MX337202B - Vacunas de conjugado carbohidrato-glicolipido. - Google Patents
Vacunas de conjugado carbohidrato-glicolipido.Info
- Publication number
- MX337202B MX337202B MX2014011242A MX2014011242A MX337202B MX 337202 B MX337202 B MX 337202B MX 2014011242 A MX2014011242 A MX 2014011242A MX 2014011242 A MX2014011242 A MX 2014011242A MX 337202 B MX337202 B MX 337202B
- Authority
- MX
- Mexico
- Prior art keywords
- carbohydrate
- vaccines
- conjugate vaccines
- vaccine
- based vaccines
- Prior art date
Links
- 108010060123 Conjugate Vaccines Proteins 0.000 title abstract 2
- 229940031670 conjugate vaccine Drugs 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 4
- 150000001720 carbohydrates Chemical class 0.000 abstract 3
- 235000014633 carbohydrates Nutrition 0.000 abstract 3
- 244000052769 pathogen Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229940023143 protein vaccine Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000005057 refrigeration Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a el campo de la síntesis y evaluación biológica de una clase novedosa de vacunas basadas en carbohidratos. Las nuevas vacunas están compuestas por una estructura multimodular que permite la aplicación aplicar la vacuna a una completa variedad de patógenos. Este método permite la preparación de vacunas contra todos los patógenos que expresan antígenos carbohidrato inmunogénicos. Dado que no se requiere la conjugación de carbohidratos antigénicos a proteínas la vacuna de conjugado es particularmente estable térmicamente. No se requiere refrigeración, una desventaja principal de las vacunas basadas en proteínas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2012054848 | 2012-03-19 | ||
PCT/EP2012/002277 WO2013178236A1 (en) | 2012-05-26 | 2012-05-26 | Carbohydrate-glycolipid conjugate vaccines |
PCT/EP2013/055719 WO2013139803A1 (en) | 2012-03-19 | 2013-03-19 | Carbohydrate-glycolipid conjugate vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014011242A MX2014011242A (es) | 2015-03-09 |
MX337202B true MX337202B (es) | 2016-02-17 |
Family
ID=47901120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014011242A MX337202B (es) | 2012-03-19 | 2013-03-19 | Vacunas de conjugado carbohidrato-glicolipido. |
Country Status (23)
Country | Link |
---|---|
US (1) | US10588962B2 (es) |
EP (1) | EP2827899B1 (es) |
JP (2) | JP5933106B2 (es) |
KR (1) | KR101675657B1 (es) |
CN (1) | CN104321079A (es) |
AR (1) | AR090386A1 (es) |
AU (1) | AU2013237497B2 (es) |
BR (1) | BR112014023193A2 (es) |
CA (1) | CA2866978C (es) |
CY (1) | CY1116706T1 (es) |
DK (1) | DK2827899T3 (es) |
ES (1) | ES2551599T3 (es) |
HK (1) | HK1205682A1 (es) |
HU (1) | HUE028144T2 (es) |
IL (1) | IL234604A (es) |
MX (1) | MX337202B (es) |
PL (1) | PL2827899T3 (es) |
PT (1) | PT2827899E (es) |
RU (1) | RU2649009C2 (es) |
SG (1) | SG11201405646TA (es) |
SI (1) | SI2827899T1 (es) |
TW (1) | TWI633112B (es) |
WO (1) | WO2013139803A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2851092A1 (en) | 2013-09-18 | 2015-03-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Protein and peptide-free synthetic vaccines against streptococcus pneumoniae type 3 |
US10487103B2 (en) | 2015-03-24 | 2019-11-26 | Gifu University | Oligonucleotide derivative, oligonucleotide construct using the same, and methods for producing them |
CN106565800B (zh) * | 2015-10-08 | 2019-08-13 | 中国人民解放军第二军医大学 | 三糖对甲氧基苯酚苷类化合物及其制备方法 |
TWI732825B (zh) * | 2016-05-20 | 2021-07-11 | 日商王子控股股份有限公司 | 圖案形成用定向自組裝組成物、圖案形成用定向自組裝組成物用單體及圖案形成方法 |
CN106620682A (zh) * | 2017-01-19 | 2017-05-10 | 华中师范大学 | 一种脂质体疫苗制剂及其用途和生产IgG抗体的方法 |
JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
CN107955082B (zh) * | 2017-12-11 | 2019-05-10 | 江南大学 | 幽门螺旋杆菌脂多糖外核心八糖的制备方法 |
CN111760021B (zh) * | 2020-05-18 | 2023-06-16 | 广州中医药大学(广州中医药研究院) | 一种含有α-半乳糖神经酰胺类似物与糖抗原的缀合物及其制备方法和应用 |
CN111760020B (zh) * | 2020-05-18 | 2023-05-26 | 广州中医药大学(广州中医药研究院) | 一种缀合物及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5936076A (en) | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
FI20010118A (fi) * | 2001-01-19 | 2002-07-20 | Carbion Oy | Uudet helicobacter pylori reseptorit ja niiden käyttö |
WO2003009812A2 (en) | 2001-07-25 | 2003-02-06 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
WO2006093524A2 (en) * | 2004-07-16 | 2006-09-08 | The General Hospital Corporation | Antigen-carbohydrate conjugates |
US8022043B2 (en) | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
AU2005280163B2 (en) | 2004-08-27 | 2011-11-24 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
GB0419846D0 (en) * | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
WO2007051004A2 (en) * | 2005-10-28 | 2007-05-03 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
CA2702344C (en) | 2007-10-12 | 2016-09-27 | Luigi Panza | Analogues of glycolipids useful as immunoadjuvants |
EP2058011A1 (en) * | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
WO2010083728A1 (en) * | 2009-01-23 | 2010-07-29 | Dapeng Zhou | Nanoparticle formulated glycolipid antigens for immunotherapy |
US8455565B2 (en) | 2011-05-18 | 2013-06-04 | 3M Innovative Properties Company | Disulfide monomers comprising ethylenically unsaturated groups suitable for dental compositions |
-
2013
- 2013-03-19 RU RU2014142043A patent/RU2649009C2/ru active
- 2013-03-19 PT PT137104220T patent/PT2827899E/pt unknown
- 2013-03-19 WO PCT/EP2013/055719 patent/WO2013139803A1/en active Application Filing
- 2013-03-19 TW TW102109653A patent/TWI633112B/zh not_active IP Right Cessation
- 2013-03-19 CN CN201380015125.5A patent/CN104321079A/zh active Pending
- 2013-03-19 JP JP2015500890A patent/JP5933106B2/ja active Active
- 2013-03-19 SI SI201330079T patent/SI2827899T1/sl unknown
- 2013-03-19 SG SG11201405646TA patent/SG11201405646TA/en unknown
- 2013-03-19 ES ES13710422.0T patent/ES2551599T3/es active Active
- 2013-03-19 PL PL13710422T patent/PL2827899T3/pl unknown
- 2013-03-19 KR KR1020147029250A patent/KR101675657B1/ko active IP Right Grant
- 2013-03-19 AU AU2013237497A patent/AU2013237497B2/en active Active
- 2013-03-19 HU HUE13710422A patent/HUE028144T2/en unknown
- 2013-03-19 EP EP13710422.0A patent/EP2827899B1/en active Active
- 2013-03-19 MX MX2014011242A patent/MX337202B/es active IP Right Grant
- 2013-03-19 US US14/385,948 patent/US10588962B2/en active Active
- 2013-03-19 CA CA2866978A patent/CA2866978C/en active Active
- 2013-03-19 DK DK13710422.0T patent/DK2827899T3/en active
- 2013-03-19 BR BR112014023193A patent/BR112014023193A2/pt not_active Application Discontinuation
- 2013-03-20 AR ARP130100898A patent/AR090386A1/es unknown
-
2014
- 2014-09-11 IL IL234604A patent/IL234604A/en active IP Right Grant
-
2015
- 2015-06-30 HK HK15106209.7A patent/HK1205682A1/xx unknown
- 2015-09-25 CY CY20151100848T patent/CY1116706T1/el unknown
-
2016
- 2016-04-27 JP JP2016089305A patent/JP6235648B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
BR112014023193A2 (pt) | 2017-08-01 |
PT2827899E (pt) | 2015-11-18 |
MX2014011242A (es) | 2015-03-09 |
IL234604A (en) | 2016-03-31 |
CN104321079A (zh) | 2015-01-28 |
KR101675657B1 (ko) | 2016-11-11 |
AU2013237497A1 (en) | 2014-10-02 |
US20150238597A1 (en) | 2015-08-27 |
JP5933106B2 (ja) | 2016-06-08 |
WO2013139803A1 (en) | 2013-09-26 |
AU2013237497B2 (en) | 2016-05-12 |
RU2649009C2 (ru) | 2018-03-29 |
JP2015514067A (ja) | 2015-05-18 |
CA2866978A1 (en) | 2013-09-26 |
AR090386A1 (es) | 2014-11-05 |
KR20140138996A (ko) | 2014-12-04 |
CY1116706T1 (el) | 2017-03-15 |
JP6235648B2 (ja) | 2017-11-22 |
ES2551599T3 (es) | 2015-11-20 |
SI2827899T1 (sl) | 2015-11-30 |
CA2866978C (en) | 2019-01-29 |
TW201343662A (zh) | 2013-11-01 |
PL2827899T3 (pl) | 2015-12-31 |
DK2827899T3 (en) | 2015-10-26 |
JP2016183166A (ja) | 2016-10-20 |
EP2827899A1 (en) | 2015-01-28 |
US10588962B2 (en) | 2020-03-17 |
TWI633112B (zh) | 2018-08-21 |
HK1205682A1 (en) | 2015-12-24 |
RU2014142043A (ru) | 2016-05-20 |
EP2827899B1 (en) | 2015-08-05 |
HUE028144T2 (en) | 2016-11-28 |
SG11201405646TA (en) | 2014-10-30 |
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