MX363529B - Vesículas de membrana externa. - Google Patents

Vesículas de membrana externa.

Info

Publication number
MX363529B
MX363529B MX2015002484A MX2015002484A MX363529B MX 363529 B MX363529 B MX 363529B MX 2015002484 A MX2015002484 A MX 2015002484A MX 2015002484 A MX2015002484 A MX 2015002484A MX 363529 B MX363529 B MX 363529B
Authority
MX
Mexico
Prior art keywords
omvs
omv
outer membrane
membrane vesicles
mammal
Prior art date
Application number
MX2015002484A
Other languages
English (en)
Other versions
MX2015002484A (es
Inventor
Grandi Guido
Margarit Y Ros Immaculada
Chiarot Emiliano
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015002484A publication Critical patent/MX2015002484A/es
Publication of MX363529B publication Critical patent/MX363529B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a una composición caracterizada porque comprende una vesícula de membrana externa (OMV) de una bacteria gramnegativa y una proteína heteróloga en su lumen, en donde la proteína heteróloga es una proteína soluble bacteriana o viral; y en donde la composición es capaz de inducir una respuesta inmunitaria a la proteína heteróloga cuando se administra a un mamífero.
MX2015002484A 2012-09-18 2013-09-18 Vesículas de membrana externa. MX363529B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702296P 2012-09-18 2012-09-18
US201361799311P 2013-03-15 2013-03-15
PCT/EP2013/069415 WO2014044728A1 (en) 2012-09-18 2013-09-18 Outer membrane vesicles

Publications (2)

Publication Number Publication Date
MX2015002484A MX2015002484A (es) 2015-06-05
MX363529B true MX363529B (es) 2019-03-27

Family

ID=49237191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015002484A MX363529B (es) 2012-09-18 2013-09-18 Vesículas de membrana externa.

Country Status (9)

Country Link
US (1) US9764027B2 (es)
EP (3) EP2897635A1 (es)
JP (1) JP6283674B2 (es)
CN (1) CN104602702B (es)
AU (1) AU2013320313B2 (es)
CA (1) CA2882382A1 (es)
MX (1) MX363529B (es)
RU (1) RU2662970C2 (es)
WO (1) WO2014044728A1 (es)

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WO2015155178A1 (en) * 2014-04-07 2015-10-15 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for producing outer membrane vesicles
BE1022553A1 (fr) * 2014-05-07 2016-05-31 Glaxosmithkline Biologicals Sa Mutants de spy0269
KR101742236B1 (ko) * 2014-10-29 2017-05-31 인하대학교 산학협력단 쯔쯔가무시병에 대한 면역 조성물 및 이의 제조방법
WO2016193370A1 (en) 2015-06-02 2016-12-08 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Surface display of antigens on gram-negative outer membrane vesicles
CN105861402B (zh) * 2015-07-20 2020-02-14 中国医学科学院医学生物学研究所 将异源蛋白呈递于大肠杆菌外膜囊泡表面的新型疫苗形式
CN106866804B (zh) * 2015-12-11 2021-03-05 中国科学院植物研究所 一种与植物光合作用相关的cam01蛋白及其编码基因和应用
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
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CA3096849A1 (en) * 2018-04-10 2019-10-17 The Administrators Of The Tulane Educational Fund Burkholderia pseudomallei complex outer membrane vesicles as adjuvants
CN109554311B (zh) * 2018-12-18 2022-01-14 中国农业科学院兰州兽医研究所 一种鼠伤寒沙门氏菌外膜囊泡的提取方法
AU2020225473A1 (en) * 2019-02-22 2021-09-30 Evelo Biosciences, Inc. Bacterial membrane preparations
JP7356742B2 (ja) * 2019-04-26 2023-10-05 エムディー ヘルスケア インコーポレイテッド ストレプトコッカスパイオジェネス細菌由来タンパク質及びその用途
CN110272910A (zh) * 2019-06-25 2019-09-24 四川农业大学 一种包括jev抗原基因的重组载体、重组菌株和递呈jev抗原的外膜囊泡及其应用
US20220378902A1 (en) * 2019-08-22 2022-12-01 Sichuan University Bacterial membrane vesicles, and separation and preparation system and method therefor
US20230340035A1 (en) 2020-01-17 2023-10-26 Université Catholique de Louvain Genetically modified bacterium with altered envelop integrity and uses thereof
WO2022026896A2 (en) * 2020-07-30 2022-02-03 Omvax, Inc. Sars-cov-2 receptor binding domain in native outer membrane vesicles
CN117065041B (zh) * 2023-04-04 2024-02-27 山东大学 一种包被载药脂质纳米粒的外膜囊泡及其制备方法和应用

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US20130022633A1 (en) * 2009-10-27 2013-01-24 University Of Florence MENINGOCOCCAL fHBP POLYPEPTIDES
BR112012022896A2 (pt) * 2010-03-18 2018-03-27 Novartis Ag vacinas adjuvantes para meningococos do sorogrupo b
GB201009861D0 (en) * 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
KR20140026392A (ko) * 2011-03-02 2014-03-05 노파르티스 아게 저용량의 항원 및/또는 보조제를 갖는 조합 백신

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EP2897635A1 (en) 2015-07-29
AU2013320313A1 (en) 2015-02-26
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CN104602702B (zh) 2021-08-27
EP3400960A1 (en) 2018-11-14
MX2015002484A (es) 2015-06-05
US20150231232A1 (en) 2015-08-20
RU2662970C2 (ru) 2018-07-31
AU2013320313B2 (en) 2018-07-12
JP2015535812A (ja) 2015-12-17
CN104602702A (zh) 2015-05-06
US9764027B2 (en) 2017-09-19
WO2014044728A1 (en) 2014-03-27
JP6283674B2 (ja) 2018-02-21
EP4056198A2 (en) 2022-09-14
CA2882382A1 (en) 2014-03-27

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