JP2015501329A5 - - Google Patents

Info

Publication number

JP2015501329A5

JP2015501329A5 JP2014539463A JP2014539463A JP2015501329A5 JP 2015501329 A5 JP2015501329 A5 JP 2015501329A5 JP 2014539463 A JP2014539463 A JP 2014539463A JP 2014539463 A JP2014539463 A JP 2014539463A JP 2015501329 A5 JP2015501329 A5 JP 2015501329A5

Authority

JP

Japan

Prior art keywords

conjugate

antigen

amino acid

acid sequence

spr0096

Prior art date

2012-11-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims description 27
• 102000036639 antigens Human genes 0.000 claims description 27
• 108091007433 antigens Proteins 0.000 claims description 27
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims description 12
• 235000000346 sugar Nutrition 0.000 claims description 12
• 150000001720 carbohydrates Chemical class 0.000 claims description 8
• 229920001184 polypeptide Polymers 0.000 claims description 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
• 239000000203 mixture Substances 0.000 claims description 7
• 150000008163 sugars Chemical class 0.000 claims description 5
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 claims description 4
• 241000124008 Mammalia Species 0.000 claims description 3
• SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
• KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 2
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 2
• 244000025254 Cannabis sativa Species 0.000 claims description 2
• 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 2
• 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 2
• 229920001503 Glucan Polymers 0.000 claims description 2
• JMBQKKAJIKAWKF-UHFFFAOYSA-N Glutethimide Chemical compound C=1C=CC=CC=1C1(CC)CCC(=O)NC1=O JMBQKKAJIKAWKF-UHFFFAOYSA-N 0.000 claims description 2
• VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 claims description 2
• SIDLZWOQUZRBRU-UHFFFAOYSA-N Methyprylon Chemical compound CCC1(CC)C(=O)NCC(C)C1=O SIDLZWOQUZRBRU-UHFFFAOYSA-N 0.000 claims description 2
• 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 2
• IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
• 229940025084 amphetamine Drugs 0.000 claims description 2
• 239000000164 antipsychotic agent Substances 0.000 claims description 2
• 229940125717 barbiturate Drugs 0.000 claims description 2
• HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 claims description 2
• 229940049706 benzodiazepine Drugs 0.000 claims description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
• RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 claims description 2
• 229960002327 chloral hydrate Drugs 0.000 claims description 2
• 239000000812 cholinergic antagonist Substances 0.000 claims description 2
• 229960003920 cocaine Drugs 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 229960002972 glutethimide Drugs 0.000 claims description 2
• 230000028993 immune response Effects 0.000 claims description 2
• 229950002454 lysergide Drugs 0.000 claims description 2
• 230000003340 mental effect Effects 0.000 claims description 2
• -1 methaquarone Chemical compound 0.000 claims description 2
• 229960000316 methyprylon Drugs 0.000 claims description 2
• 229960002715 nicotine Drugs 0.000 claims description 2
• SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 2
• 229940127240 opiate Drugs 0.000 claims description 2
• JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 claims description 2
• 229950010883 phencyclidine Drugs 0.000 claims description 2
• 229940001470 psychoactive drug Drugs 0.000 claims description 2
• 239000004089 psychotropic agent Substances 0.000 claims description 2
• 229940125723 sedative agent Drugs 0.000 claims description 2
• 239000000932 sedative agent Substances 0.000 claims description 2
• 101710123661 Venom allergen 5 Proteins 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 238000000034 method Methods 0.000 description 1