JP2020533442A5 - - Google Patents
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- JP2020533442A5 JP2020533442A5 JP2020513626A JP2020513626A JP2020533442A5 JP 2020533442 A5 JP2020533442 A5 JP 2020533442A5 JP 2020513626 A JP2020513626 A JP 2020513626A JP 2020513626 A JP2020513626 A JP 2020513626A JP 2020533442 A5 JP2020533442 A5 JP 2020533442A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- immunogenic composition
- composition according
- protein conjugate
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023009333A JP7519478B2 (ja) | 2017-09-07 | 2023-01-25 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2024109504A JP2024133653A (ja) | 2017-09-07 | 2024-07-08 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555479P | 2017-09-07 | 2017-09-07 | |
| US62/555,479 | 2017-09-07 | ||
| PCT/US2018/049309 WO2019050816A1 (en) | 2017-09-07 | 2018-09-04 | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009333A Division JP7519478B2 (ja) | 2017-09-07 | 2023-01-25 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533442A JP2020533442A (ja) | 2020-11-19 |
| JP2020533442A5 true JP2020533442A5 (enExample) | 2021-08-19 |
| JP7218358B2 JP7218358B2 (ja) | 2023-02-06 |
Family
ID=65634538
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513626A Active JP7218358B2 (ja) | 2017-09-07 | 2018-09-04 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2023009333A Active JP7519478B2 (ja) | 2017-09-07 | 2023-01-25 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2024109504A Pending JP2024133653A (ja) | 2017-09-07 | 2024-07-08 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009333A Active JP7519478B2 (ja) | 2017-09-07 | 2023-01-25 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2024109504A Pending JP2024133653A (ja) | 2017-09-07 | 2024-07-08 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11389540B2 (enExample) |
| EP (1) | EP3678652A4 (enExample) |
| JP (3) | JP7218358B2 (enExample) |
| KR (1) | KR102736151B1 (enExample) |
| CN (2) | CN111065387B (enExample) |
| AU (2) | AU2018328038B2 (enExample) |
| BR (1) | BR112020004502A8 (enExample) |
| CA (1) | CA3074711A1 (enExample) |
| MX (2) | MX394767B (enExample) |
| WO (1) | WO2019050816A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
| US11197921B2 (en) | 2017-01-31 | 2021-12-14 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| KR20240011879A (ko) | 2017-02-24 | 2024-01-26 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체의 면역원성의 증진 |
| WO2019050818A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | METHODS OF FORMULATING PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| JP2020533437A (ja) * | 2017-09-07 | 2020-11-19 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 肺炎球菌多糖体および免疫原性多糖体−キャリアタンパク質コンジュゲートでのその使用 |
| PL3678654T3 (pl) * | 2017-09-07 | 2024-12-16 | Merck Sharp & Dohme Llc | Polisacharydy pneumokokowe i ich zastosowanie w immunogennych koniugatach polisacharyd-białko nośnikowe |
| US12257295B2 (en) * | 2017-10-04 | 2025-03-25 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| US20210177957A1 (en) | 2017-12-06 | 2021-06-17 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| KR20230008923A (ko) | 2018-02-05 | 2023-01-16 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| KR20190121713A (ko) | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체 |
| WO2019212846A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| WO2019212844A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| AU2019341723C1 (en) | 2018-09-23 | 2025-04-03 | Biological E Limited | Purified capsular polysaccharides of Streptococcus pneumoniae |
| CA3123414A1 (en) | 2018-12-19 | 2020-06-25 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
Family Cites Families (71)
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|---|---|---|---|---|
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| AU2003901717A0 (en) * | 2003-04-10 | 2003-05-01 | Western Sydney Area Health Service | Identification of streptococcus pneumoniae serotypes |
| GB0313250D0 (en) | 2003-06-09 | 2003-07-16 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US20080219960A1 (en) * | 2004-12-16 | 2008-09-11 | Masja Nathalie Nierop Groot | Novel Efficient Production Process for Capsular Polysaccharides of Pathogenic Grampositive Bacteria by Heterologous Expression and Secretion of Complex Polysaccharides in Non-Pathogenic, Non-Invasive Gram-Positive Bacteria |
| CA2597489A1 (en) * | 2005-02-11 | 2006-08-17 | Ace Biosciences A/S | Surface-located streptococcus pneumoniae polypeptides |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| EP2425856A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| MX2007012337A (es) | 2005-04-08 | 2007-11-21 | Wyeth Corp | Separacion de contaminantes de polisacarido de streptococcus pneumoniae por manipulacion de ph. |
| WO2007000341A2 (en) | 2005-06-27 | 2007-01-04 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| HUE032903T2 (hu) | 2005-12-22 | 2017-11-28 | Glaxosmithkline Biologicals Sa | Streptococcus pneumoniae kapszulárispoliszacharid-konjugátumok |
| JP5285431B2 (ja) | 2005-12-28 | 2013-09-11 | ザ ユーエイビー リサーチ ファウンデイション | 肺炎球菌血清型 |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| RU2460539C2 (ru) | 2006-10-10 | 2012-09-10 | Вайет | СПОСОБ ОЧИСТКИ ПОЛИСАХАРИДОВ Streptococcus pneumoniae 3 ТИПА (ВАРИАНТЫ) |
| ES2677353T3 (es) | 2007-03-23 | 2018-08-01 | Wyeth Llc | Procedimiento abreviado de purificación para la producción de polisacáridos capsulares de Streptococcus pneumoniae |
| JP5704916B2 (ja) | 2007-05-29 | 2015-04-22 | ザ ユーエイビー リサーチ ファウンデイション | 肺炎連鎖球菌血清型６ｄ |
| US8540955B2 (en) | 2007-07-10 | 2013-09-24 | Wyeth Llc | Process for producing aluminum phosphate |
| JP2012509658A (ja) | 2008-11-26 | 2012-04-26 | グラクソ グループ リミテッド | Ｉｌ−１３に結合するリガンド |
| EP2385981B1 (en) | 2008-12-18 | 2019-09-04 | Wyeth LLC | Method for controlling streptococcus pneumoniae polysaccharide molecular weight using carbon |
| DK2379734T3 (en) * | 2008-12-18 | 2018-04-23 | Wyeth Llc | Method for Controlling the Molecular Weight of Polysaccharide of Streptococcus Pneumoniae Serotype 19A |
| CA2787429C (en) | 2009-01-27 | 2020-10-20 | World Force Technologies, Llc | A high molecular weight polysaccharide that binds and inhibits virus |
| SG177310A1 (en) | 2009-06-22 | 2012-02-28 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| US8748123B2 (en) | 2009-12-15 | 2014-06-10 | 73100-Setenta e Tres Mil e Cem, Lda. | Fucose-containing bacterial biopolymer |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
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| AU2011338723A1 (en) | 2010-12-10 | 2013-05-30 | Merck Sharp & Dohme Corp. | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
| ES2556951T3 (es) | 2011-05-27 | 2016-01-21 | Universitätsklinikum Freiburg | Polisacárido ramno del complejo clonal 17 de Enterococcus faecium y usos del mismo |
| KR101675657B1 (ko) | 2012-03-19 | 2016-11-11 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | 탄수화물-당지질 컨쥬게이트 백신 |
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| PL3363806T3 (pl) | 2012-12-20 | 2022-12-19 | Pfizer Inc. | Sposób glikokoniugacji |
| EP3096786B1 (en) | 2014-01-21 | 2021-07-07 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
| EP3096783B1 (en) | 2014-01-21 | 2021-07-07 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
| CA2937186C (en) | 2014-01-21 | 2022-11-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CA2956188A1 (en) | 2014-08-08 | 2016-02-11 | Glycovaxyn Ag | Modified host cells for use in bioconjugate production |
| BR112017013891B1 (pt) | 2015-01-15 | 2024-01-30 | Pfizer Inc | Composições imunogênicas para uso em vacinas pneumocócicas |
| NZ736238A (en) | 2015-05-04 | 2022-07-01 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| IL319202A (en) | 2015-11-17 | 2025-04-01 | Pfizer | Substrates for fermentation methods to create polysaccharides in bacterial cells |
| US10786561B2 (en) | 2015-11-20 | 2020-09-29 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| EP3436061A4 (en) | 2016-03-31 | 2019-12-04 | Liffey Biotech Limited | Saccharide-polypeptide-conjugate compositions and methods of use thereof |
| WO2018027126A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
| ES2911490T3 (es) | 2017-01-20 | 2022-05-19 | Pfizer | Composiciones inmunogénicas para su uso en vacunas antineumocócicas |
| CN110225757A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| US11197921B2 (en) | 2017-01-31 | 2021-12-14 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| CN110392690B (zh) | 2017-02-24 | 2024-01-30 | 默沙东有限责任公司 | 肺炎球菌缀合物疫苗制剂 |
| WO2019050818A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | METHODS OF FORMULATING PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN |
| WO2018156465A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier |
| KR20240011879A (ko) | 2017-02-24 | 2024-01-26 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체의 면역원성의 증진 |
| US20200061542A1 (en) | 2017-02-24 | 2020-02-27 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
| WO2019036313A1 (en) | 2017-08-16 | 2019-02-21 | Merck Sharp & Dohme Corp. | CONJUGATED PNEUMOCOCCAL VACCINE FORMULATIONS |
| JP2020533437A (ja) | 2017-09-07 | 2020-11-19 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 肺炎球菌多糖体および免疫原性多糖体−キャリアタンパク質コンジュゲートでのその使用 |
| PL3678654T3 (pl) | 2017-09-07 | 2024-12-16 | Merck Sharp & Dohme Llc | Polisacharydy pneumokokowe i ich zastosowanie w immunogennych koniugatach polisacharyd-białko nośnikowe |
| JP7218358B2 (ja) * | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US20200325020A1 (en) | 2017-10-25 | 2020-10-15 | Merck Sharp & Dohme Corp. | Adjuvanted vaccines |
| US20210177957A1 (en) | 2017-12-06 | 2021-06-17 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| WO2019212844A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| WO2019212846A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US20210223262A1 (en) | 2018-06-07 | 2021-07-22 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| EP3893926A1 (en) | 2018-12-12 | 2021-10-20 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| CA3123414A1 (en) | 2018-12-19 | 2020-06-25 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| EP3980050A4 (en) | 2019-06-05 | 2023-08-02 | Merck Sharp & Dohme LLC | <SMALLCAPS/>? ? ?p PNEUMONIA? ? ? ? METHOD OF TREATMENT OF PATIENTS WITH AN IMMUNOGENIC COMPOSITION PROTECTING AGAINST SEROTYPE 29 |
| EP3980055A4 (en) | 2019-06-05 | 2023-07-26 | Merck Sharp & Dohme LLC | An immunogenic serotype 35b pneumococcal polysaccharide-protein conjugate and conjugation process for making the same |
-
2018
- 2018-09-04 JP JP2020513626A patent/JP7218358B2/ja active Active
- 2018-09-04 EP EP18852846.7A patent/EP3678652A4/en active Pending
- 2018-09-04 AU AU2018328038A patent/AU2018328038B2/en active Active
- 2018-09-04 CN CN201880058214.0A patent/CN111065387B/zh active Active
- 2018-09-04 US US16/645,080 patent/US11389540B2/en active Active
- 2018-09-04 CN CN202311033166.9A patent/CN117018172A/zh active Pending
- 2018-09-04 MX MX2020002556A patent/MX394767B/es unknown
- 2018-09-04 BR BR112020004502A patent/BR112020004502A8/pt unknown
- 2018-09-04 CA CA3074711A patent/CA3074711A1/en active Pending
- 2018-09-04 WO PCT/US2018/049309 patent/WO2019050816A1/en not_active Ceased
- 2018-09-04 KR KR1020207009615A patent/KR102736151B1/ko active Active
-
2020
- 2020-03-05 MX MX2022009928A patent/MX2022009928A/es unknown
-
2022
- 2022-06-24 US US17/848,462 patent/US11964023B2/en active Active
- 2022-06-24 US US17/848,456 patent/US11759523B2/en active Active
-
2023
- 2023-01-25 JP JP2023009333A patent/JP7519478B2/ja active Active
-
2024
- 2024-03-07 AU AU2024201517A patent/AU2024201517A1/en active Pending
- 2024-07-08 JP JP2024109504A patent/JP2024133653A/ja active Pending
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