ES2160601T3 - Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. - Google Patents

Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina.

Info

Publication number
ES2160601T3
ES2160601T3 ES93922357T ES93922357T ES2160601T3 ES 2160601 T3 ES2160601 T3 ES 2160601T3 ES 93922357 T ES93922357 T ES 93922357T ES 93922357 T ES93922357 T ES 93922357T ES 2160601 T3 ES2160601 T3 ES 2160601T3
Authority
ES
Spain
Prior art keywords
type
cps
protein
streptococo
polisacarids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922357T
Other languages
English (en)
Inventor
Harold J Jennings
Dennis L Kasper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Brigham and Womens Hospital Inc
Original Assignee
National Research Council of Canada
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26823688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2160601(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by National Research Council of Canada, Brigham and Womens Hospital Inc filed Critical National Research Council of Canada
Application granted granted Critical
Publication of ES2160601T3 publication Critical patent/ES2160601T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

LA INVENCION SE REFIERE A MOLECULAS CONJUGADAS ANTIGENICAS QUE COMPRENDEN EL POLISACARIDO CAPSULAR DE LOS ESTREPTOCOCOS GRUPO B TIPO II LOS CUALES ESTAN ENLAZADOS DE MODO COVALENTE CON LA PROTEINA. ESTA INVENCION SE REFIERE ADEMAS A MOLECULAS CONJUGADAS ANTIGENICAS QUE COMPRENDEN EL POLISACARIDO CAPSULAR DE LOS ESTREPTOCOCOS GRUPO B TIPO V LOS CUALES ESTAN ENLAZADOS DE MODO COVALENTE CON LA PROTEINA. ESTA INVENCION TAMBIEN SE REFIERE A VACUNAS Y METODOS DE INMUNIZACION DE MAMIFEROS, INCLUYENDO A LAS PERSONAS CONTRA LA INFECCION POR ESTREPTOCOCOS GRUPO B TIPO II (GBS II) Y/O ESTREPTOCOCOS GRUPO B TIPO V (GBS V). TAMBIEN SON REIVINDICADAS LAS VACUNAS MULTIVALENTES LAS CUALES COMPRENDEN LAS MOLECULAS CONJUGADAS DE ESTA INVENCION Y LOS ANTIGENOS PARA OTRAS BACTERIAS PATOGENICAS.
ES93922357T 1992-09-24 1993-09-24 Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. Expired - Lifetime ES2160601T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94997092A 1992-09-24 1992-09-24
US12555693A 1993-09-23 1993-09-23

Publications (1)

Publication Number Publication Date
ES2160601T3 true ES2160601T3 (es) 2001-11-16

Family

ID=26823688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922357T Expired - Lifetime ES2160601T3 (es) 1992-09-24 1993-09-24 Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina.

Country Status (16)

Country Link
US (2) US5795580A (es)
EP (1) EP0667787B1 (es)
JP (3) JP4163251B2 (es)
KR (1) KR100293017B1 (es)
AT (1) ATE203167T1 (es)
AU (1) AU690525B2 (es)
CA (1) CA2145397C (es)
DE (1) DE69330464T2 (es)
DK (1) DK0667787T3 (es)
ES (1) ES2160601T3 (es)
FI (1) FI110993B (es)
GR (1) GR3036928T3 (es)
IL (1) IL107103A (es)
NO (2) NO319569B1 (es)
NZ (2) NZ248766A (es)
PT (1) PT667787E (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69719677T2 (de) * 1996-11-18 2003-09-18 Japan Storage Battery Co. Ltd., Kyoto Positivelektrode für Lithiumbatterie und Lithiumbatterie
DE69940338D1 (de) * 1998-02-05 2009-03-12 Jackson H M Found Military Med Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein-polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit
US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
ES2286133T3 (es) 2000-08-08 2007-12-01 St. Jude Children's Research Hospital Acidos nucleicos de polipeptidos de estreptococos del grupo b y composiciones terapeuticas y vacunas de los mismos.
SV2003000753A (es) * 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
US7534442B2 (en) * 2001-08-21 2009-05-19 The Brigham And Women's Hospital, Inc. Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid
US20040096461A1 (en) * 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
CA2520865A1 (en) 2003-03-31 2004-10-21 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
DE602004017864D1 (de) * 2003-06-23 2009-01-02 Baxter Int Trägerproteine für impfstoffe
WO2006050341A2 (en) * 2004-11-01 2006-05-11 The Brigham And Women's Hospital, Inc. Modified streptococcal polysaccharides and uses thereof
GB0502095D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
WO2007092451A2 (en) * 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
GB201101665D0 (en) * 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-CONTAINING PSA COMPOSITIONS, METHODS OF ISOLATION AND METHODS OF USING SAME
CN104582718B (zh) 2012-10-03 2017-10-24 诺华股份有限公司 免疫原性组合物
MX368897B (es) * 2015-05-04 2019-10-21 Pfizer Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos.
WO2017031431A1 (en) 2015-08-19 2017-02-23 President And Fellows Of Harvard College Lipidated psa compositions and methods
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
WO2020229964A1 (en) * 2019-05-10 2020-11-19 Glaxosmithkline Biologicals Sa Conjugate production

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US4324887A (en) * 1978-08-16 1982-04-13 President And Fellows Of Harvard College Type II group B Streptococci polysaccharide
US4207414A (en) * 1978-08-16 1980-06-10 President And Fellows Of Harvard College Polysaccharide antigens
PT72812B (en) * 1980-04-14 1983-02-16 Merck & Co Inc Process for preparing group b streptococcal capsular polysccha-rides
US4438261A (en) * 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
US4356263A (en) * 1980-06-09 1982-10-26 President And Fellows Of Harvard College Method of making a polysaccharide vaccine
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US4367222A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Immune globulin specific to Group B streptococci
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US4425330A (en) * 1981-05-20 1984-01-10 Cornell Research Foundation, Inc. Bovine mastitis vaccine and method for detecting efficacy thereof
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FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.

Also Published As

Publication number Publication date
US5993825A (en) 1999-11-30
FI951412A (fi) 1995-05-24
EP0667787B1 (en) 2001-07-18
JP4308174B2 (ja) 2009-08-05
GR3036928T3 (en) 2002-01-31
JP2005306884A (ja) 2005-11-04
NO951109L (no) 1995-05-22
FI951412A0 (fi) 1995-03-24
NO319569B1 (no) 2005-08-29
CA2145397A1 (en) 1994-03-31
AU5137893A (en) 1994-04-12
AU690525B2 (en) 1998-04-30
DE69330464D1 (en) 2001-08-23
CA2145397C (en) 2007-10-30
IL107103A (en) 2001-03-19
JP4163251B2 (ja) 2008-10-08
NZ248766A (en) 1996-11-26
IL107103A0 (en) 1994-08-26
JP2009132727A (ja) 2009-06-18
US5795580A (en) 1998-08-18
KR950703361A (ko) 1995-09-20
FI110993B (fi) 2003-05-15
DE69330464T2 (de) 2001-11-08
PT667787E (pt) 2001-10-31
NO951109D0 (no) 1995-03-23
DK0667787T3 (da) 2001-10-29
JPH08501563A (ja) 1996-02-20
NZ299249A (en) 2000-08-25
EP0667787A1 (en) 1995-08-23
ATE203167T1 (de) 2001-08-15
NO951152D0 (no) 1995-03-24
KR100293017B1 (ko) 2001-09-17

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