ES2160601T3 - Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. - Google Patents
Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina.Info
- Publication number
- ES2160601T3 ES2160601T3 ES93922357T ES93922357T ES2160601T3 ES 2160601 T3 ES2160601 T3 ES 2160601T3 ES 93922357 T ES93922357 T ES 93922357T ES 93922357 T ES93922357 T ES 93922357T ES 2160601 T3 ES2160601 T3 ES 2160601T3
- Authority
- ES
- Spain
- Prior art keywords
- type
- cps
- protein
- streptococo
- polisacarids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
LA INVENCION SE REFIERE A MOLECULAS CONJUGADAS ANTIGENICAS QUE COMPRENDEN EL POLISACARIDO CAPSULAR DE LOS ESTREPTOCOCOS GRUPO B TIPO II LOS CUALES ESTAN ENLAZADOS DE MODO COVALENTE CON LA PROTEINA. ESTA INVENCION SE REFIERE ADEMAS A MOLECULAS CONJUGADAS ANTIGENICAS QUE COMPRENDEN EL POLISACARIDO CAPSULAR DE LOS ESTREPTOCOCOS GRUPO B TIPO V LOS CUALES ESTAN ENLAZADOS DE MODO COVALENTE CON LA PROTEINA. ESTA INVENCION TAMBIEN SE REFIERE A VACUNAS Y METODOS DE INMUNIZACION DE MAMIFEROS, INCLUYENDO A LAS PERSONAS CONTRA LA INFECCION POR ESTREPTOCOCOS GRUPO B TIPO II (GBS II) Y/O ESTREPTOCOCOS GRUPO B TIPO V (GBS V). TAMBIEN SON REIVINDICADAS LAS VACUNAS MULTIVALENTES LAS CUALES COMPRENDEN LAS MOLECULAS CONJUGADAS DE ESTA INVENCION Y LOS ANTIGENOS PARA OTRAS BACTERIAS PATOGENICAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94997092A | 1992-09-24 | 1992-09-24 | |
US12555693A | 1993-09-23 | 1993-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160601T3 true ES2160601T3 (es) | 2001-11-16 |
Family
ID=26823688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93922357T Expired - Lifetime ES2160601T3 (es) | 1992-09-24 | 1993-09-24 | Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5795580A (es) |
EP (1) | EP0667787B1 (es) |
JP (3) | JP4163251B2 (es) |
KR (1) | KR100293017B1 (es) |
AT (1) | ATE203167T1 (es) |
AU (1) | AU690525B2 (es) |
CA (1) | CA2145397C (es) |
DE (1) | DE69330464T2 (es) |
DK (1) | DK0667787T3 (es) |
ES (1) | ES2160601T3 (es) |
FI (1) | FI110993B (es) |
GR (1) | GR3036928T3 (es) |
IL (1) | IL107103A (es) |
NO (2) | NO319569B1 (es) |
NZ (2) | NZ248766A (es) |
PT (1) | PT667787E (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69719677T2 (de) * | 1996-11-18 | 2003-09-18 | Japan Storage Battery Co. Ltd., Kyoto | Positivelektrode für Lithiumbatterie und Lithiumbatterie |
DE69940338D1 (de) * | 1998-02-05 | 2009-03-12 | Jackson H M Found Military Med | Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein-polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit |
US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
ES2286133T3 (es) | 2000-08-08 | 2007-12-01 | St. Jude Children's Research Hospital | Acidos nucleicos de polipeptidos de estreptococos del grupo b y composiciones terapeuticas y vacunas de los mismos. |
SV2003000753A (es) * | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
US20030185858A1 (en) * | 2001-08-15 | 2003-10-02 | Birkett Ashley J. | Immunogenic HBc chimer particles stabilized with an N-terminal cysteine |
US7534442B2 (en) * | 2001-08-21 | 2009-05-19 | The Brigham And Women's Hospital, Inc. | Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid |
US20040096461A1 (en) * | 2002-07-30 | 2004-05-20 | Baxter Healthcare Corporation | Chimeric multivalent polysaccharide conjugate vaccines |
CA2520865A1 (en) | 2003-03-31 | 2004-10-21 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
DE602004017864D1 (de) * | 2003-06-23 | 2009-01-02 | Baxter Int | Trägerproteine für impfstoffe |
WO2006050341A2 (en) * | 2004-11-01 | 2006-05-11 | The Brigham And Women's Hospital, Inc. | Modified streptococcal polysaccharides and uses thereof |
GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
WO2007092451A2 (en) * | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
GB201101665D0 (en) * | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-CONTAINING PSA COMPOSITIONS, METHODS OF ISOLATION AND METHODS OF USING SAME |
CN104582718B (zh) | 2012-10-03 | 2017-10-24 | 诺华股份有限公司 | 免疫原性组合物 |
MX368897B (es) * | 2015-05-04 | 2019-10-21 | Pfizer | Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos. |
WO2017031431A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
WO2018014012A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
WO2020229964A1 (en) * | 2019-05-10 | 2020-11-19 | Glaxosmithkline Biologicals Sa | Conjugate production |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4324887A (en) * | 1978-08-16 | 1982-04-13 | President And Fellows Of Harvard College | Type II group B Streptococci polysaccharide |
US4207414A (en) * | 1978-08-16 | 1980-06-10 | President And Fellows Of Harvard College | Polysaccharide antigens |
PT72812B (en) * | 1980-04-14 | 1983-02-16 | Merck & Co Inc | Process for preparing group b streptococcal capsular polysccha-rides |
US4438261A (en) * | 1980-05-19 | 1984-03-20 | Riker Laboratories, Inc. | Anticoagulant substance |
US4356263A (en) * | 1980-06-09 | 1982-10-26 | President And Fellows Of Harvard College | Method of making a polysaccharide vaccine |
US4367221A (en) * | 1980-06-09 | 1983-01-04 | President And Fellows Of Harvard College | Immunization against Group B streptococci |
US4367223A (en) * | 1980-06-09 | 1983-01-04 | President And Fellows Of Harvard College | Vaccine against Group B streptococci |
US4367222A (en) * | 1980-06-09 | 1983-01-04 | President And Fellows Of Harvard College | Immune globulin specific to Group B streptococci |
US4284537A (en) * | 1980-07-03 | 1981-08-18 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate of streptococcal M protein peptide vaccine |
US4425330A (en) * | 1981-05-20 | 1984-01-10 | Cornell Research Foundation, Inc. | Bovine mastitis vaccine and method for detecting efficacy thereof |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4619828A (en) * | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
US4757134A (en) * | 1982-12-02 | 1988-07-12 | The Rockefeller University | IgA binding protein |
EP0175261B1 (en) * | 1984-09-12 | 1991-12-11 | Chiron Corporation | Hybrid particle immunogens |
FR2581877B1 (fr) * | 1985-05-14 | 1987-12-18 | Louvain Universite Catholique | Conjugue constitue d'une adhesine de paroi de s. mutans, de nature proteique et d'un polysaccharide de s. mutans, sa preparation et son utilisation notamment dans des vaccins anti-caries |
EP0302887B1 (en) * | 1986-04-16 | 1994-06-22 | The Brigham And Women's Hospital, Inc. | Bacterial antigens, antibodies, vaccines, and methods of manufacture |
US5302386A (en) * | 1986-04-16 | 1994-04-12 | Brigham And Women's Hospital, Inc. | Bacterial antigens, antibodies, vaccines and methods of manufacture |
EP0419462A4 (en) * | 1987-07-17 | 1991-07-17 | Xoma Corporation | Improved immunotoxin therapies utilizing purified ricin a-chain species |
IL95578A (en) * | 1989-09-15 | 1998-08-16 | Gen Hospital Corp | A vaccine made from polysaccharide and protein |
ATE121947T1 (de) * | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
-
1993
- 1993-09-24 ES ES93922357T patent/ES2160601T3/es not_active Expired - Lifetime
- 1993-09-24 NZ NZ248766A patent/NZ248766A/en not_active IP Right Cessation
- 1993-09-24 EP EP93922357A patent/EP0667787B1/en not_active Expired - Lifetime
- 1993-09-24 DK DK93922357T patent/DK0667787T3/da active
- 1993-09-24 NZ NZ299249A patent/NZ299249A/xx not_active IP Right Cessation
- 1993-09-24 DE DE69330464T patent/DE69330464T2/de not_active Expired - Fee Related
- 1993-09-24 AT AT93922357T patent/ATE203167T1/de not_active IP Right Cessation
- 1993-09-24 CA CA002145397A patent/CA2145397C/en not_active Expired - Fee Related
- 1993-09-24 KR KR1019950701137A patent/KR100293017B1/ko not_active IP Right Cessation
- 1993-09-24 AU AU51378/93A patent/AU690525B2/en not_active Ceased
- 1993-09-24 JP JP50844194A patent/JP4163251B2/ja not_active Expired - Fee Related
- 1993-09-24 PT PT93922357T patent/PT667787E/pt unknown
- 1993-09-24 IL IL10710393A patent/IL107103A/en not_active IP Right Cessation
-
1995
- 1995-03-23 NO NO19951109A patent/NO319569B1/no not_active IP Right Cessation
- 1995-03-24 FI FI951412A patent/FI110993B/fi active
- 1995-03-24 NO NO951152A patent/NO951152D0/no unknown
- 1995-06-07 US US08/483,647 patent/US5795580A/en not_active Expired - Lifetime
-
1998
- 1998-02-13 US US09/023,526 patent/US5993825A/en not_active Expired - Fee Related
-
2001
- 2001-10-18 GR GR20010401795T patent/GR3036928T3/el not_active IP Right Cessation
-
2005
- 2005-07-05 JP JP2005196902A patent/JP4308174B2/ja not_active Expired - Fee Related
-
2009
- 2009-03-09 JP JP2009055767A patent/JP2009132727A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5993825A (en) | 1999-11-30 |
FI951412A (fi) | 1995-05-24 |
EP0667787B1 (en) | 2001-07-18 |
JP4308174B2 (ja) | 2009-08-05 |
GR3036928T3 (en) | 2002-01-31 |
JP2005306884A (ja) | 2005-11-04 |
NO951109L (no) | 1995-05-22 |
FI951412A0 (fi) | 1995-03-24 |
NO319569B1 (no) | 2005-08-29 |
CA2145397A1 (en) | 1994-03-31 |
AU5137893A (en) | 1994-04-12 |
AU690525B2 (en) | 1998-04-30 |
DE69330464D1 (en) | 2001-08-23 |
CA2145397C (en) | 2007-10-30 |
IL107103A (en) | 2001-03-19 |
JP4163251B2 (ja) | 2008-10-08 |
NZ248766A (en) | 1996-11-26 |
IL107103A0 (en) | 1994-08-26 |
JP2009132727A (ja) | 2009-06-18 |
US5795580A (en) | 1998-08-18 |
KR950703361A (ko) | 1995-09-20 |
FI110993B (fi) | 2003-05-15 |
DE69330464T2 (de) | 2001-11-08 |
PT667787E (pt) | 2001-10-31 |
NO951109D0 (no) | 1995-03-23 |
DK0667787T3 (da) | 2001-10-29 |
JPH08501563A (ja) | 1996-02-20 |
NZ299249A (en) | 2000-08-25 |
EP0667787A1 (en) | 1995-08-23 |
ATE203167T1 (de) | 2001-08-15 |
NO951152D0 (no) | 1995-03-24 |
KR100293017B1 (ko) | 2001-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2160601T3 (es) | Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. | |
ES8704350A1 (es) | Procedimiento para la preparacion de un conjugado bacteriano | |
CA1276109C (en) | Immunogenic conjugates | |
CA1181344A (en) | Immunogenic polysaccharide-protein conjugates | |
PT81338A (en) | Antigens particularly envelope antigens of the virus of lymphadenopathies and of the acquired immuno-depressive syndrome and virus process for producing virus envelope antigens in the preparation of immunogenic compositions or for the diagnosis of the presence of antibodies against this virus | |
NO913518L (no) | Vaksiner for ikke typebestembar haemophilus influenzae. | |
US5192540A (en) | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine | |
JPH04230634A (ja) | 複合ワクチンのキヤリヤー分子としての、百日咳菌の繊維状赤血球凝集素 | |
CA2171942A1 (en) | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs | |
LU91609I2 (fr) | Sérotype pneumococcique polysaccharidique 1,4,5,6B,7F,9V,14 et 23F conjugé aux protéines D (dérivé du non-typable Haemophilus influenzae); Sérotype pneumococcique polysaccaridique 18C conjugé au transporteur anatoxine tétanique protéines; Sérotype pneumococcique polysaccharidique 19F conjugé au transporteur anatoxine diphtérique protéines (SYNFLORIX - Vaccin pneumococcique polysaccharidique conjugé (adsorbé) | |
RU99101850A (ru) | Поливалентные ассоциированные коклюшно-дифтерийно-столбнячно(акдс)-полиомиелитные вакцины | |
CA2329772A1 (en) | Artificial t helper cell epitopes as immune stimulators for synthetic peptide immunogens | |
PT959905E (pt) | Conjugados de polissacárido e péptido | |
DE3477883D1 (en) | Antigenic materials | |
Fattom et al. | Synthesis and physicochemical and immunological characterization of pneumococcus type 12F polysaccharide-diphtheria toxoid conjugates | |
EP0338265B1 (en) | Haemophilus influenzae type B polysaccharide-outer membrane protein conjugate vaccine | |
US6165468A (en) | Antigenic carbohydrate linked to an immunogenic carrier | |
UA27754C2 (uk) | Комбінована педіатрична вакцина, спосіб одночасної комбінованої вакцинації | |
WO1993014206A3 (en) | Synthetic peptides for a rubella vaccine | |
Jennings et al. | Tetanus toxoid conjugates of the meningococcal polysaccharides. | |
Lüscher et al. | Induction of immunological tolerance to the penicilloyl antigenic determinant—iv. The effect of BPO-oligolysines and cholestanol-bearing BPO-oligolysines on murine IgE responses | |
FR2685333B1 (fr) | Nouveau peptide notamment pour la realisation de conjugues immunogenes anti-lhrh, vaccins les incorporant et ensemble de vaccination y relatif. | |
PT82373A (en) | Process for preparing a klebsiella capsular polysaccharide vaccine | |
TH5452EX (th) | วัคซีนสังเคราะห์เพื่อต่อต้านฟันผุ | |
TH5452A (th) | วัคซีนสังเคราะห์เพื่อต่อต้านฟันผุ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 667787 Country of ref document: ES |