP2001519817A
(ja)
|
1997-03-26 |
2001-10-23 |
ブリガム アンド ウイメンズ ホスピタル |
糖断片生成法
|
|
US6399071B1
(en)
*
|
1997-04-18 |
2002-06-04 |
Novartis Ag |
Neoglycoproteins
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
AU1145699A
(en)
|
1997-09-05 |
1999-03-22 |
Smithkline Beecham Biologicals (Sa) |
Oil in water emulsions containing saponins
|
|
KR100680014B1
(ko)
*
|
1997-10-03 |
2007-02-09 |
갈레니카 파마슈티칼스 인크. |
이민 형성 폴리사카라이드, 이의 제조 방법 및 이것의 아쥬반트 및 면역자극제로서의 용도
|
|
EP1900818A3
(en)
|
1997-11-06 |
2008-06-11 |
Novartis Vaccines and Diagnostics S.r.l. |
Neisserial antigens
|
|
JP2002536958A
(ja)
|
1997-11-21 |
2002-11-05 |
ジェンセット |
Chlamydiapneumoniaeゲノム配列およびポリペプチド、それらのフラグメント、ならびに特に感染症の診断、予防および治療のためのそれらの使用
|
|
EP2218732A1
(en)
|
1997-11-28 |
2010-08-18 |
Merck Serono Biodevelopment |
Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
CA2316975C
(en)
*
|
1997-12-23 |
2009-03-24 |
North American Vaccine, Inc. |
Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines
|
|
US20010051364A1
(en)
*
|
1997-12-23 |
2001-12-13 |
Francis Michon |
Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines
|
|
WO1999036544A2
(en)
|
1998-01-14 |
1999-07-22 |
Chiron S.P.A. |
Neisseria meningitidis antigens
|
|
EP1318171A1
(en)
*
|
1998-01-16 |
2003-06-11 |
Unilever N.V. |
Polysaccharide conjugate capable of binding cellulose
|
|
EP1053015A2
(en)
|
1998-02-12 |
2000-11-22 |
American Cyanamid Company |
Pneumococcal and meningococcal vaccines formulated with interleukin-12
|
|
US7018637B2
(en)
|
1998-02-23 |
2006-03-28 |
Aventis Pasteur, Inc |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
|
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
|
US6645503B1
(en)
*
|
1998-03-10 |
2003-11-11 |
Wyeth Holdings Corporation |
Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria
|
|
WO1999052549A1
(en)
|
1998-04-09 |
1999-10-21 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
|
WO1999055715A2
(en)
*
|
1998-04-28 |
1999-11-04 |
Galenica Pharmaceuticals, Inc. |
Polysaccharide-antigen conjugates
|
|
EP2261347A3
(en)
|
1998-05-01 |
2012-01-11 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
CN1263510C
(zh)
*
|
1998-08-19 |
2006-07-12 |
巴克斯特健康护理股份有限公司 |
多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用
|
|
MXPA01003557A
(es)
|
1998-10-09 |
2004-04-05 |
Chiron Corp |
Secuencias genomicas de neisseria y metodos para su uso.
|
|
AU750587B2
(en)
|
1998-10-16 |
2002-07-25 |
Smithkline Beecham Biologicals (Sa) |
Adjuvant systems and vaccines
|
|
AU1722300A
(en)
|
1998-11-12 |
2000-05-29 |
Regents Of The University Of California, The |
Chlamydia pneumoniae genome sequence
|
|
GB9828000D0
(en)
|
1998-12-18 |
1999-02-10 |
Chiron Spa |
Antigens
|
|
US6146902A
(en)
|
1998-12-29 |
2000-11-14 |
Aventis Pasteur, Inc. |
Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
|
|
EP1034792A1
(en)
|
1999-03-11 |
2000-09-13 |
Pasteur Merieux Serums Et Vaccins |
Intranasal delivery of pneumococcal polysaccharide vaccines
|
|
JP2002539273A
(ja)
|
1999-03-19 |
2002-11-19 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
CO5200838A1
(es)
|
1999-09-24 |
2002-09-27 |
Smithkline Beecham Corp |
Vacunas
|
|
JP2003509473A
(ja)
|
1999-09-24 |
2003-03-11 |
スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
CA2871789C
(en)
|
2000-01-17 |
2017-04-04 |
Novartis Vaccines And Diagnostics S.R.L. |
Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
|
|
US20010044416A1
(en)
|
2000-01-20 |
2001-11-22 |
Mccluskie Michael J. |
Immunostimulatory nucleic acids for inducing a Th2 immune response
|
|
CA2414884A1
(en)
|
2000-07-03 |
2002-01-10 |
Chiron S.P.A. |
Immunisation against chlamydia pneumoniae
|
|
US7892552B2
(en)
*
|
2001-08-08 |
2011-02-22 |
University Of Utah Research Foundation |
Group B Streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
|
|
AU2001281168A1
(en)
*
|
2000-08-08 |
2002-02-18 |
St. Jude Children's Research Hospital |
Group b streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
|
|
ATE384072T1
(de)
|
2000-09-26 |
2008-02-15 |
Idera Pharmaceuticals Inc |
Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
|
|
ATE439372T1
(de)
*
|
2000-10-27 |
2009-08-15 |
Novartis Vaccines & Diagnostic |
Nukleinsäuren und proteine von gruppen a und b- streptokokken
|
|
US20030035806A1
(en)
|
2001-05-11 |
2003-02-20 |
D'ambra Anello J. |
Novel meningitis conjugate vaccine
|
|
GB0115176D0
(en)
*
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
EP1409013B1
(en)
|
2001-07-26 |
2009-11-18 |
Novartis Vaccines and Diagnostics S.r.l. |
Vaccines comprising aluminium adjuvants and histidine
|
|
US7534442B2
(en)
*
|
2001-08-21 |
2009-05-19 |
The Brigham And Women's Hospital, Inc. |
Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid
|
|
CA2492823A1
(en)
|
2001-09-14 |
2003-03-27 |
Cytos Biotechnology Ag |
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
|
|
EP1450856B1
(en)
|
2001-09-14 |
2009-11-11 |
Cytos Biotechnology AG |
Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
|
|
US7265085B2
(en)
*
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
GB0210128D0
(en)
|
2002-05-02 |
2002-06-12 |
Chiron Spa |
Nucleic acids and proteins from streptococcus groups A & B
|
|
US20040096461A1
(en)
*
|
2002-07-30 |
2004-05-20 |
Baxter Healthcare Corporation |
Chimeric multivalent polysaccharide conjugate vaccines
|
|
WO2004018646A2
(en)
|
2002-08-26 |
2004-03-04 |
Chiron Corporation |
Conserved and specific streptococcal genomes
|
|
WO2004041157A2
(en)
*
|
2002-09-13 |
2004-05-21 |
Chiron Corporation |
Group b streptococcus vaccine
|
|
US7521062B2
(en)
|
2002-12-27 |
2009-04-21 |
Novartis Vaccines & Diagnostics, Inc. |
Thiosemicarbazones as anti-virals and immunopotentiators
|
|
EP1594524B1
(en)
|
2003-01-21 |
2012-08-15 |
Novartis Vaccines and Diagnostics, Inc. |
Use of tryptanthrin compounds for immune potentiation
|
|
ES2461350T3
(es)
*
|
2003-01-30 |
2014-05-19 |
Novartis Ag |
Vacunas inyectables contra múltiples serogrupos de meningococos
|
|
EP1620460A2
(en)
*
|
2003-05-07 |
2006-02-01 |
Intercell AG |
Streptococcus agalactiae antigens i + ii
|
|
JP4875490B2
(ja)
*
|
2003-07-31 |
2012-02-15 |
ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド |
StreptococcusPyogenesについての免疫原組成物
|
|
CA2844154C
(en)
*
|
2003-08-06 |
2016-12-20 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Polysaccharide-protein conjugate vaccines
|
|
US8048432B2
(en)
*
|
2003-08-06 |
2011-11-01 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Polysaccharide-protein conjugate vaccines
|
|
US20060198819A1
(en)
*
|
2003-08-08 |
2006-09-07 |
Novo Nordisk Healthcare A/G |
Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
|
|
CA2556169C
(en)
*
|
2004-01-29 |
2011-11-22 |
Andrew Lees |
Use of amino-oxy functional groups in the preparation of vaccines
|
|
CN101107010A
(zh)
*
|
2004-11-01 |
2008-01-16 |
布里格海姆妇女医院公司 |
经修饰的链球菌多糖及其用途
|
|
GB0502096D0
(en)
*
|
2005-02-01 |
2005-03-09 |
Chiron Srl |
Purification of streptococcal capsular polysaccharide
|
|
GB0502095D0
(en)
*
|
2005-02-01 |
2005-03-09 |
Chiron Srl |
Conjugation of streptococcal capsular saccharides
|
|
EP1937304A2
(en)
*
|
2005-08-24 |
2008-07-02 |
Novartis Vaccines and Diagnostics S.r.l. |
Zwitterionization of capsular saccharides
|
|
US7700578B2
(en)
*
|
2005-09-21 |
2010-04-20 |
The United States Of America As Represented By The Secretary Of The Navy |
Capsule composition for use as immunogen against Campylobacter jejuni
|
|
GB0522303D0
(en)
*
|
2005-11-01 |
2005-12-07 |
Chiron Srl |
Culture method
|
|
AU2007221154A1
(en)
*
|
2006-02-24 |
2007-09-07 |
Novartis Ag |
Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
|
|
JP5555623B2
(ja)
*
|
2007-06-20 |
2014-07-23 |
バクスター・インターナショナル・インコーポレイテッド |
コンジュゲートワクチン用修飾多糖
|
|
GB0713880D0
(en)
*
|
2007-07-17 |
2007-08-29 |
Novartis Ag |
Conjugate purification
|
|
CN102481349B
(zh)
*
|
2009-01-12 |
2014-10-15 |
诺华股份有限公司 |
抗革兰氏阳性细菌疫苗中的Cna_B结构域
|
|
GB201101665D0
(en)
*
|
2011-01-31 |
2011-03-16 |
Novartis Ag |
Immunogenic compositions
|